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Science 18 March 1994:
Vol. 263. no. 5153, pp. 1578 - 1584
DOI: 10.1126/science.8128244
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Articles

Science, Vol 263, Issue 5153, 1578-1584
Copyright © 1994 by American Association for the Advancement of Science

articles

Negative feedback defining a circadian clock: autoregulation of the clock gene frequency

BD Aronson, KA Johnson, JJ Loros, and JC Dunlap

Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794.

The frequency (frq) locus of Neurospora crassa was originally identified in searches for loci encoding components of the circadian clock. The frq gene is now shown to encode a central component in a molecular feedback loop in which the product of frq negatively regulated its own transcript, which resulted in a daily oscillation in the amount of frq transcript. Rhythmic messenger RNA expression was essential for overt rhythmicity in the organism and no amount of constitutive expression rescued normal rhythmicity in frq loss-of-function mutants. Step reductions in the amount of FRQ-encoding transcript set the clock to a specific and predicted phase. These results establish frq as encoding a central component in a circadian oscillator.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Circadian Clock-Specific Roles for the Light Response Protein WHITE COLLAR-2.
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J Biol Rhythms 14, 469-479
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The Physiology and Molecular Bases of the Plant Circadian Clock.
D. E. Somers (1999)
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J Biol Rhythms 14, 213-220
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A Mathematical Model for the Intracellular Circadian Rhythm Generator.
T. o. Scheper, D. Klinkenberg, C. Pennartz, and J. van Pelt (1999)
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Expression of a Gene Cluster kaiABC as a Circadian Feedback Process in Cyanobacteria.
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Molecular Circadian Oscillators: An Alternative Hypothesis.
T. Roenneberg and M. Merrow (1998)
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R. D. Ross (1998)
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A. Ousley, K. Zafarullah, Y. Chen, M. Emerson, L. Hickman, and A. Sehgal (1998)
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The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana.
D. Somers, A. Webb, M Pearson, and S. Kay (1998)
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Luteinizing Hormone-Releasing Hormone (LHRH) Neurons Maintained in Hypothalamic Slice Explant Cultures Exhibit a Rapid LHRH mRNA Turnover Rate.
J. A. Maurer and S. Wray (1997)
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Circadian Phase Shifts to Neuropeptide Y In Vitro: Cellular Communication and Signal Transduction.
S. M. Biello, D. A. Golombek, K. M. Schak, and M. E. Harrington (1997)
J. Neurosci. 17, 8468-8475
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AtGRP7, a nuclear RNA-binding protein as a component of a circadian-regulated negative feedback loop in Arabidopsis thaliana.
C. Heintzen, M. Nater, K. Apel, and D. Staiger (1997)
PNAS 94, 8515-8520
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Quantitative Analysis of Drosophila period Gene Transcription in Living Animals.
J. D. Plautz, M. Straume, R. Stanewsky, C. F. Jamison, C. Brandes, H. B. Dowse, J. C. Hall, and S. A. Kay (1997)
J Biol Rhythms 12, 204-217
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Dissection of a circadian oscillation into discrete domains.
M. W. Merrow, N. Y. Garceau, and J. C. Dunlap (1997)
PNAS 94, 3877-3882
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Circadian timekeeping: Loops and layers of transcriptional control.
C. J. Weitz (1996)
PNAS 93, 14308-14309
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Transcriptional control of circadian hormone synthesis via the CREM feedback loop.
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Circadian clock-controlled genes isolated from Neurospora crassa are late night- to early morning-specific.
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PNAS 93, 13096-13101
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The Use of a Reversible Transcription Inhibitor, DRB, to Investigate the Involvement of Specific Proteins in the Ocular Circadian System of Aplysia.
C. Koumenis, Q. Tran, and A. Eskin (1996)
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Phased Protein Synthesis at Several Circadian Times Does Not Change Protein Levels in Gonyaulax.
P. Markovic, T. Roenneberg, and D. Morse (1996)
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A Drosophila Circadian Clock.
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Cold Spring Harb Symp Quant Biol 61, 265-278
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Forward Genetic Approaches to Circadian Clocks in Mice.
D.P. King and J.S. Takahashi (1996)
Cold Spring Harb Symp Quant Biol 61, 295-302
   Abstract »    PDF »


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