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Science 4 March 1994:
Vol. 263. no. 5151, pp. 1287 - 1289
DOI: 10.1126/science.8122113
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Articles

Science, Vol 263, Issue 5151, 1287-1289
Copyright © 1994 by American Association for the Advancement of Science

articles

Modulation of cortical motor output maps during development of implicit and explicit knowledge

A Pascual-Leone, J Grafman, and M Hallett

Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892.

The excitability of the human motor cortex during the development of implicit and declarative knowledge of a motor task was examined. During a serial reaction time test, subjects developed implicit knowledge of the test sequence, which was reflected by diminishing response times. Motor cortical mapping with transcranial magnetic stimulation revealed that the cortical output maps to the muscles involved in the task became progressively larger until explicit knowledge was achieved, after which they returned to their baseline topography. These results illustrate the rapid functional plasticity of cortical outputs associated with learning and with the transfer of knowledge from an implicit to explicit state.


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