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Science 18 February 1994:
Vol. 263. no. 5149, pp. 977 - 980
DOI: 10.1126/science.8310297
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Articles

Science, Vol 263, Issue 5149, 977-980
Copyright © 1994 by American Association for the Advancement of Science

articles

Paralysis and early death in cysteine string protein mutants of Drosophila

KE Zinsmaier, KK Eberle, E Buchner, N Walter, and S Benzer

California Institute of Technology, Division of Biology, Pasadena 91125.

Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.


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Heat-shock-induced thermoprotection of hindleg motor control in the locust.
J. Barclay and R. Robertson (2000)
J. Exp. Biol. 203, 941-950
   Abstract »    PDF »
Overexpression of Cysteine-String Proteins in Drosophila Reveals Interactions with Syntaxin.
Z. Nie, R. Ranjan, J. J. Wenniger, S. N. Hong, P. Bronk, and K. E. Zinsmaier (1999)
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   Abstract »    Full Text »    PDF »
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K. Ray, S. E. Perez, Z. Yang, J. Xu, B. W. Ritchings, H. Steller, and L. S.B. Goldstein (1999)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Mutational analysis of cysteine-string protein function in insulin exocytosis.
H Zhang, W. Kelley, L. Chamberlain, R. Burgoyne, and J Lang (1999)
J. Cell Sci. 112, 1345-1351
   Abstract »    PDF »
The kakapo Mutation Affects Terminal Arborization and Central Dendritic Sprouting of Drosophila Motorneurons.
A. Prokop, J. Uhler, J. Roote, and M. Bate (1998)
J. Cell Biol. 143, 1283-1294
   Abstract »    Full Text »    PDF »
Morphologically Docked Synaptic Vesicles Are Reduced in synaptotagmin Mutants of Drosophila.
N. E. Reist, J. Buchanan, J. Li, A. DiAntonio, E. M. Buxton, and T. L. Schwarz (1998)
J. Neurosci. 18, 7662-7673
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Cysteine String Protein Functions Directly in Regulated Exocytosis.
L. H. Chamberlain and R. D. Burgoyne (1998)
Mol. Biol. Cell 9, 2259-2267
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Interaction of Cysteine String Proteins with the alpha 1A Subunit of the P/Q-type Calcium Channel.
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J. Biol. Chem. 273, 13488-13492
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Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.
S. P. Srinivasa, L. S. Bernstein, K. J. Blumer, and M. E. Linder (1998)
PNAS 95, 5584-5589
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Attenuated Influx of Calcium Ions at Nerve Endings of csp and shibire Mutant Drosophila.
J. A. Umbach, M. Saitoe, Y. Kidokoro, and C. B. Gundersen (1998)
J. Neurosci. 18, 3233-3240
   Abstract »    Full Text »    PDF »
Kinesin Light Chains Are Essential for Axonal Transport in Drosophila.
J. G. Gindhart Jr., C. J. Desai, S. Beushausen, K. Zinn, and L. S.B. Goldstein (1998)
J. Cell Biol. 141, 443-454
   Abstract »    Full Text »    PDF »
Distinct Requirements for Evoked and Spontaneous Release of Neurotransmitter Are Revealed by Mutations in the Drosophila Gene neuronal-synaptobrevin.
D. L. Deitcher, A. Ueda, B. A. Stewart, R. W. Burgess, Y. Kidokoro, and T. L. Schwarz (1998)
J. Neurosci. 18, 2028-2039
   Abstract »    Full Text »    PDF »
Cysteine String Protein Is Required for Calcium Secretion Coupling of Evoked Neurotransmission in Drosophila But Not for Vesicle Recycling.
R. Ranjan, P. Bronk, and K. E. Zinsmaier (1998)
J. Neurosci. 18, 956-964
   Abstract »    Full Text »    PDF »
Analysis of Temperature-Sensitive Mutants Reveals New Genes Involved in the Courtship Song of Drosophila.
A. A. Peixoto and J. C. Hall (1998)
Genetics 148, 827-838
   Abstract »    Full Text »    PDF »
The Molecular Chaperone Function of the Secretory Vesicle Cysteine String Proteins.
L. H. Chamberlain and R. D. Burgoyne (1997)
J. Biol. Chem. 272, 31420-31426
   Abstract »    Full Text »    PDF »
Evidence That Cysteine String Proteins Regulate an Early Step in the Ca2+-Dependent Secretion of Neurotransmitter at Drosophila Neuromuscular Junctions.
J. A. Umbach and C. B. Gundersen (1997)
J. Neurosci. 17, 7203-7209
   Abstract »    Full Text »    PDF »
Insertional Mutation of the Drosophila Nuclear Lamin Dm0 Gene Results in Defective Nuclear Envelopes, Clustering of Nuclear Pore Complexes, and Accumulation of Annulate Lamellae.
B. Lenz-Bohme, J. Wismar, S. Fuchs, R. Reifegerste, E. Buchner, H. Betz, and B. Schmitt (1997)
J. Cell Biol. 137, 1001-1016
   Abstract »    Full Text »    PDF »
Cysteine String Proteins Associated with Secretory Granules of the Rat Neurohypophysis.
S. Pupier, C. Leveque, B. Marqueze, M. Kataoka, M. Takahashi, and M. J. Seagar (1997)
J. Neurosci. 17, 2722-2727
   Abstract »    Full Text »    PDF »
The Drosophila erg K+ Channel Polypeptide Is Encoded by the Seizure Locus.
S. A. Titus, J. W. Warmke, and B. Ganetzky (1997)
J. Neurosci. 17, 875-881
   Abstract »    Full Text »    PDF »
Traffic of Dynamin within Individual Drosophila Synaptic Boutons Relative to Compartment-Specific Markers.
P. S. Estes, J. Roos, A. van der Bliek, R. B. Kelly, K. S. Krishnan, and M. Ramaswami (1996)
J. Neurosci. 16, 5443-5456
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Cysteine String Proteins Are Associated with Chromaffin Granules.
L. H. Chamberlain, J. Henry, and R. D. Burgoyne (1996)
J. Biol. Chem. 271, 19514-19517
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Identification of a Novel Cysteine String Protein Variant and Expression of Cysteine String Proteins in Non-neuronal Cells.
L. H. Chamberlain and R. D. Burgoyne (1996)
J. Biol. Chem. 271, 7320-7323
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Insights into the Molecular Mechanisms of Synaptic Vesicle Docking and Fusion.
A.E. Ting and R.H. Scheller (1995)
Cold Spring Harb Symp Quant Biol 60, 361-369
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Drosophila Genetics and the Functions of Synaptic Proteins.
K. Parfitt, N. Reist, J. Li, R. Burgess, D. Deitcher, A. DiAntonio, and T.L. Schwartz (1995)
Cold Spring Harb Symp Quant Biol 60, 371-377
   Abstract »    PDF »
The mating of a fly.
J. Hall (1994)
Science 264, 1702-1714
   Abstract »    PDF »


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