Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 February 1994:
Vol. 263. no. 5149, pp. 981 - 982
DOI: 10.1126/science.7906056
Prev | Table of Contents | Next

Articles

Science, Vol 263, Issue 5149, 981-982
Copyright © 1994 by American Association for the Advancement of Science

articles

Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels

A Mastrogiacomo, SM Parsons, GA Zampighi, DJ Jenden, JA Umbach, and CB Gundersen

Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90024.

Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels. Subcellular fractionation revealed that cysteine string proteins copurify with synaptic vesicles. An average vesicle had eight protein monomers with both the amino and carboxyl termini detected on the cytoplasmic face. Thus, docked synaptic vesicles may regulate presynaptic calcium channels and neurotransmitter release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells.
N. Weng, M. D. Baumler, D. D. H. Thomas, M. A. Falkowski, L. A. Swayne, J. E. A. Braun, and G. E. Groblewski (2009)
Am J Physiol Gastrointest Liver Physiol 296, G1030-G1039
   Abstract »    Full Text »    PDF »
Cysteine String Protein Promotes Proteasomal Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Increasing Its Interaction with the C Terminus of Hsp70-interacting Protein and Promoting CFTR Ubiquitylation.
B. Z. Schmidt, R. J. Watts, M. Aridor, and R. A. Frizzell (2009)
J. Biol. Chem. 284, 4168-4178
   Abstract »    Full Text »    PDF »
From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery.
E. Meimaridou, S. B Gooljar, and J P. Chapple (2009)
J. Mol. Endocrinol. 42, 1-9
   Abstract »    Full Text »    PDF »
Dual Role of the Cysteine-String Domain in Membrane Binding and Palmitoylation-dependent Sorting of the Molecular Chaperone Cysteine-String Protein.
J. Greaves and L. H. Chamberlain (2006)
Mol. Biol. Cell 17, 4748-4759
   Abstract »    Full Text »    PDF »
Characterization of the G{alpha}s Regulator Cysteine String Protein.
M. Natochin, T. N. Campbell, B. Barren, L. C. Miller, S. Hameed, N. O. Artemyev, and J. E. A. Braun (2005)
J. Biol. Chem. 280, 30236-30241
   Abstract »    Full Text »    PDF »
Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach.
D. G. Hay, K. Sathasivam, S. Tobaben, B. Stahl, M. Marber, R. Mestril, A. Mahal, D. L. Smith, B. Woodman, and G. P. Bates (2004)
Hum. Mol. Genet. 13, 1389-1405
   Abstract »    Full Text »    PDF »
Structure-function analysis of the cysteine string protein in Drosophila: cysteine string, linker and C terminus.
C. Arnold, N. Reisch, C. Leibold, S. Becker, K. Prufert, K. Sautter, D. Palm, S. Jatzke, S. Buchner, and E. Buchner (2004)
J. Exp. Biol. 207, 1323-1334
   Abstract »    Full Text »    PDF »
Cysteine String Protein (CSP) Inhibition of N-type Calcium Channels Is Blocked by Mutant Huntingtin.
L. C. Miller, L. A. Swayne, L. Chen, Z.-P. Feng, J. L. Wacker, P. J. Muchowski, G. W. Zamponi, and J. E. A. Braun (2003)
J. Biol. Chem. 278, 53072-53081
   Abstract »    Full Text »    PDF »
Syntaxin 1A Modulates the Voltage-gated L-type Calcium Channel (Cav1.2) in a Cooperative Manner.
H. Arien, O. Wiser, I. T. Arkin, H. Leonov, and D. Atlas (2003)
J. Biol. Chem. 278, 29231-29239
   Abstract »    Full Text »    PDF »
Molecular determinants of cysteine string protein modulation of N-type calcium channels.
L. C. Miller, L. A. Swayne, J. G. Kay, Z.-P. Feng, S. E. Jarvis, G. W. Zamponi, and J. E. A. Braun (2003)
J. Cell Sci. 116, 2967-2974
   Abstract »    Full Text »    PDF »
Cysteine String Protein Interacts with and Modulates the Maturation of the Cystic Fibrosis Transmembrane Conductance Regulator.
H. Zhang, K. W. Peters, F. Sun, C. R. Marino, J. Lang, R. D. Burgoyne, and R. A. Frizzell (2002)
J. Biol. Chem. 277, 28948-28958
   Abstract »    Full Text »    PDF »
Enhancement of presynaptic calcium current by cysteine string protein.
S. Chen, X. Zheng, K. L Schulze, T. Morris, H. Bellen, and E. F Stanley (2002)
J. Physiol. 538, 383-389
   Abstract »    Full Text »    PDF »
Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila.
A. Razzaq, I. M. Robinson, H. T. McMahon, J. N. Skepper, Y. Su, A. C. Zelhof, A. P. Jackson, N. J. Gay, and C. J. O'Kane (2001)
Genes & Dev. 15, 2967-2979
   Abstract »    Full Text »    PDF »
Drosophila Stoned Proteins Regulate the Rate and Fidelity of Synaptic Vesicle Internalization.
D. T. Stimson, P. S. Estes, S. Rao, K. S. Krishnan, L. E. Kelly, and M. Ramaswami (2001)
J. Neurosci. 21, 3034-3044
   Abstract »    Full Text »    PDF »
The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4.
L. Chamberlain, M. Graham, S Kane, J. Jackson, V. Maier, R. Burgoyne, and G. Gould (2001)
J. Cell Sci. 114, 445-455
   Abstract »    PDF »
Cysteine-String Protein Increases the Calcium Sensitivity of Neurotransmitter Exocytosis in Drosophila.
K. Dawson-Scully, P. Bronk, H. L. Atwood, and K. E. Zinsmaier (2000)
J. Neurosci. 20, 6039-6047
   Abstract »    Full Text »    PDF »
Syntaxin Modulation of Slow Inactivation of N-Type Calcium Channels.
V. E. Degtiar, R. H. Scheller, and R. W. Tsien (2000)
J. Neurosci. 20, 4355-4367
   Abstract »    Full Text »    PDF »
Syntaxin Modulation of Calcium Channels in Cortical Synaptosomes As Revealed by Botulinum Toxin C1.
J. B. Bergsman and R. W. Tsien (2000)
J. Neurosci. 20, 4368-4378
   Abstract »    Full Text »    PDF »
Comparison of Cysteine String Protein (Csp) and Mutant alpha -SNAP Overexpression Reveals a Role for Csp in Late Steps of Membrane Fusion in Dense-Core Granule Exocytosis in Adrenal Chromaffin Cells.
M. E. Graham and R. D. Burgoyne (2000)
J. Neurosci. 20, 1281-1289
   Abstract »    Full Text »    PDF »
Overexpression of Cysteine-String Proteins in Drosophila Reveals Interactions with Syntaxin.
Z. Nie, R. Ranjan, J. J. Wenniger, S. N. Hong, P. Bronk, and K. E. Zinsmaier (1999)
J. Neurosci. 19, 10270-10279
   Abstract »    Full Text »    PDF »
Antibodies Against Cysteine String Proteins Inhibit Evoked Neurotransmitter Release at Xenopus Neuromuscular Junctions.
R. E. Poage, S. D. Meriney, C. B. Gundersen, and J. A. Umbach (1999)
J Neurophysiol 82, 50-59
   Abstract »    Full Text »    PDF »
Amino-terminal Cysteine Residues of RGS16 Are Required for Palmitoylation and Modulation of Gi- and Gq-mediated Signaling.
K. M. Druey, O. Ugur, J. M. Caron, C.-K. Chen, P. S. Backlund, and T. L. Z. Jones (1999)
J. Biol. Chem. 274, 18836-18842
   Abstract »    Full Text »    PDF »
Neuroprotection at Drosophila Synapses Conferred by Prior Heat Shock.
S. Karunanithi, J. W. Barclay, R. M. Robertson, I. R. Brown, and H. L. Atwood (1999)
J. Neurosci. 19, 4360-4369
   Abstract »    Full Text »    PDF »
rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases.
J. Debnath, M. Chamorro, M. J. Czar, E. M. Schaeffer, M. J. Lenardo, H. E. Varmus, and P. L. Schwartzberg (1999)
Mol. Cell. Biol. 19, 1498-1507
   Abstract »    Full Text »    PDF »
Mutational analysis of cysteine-string protein function in insulin exocytosis.
H Zhang, W. Kelley, L. Chamberlain, R. Burgoyne, and J Lang (1999)
J. Cell Sci. 112, 1345-1351
   Abstract »    PDF »
Morphologically Docked Synaptic Vesicles Are Reduced in synaptotagmin Mutants of Drosophila.
N. E. Reist, J. Buchanan, J. Li, A. DiAntonio, E. M. Buxton, and T. L. Schwarz (1998)
J. Neurosci. 18, 7662-7673
   Abstract »    Full Text »    PDF »
KCR1, a Membrane Protein That Facilitates Functional Expression of Non-inactivating K+ Currents Associates with Rat EAG Voltage-dependent K+ Channels.
N. Hoshi, H. Takahashi, M. Shahidullah, S. Yokoyama, and H. Higashida (1998)
J. Biol. Chem. 273, 23080-23085
   Abstract »    Full Text »    PDF »
Cysteine String Protein Functions Directly in Regulated Exocytosis.
L. H. Chamberlain and R. D. Burgoyne (1998)
Mol. Biol. Cell 9, 2259-2267
   Abstract »    Full Text »
Interaction of Cysteine String Proteins with the alpha 1A Subunit of the P/Q-type Calcium Channel.
C. Leveque, S. Pupier, B. Marqueze, L. Geslin, M. Kataoka, M. Takahashi, M. De Waard, and M. Seagar (1998)
J. Biol. Chem. 273, 13488-13492
   Abstract »    Full Text »    PDF »
Attenuated Influx of Calcium Ions at Nerve Endings of csp and shibire Mutant Drosophila.
J. A. Umbach, M. Saitoe, Y. Kidokoro, and C. B. Gundersen (1998)
J. Neurosci. 18, 3233-3240
   Abstract »    Full Text »    PDF »
Cysteine String Protein Is Required for Calcium Secretion Coupling of Evoked Neurotransmission in Drosophila But Not for Vesicle Recycling.
R. Ranjan, P. Bronk, and K. E. Zinsmaier (1998)
J. Neurosci. 18, 956-964
   Abstract »    Full Text »    PDF »
Analysis of Temperature-Sensitive Mutants Reveals New Genes Involved in the Courtship Song of Drosophila.
A. A. Peixoto and J. C. Hall (1998)
Genetics 148, 827-838
   Abstract »    Full Text »    PDF »
The Molecular Chaperone Function of the Secretory Vesicle Cysteine String Proteins.
L. H. Chamberlain and R. D. Burgoyne (1997)
J. Biol. Chem. 272, 31420-31426
   Abstract »    Full Text »    PDF »
Evidence That Cysteine String Proteins Regulate an Early Step in the Ca2+-Dependent Secretion of Neurotransmitter at Drosophila Neuromuscular Junctions.
J. A. Umbach and C. B. Gundersen (1997)
J. Neurosci. 17, 7203-7209
   Abstract »    Full Text »    PDF »
Cysteine String Proteins Associated with Secretory Granules of the Rat Neurohypophysis.
S. Pupier, C. Leveque, B. Marqueze, M. Kataoka, M. Takahashi, and M. J. Seagar (1997)
J. Neurosci. 17, 2722-2727
   Abstract »    Full Text »    PDF »
GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Galpha i subunits.
L. De Vries, E. Elenko, L. Hubler, T. L. Z. Jones, and M. G. Farquhar (1996)
PNAS 93, 15203-15208
   Abstract »    Full Text »    PDF »
The Cysteine String Secretory Vesicle Protein Activates Hsc70 ATPase.
J. E.A. Braun, S. M. Wilbanks, and R. H. Scheller (1996)
J. Biol. Chem. 271, 25989-25993
   Abstract »    Full Text »    PDF »
Cysteine String Proteins Are Associated with Chromaffin Granules.
L. H. Chamberlain, J. Henry, and R. D. Burgoyne (1996)
J. Biol. Chem. 271, 19514-19517
   Abstract »    Full Text »    PDF »
Identification of a Novel Cysteine String Protein Variant and Expression of Cysteine String Proteins in Non-neuronal Cells.
L. H. Chamberlain and R. D. Burgoyne (1996)
J. Biol. Chem. 271, 7320-7323
   Abstract »    Full Text »    PDF »
Paralysis and early death in cysteine string protein mutants of Drosophila.
K. Zinsmaier, K. Eberle, E Buchner, N Walter, and S Benzer (1994)
Science 263, 977-980
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)