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Science 25 February 1994:
Vol. 263. no. 5150, pp. 1136 - 1139
DOI: 10.1126/science.7509083
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Articles

Science, Vol 263, Issue 5150, 1136-1139
Copyright © 1994 by American Association for the Advancement of Science

articles

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

M Iwashima, BA Irving, NS van Oers, AC Chan, and A Weiss

Howard Hughes Medical Institute, University of California, San Francisco 94143.

The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCR zeta and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.


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CAST, a Novel CD3epsilon -binding Protein Transducing Activation Signal for Interleukin-2 Production in T Cells.
T. Yamazaki, Y. Hamano, H. Tashiro, K. Itoh, H. Nakano, S. Miyatake, and T. Saito (1999)
J. Biol. Chem. 274, 18173-18180
   Abstract »    Full Text »    PDF »
SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity.
N. Fang and G. A. Koretzky (1999)
J. Biol. Chem. 274, 16206-16212
   Abstract »    Full Text »    PDF »
Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck.
M. Pelosi, V. Di Bartolo, V. Mounier, D. Mege, J.-M. Pascussi, E. Dufour, A. Blondel, and O. Acuto (1999)
J. Biol. Chem. 274, 14229-14237
   Abstract »    Full Text »    PDF »
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
M. Lagunoff, R. Majeti, A. Weiss, and D. Ganem (1999)
PNAS 96, 5704-5709
   Abstract »    Full Text »    PDF »
Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines.
R. Weil, J.-P. Levraud, M. D. Dodon, C. Bessia, U. Hazan, P. Kourilsky, and A. Israël (1999)
J. Virol. 73, 3709-3717
   Abstract »    Full Text »
ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4+8+ Thymocytes with Limiting p56lck.
J. M. Ashe, D. L. Wiest, R. Abe, and A. Singer (1999)
J. Exp. Med. 189, 1163-1168
   Abstract »    Full Text »    PDF »
Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling.
V. Di Bartolo, D. Mege, V. Germain, M. Pelosi, E. Dufour, F. Michel, G. Magistrelli, A. Isacchi, and O. Acuto (1999)
J. Biol. Chem. 274, 6285-6294
   Abstract »    Full Text »    PDF »
Rapid tyrosine phosphorylation of Lck following ligation of the tumor-associated cell surface molecule A6H.
T. Labuda, J. Gerwien, N. Odum, and M. Dohlsten (1999)
Int. Immunol. 11, 427-433
   Abstract »    Full Text »    PDF »
Surface Expression and Functional Competence of CD3-Independent TCR {zeta}-Chains in Immature Thymocytes.
F. Grassi, E. Barbier, S. Porcellini, H. von Boehmer, and P.-A. Cazenave (1999)
J. Immunol. 162, 2589-2596
   Abstract »    Full Text »    PDF »
The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling.
M. F. Denny, H. C. Kaufman, A. C. Chan, and D. B. Straus (1999)
J. Biol. Chem. 274, 5146-5152
   Abstract »    Full Text »    PDF »
Molecular Requirements for T Cell Recognition by a Major Histocompatibility Complex Class II-restricted T Cell Receptor: The Involvement of the Fourth Hypervariable Loop of the Valpha Domain.
J. Thatte, A. Qadri, C. Radu, and E. S. Ward (1999)
J. Exp. Med. 189, 509-520
   Abstract »    Full Text »    PDF »
Interaction between CD45-AP and Protein-tyrosine Kinases Involved in T Cell Receptor Signaling.
S. Motoya, K. Kitamura, A. Matsuda, A. L. Maizel, H. Yamamoto, and A. Takeda (1999)
J. Biol. Chem. 274, 1407-1414
   Abstract »    Full Text »    PDF »
Cooperative Inhibition of  T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase.
J.-F. Cloutier and A. Veillette (1999)
J. Exp. Med. 189, 111-121
   Abstract »    Full Text »    PDF »
Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes.
Q. Zhao, B. L. Williams, R. T. Abraham, and A. Weiss (1999)
Mol. Cell. Biol. 19, 948-956
   Abstract »    Full Text »    PDF »


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