Science 11 March 1994: Vol. 263. no. 5152, pp. 1453 - 1454 DOI: 10.1126/science.8128231

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Articles

Potential Contribution of IL-7 to Allergen-Induced Eosinophilic Airway Inflammation in Asthma.

E. A. B. Kelly, C. J. Koziol-White, K. J. Clay, L. Y. Liu, M. E. Bates, P. J. Bertics, and N. N. Jarjour (2009)
J. Immunol. 182, 1404-1410
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Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.

C.-L. Hsu, K. Kikuchi, and M. Kondo (2007)
Blood 110, 1420-1428
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Constitutive Activation of STAT5 Supersedes the Requirement for Cytokine and TCR Engagement of CD4+ T Cells in Steady-State Homeostasis.

D. K. Taylor, P. T. Walsh, D. F. LaRosa, J. Zhang, M. A. Burchill, M. A. Farrar, and L. A. Turka (2006)
J. Immunol. 177, 2216-2223
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A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells.

L. Lai, R. A. Zeff, and I. Goldschneider (2006)
Blood 107, 1776-1784
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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice.

F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada (2005)
Blood 106, 1565-1573
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A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development.

A. Al-Shami, R. Spolski, J. Kelly, T. Fry, P. L. Schwartzberg, A. Pandey, C. L. Mackall, and W. J. Leonard (2004)
J. Exp. Med. 200, 159-168
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Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.

M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med. 350, 913-922
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Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis.

S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo (2003)
Endocrinology 144, 3524-3531
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Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
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Interleukin-7: from bench to clinic.

T. J. Fry and C. L. Mackall (2002)
Blood 99, 3892-3904
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Effects of exogenous interleukin-7 on human thymus function.

Y. Okamoto, D. C. Douek, R. D. McFarland, and R. A. Koup (2002)
Blood 99, 2851-2858
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Structural Basis for Binding Multiple Ligands by the Common Cytokine Receptor gamma -Chain.

F. Olosz and T. R. Malek (2002)
J. Biol. Chem. 277, 12047-12052
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IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT.

E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs (2002)
J. Immunol. 168, 597-603
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Characterization of the Interleukin-4 Receptor Complex in Human Corneal Fibroblasts.

K. Fukuda, Y. Fujitsu, N. Kumagai, and T. Nishida (2002)
Invest. Ophthalmol. Vis. Sci. 43, 183-188
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Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.

O. Alpdogan, C. Schmaltz, S. J. Muriglan, B. J. Kappel, M.-A. Perales, J. A. Rotolo, J. A. Halm, B. E. Rich, and M. R. M. van den Brink (2001)
Blood 98, 2256-2265
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A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
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Bcl-3 Expression Promotes Cell Survival following Interleukin-4 Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors.

A. Rebollo, L. Dumoutier, J.-C. Renauld, A. Zaballos, V. Ayllón, and C. Martínez-A. (2000)
Mol. Cell. Biol. 20, 3407-3416
 |  Abstract »  |  Full Text »

{kappa}-Opioid Regulation of Thymocyte IL-7 Receptor and C-C Chemokine Receptor 2 Expression.

L. Zhang and T. J. Rogers (2000)
J. Immunol. 164, 5088-5093
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Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo.

D. T. M. Leung, S. Morefield, and D. M. Willerford (2000)
J. Immunol. 164, 3527-3534
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Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Ralpha.

N. Benbernou, K. Muegge, and S. K. Durum (2000)
J. Biol. Chem. 275, 7060-7065
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Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly.

F. M. Smart and A. R. Venkitaraman (2000)
J. Exp. Med. 191, 737-742
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Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7R{alpha}, Terminal Deoxynucleotidyltransferase, and c{micro} Expression.

C. Wei, R. Zeff, and I. Goldschneider (2000)
J. Immunol. 164, 1961-1970
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Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach.

M. Lo, M. L. Bloom, K. Imada, M. Berg, J. M. Bollenbacher, E. T. Bloom, B. L. Kelsall, and W. J. Leonard (1999)
Blood 94, 3027-3036
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IgE Hyperproduction Through Enhanced Tyrosine Phosphorylation of Janus Kinase 3 in NC/Nga Mice, a Model for Human Atopic Dermatitis.

M. Matsumoto, C. Ra, K. Kawamoto, H. Sato, A. Itakura, J. Sawada, H. Ushio, H. Suto, K. Mitsuishi, Y. Hikasa, et al. (1999)
J. Immunol. 162, 1056-1063
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Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
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Lymphoid Development from Stem Cells and the Common Lymphocyte Progenitors.

K. AKASHI, M. KONDO, S. CHESHIER, J. SHIZURU, K. GANDY, J. DOMEN, R. MEBIUS, D. TRAVER, and I.L. WEISSMAN (1999)
Cold Spring Harb Symp Quant Biol 64, 1-12
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Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
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Interleukin 7 Receptor Control of  T Cell Receptor gamma  Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility.

S. K. Durum, S. Candeias, H. Nakajima, W. J. Leonard, A. M. Baird, L. J. Berg, and K. Muegge (1998)
J. Exp. Med. 188, 2233-2241
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Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation.

A. Cerezo, C. Martínez-A, D. Lanzarot, S. Fischer, T. F. Franke, and A. Rebollo (1998)
Mol. Biol. Cell 9, 3107-3118
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Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
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Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes.

H. Ogata, D. Ford, N. Kouttab, T. C. King, N. Vita, A. Minty, J. Stoeckler, D. Morgan, C. Girasole, J. W. Morgan, et al. (1998)
J. Biol. Chem. 273, 9864-9871
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Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
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Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice.

S. D. McKenna, F. Chen, L. Lai, and I. Goldschneider (1998)
J. Immunol. 160, 2272-2279
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of  T and B Cell Development by Treatment with a Type I Interferon.

Q. Lin, C. Dong, and M. D. Cooper (1998)
J. Exp. Med. 187, 79-87
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3'-Kinase Pathway.

H. Ueno, K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1998)
Blood 91, 46-53
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Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7 Upregulates the Interleukin-2-Gene Expression in Activated Human T Lymphocytes at the Transcriptional Level by Enhancing the DNA Binding Activities of Both Nuclear Factor of Activated T Cells and Activator Protein-1.

S. I. Gringhuis, L. F.M.H. de Leij, E. W. Verschuren, P. Borger, and E. Vellenga (1997)
Blood 90, 2690-2700
 |  Abstract »  |  Full Text »  |  PDF »

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4.

A. Vella, T. K. Teague, J. Ihle, J. Kappler, and P. Marrack (1997)
J. Exp. Med. 186, 325-330
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.

Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.

N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.

B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function.

D. C. Thomis and L. J. Berg (1997)
J. Exp. Med. 185, 197-206
 |  Abstract »  |  Full Text »  |  PDF »

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells.

K. Saijo, S. Y. Park, Y. Ishida, H. Arase, and T. Saito (1997)
J. Exp. Med. 185, 351-356
 |  Abstract »  |  Full Text »  |  PDF »

Atypical X-Linked Severe Combined Immunodeficiency Due to Possible Spontaneous Reversion of the Genetic Defect in T Cells.

V. Stephan, V. Wahn, F. Le Deist, U. Dirksen, B. Broker, I. Muller-Fleckenstein, G. Horneff, H. Schroten, A. Fischer, and G. de Saint Basile (1996)
N. Engl. J. Med. 335, 1563-1567
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Tissue-specific Activity of the gamma c Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein.

S. Markiewicz, R. Bosselut, F. L. Deist, J.-P. d. Villartay, C. Hivroz, J. Ghysdael, A. Fischer, and G. d. S. Basile (1996)
J. Biol. Chem. 271, 14849-14855
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of Human Stat5B.

J.-X. Lin, J. Mietz, W. S. Modi, S. John, and W. J. Leonard (1996)
J. Biol. Chem. 271, 10738-10744
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients.

K. Izuhara, T. Heike, T. Otsuka, K. Yamaoka, M. Mayumi, T. Imamura, Y. Niho, and N. Harada (1996)
J. Biol. Chem. 271, 619-622
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of the Human Interleukin-15 Receptor alpha Chain and Close Linkage of IL15RA and IL2RA Genes.

D. M. Anderson, S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. (1995)
J. Biol. Chem. 270, 29862-29869
 |  Abstract »  |  Full Text »  |  PDF »

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development.

S. M. Russell, N. Tayebi, H. Nakajima, M. C. Riedy, J. L. Roberts, M. J. Aman, T.-S. Migone, M. Noguchi, M. L. Markert, R. H. Buckley, et al. (1995)
Science 270, 797-800
 |  Abstract »  |  PDF »

Growth Signal Transduction by the Human Interleukin-2 Receptor Requires Cytoplasmic Tyrosines of the beta Chain and Non-tyrosine Residues of the [IMAGE](c) Chain.

M. A. Goldsmith, S. Y. Lai, W. Xu, M. C. Amaral, E. S. Kuczek, L. J. Parent, G. B. Mills, K. L. Tarr, G. D. Longmore, and W. C. Greene (1995)
J. Biol. Chem. 270, 21729-21737
 |  Abstract »  |  Full Text »  |  PDF »

The Primary Immunodeficiencies.

F. S. Rosen, M. D. Cooper, and R. J.P. Wedgwood (1995)
N. Engl. J. Med. 333, 431-440
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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

T. Migone, J. Lin, A Cereseto, J. Mulloy, J. O'Shea, G Franchini, and W. Leonard (1995)
Science 269, 79-81
 |  Abstract »  |  PDF »

[IMAGE]Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors.

A. Pernis, S. Gupta, J. Yopp, E. Garfein, H. Kashleva, C. Schindler, and P. Rothman (1995)
J. Biol. Chem. 270, 14517-14522
 |  Abstract »  |  Full Text »  |  PDF »

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor.

S. M. Zurawski, P. Chomarat, O. Djossou, C. Bidaud, A. N. J. McKenzie, P. Miossec, J. Banchereau, and G. Zurawski (1995)
J. Biol. Chem. 270, 13869-13878
 |  Abstract »  |  Full Text »  |  PDF »

Receptor for Interleukin 13.

N. I. Obiri, W. Debinski, W. J. Leonard, and R. K. Puri (1995)
J. Biol. Chem. 270, 8797-8804
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine signaling through nonreceptor protein tyrosine kinases.

T Taniguchi (1995)
Science 268, 251-255
 |  Abstract »  |  PDF »

Functional Analysis of the Human Interleukin 2 Receptor [IMAGE] Chain Gene Promoter.

K. Ohbo, N. Takasawa, N. Ishii, N. Tanaka, M. Nakamura, and K. Sugamura (1995)
J. Biol. Chem. 270, 7479-7486
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.

S. Russell, J. Johnston, M Noguchi, M Kawamura, C. Bacon, M Friedmann, M Berg, D. McVicar, B. Witthuhn, O Silvennoinen, et al. (1994)
Science 266, 1042-1045
 |  Abstract »  |  PDF »

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.

T Miyazaki, A Kawahara, H Fujii, Y Nakagawa, Y Minami, Z. Liu, I Oishi, O Silvennoinen, B. Witthuhn, J. Ihle, et al. (1994)
Science 266, 1045-1047
 |  Abstract »  |  PDF »

Three Loops of the Common gamma Chain Ectodomain Required for the Binding of Interleukin-2 and Interleukin-7.

F. Olosz and T. R. Malek (2000)
J. Biol. Chem. 275, 30100-30105
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-independent Jak3 Activation upon T Cell Receptor (TCR) Stimulation through Direct Association of Jak3 and the TCR Complex.

K. Tomita, K. Saijo, S. Yamasaki, T. Iida, F. Nakatsu, H. Arase, H. Ohno, T. Shirasawa, T. Kuriyama, J. J. O'Shea, et al. (2001)
J. Biol. Chem. 276, 25378-25385
 |  Abstract »  |  Full Text »  |  PDF »

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