Science 18 March 1994: Vol. 263. no. 5153, pp. 1615 - 1618 DOI: 10.1126/science.8128249

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Articles

Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3{varepsilon}.

J.-F. Brodeur, S. Li, O. Damlaj, and V. P. Dave (2009)
Int. Immunol. 21, 1317-1327
 |  Abstract »  |  Full Text »  |  PDF »

A Single Peptide-MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire.

B. Wang, T. M. Primeau, N. Myers, H. W. Rohrs, M. L. Gross, L. Lybarger, T. H. Hansen, and J. M. Connolly (2009)
Science 326, 871-874
 |  Abstract »  |  Full Text »  |  PDF »

Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression.

L. M. Relland, M. K. Mishra, D. Haribhai, B. Edwards, J. Ziegelbauer, and C. B. Williams (2009)
J. Immunol. 182, 1341-1350
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT.

V. Posevitz, B. Arndt, T. Krieger, N. Warnecke, B. Schraven, and L. Simeoni (2008)
J. Immunol. 180, 1634-1642
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cell Activation Is Governed by TCR-Peptide/MHC Affinity, Not Dissociation Rate.

S. Tian, R. Maile, E. J. Collins, and J. A. Frelinger (2007)
J. Immunol. 179, 2952-2960
 |  Abstract »  |  Full Text »  |  PDF »

{Delta}Np63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

E. Candi, A. Rufini, A. Terrinoni, A. Giamboi-Miraglia, A. M. Lena, R. Mantovani, R. Knight, and G. Melino (2007)
PNAS 104, 11999-12004
 |  Abstract »  |  Full Text »  |  PDF »

The same genomic region conditions clonal deletion and clonal deviation to the CD8{alpha}{alpha} and regulatory T cell lineages in NOD versus C57BL/6 mice.

P. D. Holler, T. Yamagata, W. Jiang, M. Feuerer, C. Benoist, and D. Mathis (2007)
PNAS 104, 7187-7192
 |  Abstract »  |  Full Text »  |  PDF »

TCR-{alpha} CDR3 Loop Audition Regulates Positive Selection.

C. Ferreira, A. Furmanski, M. Millrain, I. Bartok, P. Guillaume, R. Lees, E. Simpson, H. R. MacDonald, and J. Dyson (2006)
J. Immunol. 177, 2477-2485
 |  Abstract »  |  Full Text »  |  PDF »

Impact of effector cell differentiation on CD4+ T cells that evade negative selection by a self-peptide.

A. Boesteanu, A. L. Rankin, and A. J. Caton (2006)
Int. Immunol. 18, 1017-1027
 |  Abstract »  |  Full Text »  |  PDF »

T-bet Down-Modulation in Tolerized Th1 Effector CD4 Cells Confers a TCR-Distal Signaling Defect That Selectively Impairs IFN-{gamma} Expression.

M. Long, A. M. Slaiby, A. T. Hagymasi, M. A. Mihalyo, A. C. Lichtler, S. L. Reiner, and A. J. Adler (2006)
J. Immunol. 176, 1036-1045
 |  Abstract »  |  Full Text »  |  PDF »

Plasticity in the positive selection of T cells: affinity of the selecting antigen and IL-7 affect T cell responsiveness.

R. L. Rubin and T. M. Hermanson (2005)
Int. Immunol. 17, 959-971
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of Six-Transmembrane Epithelial Antigen of the Prostate-Expressing Tumor Cells by Peptide Antigen-Induced Cytotoxic T Lymphocytes.

D. A. Rodeberg, R. A. Nuss, S. F. Elsawa, and E. Celis (2005)
Clin. Cancer Res. 11, 4545-4552
 |  Abstract »  |  Full Text »  |  PDF »

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.

H. Kao and P. M. Allen (2005)
J. Exp. Med. 201, 149-158
 |  Abstract »  |  Full Text »  |  PDF »

2,3,7,8-Tetrachlorodibenzo-p-dioxin Enhances Negative Selection of T Cells in the Thymus but Allows Autoreactive T Cells to Escape Deletion and Migrate to the Periphery.

M. T. Fisher, M. Nagarkatti, and P. S. Nagarkatti (2005)
Mol. Pharmacol. 67, 327-335
 |  Abstract »  |  Full Text »  |  PDF »

Functional Reprogramming of the Primary Immune Response by T Cell Receptor Antagonism.

D. Haribhai, B. Edwards, M. L. Williams, and C. B. Williams (2004)
J. Exp. Med. 200, 1371-1382
 |  Abstract »  |  Full Text »  |  PDF »

The Fourth Way? Harnessing Aggressive Tendencies in the Thymus.

T. A. Baldwin, K. A. Hogquist, and S. C. Jameson (2004)
J. Immunol. 173, 6515-6520
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ CD25+ Regulatory T Cell Repertoire Formation in Response to Varying Expression of a neo-Self-Antigen.

M. A. Lerman, J. Larkin III, C. Cozzo, M. S. Jordan, and A. J. Caton (2004)
J. Immunol. 173, 236-244
 |  Abstract »  |  Full Text »  |  PDF »

An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice.

B. W. Busser, M. P. Cancro, and T. M. Laufer (2004)
Int. Immunol. 16, 1001-1007
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Expansion of the Residual Tumor Antigen-Specific CD8+ T Lymphocytes That Survive Negative Selection in Simian Virus 40 T-Antigen-Transgenic Mice.

T. D. Schell (2004)
J. Virol. 78, 1751-1762
 |  Abstract »  |  Full Text »  |  PDF »

The Impact of Thymic Antigen Diversity on the Size of the Selected T Cell Repertoire.

J. Faro, S. Velasco, A. Gonzalez-Fernandez, and A. Bandeira (2004)
J. Immunol. 172, 2247-2255
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex.

J. D. Mintern, M. M. Maurice, H. L. Ploegh, and E. Schott (2004)
J. Immunol. 172, 699-708
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Treatment of Class II MHC-Deficient Mice with Anti-TCR Antibody Restores the Generation of Circulating CD4 T Cells and Optimal Architecture of Thymic Medulla.

M. Nasreen, T. Ueno, F. Saito, and Y. Takahama (2003)
J. Immunol. 171, 3394-3400
 |  Abstract »  |  Full Text »  |  PDF »

TCR Binding Kinetics Measured with MHC Class I Tetramers Reveal a Positive Selecting Peptide with Relatively High Affinity for TCR.

K. Holmberg, S. Mariathasan, T. Ohteki, P. S. Ohashi, and N. R. J. Gascoigne (2003)
J. Immunol. 171, 2427-2434
 |  Abstract »  |  Full Text »  |  PDF »

Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.

C. Viret, X. He, and C. A. Janeway Jr. (2003)
PNAS 100, 5354-5359
 |  Abstract »  |  Full Text »  |  PDF »

CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells.

T. Chun, M. J. Page, L. Gapin, J. L. Matsuda, H. Xu, H. Nguyen, H.-S. Kang, A. K. Stanic, S. Joyce, W. A. Koltun, et al. (2003)
J. Exp. Med. 197, 907-918
 |  Abstract »  |  Full Text »  |  PDF »

Ligation of Retinoic Acid Receptor {alpha} Regulates Negative Selection of Thymocytes by Inhibiting Both DNA Binding of nur77 and Synthesis of Bim.

E. Szegezdi, I. Kiss, A. Simon, B. Blasko, U. Reichert, S. Michel, M. Sandor, L. Fesus, and Z. Szondy (2003)
J. Immunol. 170, 3577-3584
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Life and Death in the Thymus: Timing Is Everything.

G. Werlen, B. Hausmann, D. Naeher, and E. Palmer (2003)
Science 299, 1859-1863
 |  Abstract »  |  Full Text »  |  PDF »

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation.

Y. Zhan, J. F. Purton, D. I. Godfrey, T. J. Cole, W. R. Heath, and A. M. Lew (2003)
PNAS 100, 1197-1202
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of a Specific Self-Peptide: Self-MHC Class II Complex Is Critical for Positive Selection of Thymocytes Expressing the D10 TCR.

T. Dao, J. M. Blander, and D. B. Sant'Angelo (2003)
J. Immunol. 170, 48-54
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Nicotine Exposure on T Cell Development in Fetal Thymus Organ Culture: Arrest of T Cell Maturation.

A. J. Middlebrook, C. Martina, Y. Chang, R. J. Lukas, and D. DeLuca (2002)
J. Immunol. 169, 2915-2924
 |  Abstract »  |  Full Text »  |  PDF »

Contributions of the T Cell Receptor-associated CD3{gamma}-ITAM to Thymocyte Selection.

M. C. Haks, E. Pepin, J. H.N. van den Brakel, S. A.A. Smeele, S. M. Belkowski, H. W.H.G. Kessels, P. Krimpenfort, and A. M. Kruisbeek (2002)
J. Exp. Med. 196, 1-13
 |  Abstract »  |  Full Text »  |  PDF »

Negative selection of thymocytes expressing the D10 TCR.

D. B. Sant'Angelo and C. A. Janeway Jr. (2002)
PNAS 99, 6931-6936
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance: The Mechanism by Which the IDDM2 Locus May Predispose to Diabetes.

A. A. Chentoufi and C. Polychronakos (2002)
Diabetes 51, 1383-1390
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.

L. K. McNeil and B. D. Evavold (2002)
PNAS 99, 4520-4525
 |  Abstract »  |  Full Text »  |  PDF »

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?.

R. K. Burt, S. Slavin, W. H. Burns, and A. M. Marmont (2002)
Blood 99, 768-784
 |  Abstract »  |  Full Text »  |  PDF »

Can the Low-Avidity Self-Specific T Cell Repertoire Be Exploited for Tumor Rejection?.

T. A. Cordaro, K. E. de Visser, F. H. Tirion, T. N. M. Schumacher, and A. M. Kruisbeek (2002)
J. Immunol. 168, 651-660
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Ca2+/Calmodulin-Dependent Kinase Type IV/Gr in Setting the Thymocyte Selection Threshold.

V. Raman, F. Blaeser, N. Ho, D. L. Engle, C. B. Williams, and T. A. Chatila (2001)
J. Immunol. 167, 6270-6278
 |  Abstract »  |  Full Text »  |  PDF »

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection.

S. Mariathasan, A. Zakarian, D. Bouchard, A. M. Michie, J. C. Zuniga-Pflucker, and P. S. Ohashi (2001)
J. Immunol. 167, 4966-4973
 |  Abstract »  |  Full Text »  |  PDF »

A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor.

T. Sasada, Y. Ghendler, J. M. Neveu, W. S. Lane, and E. L. Reinherz (2001)
J. Exp. Med. 194, 883-892
 |  Abstract »  |  Full Text »  |  PDF »

Low-Avidity Self-Specific T Cells Display a Pronounced Expansion Defect That Can Be Overcome by Altered Peptide Ligands.

K. E. de Visser, T. A. Cordaro, H. W. H. G. Kessels, F. H. Tirion, T. N. M. Schumacher, and A. M. Kruisbeek (2001)
J. Immunol. 167, 3818-3828
 |  Abstract »  |  Full Text »  |  PDF »

Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes.

P. Vafiadis, H. Ounissi-Benkalha, M. Palumbo, R. Grabs, M. Rousseau, C. G. Goodyer, and C. Polychronakos (2001)
J. Clin. Endocrinol. Metab. 86, 3705-3710
 |  Abstract »  |  Full Text »  |  PDF »

Presidential Address to The American Association of Immunologists : Major Histocompatibility Complex Proteins and TCRs: Do They Really Go Together Like a Horse and Carriage?.

P. Marrack, J. Bender, M. Jordan, W. Rees, J. Robertson, B. C. Schaefer, and J. Kappler (2001)
J. Immunol. 167, 617-621
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Flexibility in MHC and TCR Recognition: Degenerate Specificity at the T Cell Level in the Recognition of Promiscuous Th Epitopes Exhibiting No Primary Sequence Homology.

S. K. Joshi, P. R. Suresh, and V. S. Chauhan (2001)
J. Immunol. 166, 6693-6703
 |  Abstract »  |  Full Text »  |  PDF »

A Requirement for IL-2/IL-2 Receptor Signaling in Intrathymic Negative Selection.

H. Bassiri and S. R. Carding (2001)
J. Immunol. 166, 5945-5954
 |  Abstract »  |  Full Text »  |  PDF »

Nonobese Diabetic Mice Display Elevated Levels of Class II-Associated Invariant Chain Peptide Associated with I-Ag7 on the Cell Surface.

A. Bhatnagar, P. J. Milburn, M. Lobigs, R. V. Blanden, and A. M. Gautam (2001)
J. Immunol. 166, 4490-4497
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells.

M. Capone, P. Romagnoli, F. Beermann, H. R. MacDonald, and J. P. M. van Meerwijk (2001)
Blood 97, 1336-1342
 |  Abstract »  |  Full Text »  |  PDF »

The Quantity of TCR Signal Determines Positive Selection and Lineage Commitment of T Cells.

N. Watanabe, H. Arase, M. Onodera, P. S. Ohashi, and T. Saito (2000)
J. Immunol. 165, 6252-6261
 |  Abstract »  |  Full Text »  |  PDF »

A Physiological Ligand of Positive Selection Is Recognized as a Weak Agonist.

R. E. Berg, S. Irion, S. Kattman, M. F. Princiotta, and U. D. Staerz (2000)
J. Immunol. 165, 4209-4216
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of Cyclophilin B and Caspase-Activated Deoxyribonuclease in the Induction of Chromosomal DNA Degradation in TCR-Stimulated Thymocytes.

T. Nagata, H. Kishi, Q. L. Liu, T. Yoshino, T. Matsuda, Z. X. Jin, K. Murayama, K. Tsukada, and A. Muraguchi (2000)
J. Immunol. 165, 4281-4289
 |  Abstract »  |  Full Text »  |  PDF »

TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type.

K. Yasutomo, B. Lucas, and R. N. Germain (2000)
J. Immunol. 165, 3015-3022
 |  Abstract »  |  Full Text »  |  PDF »

Affinity of thymic self-peptides for the TCR determines the selection of CD8+ T lymphocytes in the thymus.

B. T. Ober, Q. Hu, J. T. Opferman, S. Hagevik, N. Chiu, C.-R. Wang, and P. G. Ashton-Rickardt (2000)
Int. Immunol. 12, 1353-1363
 |  Abstract »  |  Full Text »  |  PDF »

Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement.

B. Lucas and R. N. Germain (2000)
J. Immunol. 165, 1889-1895
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-Specific Selection of MHC Class II-Restricted Thymocytes in Fetal Thymic Organ Culture.

G. J. Kersh, D. L. Engle, C. B. Williams, and P. M. Allen (2000)
J. Immunol. 164, 5675-5682
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor {kappa}b Activation, and Bcl-XL Levels in Vivo.

R. G. Jones, M. Parsons, M. Bonnard, V. S.F. Chan, W.-C. Yeh, J. R. Woodgett, and P. S. Ohashi (2000)
J. Exp. Med. 191, 1721-1734
 |  Abstract »  |  Full Text »  |  PDF »

A Physiological Ligand of Positive Selection Is Seen with High Specificity.

S. Irion, R. E. Berg, and U. D. Staerz (2000)
J. Immunol. 164, 4601-4606
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Dendritic Cells Express Inducible Nitric Oxide Synthase and Generate Nitric Oxide in Response to Self- and Alloantigens.

S. Aiello, M. Noris, G. Piccinini, S. Tomasoni, F. Casiraghi, S. Bonazzola, M. Mister, M. H. Sayegh, and G. Remuzzi (2000)
J. Immunol. 164, 4649-4658
 |  Abstract »  |  Full Text »  |  PDF »

Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations.

H. E. Stefanski, S. C. Jameson, and K. A. Hogquist (2000)
J. Immunol. 164, 3519-3526
 |  Abstract »  |  Full Text »  |  PDF »

MEK Activity Regulates Negative Selection of Immature CD4+CD8+ Thymocytes.

U. Bommhardt, Y. Scheuring, C. Bickel, R. Zamoyska, and T. Hunig (2000)
J. Immunol. 164, 2326-2337
 |  Abstract »  |  Full Text »  |  PDF »

The Use of HLA A2.1/p53 Peptide Tetramers to Visualize the Impact of Self Tolerance on the TCR Repertoire.

J. Hernandez, P. P. Lee, M. M. Davis, and L. A. Sherman (2000)
J. Immunol. 164, 596-602
 |  Abstract »  |  Full Text »  |  PDF »

The Selection of M3-Restricted T Cells Is Dependent on M3 Expression and Presentation of N-Formylated Peptides in the Thymus.

N. M. Chiu, B. Wang, K. M. Kerksiek, R. Kurlander, E. G. Pamer, and C.-R. Wang (1999)
J. Exp. Med. 190, 1869-1878
 |  Abstract »  |  Full Text »  |  PDF »

The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.

J. D. Carter, B. G. Neel, and U. Lorenz (1999)
Int. Immunol. 11, 1999-2014
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Avidity and Costimulation Specify the Intracellular Ca2+ Signaling Pattern in Cd4+Cd8+ Thymocytes.

B. D. Freedman, Q.-H. Liu, S. Somersan, M. I. Kotlikoff, and J. A. Punt (1999)
J. Exp. Med. 190, 943-952
 |  Abstract »  |  Full Text »  |  PDF »

A minimal level of MHC class II expression is sufficient to abrogate autoreactivity.

E. S. J. M. de Bont, C. R. Reilly, D. Lo, L. H. Glimcher, and T. M. Laufer (1999)
Int. Immunol. 11, 1295-1306
 |  Abstract »  |  Full Text »  |  PDF »

A Kinetic Threshold between Negative and Positive Selection Based on the Longevity of the T Cell Receptor-Ligand Complex.

C. B. Williams, D. L. Engle, G. J. Kersh, J. Michael White, and P. M. Allen (1999)
J. Exp. Med. 189, 1531-1544
 |  Abstract »  |  Full Text »  |  PDF »

Differential Presentation of an Altered Peptide Within Fetal Central and Peripheral Organs Supports an Avidity Model for Thymic T Cell Development and Implies a Peripheral Readjustment for Activation.

K. L. Legge, B. Min, C. Pack, J. Caprio, and H. Zaghouani (1999)
J. Immunol. 162, 5738-5746
 |  Abstract »  |  Full Text »  |  PDF »

Limiting TCR Expression Leads to Quantitative But Not Qualitative Changes in Thymic Selection.

V. P. Dave, D. Allman, D. L. Wiest, and D. J. Kappes (1999)
J. Immunol. 162, 5764-5774
 |  Abstract »  |  Full Text »  |  PDF »

Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints.

F. Chen, D. Chen, and E. V. Rothenberg (1999)
Int. Immunol. 11, 677-688
 |  Abstract »  |  Full Text »  |  PDF »

Autoantigen-Independent Deletion of Diabetogenic CD4+ Thymocytes by Protective MHC Class II Molecules.

D. Schmidt, A. Amrani, J. Verdaguer, S. Bou, and P. Santamaria (1999)
J. Immunol. 162, 4627-4636
 |  Abstract »  |  Full Text »  |  PDF »

In vitro differentiation of a CD4/CD8 double-positive equivalent thymocyte subset in adult Xenopus.

J. Robert and N. Cohen (1999)
Int. Immunol. 11, 499-508
 |  Abstract »  |  Full Text »  |  PDF »

TCR Signaling Thresholds Regulating T Cell Development and Activation Are Dependent upon SHP-1.

K. G. Johnson, F. G. LeRoy, L. K. Borysiewicz, and R. J. Matthews (1999)
J. Immunol. 162, 3802-3813
 |  Abstract »  |  Full Text »  |  PDF »

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis.

A. Hakem, T. Sasaki, I. Kozieradzki, and J. M. Penninger (1999)
J. Exp. Med. 189, 957-968
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Negative Selection of Immature Thymocytes by a Few Peptide-MHC Complexes: Differential Sensitivity of Immature and Mature T Cells.

D. A. Peterson, R. J. DiPaolo, O. Kanagawa, and E. R. Unanue (1999)
J. Immunol. 162, 3117-3120
 |  Abstract »  |  Full Text »  |  PDF »

The Orientation and Nature of the Interaction Between Beef Insulin-Specific TCRs and the Insulin/Class II MHC Complex.

J. E. Wither and B. Vukusic (1999)
J. Immunol. 162, 2113-2122
 |  Abstract »  |  Full Text »  |  PDF »

Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4+CD8+ thymocytes.

D. Amsen, C. R. Calvo, B. A. Osborne, and A. M. Kruisbeek (1999)
PNAS 96, 622-627
 |  Abstract »  |  Full Text »  |  PDF »

A T Cell Receptor-specific Blockade of Positive Selection.

K. K. Baldwin, P. A. Reay, L. Wu, A. Farr, and M. M. Davis (1999)
J. Exp. Med. 189, 13-24
 |  Abstract »  |  Full Text »  |  PDF »

Signaling in Primary Thymocytes after Presentation of Altered Peptide Ligands by Antigen-presenting Cells or MHC-peptide Tetramers.

L.A. SMYTH, L. REYNOLDS, R. TYRRELL, O. WILLIAMS, T. NORTON, T. SCHUMACHER, V. TYBULEWICZ, S.C. LEY, and D. KIOUSSIS (1999)
Cold Spring Harb Symp Quant Biol 64, 275-282
 |  Abstract »  |  PDF »

In the Normal Repertoire of CD4+ T Cells, a Single Class II MHC/Peptide Complex Positively Selects TCRs with Various Antigen Specificities.

B. Chmielowski, P. Muranski, and L. Ignatowicz (1999)
J. Immunol. 162, 95-105
 |  Abstract »  |  Full Text »  |  PDF »

Altered thymic positive selection and intracellular signals in Cbl-deficient mice.

M. Naramura, H. K. Kole, R.-J. Hu, and H. Gu (1998)
PNAS 95, 15547-15552
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response.

W. M. Ridgway, H. Ito, M. Fasso, C. Yu, and C. Garrison Fathman (1998)
J. Exp. Med. 188, 2267-2275
 |  Abstract »  |  Full Text »  |  PDF »

Vav Regulates Peptide-specific Apoptosis in Thymocytes.

Y.-Y. Kong, K.-D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. M. Penninger (1998)
J. Exp. Med. 188, 2099-2111
 |  Abstract »  |  Full Text »  |  PDF »

Degree of TCR Internalization and Ca2+ Flux Correlates with Thymocyte Selection.

S. Mariathasan, M. F. Bachmann, D. Bouchard, T. Ohteki, and P. S. Ohashi (1998)
J. Immunol. 161, 6030-6037
 |  Abstract »  |  Full Text »  |  PDF »

Central T Cell Tolerance in Lupus-Prone Mice: Influence of Autoimmune Background and the lpr Mutation.

S. Fatenejad, S. L. Peng, O. Disorbo, and J. Craft (1998)
J. Immunol. 161, 6427-6432
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide.

C. N. Levelt, E. Mizoguchi, X. Huang, R. Zacks, A. K. Bhan, and S. Tonegawa (1998)
PNAS 95, 14349-14354
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Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells.

G. M. Davey, S. L. Schober, B. T. Endrizzi, A. K. Dutcher, S. C. Jameson, and K. A. Hogquist (1998)
J. Exp. Med. 188, 1867-1874
 |  Abstract »  |  Full Text »  |  PDF »

Development of Peptide-Selected CD8 T Cells in Fetal Thymic Organ Culture Occurs via the Conventional Pathway.

K. A. Hogquist and J. L. Bonnevier (1998)
J. Immunol. 161, 3896-3901
 |  Abstract »  |  Full Text »  |  PDF »

Antagonist Peptide Selects Thymocytes Expressing a Class II Major Histocompatibility Complex-restricted T Cell Receptor into the CD8 Lineage.

A. Volkmann, T. Barthlott, S. Weiss, R. Frank, and B. Stockinger (1998)
J. Exp. Med. 188, 1083-1089
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Tolerance to a Minor, But Not to a Major, Antigenic Surface of the Self Antigen, Cytochrome c.

R. Jemmerson, J. M. Minnerath, S. M. Hedrick, and S. Oehen (1998)
J. Immunol. 161, 2841-2847
 |  Abstract »  |  Full Text »  |  PDF »

Highly Restricted T Cell Repertoire Shaped by a Single Major Histocompatibility Complex-Peptide Ligand in the Presence of a Single Rearranged T Cell Receptor {beta} Chain.

Y. Fukui, O. Hashimoto, A. Inayoshi, T. Gyotoku, T. Sano, T. Koga, T. Gushima, and T. Sasazuki (1998)
J. Exp. Med. 188, 897-907
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-Specific Allelic Exclusion of TCRV{alpha}-Chains During Development.

R. Boyd, I. Kozieradzki, A. Chidgey, H.-W. Mittrucker, D. Bouchard, E. Timms, K. Kishihara, C. J. Ong, D. Chui, J. D. Marth, et al. (1998)
J. Immunol. 161, 1718-1727
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Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.

L. A. Smyth, O. Williams, R. D. J. Huby, T. Norton, O. Acuto, S. C. Ley, and D. Kioussis (1998)
PNAS 95, 8193-8198
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Expression of a TCR Antagonist: T Cells Escape Central Tolerance But Are Antagonized in the Periphery.

C. B. Williams, K. Vidal, D. Donermeyer, D. A. Peterson, J. M. White, and P. M. Allen (1998)
J. Immunol. 161, 128-137
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire.

O. S. Targoni and P. V. Lehmann (1998)
J. Exp. Med. 187, 2055-2063
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis of the T Cell Repertoire Selected by a Single Peptide-Major Histocompatibility Complex.

L. Gapin, Y. Fukui, J. Kanellopoulos, T. Sano, A. Casrouge, V. Malier, E. Beaudoing, D. Gautheret, J.-M. Claverie, T. Sasazuki, et al. (1998)
J. Exp. Med. 187, 1871-1883
 |  Abstract »  |  Full Text »  |  PDF »

T Cells Expressing Receptors of Different Affinity for Antigen Ligands Reveal a Unique Role for p59fyn in T Cell Development and Optimal Stimulation of T Cells by Antigen.

O. Utting, S.-J. Teh, and H.-S. Teh (1998)
J. Immunol. 160, 5410-5419
 |  Abstract »  |  Full Text »  |  PDF »

Consequences of Intrathymic TCR Engagement by Partial Agonist on Selection Events and Peripheral T Cell Activation Program.

N. Auphan, A. K. Simon, H. Asnagli, R. J. Phillips, M. Rincon, S. Ghosh, R. A. Flavell, and A.-M. Schmitt-Verhulst (1998)
J. Immunol. 160, 4810-4821
 |  Abstract »  |  Full Text »  |  PDF »

Interactions with multiple peptide ligands determine the fate of developing thymocytes.

O. Williams, R. Tarazona, A. Wack, N. Harker, K. Roderick, and D. Kioussis (1998)
PNAS 95, 5706-5711
 |  Abstract »  |  Full Text »  |  PDF »

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