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Science 25 February 1994:
Vol. 263. no. 5150, pp. 1146 - 1149
DOI: 10.1126/science.8108733
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Articles

Science, Vol 263, Issue 5150, 1146-1149
Copyright © 1994 by American Association for the Advancement of Science

articles

Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking

N Calakos, MK Bennett, KE Peterson, and RH Scheller

Howard Hughes Medical Institute, Stanford University Medical Center, CA 94305.

Intracellular vesicles destined to fuse with the plasma membrane and secrete their contents must have a mechanism for specifically interacting with the appropriate target membrane. Such a mechanism is now suggested by the demonstration of specific interaction between vesicular proteins and plasma membrane proteins. The vesicle-associated membrane proteins (VAMPs) 1 and 2 specifically bind the acceptor membrane proteins syntaxin 1A and 4 but not syntaxin 2 or 3. The binding site is within amino acids 194 to 267 of syntaxin 1A, and the approximate equilibrium dissociation constants is 4.7 x 10(-6) molar. These data suggest a physical basis for the specificity of intracellular vesicular transport.


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H. Ogawa, S.-i. Harada, T. Sassa, H. Yamamoto, and R. Hosono (1998)
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Vesicle-associated Membrane Protein 2 Plays a Specific Role in the Insulin-dependent Trafficking of the Facilitative Glucose Transporter GLUT4 in 3T3-L1 Adipocytes.
L. B. Martin, A. Shewan, C. A. Millar, G. W. Gould, and D. E. James (1998)
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Two distinct populations of synaptic-like vesicles from rat brain.
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Expression of syntaxins in rat kidney.
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Regulated Secretion in Platelets: Identification of Elements of the Platelet Exocytosis Machinery.
P. P. Lemons, D. Chen, A. M. Bernstein, M. K. Bennett, and S.W. Whiteheart (1997)
Blood 90, 1490-1500
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Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport.
J. A. McNew, M. Sogaard, N. M. Lampen, S. Machida, R. R. Ye, L. Lacomis, P. Tempst, J. E. Rothman, and T. H. Sollner (1997)
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G. Rossi, A. Salminen, L. M. Rice, A. T. Brunger, and P. Brennwald (1997)
J. Biol. Chem. 272, 16610-16617
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Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles.
H. Otto, P. I. Hanson, and R. Jahn (1997)
PNAS 94, 6197-6201
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Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I.
Z.-H. Sheng, C. T. Yokoyama, and W. A. Catterall (1997)
PNAS 94, 5405-5410
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Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes. PUTATIVE ROLE IN INSULIN-DEPENDENT MOVEMENT OF GLUT-4.
J. T. Tellam, S. L. Macaulay, S. McIntosh, D. R. Hewish, C. W. Ward, and D. E. James (1997)
J. Biol. Chem. 272, 6179-6186
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Effect of Mutations in Vesicle-Associated Membrane Protein (VAMP) on the Assembly of Multimeric Protein Complexes.
J. C. Hao, N. Salem, X.-R. Peng, R. B. Kelly, and M. K. Bennett (1997)
J. Neurosci. 17, 1596-1603
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A Structural Change Occurs upon Binding of Syntaxin to SNAP-25.
D. Fasshauer, D. Bruns, B. Shen, R. Jahn, and AxelT. Brunger (1997)
J. Biol. Chem. 272, 4582-4590
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Cooperative Exosite-dependent Cleavage of Synaptobrevin by Tetanus Toxin Light Chain.
F. Cornille, L. Martin, C. Lenoir, D. Cussac, B. P. Roques, and M.-C. Fournie-Zaluski (1997)
J. Biol. Chem. 272, 3459-3464
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Syndet is a novel SNAP-25 related protein expressed in many tissues.
G Wang, J. Witkin, G Hao, V. Bankaitis, P. Scherer, and G Baldini (1997)
J. Cell Sci. 110, 505-513
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
B. Cheatham, A. Volchuk, C. R. Kahn, L. Wang, C. J. Rhodes, and A. Klip (1996)
PNAS 93, 15169-15173
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SNAP-25 Is Required for a Late Postdocking Step in Ca2+-dependent Exocytosis.
A. Banerjee, J. A. Kowalchyk, B. R. DasGupta, and T. F.J. Martin (1996)
J. Biol. Chem. 271, 20227-20230
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Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues.
V. Ravichandran, A. Chawla, and P. A. Roche (1996)
J. Biol. Chem. 271, 13300-13303
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Evidence That Syntaxin 1A Is Involved in Storage in the Secretory Pathway.
M. A. Bittner, M. K. Bennett, and R. W. Holz (1996)
J. Biol. Chem. 271, 11214-11221
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Mammalian Vesicle Trafficking Proteins of the Endoplasmic Reticulum and Golgi Apparatus.
J. C. Hay, H. Hirling, and R. H. Scheller (1996)
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A. Kibble, R. Barnard, and R. Burgoyne (1996)
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Functional Diversity of C2 Domains of Synaptotagmin Family.
M. Fukuda, T. Kojima, J. Aruga, M. Niinobe, and K. Mikoshiba (1995)
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Ca[IMAGE] Regulates the Interaction between Synaptotagmin and Syntaxin 1.
E. R. Chapman, P. I. Hanson, S. An, and R. Jahn (1995)
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J. Biol. Chem. 270, 16826-16832
   Abstract »    Full Text »    PDF »
The N-Ethylmaleimide-sensitive Fusion Protein and [IMAGE]-SNAP Induce a Conformational Change in Syntaxin.
P. I. Hanson, H. Otto, N. Barton, and R. Jahn (1995)
J. Biol. Chem. 270, 16955-16961
   Abstract »    Full Text »    PDF »
Syntaxin 1 (HPC-1) Is Associated with Chromaffin Granules.
M. Tagaya, S. Toyonaga, M. Takahashi, A. Yamamoto, T. Fujiwara, K. Akagawa, Y. Moriyama, and S. Mizushima (1995)
J. Biol. Chem. 270, 15930-15933
   Abstract »    Full Text »    PDF »
A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.
Y. Hata and T. C. Südhof (1995)
J. Biol. Chem. 270, 13022-13028
   Abstract »    Full Text »    PDF »
Botulinum Neurotoxin Type C Cleaves a Single Lys-Ala Bond within the Carboxyl-terminal Region of Syntaxins.
G. Schiavo, C. C. Shone, M. K. Bennett, R. H. Scheller, and C. Montecucco (1995)
J. Biol. Chem. 270, 10566-10570
   Abstract »    Full Text »    PDF »
Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues.
J. T. Tellam, S. McIntosh, and D. E. James (1995)
J. Biol. Chem. 270, 5857-5863
   Abstract »    Full Text »    PDF »
The Biochemistry of Neurotransmitter Secretion.
S. M. Bajjalieh and R. H. Scheller (1995)
J. Biol. Chem. 270, 1971-1974
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Vesicle-associated Membrane Protein (VAMP)/Synaptobrevin-2 Is Associated with Dense Core Secretory Granules in PC12 Neuroendocrine Cells.
E. Papini, O. Rossetto, and D. F. Cutler (1995)
J. Biol. Chem. 270, 1332-1336
   Abstract »    Full Text »    PDF »
SNAREs Involved in Traffic through the Golgi Complex.
H.R.B. Pelham, D.K. Banfield, and M.J. Lewis (1995)
Cold Spring Harb Symp Quant Biol 60, 105-111
   Abstract »    PDF »
Control of Exocytosis in Yeast.
P. Novick, M.D. Garrett, P. Brennwald, A. Lauring, F.P. Finger, R. Collins, and D.R. TeeBush (1995)
Cold Spring Harb Symp Quant Biol 60, 171-177
   Abstract »    PDF »
Botulinum and Tetanus Neurotoxins: Emerging Tools for the Study of Membrane Fusion.
R. Jahn, P.I. Hanson, H. Otto, and G. Ahnert-Hilger (1995)
Cold Spring Harb Symp Quant Biol 60, 329-335
   Abstract »    PDF »


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