Science 18 March 1994: Vol. 263. no. 5153, pp. 1609 - 1612 DOI: 10.1126/science.8128248

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Articles

cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 {beta}/{alpha} in rat hepatocytes.

A. Gates, S. Hohenester, M. S. Anwer, and C. R. L. Webster (2009)
Am J Physiol Gastrointest Liver Physiol 296, G764-G774
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Growth Factor 1 Receptor/PI3K/AKT Survival Pathway in Outer Segment Membranes of Rod Photoreceptors.

A. K. Dilly and R. V. S. Rajala (2008)
Invest. Ophthalmol. Vis. Sci. 49, 4765-4773
 |  Abstract »  |  Full Text »  |  PDF »

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors.

M. Ouyang, J. Sun, S. Chien, and Y. Wang (2008)
PNAS 105, 14353-14358
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development.

C. O'Neill (2008)
Reproduction 136, 147-156
 |  Abstract »  |  Full Text »  |  PDF »

Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity.

R. Pincheira, A. F. Castro, O. N. Ozes, P. S. Idumalla, and D. B. Donner (2008)
J. Immunol. 181, 1288-1298
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-like Growth Factor-I Stimulates Shc-dependent Phosphatidylinositol 3-Kinase Activation via Grb2-associated p85 in Vascular Smooth Muscle Cells.

Y. Radhakrishnan, L. A. Maile, Y. Ling, L. M. Graves, and D. R. Clemmons (2008)
J. Biol. Chem. 283, 16320-16331
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Mechanism of HIV-1 gp120 and Virion-Induced IL-1{beta} Release in Primary Human Macrophages.

R. Cheung, V. Ravyn, L. Wang, A. Ptasznik, and R. G. Collman (2008)
J. Immunol. 180, 6675-6684
 |  Abstract »  |  Full Text »  |  PDF »

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

F. Garcon, D. T. Patton, J. L. Emery, E. Hirsch, R. Rottapel, T. Sasaki, and K. Okkenhaug (2008)
Blood 111, 1464-1471
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Influenza A Virus NS1 Protein to the Inter-SH2 Domain of p85 Suggests a Novel Mechanism for Phosphoinositide 3-Kinase Activation.

B. G. Hale, I. H. Batty, C. P. Downes, and R. E. Randall (2008)
J. Biol. Chem. 283, 1372-1380
 |  Abstract »  |  Full Text »  |  PDF »

Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.

L. Liu, X. Zhao, S. V. Pierre, and A. Askari (2007)
Am J Physiol Cell Physiol 293, C1489-C1497
 |  Abstract »  |  Full Text »  |  PDF »

PKC{delta} and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin {alpha}5 but not its tailless mutant.

M.-A Oh, E.-S. Kang, S.-A. Lee, E.-O. Lee, Y.-B. Kim, S.-H. Kim, and J. W. Lee (2007)
J. Cell Sci. 120, 2717-2730
 |  Abstract »  |  Full Text »  |  PDF »

A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.

N. Yano, V. Ianus, T. C. Zhao, A. Tseng, J. F. Padbury, and Y.-T. Tseng (2007)
Am J Physiol Heart Circ Physiol 293, H385-H393
 |  Abstract »  |  Full Text »  |  PDF »

Epigallocatechin Gallate, a Green Tea Polyphenol, Mediates NO-dependent Vasodilation Using Signaling Pathways in Vascular Endothelium Requiring Reactive Oxygen Species and Fyn.

J.-a Kim, G. Formoso, Y. Li, M. A. Potenza, F. L. Marasciulo, M. Montagnani, and M. J. Quon (2007)
J. Biol. Chem. 282, 13736-13745
 |  Abstract »  |  Full Text »  |  PDF »

In vivo selection for metastasis promoting genes in the mouse.

K. Gumireddy, F. Sun, A. J. Klein-Szanto, J. M. Gibbins, P. A. Gimotty, A. J. Saunders, P. G. Schultz, and Q. Huang (2007)
PNAS 104, 6696-6701
 |  Abstract »  |  Full Text »  |  PDF »

Class A scavenger receptor-mediated cell adhesion requires the sequential activation of Lyn and PI3-kinase.

D. M. Nikolic, J. Cholewa, C. Gass, M. C. Gong, and S. R. Post (2007)
Am J Physiol Cell Physiol 292, C1450-C1458
 |  Abstract »  |  Full Text »  |  PDF »

Srcasm Corrects Fyn-induced Epidermal Hyperplasia by Kinase Down-regulation.

W. Li, C. Marshall, L. Mei, J. Gelfand, and J. T. Seykora (2007)
J. Biol. Chem. 282, 1161-1169
 |  Abstract »  |  Full Text »  |  PDF »

Perlecan Proteolysis Induces an {alpha}2beta1 Integrin- and Src Family Kinase-dependent Anti-apoptotic Pathway in Fibroblasts in the Absence of Focal Adhesion Kinase Activation.

P. Laplante, M.-A. Raymond, A. Labelle, J.-I. Abe, R. V. Iozzo, and M.-J. Hebert (2006)
J. Biol. Chem. 281, 30383-30392
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of TNF-{alpha} converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

Q. Zhang, S. M. Thomas, V. W. Y. Lui, S. Xi, J. M. Siegfried, H. Fan, T. E. Smithgall, G. B. Mills, and J. R. Grandis (2006)
PNAS 103, 6901-6906
 |  Abstract »  |  Full Text »  |  PDF »

Corneal Cell Survival in Adenovirus Type 19 Infection Requires Phosphoinositide 3-Kinase/Akt Activation.

M. S. Rajala, R. V. S. Rajala, R. A. Astley, A. L. Butt, and J. Chodosh (2005)
J. Virol. 79, 12332-12341
 |  Abstract »  |  Full Text »  |  PDF »

Progressive Degeneration of Human Mesencephalic Neuron-Derived Cells Triggered by Dopamine-Dependent Oxidative Stress Is Dependent on the Mixed-Lineage Kinase Pathway.

J. Lotharius, J. Falsig, J. van Beek, S. Payne, R. Dringen, P. Brundin, and M. Leist (2005)
J. Neurosci. 25, 6329-6342
 |  Abstract »  |  Full Text »  |  PDF »

Recruitment of Phosphoinositide 3-Kinase Defines a Positive Contribution of Tyrosine Kinase Signaling to E-cadherin Function.

J.-H. Pang, A. Kraemer, S. J. Stehbens, M. C. Frame, and A. S. Yap (2005)
J. Biol. Chem. 280, 3043-3050
 |  Abstract »  |  Full Text »  |  PDF »

ErbB4 Expression in Neural Progenitor Cells (ST14A) Is Necessary to Mediate Neuregulin-1{beta}1-induced Migration.

G. Gambarotta, D. Garzotto, E. Destro, B. Mautino, C. Giampietro, S. Cutrupi, C. Dati, E. Cattaneo, A. Fasolo, and I. Perroteau (2004)
J. Biol. Chem. 279, 48808-48816
 |  Abstract »  |  Full Text »  |  PDF »

3,3',5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

J. Lei, C. N. Mariash, and D. H. Ingbar (2004)
J. Biol. Chem. 279, 47589-47600
 |  Abstract »  |  Full Text »  |  PDF »

Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I.

M. Digicaylioglu, G. Garden, S. Timberlake, L. Fletcher, and S. A. Lipton (2004)
PNAS 101, 9855-9860
 |  Abstract »  |  Full Text »  |  PDF »

Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Envelope Glycoprotein gB Induces the Integrin-Dependent Focal Adhesion Kinase-Src-Phosphatidylinositol 3-Kinase-Rho GTPase Signal Pathways and Cytoskeletal Rearrangements.

N. Sharma-Walia, P. P. Naranatt, H. H. Krishnan, L. Zeng, and B. Chandran (2004)
J. Virol. 78, 4207-4223
 |  Abstract »  |  Full Text »  |  PDF »

Osteopontin Induces AP-1-mediated Secretion of Urokinase-type Plasminogen Activator through c-Src-dependent Epidermal Growth Factor Receptor Transactivation in Breast Cancer Cells.

R. Das, G. H. Mahabeleshwar, and G. C. Kundu (2004)
J. Biol. Chem. 279, 11051-11064
 |  Abstract »  |  Full Text »  |  PDF »

c-Kit-Mediated Overlapping and Unique Functional and Biochemical Outcomes via Diverse Signaling Pathways.

L. Hong, V. Munugalavadla, and R. Kapur (2004)
Mol. Cell. Biol. 24, 1401-1410
 |  Abstract »  |  Full Text »  |  PDF »

Agonist-specific Transactivation of Phosphoinositide 3-Kinase Signaling Pathway Mediated by the Dopamine D2 Receptor.

V. D. Nair and S. C. Sealfon (2003)
J. Biol. Chem. 278, 47053-47061
 |  Abstract »  |  Full Text »  |  PDF »

The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLC{gamma}2.

M. Spaargaren, E. A. Beuling, M. L. Rurup, H. P. Meijer, M. D. Klok, S. Middendorp, R. W. Hendriks, and S. T. Pals (2003)
J. Exp. Med. 198, 1539-1550
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85{alpha}, Androgen Receptor, and Src.

M. Sun, L. Yang, R. I. Feldman, X.-m. Sun, K. N. Bhalla, R. Jove, S. V. Nicosia, and J. Q. Cheng (2003)
J. Biol. Chem. 278, 42992-43000
 |  Abstract »  |  Full Text »  |  PDF »

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades.

Y. Lu, Q. Yu, J. H. Liu, J. Zhang, H. Wang, D. Koul, J. S. McMurray, X. Fang, W.K. A. Yung, K. A. Siminovitch, et al. (2003)
J. Biol. Chem. 278, 40057-40066
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Interacts with the Adaptor Protein Dab1 in Response to Reelin Signaling and Is Required for Normal Cortical Lamination.

H. H. Bock, Y. Jossin, P. Liu, E. Forster, P. May, A. M. Goffinet, and J. Herz (2003)
J. Biol. Chem. 278, 38772-38779
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis B Virus X Protein Activates a Survival Signaling by Linking Src to Phosphatidylinositol 3-Kinase.

W.-L. Shih, M.-L. Kuo, S.-E. Chuang, A.-L. Cheng, and S.-L. Doong (2003)
J. Biol. Chem. 278, 31807-31813
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor-Mediated Syk-Independent Activation of Phosphatidylinositol 3-Kinase, Ras, and Mitogen-Activated Protein Kinase Pathways.

T. Yokozeki, K. Adler, D. Lankar, and C. Bonnerot (2003)
J. Immunol. 171, 1328-1335
 |  Abstract »  |  Full Text »  |  PDF »

The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src.

J. M. Summy, Y. Qian, B.-H. Jiang, A. Guappone-Koay, A. Gatesman, X. Shi, and D. C. Flynn (2003)
J. Cell Sci. 116, 2585-2598
 |  Abstract »  |  Full Text »  |  PDF »

Membrane Rafts Play a Crucial Role in Receptor Activator of Nuclear Factor kappa B Signaling and Osteoclast Function.

H. Ha, H. B. Kwak, S. K. Lee, D. S. Na, C. E. Rudd, Z. H. Lee, and H.-H. Kim (2003)
J. Biol. Chem. 278, 18573-18580
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.

M. Baumgartner, P. Angelisova, N. Setterblad, N. Mooney, D. Werling, V. Horejsi, and G. Langsley (2003)
Blood 101, 1874-1881
 |  Abstract »  |  Full Text »  |  PDF »

The p85 Regulatory Subunit Controls Sequential Activation of Phosphoinositide 3-Kinase by Tyr Kinases and Ras.

C. Jimenez, C. Hernandez, B. Pimentel, and A. C. Carrera (2002)
J. Biol. Chem. 277, 41556-41562
 |  Abstract »  |  Full Text »  |  PDF »

Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells.

A. Ptasznik, E. Urbanowska, S. Chinta, M. A. Costa, B. A. Katz, M. A. Stanislaus, G. Demir, D. Linnekin, Z. K. Pan, and A. M. Gewirtz (2002)
J. Exp. Med. 196, 667-678
 |  Abstract »  |  Full Text »  |  PDF »

The Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Modulates the Endocrine Differentiation of Trophoblast Cells.

T. Kamei, S. R. Jones, B. M. Chapman, K. L. MCGonigle, G. Dai, and M. J. Soares (2002)
Mol. Endocrinol. 16, 1469-1481
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of B lymphocyte signalling by the B subunit of Escherichia coli heat-labile enterotoxin.

H. Bone, S. Eckholdt, and N. A. Williams (2002)
Int. Immunol. 14, 647-658
 |  Abstract »  |  Full Text »  |  PDF »

Critical Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Anchorage-independent Growth and Hematogeneous Intrahepatic Metastasis of Liver Cancer.

K. Nakanishi, M. Sakamoto, J. Yasuda, M. Takamura, N. Fujita, T. Tsuruo, S. Todo, and S. Hirohashi (2002)
Cancer Res. 62, 2971-2975
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of the Insulin Receptor {beta}-Subunit with Phosphatidylinositol 3-Kinase in Bovine ROS.

R. V. S. Rajala and R. E. Anderson (2001)
Invest. Ophthalmol. Vis. Sci. 42, 3110-3117
 |  Abstract »  |  Full Text »  |  PDF »

Heregulin-dependent Activation of Phosphoinositide 3-Kinase and Akt via the ErbB2/ErbB3 Co-receptor.

N. J. Hellyer, M.-S. Kim, and J. G. Koland (2001)
J. Biol. Chem. 276, 42153-42161
 |  Abstract »  |  Full Text »  |  PDF »

Human Cytomegalovirus Up-Regulates the Phosphatidylinositol 3-Kinase (PI3-K) Pathway: Inhibition of PI3-K Activity Inhibits Viral Replication and Virus-Induced Signaling.

R. A. Johnson, X. Wang, X.-L. Ma, S.-M. Huong, and E.-S. Huang (2001)
J. Virol. 75, 6022-6032
 |  Abstract »  |  Full Text »  |  PDF »

A CD44 Survival Pathway Triggers Chemoresistance via Lyn Kinase and Phosphoinositide 3-Kinase/Akt in Colon Carcinoma Cells.

R. C. Bates, N. S. Edwards, G. F. Burns, and D. E. Fisher (2001)
Cancer Res. 61, 5275-5283
 |  Abstract »  |  Full Text »  |  PDF »

Src Family Kinases Are Required for Prolactin Induction of Cell Proliferation.

J. A. F. Vara, M. A. D. Caceres, A. Silva, and J. Martin-Perez (2001)
Mol. Biol. Cell 12, 2171-2183
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-{{kappa}}B activation in primary B cells.

H. Bone and N. A. Williams (2001)
Int. Immunol. 13, 807-816
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the EBV/C3d Receptor (CR2, CD21) on Human B Lymphocyte Surface Triggers Tyrosine Phosphorylation of the 95-kDa Nucleolin and Its Interaction with Phosphatidylinositol 3 Kinase.

M. Barel, M. Le Romancer, and R. Frade (2001)
J. Immunol. 166, 3167-3173
 |  Abstract »  |  Full Text »  |  PDF »

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.

L. Xing, A. M. Venegas, A. Chen, L. Garrett-Beal, B. F. Boyce, H. E. Varmus, and P. L. Schwartzberg (2001)
Genes & Dev. 15, 241-253
 |  Abstract »  |  Full Text »

Invasion of Human Epithelial Cells by Pseudomonas aeruginosa Involves Src-Like Tyrosine Kinases p60Src and p59Fyn.

M. Esen, H. Grassme, J. Riethmuller, A. Riehle, K. Fassbender, and E. Gulbins (2001)
Infect. Immun. 69, 281-287
 |  Abstract »  |  Full Text »  |  PDF »

Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85alpha Regulatory Subunit.

K. Ueki, P. Algenstaedt, F. Mauvais-Jarvis, and C. R. Kahn (2000)
Mol. Cell. Biol. 20, 8035-8046
 |  Abstract »  |  Full Text »

Regulation of Cyclin D1 Expression and DNA Synthesis by Phosphatidylinositol 3-Kinase in Airway Smooth Muscle Cells.

K. Page, J. Li, Y. Wang, S. Kartha, R. G. Pestell, and M. B. Hershenson (2000)
Am. J. Respir. Cell Mol. Biol. 23, 436-443
 |  Abstract »  |  Full Text »

Both Src-Dependent and -Independent Mechanisms Mediate Phosphatidylinositol 3-Kinase Regulation of Colony-Stimulating Factor 1-Activated Mitogen-Activated Protein Kinases in Myeloid Progenitors.

A. W.-M. Lee and D. J. States (2000)
Mol. Cell. Biol. 20, 6779-6798
 |  Abstract »  |  Full Text »

Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1.

A. Grey, Y. Chen, I. Paliwal, K. Carlberg, and K. Insogna (2000)
Endocrinology 141, 2129-2138
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene D4 Triggers an Association between Gbeta gamma Subunits and Phospholipase C-gamma 1 in Intestinal Epithelial Cells.

C. K. Thodeti, J. Adolfsson, M. Juhas, and A. Sjolander (2000)
J. Biol. Chem. 275, 9849-9853
 |  Abstract »  |  Full Text »  |  PDF »

Sequential Requirements of the N-Terminal Palmitoylation Site and SH2 Domain of Src Family Kinases in the Initiation and Progression of Fcvarepsilon RI Signaling.

Z.-i. Honda, T. Suzuki, H. Kono, M. Okada, T. Yamamoto, C. Ra, Y. Morita, and K. Yamamoto (2000)
Mol. Cell. Biol. 20, 1759-1771
 |  Abstract »  |  Full Text »

Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the janus kinases.

F. Dong and A. C. Larner (2000)
Blood 95, 1656-1662
 |  Abstract »  |  Full Text »  |  PDF »

E5 Oncoprotein Mutants Activate Phosphoinositide 3-Kinase Independently of Platelet-derived Growth Factor Receptor Activation.

F. A. Suprynowicz, J. Sparkowski, A. Baege, and R. Schlegel (2000)
J. Biol. Chem. 275, 5111-5119
 |  Abstract »  |  Full Text »  |  PDF »

The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.

R Hooshmand-Rad, L Hajkova, P Klint, R Karlsson, B Vanhaesebroeck, L Claesson-Welsh, and C. Heldin (2000)
J. Cell Sci. 113, 207-214
 |  Abstract »  |  PDF »

Selective Regulation of Galpha q/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2.

C. V. Carman, J.-L. Parent, P. W. Day, A. N. Pronin, P. M. Sternweis, P. B. Wedegaertner, A. G. Gilman, J. L. Benovic, and T. Kozasa (1999)
J. Biol. Chem. 274, 34483-34492
 |  Abstract »  |  Full Text »  |  PDF »

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling.

L. O. Beitz, D. A. Fruman, T. Kurosaki, L. C. Cantley, and A. M. Scharenberg (1999)
J. Biol. Chem. 274, 32662-32666
 |  Abstract »  |  Full Text »  |  PDF »

Syk and Bruton's Tyrosine Kinase Are Required for B Cell Antigen Receptor-mediated Activation of the Kinase Akt.

A. Craxton, A. Jiang, T. Kurosaki, and E. A. Clark (1999)
J. Biol. Chem. 274, 30644-30650
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Movement of Green Fluorescent Protein–tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling.

H. Gillham, M. C.H.M. Golding, R. Pepperkok, and W. J. Gullick (1999)
J. Cell Biol. 146, 869-880
 |  Abstract »  |  Full Text »  |  PDF »

The B Cell Antigen Receptor Activates the Akt (Protein Kinase B)/Glycogen Synthase Kinase-3 Signaling Pathway Via Phosphatidylinositol 3-Kinase.

M. R. Gold, M. P. Scheid, L. Santos, M. Dang-Lawson, R. A. Roth, L. Matsuuchi, V. Duronio, and D. L. Krebs (1999)
J. Immunol. 163, 1894-1905
 |  Abstract »  |  Full Text »  |  PDF »

Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKB Receptors.

L. Daulhac, A. Kowalski-Chauvel, L. Pradayrol, N. Vaysse, and C. Seva (1999)
J. Biol. Chem. 274, 20657-20663
 |  Abstract »  |  Full Text »  |  PDF »

Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways.

E. Penuel and G. S. Martin (1999)
Mol. Biol. Cell 10, 1693-1703
 |  Abstract »  |  Full Text »

Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets.

A. Pigazzi, S. Heydrick, F. Folli, S. Benoit, A. Michelson, and J. Loscalzo (1999)
J. Biol. Chem. 274, 14368-14375
 |  Abstract »  |  Full Text »  |  PDF »

Intermolecular Interactions of the p85alpha Regulatory Subunit of Phosphatidylinositol 3-Kinase.

A. G. Harpur, M. J. Layton, P. Das, M. J. Bottomley, G. Panayotou, P. C. Driscoll, and M. D. Waterfield (1999)
J. Biol. Chem. 274, 12323-12332
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Pathway for Tumor Necrosis Factor-alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21ras, and Phosphatidylinositol 3-Kinase.

A. N. Hanna, E. Y. W. Chan, J. Xu, J. C. Stone, and D. N. Brindley (1999)
J. Biol. Chem. 274, 12722-12729
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton's Tyrosine Kinase.

A. M. Buhl and J. C. Cambier (1999)
J. Immunol. 162, 4438-4446
 |  Abstract »  |  Full Text »  |  PDF »

Binding of a Diphosphotyrosine-containing Peptide That Mimics Activated Platelet-derived Growth Factor Receptor beta  Induces Oligomerization of Phosphatidylinositol 3-Kinase.

M. J. Layton, A. G. Harpur, G. Panayotou, P. I. H. Bastiaens, and M. D. Waterfield (1998)
J. Biol. Chem. 273, 33379-33385
 |  Abstract »  |  Full Text »  |  PDF »

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains.

M. Yamabhai, N. G. Hoffman, N. L. Hardison, P. S. McPherson, L. Castagnoli, G. Cesareni, and B. K. Kay (1998)
J. Biol. Chem. 273, 31401-31407
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase.

Y. Lu, B. Cuevas, S. Gibson, H. Khan, R. LaPushin, J. Imboden, and G. B. Mills (1998)
J. Immunol. 161, 5404-5412
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the p85/p110alpha Phosphatidylinositol 3'-Kinase. DISTINCT ROLES FOR THE N-TERMINAL AND C-TERMINAL SH2 DOMAINS.

J. Yu, C. Wjasow, and J. M. Backer (1998)
J. Biol. Chem. 273, 30199-30203
 |  Abstract »  |  Full Text »  |  PDF »

The Src Homology Domain 3 (SH3) of a Yeast Type I Myosin, Myo5p, Binds to Verprolin and Is Required for Targeting to Sites of Actin Polarization.

B. L. Anderson, I. Boldogh, M. Evangelista, C. Boone, L. A. Greene, and L. A. Pon (1998)
J. Cell Biol. 141, 1357-1370
 |  Abstract »  |  Full Text »  |  PDF »

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway.

H. Chin, A. Arai, H. Wakao, R. Kamiyama, N. Miyasaka, and O. Miura (1998)
Blood 91, 3734-3745
 |  Abstract »  |  Full Text »  |  PDF »

c-Src Is Required for Stimulation of Gelsolin-associated Phosphatidylinositol 3-Kinase.

M. Chellaiah, C. Fitzgerald, U. Alvarez, and K. Hruska (1998)
J. Biol. Chem. 273, 11908-11916
 |  Abstract »  |  Full Text »  |  PDF »

Parallel Contractile Signal Transduction Pathways Activated by Receptors for Thrombin and Epidermal Growth Factor-Urogastrone in Guinea Pig Gastric Smooth Muscle: Blockade by Inhibitors of Mitogen-Activated Protein Kinase-Kinase and Phosphatidyl Inositol 3'-Kinase.

X.-L. Zheng, B. Renaux, and M. D. Hollenberg (1998)
J. Pharmacol. Exp. Ther. 285, 325-334
 |  Abstract »  |  Full Text »

Analysis of Signal Transduction Pathways in Human Eosinophils Activated by Chemoattractants and the T-Helper 2-Derived Cytokines Interleukin-4 and Interleukin-5.

P. J. Coffer, R. C. Schweizer, G. R. Dubois, T. Maikoe, J.-W. J. Lammers, and L. Koenderman (1998)
Blood 91, 2547-2557
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the p85/p110 Phosphatidylinositol 3'-Kinase: Stabilization and Inhibition of the p110alpha Catalytic Subunit by the p85 Regulatory Subunit.

J. Yu, Y. Zhang, J. McIlroy, T. Rordorf-Nikolic, G. A. Orr, and J. M. Backer (1998)
Mol. Cell. Biol. 18, 1379-1387
 |  Abstract »  |  Full Text »

A Role for CAP, a Novel, Multifunctional Src Homology 3 Domain-containing Protein in Formation of Actin Stress Fibers and Focal Adhesions.

V. Ribon, R. Herrera, B. K. Kay, and A. R. Saltiel (1998)
J. Biol. Chem. 273, 4073-4080
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Tyrosine Phosphorylation in Human MHC Class II-Positive Antigen-Presenting Cells by Stimulation with Contact Sensitizers.

U. Kuhn, P. Brand, J. Willemsen, H. Jonuleit, A. H. Enk, R. van Brandwijk-Petershans, J. Saloga, J. Knop, and D. Becker (1998)
J. Immunol. 160, 667-673
 |  Abstract »  |  Full Text »  |  PDF »

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization.

A. M. Buhl, C. M. Pleiman, R. C. Rickert, and J. C. Cambier (1997)
J. Exp. Med. 186, 1897-1910
 |  Abstract »  |  Full Text »  |  PDF »

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase.

A. August, A. Sadra, B. Dupont, and H. Hanafusa (1997)
PNAS 94, 11227-11232
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphorylation of the CD3-epsilon Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells.

I. de Aos, M. H. Metzger, M. Exley, C. E. Dahl, S. Misra, D. Zheng, L. Varticovski, C. Terhorst, and J. Sancho (1997)
J. Biol. Chem. 272, 25310-25318
 |  Abstract »  |  Full Text »  |  PDF »

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

A. E. Salcini, S. Confalonieri, M. Doria, E. Santolini, E. Tassi, O. Minenkova, G. Cesareni, P. G. Pelicci, and P. P. Di Fiore (1997)
Genes & Dev. 11, 2239-2249
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3-Kinase.

S. Hunter, B. L. Koch, and S. M. Anderson (1997)
Mol. Endocrinol. 11, 1213-1222
 |  Abstract »  |  Full Text »

Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle.

P. R. Shepherd, B. T. Nave, J. Rincon, L. A. Nolte, A. P. Bevan, K. Siddle, J. R. Zierath, and H. Wallberg-Henriksson (1997)
J. Biol. Chem. 272, 19000-19007
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59fyn in Human T-lymphocytes.

A. Marie-Cardine, E. Bruyns, C. Eckerskorn, H. Kirchgessner, S. C. Meuer, and B. Schraven (1997)
J. Biol. Chem. 272, 16077-16080
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells.

T. Jascur, J. Gilman, and T. Mustelin (1997)
J. Biol. Chem. 272, 14483-14488
 |  Abstract »  |  Full Text »  |  PDF »

Defective Signaling through the B Cell Antigen Receptor in Epstein-Barr Virus-transformed Ataxia-Telangiectasia Cells.

K. K. Khanna, J. Yan, D. Watters, K. Hobson, H. Beamish, K. Spring, Y. Shiloh, R. A. Gatti, and M. F. Lavin (1997)
J. Biol. Chem. 272, 9489-9495
 |  Abstract »  |  Full Text »  |  PDF »

Ras-independent transformation by v-Src.

D. T. Aftab, J. Kwan, and G. S. Martin (1997)
PNAS 94, 3028-3033
 |  Abstract »  |  Full Text »  |  PDF »

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal..

S G Kennedy, A J Wagner, S D Conzen, J Jordan, A Bellacosa, P N Tsichlis, and N Hay (1997)
Genes & Dev. 11, 701-713
 |  Abstract »  |  PDF »

Granulocyte-Macrophage Colony-Stimulating Factor-Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3-Kinase and Inhibition by Phorbol Esters.

A. Al-Shami, S. G. Bourgoin, and P. H. Naccache (1997)
Blood 89, 1035-1044
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Cbl following Stimulation with Interleukin-3 and Its Association with Grb2, Fyn, and Phosphatidylinositol 3-Kinase.

S. M. Anderson, E. A. Burton, and B. L. Koch (1997)
J. Biol. Chem. 272, 739-745
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85alpha  subunit.

A. Musacchio, L. C. Cantley, and S. C. Harrison (1996)
PNAS 93, 14373-14378
 |  Abstract »  |  Full Text »  |  PDF »

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase. ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS.

K. Datta, A. Bellacosa, T. O. Chan, and P. N. Tsichlis (1996)
J. Biol. Chem. 271, 30835-30839
 |  Abstract »  |  Full Text »  |  PDF »

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils.

A. Ptasznik, E. R. Prossnitz, D. Yoshikawa, A. Smrcka, A. E. Traynor-Kaplan, and G. M. Bokoch (1996)
J. Biol. Chem. 271, 25204-25207
 |  Abstract »  |  Full Text »  |  PDF »

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