Science 18 March 1994: Vol. 263. no. 5153, pp. 1603 - 1606 DOI: 10.1126/science.8128246

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Articles

Mendelian Inheritance of Pupal Diapause in the Flesh Fly, Sarcophaga bullata.

B. Han and D. L. Denlinger (2009)
J. Hered. 100, 251-255
 |  Abstract »  |  Full Text »  |  PDF »

Modeling the Drosophila melanogaster Circadian Oscillator via Phase Optimization.

N. Bagheri, M. J. Lawson, J. Stelling, and F. J. Doyle (2008)
J Biol Rhythms 23, 525-537
 |  Abstract »  |  PDF »

A Tribute to Seymour Benzer, 1921-2007.

N. M. Bonini (2008)
Genetics 180, 1265-1273
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Peripheral circadian clock for the cuticle deposition rhythm in Drosophila melanogaster.

C. Ito, S. G. Goto, S. Shiga, K. Tomioka, and H. Numata (2008)
PNAS 105, 8446-8451
 |  Abstract »  |  Full Text »  |  PDF »

Axonal Injury and Regeneration in the Adult Brain of Drosophila.

D. Ayaz, M. Leyssen, M. Koch, J. Yan, M. Srahna, V. Sheeba, K. J. Fogle, T. C. Holmes, and B. A. Hassan (2008)
J. Neurosci. 28, 6010-6021
 |  Abstract »  |  Full Text »  |  PDF »

Electrical Silencing of PDF Neurons Advances the Phase of non-PDF Clock Neurons in Drosophila.

Y. Wu, G. Cao, and M. N. Nitabach (2008)
J Biol Rhythms 23, 117-128
 |  Abstract »  |  PDF »

Probing the Relative Importance of Molecular Oscillations in the Circadian Clock.

X. Zheng and A. Sehgal (2008)
Genetics 178, 1147-1155
 |  Abstract »  |  Full Text »  |  PDF »

Salad Days in the Rhythms Trade.

J. C. Dunlap (2008)
Genetics 178, 1-13
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The 2006 Pittendrigh/Aschoff Lecture: New Roles for Old Proteins in the Drosophila Circadian Clock.

P. Meyer and M. W. Young (2007)
J Biol Rhythms 22, 283-290
 |  Abstract »  |  PDF »

A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.

A. Matsumoto, M. Ukai-Tadenuma, R. G. Yamada, J. Houl, K. D. Uno, T. Kasukawa, B. Dauwalder, T. Q. Itoh, K. Takahashi, R. Ueda, et al. (2007)
Genes & Dev. 21, 1687-1700
 |  Abstract »  |  Full Text »  |  PDF »

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.

S. Kadener, D. Stoleru, M. McDonald, P. Nawathean, and M. Rosbash (2007)
Genes & Dev. 21, 1675-1686
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Drosophila Behavioral and Molecular Circadian Rhythms by Temperature Steps in Constant Light.

T. Yoshii, K. Fujii, and K. Tomioka (2007)
J Biol Rhythms 22, 103-114
 |  Abstract »  |  PDF »

A PER/TIM/DBT Interval Timer for Drosophila's Circadian Clock.

L. Saez, P. Meyer, and M. W. Young (2007)
Cold Spring Harb Symp Quant Biol 72, 69-74
 |  Abstract »  |  PDF »

Principles and Problems Revolving Round Rhythm-related Genetic Variants.

J. C. Hall, D. C. Chang, and E. Dolezelova (2007)
Cold Spring Harb Symp Quant Biol 72, 215-232
 |  Abstract »  |  PDF »

Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock.

N. Peschel, S. Veleri, and R. Stanewsky (2006)
PNAS 103, 17313-17318
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: A Drosophila model for age-associated changes in sleep:wake cycles.

K. Koh, J. M. Evans, J. C. Hendricks, and A. Sehgal (2006)
PNAS 103, 13843-13847
 |  Abstract »  |  Full Text »  |  PDF »

Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila.

S. Kadener, A. Villella, E. Kula, K. Palm, E. Pyza, J. Botas, J. C. Hall, and M. Rosbash (2006)
PNAS 103, 13537-13542
 |  Abstract »  |  Full Text »  |  PDF »

Clock-Gated Photic Stimulation of Timeless Expression at Cold Temperatures and Seasonal Adaptation in Drosophila.

W.-F. Chen, J. Majercak, and I. Edery (2006)
J Biol Rhythms 21, 256-271
 |  Abstract »  |  PDF »

Drosophila Olfactory Response Rhythms Require Clock Genes but Not Pigment Dispersing Factor or Lateral Neurons.

X. Zhou, C. Yuan, and A. Guo (2005)
J Biol Rhythms 20, 237-244
 |  Abstract »  |  PDF »

The Double-Time Protein Kinase Regulates the Subcellular Localization of the Drosophila Clock Protein Period.

S. A. Cyran, G. Yiannoulos, A. M. Buchsbaum, L. Saez, M. W. Young, and J. Blau (2005)
J. Neurosci. 25, 5430-5437
 |  Abstract »  |  Full Text »  |  PDF »

The Novel Drosophila timblind Mutation Affects Behavioral Rhythms but Not Periodic Eclosion.

C. Wulbeck, G. Szabo, O. T. Shafer, C. Helfrich-Forster, and R. Stanewsky (2005)
Genetics 169, 751-766
 |  Abstract »  |  Full Text »  |  PDF »

Finding New Clock Components: Past and Future.

J. S. Takahashi (2004)
J Biol Rhythms 19, 339-347
 |  Abstract »  |  PDF »

Splicing of the period Gene 3'-Terminal Intron Is Regulated by Light, Circadian Clock Factors, and Phospholipase C.

J. Majercak, W.-F. Chen, and I. Edery (2004)
Mol. Cell. Biol. 24, 3359-3372
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila doubletime Mutations Which either Shorten or Lengthen the Period of Circadian Rhythms Decrease the Protein Kinase Activity of Casein Kinase I.

F. Preuss, J.-Y. Fan, M. Kalive, S. Bao, E. Schuenemann, E. S. Bjes, and J. L. Price (2004)
Mol. Cell. Biol. 24, 886-898
 |  Abstract »  |  Full Text »  |  PDF »

Noncircadian Regulation and Function of Clock Genes Period and Timeless in Oogenesis of Drosophila Melanogaster.

L. M. Beaver, B. L. Rush, B. O. Gvakharia, and J. M. Giebultowicz (2003)
J Biol Rhythms 18, 463-472
 |  Abstract »  |  PDF »

Requirement of Mammalian Timeless for Circadian Rhythmicity.

J. W. Barnes, S. A. Tischkau, J. A. Barnes, J. W. Mitchell, P. W. Burgoon, J. R. Hickok, and M. U. Gillette (2003)
Science 302, 439-442
 |  Abstract »  |  Full Text »  |  PDF »

Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism.

J. A. T. DOW and S. A. DAVIES (2003)
Physiol Rev 83, 687-729
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Models in Applied Physiology: Invited Review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms.

J. C. Hendricks (2003)
J Appl Physiol 94, 1660-1672
 |  Abstract »  |  Full Text »  |  PDF »

Mapping of Elements Involved in Regulating Normal Temporal period and timeless RNA Expression Patterns in Drosophila melanogaster.

R. Stanewsky, K. S. Lynch, C. Brandes, and J. C. Hall (2002)
J Biol Rhythms 17, 293-306
 |  Abstract »  |  PDF »

Sequential Nuclear Accumulation of the Clock Proteins Period and Timeless in the Pacemaker Neurons of Drosophila melanogaster.

O. T. Shafer, M. Rosbash, and J. W. Truman (2002)
J. Neurosci. 22, 5946-5954
 |  Abstract »  |  Full Text »  |  PDF »

Genome-wide Transcriptional Orchestration of Circadian Rhythms in Drosophila.

H. R. Ueda, A. Matsumoto, M. Kawamura, M. Iino, T. Tanimura, and S. Hashimoto (2002)
J. Biol. Chem. 277, 14048-14052
 |  Abstract »  |  Full Text »  |  PDF »

Loss of circadian clock function decreases reproductive fitness in males of Drosophilamelanogaster.

L. M. Beaver, B. O. Gvakharia, T. S. Vollintine, D. M. Hege, R. Stanewsky, and J. M. Giebultowicz (2002)
PNAS 99, 2134-2139
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Circadian-Clock-Regulated Enhancers and Genes of Drosophila melanogaster by Transposon Mobilization and Luciferase Reporting of Cyclical Gene Expression.

T. Stempfl, M. Vogel, G. Szabo, C. Wulbeck, J. Liu, J. C. Hall, and R. Stanewsky (2002)
Genetics 160, 571-593
 |  Abstract »  |  Full Text »  |  PDF »

PAS Domain-Mediated WC-1/WC-2 Interaction Is Essential for Maintaining the Steady-State Level of WC-1 and the Function of Both Proteins in Circadian Clock and Light Responses of Neurospora.

P. Cheng, Y. Yang, K. H. Gardner, and Y. Liu (2002)
Mol. Cell. Biol. 22, 517-524
 |  Abstract »  |  Full Text »  |  PDF »

A Receptor-type Guanylyl Cyclase Expression Is Regulated under Circadian Clock in Peripheral Tissues of the Silk Moth. LIGHT-INDUCED SHIFTING OF THE EXPRESSION RHYTHM AND CORRELATION WITH ECLOSION.

S. Tanoue and T. Nishioka (2001)
J. Biol. Chem. 276, 46765-46769
 |  Abstract »  |  Full Text »  |  PDF »

Book Review: Molecular Regulation of Circadian Rhythms in Drosophila and Mammals.

E. L. Meyer-Bernstein and A. Sehgal (2001)
Neuroscientist 7, 496-505
 |  Abstract »  |  PDF »

Clockless Yeast and the Gears of the Clock: How Do They Mesh?.

R. Baler (2001)
J Biol Rhythms 16, 516-522
 |  Abstract »  |  PDF »

Photic Signaling by Cryptochrome in the Drosophila Circadian System.

F.-J. Lin, W. Song, E. Meyer-Bernstein, N. Naidoo, and A. Sehgal (2001)
Mol. Cell. Biol. 21, 7287-7294
 |  Abstract »  |  Full Text »  |  PDF »

The Drosophila double-timeS Mutation Delays the Nuclear Accumulation of period Protein and Affects the Feedback Regulation of period mRNA.

S. Bao, J. Rihel, E. Bjes, J.-Y. Fan, and J. L. Price (2001)
J. Neurosci. 21, 7117-7126
 |  Abstract »  |  Full Text »  |  PDF »

Phase Response Curves of a Molecular Model Oscillator: Implications for Mutual Coupling of Paired Oscillators.

B. Petri and M. Stengl (2001)
J Biol Rhythms 16, 125-141
 |  Abstract »  |  PDF »

Specific Sequences Outside the E-box Are Required for Proper per Expression and Behavioral Rescue.

L. C. Lyons, T. K. Darlington, H. Hao, J. Houl, S. A. Kay, and P. E. Hardin (2000)
J Biol Rhythms 15, 472-482
 |  Abstract »  |  PDF »

Specific Genetic Interference With Behavioral Rhythms in Drosophila by Expression of Inverted Repeats.

S. Martinek and M. W. Young (2000)
Genetics 156, 1717-1725
 |  Abstract »  |  Full Text »

Isolation and Analysis of Six timeless Alleles That Cause Short- or Long-Period Circadian Rhythms in Drosophila.

A. Rothenfluh, M. Abodeely, J. L. Price, and M. W. Young (2000)
Genetics 156, 665-675
 |  Abstract »  |  Full Text »

Circadian rhythms in a nutshell.

I. EDERY (2000)
Physiol Genomics 3, 59-74
 |  Abstract »  |  Full Text »  |  PDF »

Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations.

A. J. Hunter, P. M. Nolan, and S. D.M. Brown (2000)
Hum. Mol. Genet. 9, 893-900
 |  Abstract »  |  Full Text »  |  PDF »

dCLOCK Is Present in Limiting Amounts and Likely Mediates Daily Interactions between the dCLOCK-CYC Transcription Factor and the PER-TIM Complex.

K. Bae, C. Lee, P. E. Hardin, and I. Edery (2000)
J. Neurosci. 20, 1746-1753
 |  Abstract »  |  Full Text »  |  PDF »

Altered Entrainment and Feedback Loop Function Effected by a Mutant Period Protein.

P. Schotland, M. Hunter-Ensor, T. Lawrence, and A. Sehgal (2000)
J. Neurosci. 20, 958-968
 |  Abstract »  |  Full Text »  |  PDF »

Interlocked Feedback Loops Within the Drosophila Circadian Oscillator.

N. R. Glossop, L. C. Lyons, and P. E. Hardin (1999)
Science 286, 766-768
 |  Abstract »  |  Full Text »

Requirement of Circadian Genes for Cocaine Sensitization in Drosophila.

R. Andretic, S. Chaney, and J. Hirsh (1999)
Science 285, 1066-1068
 |  Abstract »  |  Full Text »

Biological clocks.

N. Ishida, M. Kaneko, and R. Allada (1999)
PNAS 96, 8819-8820
 |  Abstract »  |  Full Text »  |  PDF »

PER and TIM Inhibit the DNA Binding Activity of a Drosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription.

C. Lee, K. Bae, and I. Edery (1999)
Mol. Cell. Biol. 19, 5316-5325
 |  Abstract »  |  Full Text »  |  PDF »

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei.

K. Obrietan, S. Impey, D. Smith, J. Athos, and D. R. Storm (1999)
J. Biol. Chem. 274, 17748-17756
 |  Abstract »  |  Full Text »  |  PDF »

A Model of Molecular Circadian Clocks: Multiple Mechanisms for Phase Shifting and a Requirement for Strong Nonlinear Interactions.

T. O. Scheper, D. Klinkenberg, J. van Pelt, and C. Pennartz (1999)
J Biol Rhythms 14, 213-220
 |  Abstract »  |  PDF »

The 69 bp Circadian Regulatory Sequence (CRS) Mediates per-Like Developmental, Spatial, and Circadian Expression and Behavioral Rescue in Drosophila.

H. Hao, N. R. J. Glossop, L. Lyons, J. Qiu, B. Morrish, Y. Cheng, C. Helfrich-Forster, and P. Hardin (1999)
J. Neurosci. 19, 987-994
 |  Abstract »  |  Full Text »  |  PDF »

Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators.

K. Bae, C. Lee, D. Sidote, K.-y. Chuang, and I. Edery (1998)
Mol. Cell. Biol. 18, 6142-6151
 |  Abstract »  |  Full Text »

Alterations of per RNA in Noncoding Regions Affect Periodicity of Circadian Behavioral Rhythms.

Y. Chen, M. Hunter-Ensor, P. Schotland, and A. Sehgal (1998)
J Biol Rhythms 13, 364-379
 |  Abstract »  |  PDF »

The timSL Mutant Affects a Restricted Portion of the Drosophila melanogaster Circadian Cycle.

J. E. Rutila, O. Maltseva, and M. Rosbash (1998)
J Biol Rhythms 13, 380-392
 |  Abstract »  |  PDF »

Differential Effects of Light and Heat on the Drosophila Circadian Clock Proteins PER and TIM.

D. Sidote, J. Majercak, V. Parikh, and I. Edery (1998)
Mol. Cell. Biol. 18, 2004-2013
 |  Abstract »  |  Full Text »

The Suprachiasmatic Nucleus: A 25-Year Retrospective.

D. R. Weaver (1998)
J Biol Rhythms 13, 100-112
 |  Abstract »  |  PDF »

A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins.

J.-C. Leloup and A. Goldbeter (1998)
J Biol Rhythms 13, 70-87
 |  Abstract »  |  PDF »

Conserved Regions of the timeless (tim) Clock Gene in Drosophila Analyzed Through Phylogenetic and Functional Studies.

A. Ousley, K. Zafarullah, Y. Chen, M. Emerson, L. Hickman, and A. Sehgal (1998)
Genetics 148, 815-826
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila Photoreceptors Contain an Autonomous Circadian Oscillator That Can Function without period mRNA Cycling.

Y. Cheng and P. E. Hardin (1998)
J. Neurosci. 18, 741-750
 |  Abstract »  |  Full Text »  |  PDF »

Independent Photoreceptive Circadian Clocks Throughout Drosophila.

J. D. Plautz, M. Kaneko, J. C. Hall, and S. A. Kay (1997)
Science 278, 1632-1635
 |  Abstract »  |  Full Text »

Spatial and Temporal Expression of the period and timeless Genes in the Developing Nervous System of Drosophila: Newly Identified Pacemaker Candidates and Novel Features of Clock Gene Product Cycling.

M. Kaneko, C. Helfrich-Forster, and J. C. Hall (1997)
J. Neurosci. 17, 6745-6760
 |  Abstract »  |  Full Text »  |  PDF »

Rhythmic Expression of a PER-Reporter in the Malpighian Tubules of Decapitated Drosophila: Evidence for a Brain-Independent Circadian Clock.

D. M. Hege, R. Stanewsky, J. C. Hall, and J. M. Giebultowicz (1997)
J Biol Rhythms 12, 300-308
 |  Abstract »  |  PDF »

REVIEW {blacksquare} : The Suprachiasmatic Nucleus: A Circadian Oscillator.

Y. Ibata, M. Tanaka, Y. Tamada, S. Hayashi, F. Kawakami, T. Takamatsu, Y. Hisa, and H. Okamura (1997)
Neuroscientist 3, 215-225
 |  Abstract »  |  PDF »

Quantitative Analysis of Drosophila period Gene Transcription in Living Animals.

J. D. Plautz, M. Straume, R. Stanewsky, C. F. Jamison, C. Brandes, H. B. Dowse, J. C. Hall, and S. A. Kay (1997)
J Biol Rhythms 12, 204-217
 |  Abstract »  |  PDF »

Rhythms of Drosophila period gene expression in culture.

I. F. Emery, J. M. Noveral, C. F. Jamison, and K. K. Siwicki (1997)
PNAS 94, 4092-4096
 |  Abstract »  |  Full Text »  |  PDF »

Circadian Cycling of a PERIOD-{beta}-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation.

M. E. Dembinska, R. Stanewsky, J. C. Hall, and M. Rosbash (1997)
J Biol Rhythms 12, 157-172
 |  Abstract »  |  PDF »

Temporal and Spatial Expression Patterns of Transgenes Containing Increasing Amounts of the Drosophila Clock Gene period and a lacZ Reporter: Mapping Elements of the PER Protein Involved in Circadian Cycling.

R. Stanewsky, B. Frisch, C. Brandes, M. J. Hamblen-Coyle, M. Rosbash, and J. C. Hall (1997)
J. Neurosci. 17, 676-696
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin.

C. B. Green and J. C. Besharse (1996)
PNAS 93, 14884-14888
 |  Abstract »  |  Full Text »  |  PDF »

A Drosophila Circadian Clock.

M. Rosbash, R. Allada, M. Dembinska, W.Q. Guo, M. Le, S. Marrus, Z. Qian, J. Rutila, J. Yaglom, and H. Zeng (1996)
Cold Spring Harb Symp Quant Biol 61, 265-278
 |  Abstract »  |  PDF »

Molecular Anatomy of a Light-sensitive Circadian Pacemaker in Drosophila.

M.W. Young, K. Wager-Smith, L. Vosshall, L. Saez, and M.P. Myers (1996)
Cold Spring Harb Symp Quant Biol 61, 279-284
 |  Abstract »  |  PDF »

Forward Genetic Approaches to Circadian Clocks in Mice.

D.P. King and J.S. Takahashi (1996)
Cold Spring Harb Symp Quant Biol 61, 295-302
 |  Abstract »  |  PDF »

Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless.

M. P. Myers, K. Wager-Smith, C. S. Wesley, M. W. Young, and A. Sehgal (1995)
Science 270, 805-808
 |  Abstract »  |  PDF »

Rhythmic Expression of timeless: A Basis for Promoting Circadian Cycles in period Gene Autoregulation.

A. Sehgal, A. Rothenfluh-Hilfiker, M. Hunter-Ensor, Y. Chen, M. P. Myers, and M. W. Young (1995)
Science 270, 808-810
 |  Abstract »  |  PDF »

Isolation of timeless by PER Protein Interaction: Defective Interaction Between timeless Protein and Long-Period Mutant PER^L.

N. Gekakis, L. Saez, A.-M. Delahaye-Brown, M. P. Myers, A. Sehgal, M. W. Young, and C. J. Weitz (1995)
Science 270, 811-815
 |  Abstract »  |  PDF »

An Ultrashort Clock Mutation at the period Locus of Drosophila melanogaster That Reveals Some New Features of the Fly's Circadian System.

R. J. Konopka, M. J. Hamblen-Coyle, C. F. Jamison, and J. C. Hall (1994)
J Biol Rhythms 9, 189-216
 |  Abstract »  |  PDF »

The mating of a fly.

J. Hall (1994)
Science 264, 1702-1714
 |  Abstract »  |  PDF »

Time is the essence: molecular analysis of the biological clock.

T. Page (1994)
Science 263, 1570-1572
 |  PDF »

Block in nuclear localization of period protein by a second clock mutation, timeless.

L. Vosshall, J. Price, A Sehgal, L Saez, and M. Young (1994)
Science 263, 1606-1609
 |  Abstract »  |  PDF »

Circadian Activation of Bullfrog Retinal Mitogen-activated Protein Kinase Associates with Oscillator Function.

Y. Harada, K. Sanada, and Y. Fukada (2000)
J. Biol. Chem. 275, 37078-37085
 |  Abstract »  |  Full Text »  |  PDF »

Circadian rhythms of female mating activity governed by clock genes in Drosophila.

T. Sakai and N. Ishida (2001)
PNAS 98, 9221-9225
 |  Abstract »  |  Full Text »  |  PDF »

Oscillation and Light Induction of timeless mRNA in the Mammalian Circadian Clock.

S. A. Tischkau, J. A. Barnes, F.-J. Lin, E. M. Myers, J. W. Soucy, E. L. Meyer-Bernstein, W. J. Hurst, P. W. Burgoon, D. Chen, A. Sehgal, et al. (1999)
J. Neurosci. 19, RC15
 |  Abstract »  |  Full Text »  |  PDF »

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