Science 18 February 1994: Vol. 263. no. 5149, pp. 966 - 969 DOI: 10.1126/science.7906055

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Articles

Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells.

M. S. Joshi, T. B. Ferguson Jr., F. K. Johnson, R. A. Johnson, S. Parthasarathy, and J. R. Lancaster Jr. (2007)
PNAS 104, 9982-9987
 |  Abstract »  |  Full Text »  |  PDF »

Arginine Metabolism: Boundaries of Our Knowledge.

S. M. Morris Jr. (2007)
J. Nutr. 137, 1602S-1609S
 |  Abstract »  |  Full Text »  |  PDF »

Activities of DL-{alpha}-Difluoromethylarginine and Polyamine Analogues against Cryptosporidium parvum Infection in a T-Cell Receptor Alpha-Deficient Mouse Model.

N. Yarlett, W. R. Waters, J. A. Harp, M. J. Wannemuehler, M. Morada, J. Bellcastro, S. J. Upton, L. J. Marton, and B. J. Frydman (2007)
Antimicrob. Agents Chemother. 51, 1234-1239
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Basis for the Antiproliferative Effect of Agmatine in Tumor Cells of Colonic, Hepatic, and Neuronal Origin.

C. Wolf, M. Bruss, B. Hanisch, M. Gothert, I. von Kugelgen, and G. J. Molderings (2007)
Mol. Pharmacol. 71, 276-283
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Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity.

A. J. Lopez-Contreras, C. Lopez-Garcia, C. Jimenez-Cervantes, A. Cremades, and R. Penafiel (2006)
J. Biol. Chem. 281, 30896-30906
 |  Abstract »  |  Full Text »  |  PDF »

The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception..

A. Dogrul, I. Coskun, and T. Uzbay (2006)
Anesth. Analg. 103, 471-7, table of contents
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Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings..

D.J. Kim, D.I. Kim, S.K. Lee, S.H. Suh, Y.J. Lee, J. Kim, T.S. Chung, and J.E. Lee (2006)
AJNR Am. J. Neuroradiol. 27, 780-785
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacodynamic and Pharmacokinetic Studies of Agmatine after Spinal Administration in the Mouse.

J. C. Roberts, B. M. Grocholski, K. F. Kitto, and C. A. Fairbanks (2005)
J. Pharmacol. Exp. Ther. 314, 1226-1233
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Role of L-Arginine in the Pathogenesis and Treatment of Renal Disease.

G. Cherla and E. A. Jaimes (2004)
J. Nutr. 134, 2801S-2806S
 |  Abstract »  |  Full Text »  |  PDF »

The Antinociceptive Potencies and Interactions of Endogenous Ligands During Continuous Intrathecal Administration: Adenosine, Agmatine, and Endomorphin-1.

G. Kekesi, I. Dobos, G. Benedek, and G. Horvath (2004)
Anesth. Analg. 98, 420-426
 |  Abstract »  |  Full Text »  |  PDF »

Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological Evidence.

H. Dayoub, V. Achan, S. Adimoolam, J. Jacobi, M. C. Stuehlinger, B.-y. Wang, P. S. Tsao, M. Kimoto, P. Vallance, A. J. Patterson, et al. (2003)
Circulation 108, 3042-3047
 |  Abstract »  |  Full Text »  |  PDF »

Relevance of Imidazoline Receptors and Agmatine to Psychiatry: A Decade of Progress.

A HALARIS and J E. PILETZ (2003)
Ann. N.Y. Acad. Sci. 1009, 1-20
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Inducible Nitric Oxide Synthase and Agmatine Synthesis in Macrophages and Astrocytes.

S. REGUNATHAN and J. E. PILETZ (2003)
Ann. N.Y. Acad. Sci. 1009, 20-29
 |  Abstract »  |  Full Text »  |  PDF »

Vertebrate Agmatinases: What Role Do They Play in Agmatine Catabolism?.

S. M. MORRIS JR (2003)
Ann. N.Y. Acad. Sci. 1009, 30-33
 |  Abstract »  |  Full Text »  |  PDF »

Structure-Activity Analysis of Guanidine Group in Agmatine for Brain Agmatinase.

M-J HUANG, S REGUNATHAN, M BOTTA, K LEE, E MCCLENDON, G B YI, M L PEDERSEN, D B BERKOWITZ, G WANG, M TRAVAGLI, et al. (2003)
Ann. N.Y. Acad. Sci. 1009, 52-63
 |  Abstract »  |  Full Text »  |  PDF »

Agmatine Crosses the Blood-Brain Barrier.

J E. PILETZ, P J. MAY, G WANG, and H ZHU (2003)
Ann. N.Y. Acad. Sci. 1009, 64-74
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Agmatine on Acute and Mononeuropathic Pain.

F. ARICIOGLU, E. KORCEGEZ, A. BOZKURT, and S. OZYALCIN (2003)
Ann. N.Y. Acad. Sci. 1009, 106-115
 |  Abstract »  |  Full Text »  |  PDF »

Spinal and Supraspinal Agmatine Activate Different Receptors to Enhance Spinal Morphine Antinociception.

S. C. ROERIG (2003)
Ann. N.Y. Acad. Sci. 1009, 116-126
 |  Abstract »  |  Full Text »  |  PDF »

Is Agmatine an Endogenous Anxiolytic/Antidepressant Agent?.

F. ARICIOGLU and H. ALTUNBAS (2003)
Ann. N.Y. Acad. Sci. 1009, 136-140
 |  Abstract »  |  Full Text »  |  PDF »

Agmatine Inhibits Naloxone-Induced Contractions in Morphine-Dependent Guinea Pig Ileum.

F. ARICIOGLU, E. ERCIL, and G. DULGER (2003)
Ann. N.Y. Acad. Sci. 1009, 147-151
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous {beta}-Carbolines as Clonidine-Displacing Substances.

E. ROBINSON, N. ANDERSON, J CROSBY, D. NUTT, and A. HUDSON (2003)
Ann. N.Y. Acad. Sci. 1009, 157-166
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes.

N J. ANDERSON, E. J. ROBINSON, S M. HUSBANDS, P DELAGRANGE, D J. NUTT, and A L. HUDSON (2003)
Ann. N.Y. Acad. Sci. 1009, 175-179
 |  Abstract »  |  Full Text »  |  PDF »

No Evidence for Activation of {alpha}2-Adrenoceptors by Methanolic Extracts of Bovine Brain and Lung Containing Clonidine-Displacing Substance.

D PINTHONG, D. KENDALL, S. MACLENNAN, R. EGLEN, and V. WILSON (2003)
Ann. N.Y. Acad. Sci. 1009, 201-215
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Imidazoline Receptor Ligands Relax Rat Aorta by an Endothelium-Dependent Mechanism.

I. F. MUSGRAVE, A. VAN DER ZYPP, M. GRIGG, and C. J. BARROW (2003)
Ann. N.Y. Acad. Sci. 1009, 222-227
 |  Abstract »  |  Full Text »  |  PDF »

The Effects of Chronic Administration of Inhibitors of Flavin and Quinone Amine Oxidases on Imidazoline I1 Receptor Density in Rat Whole Brain.

A. HOLT, K. G. TODD, and G. B. BAKER (2003)
Ann. N.Y. Acad. Sci. 1009, 309-322
 |  Abstract »  |  Full Text »  |  PDF »

Modification of Noradrenaline Release in Pithed Spontaneously Hypertensive Rats by I1-Binding Sites in Addition to alpha 2-Adrenoceptors.

W. Raasch, B. Jungbluth, U. Schafer, W. Hauser, and P. Dominiak (2003)
J. Pharmacol. Exp. Ther. 304, 1063-1071
 |  Abstract »  |  Full Text »  |  PDF »

Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2).

D. Grundemann, C. Hahne, R. Berkels, and E. Schomig (2003)
J. Pharmacol. Exp. Ther. 304, 810-817
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Polyamines on the Release of Gonadotropin-Releasing Hormone and Gonadotropins in Developing Female Rats.

S. M. Thyssen, P. F. Hockl, A. Chamson, V. A.R. Lux-Lantos, and C. Libertun (2002)
Experimental Biology and Medicine 227, 276-281
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.

S. K. Mistry, T. J. Burwell, R. M. Chambers, L. Rudolph-Owen, F. Spaltmann, W. J. Cook, and S. M. Morris Jr (2002)
Am J Physiol Gastrointest Liver Physiol 282, G375-G381
 |  Abstract »  |  Full Text »  |  PDF »

Polyamine transport system mediates agmatine transport in mammalian cells.

J. Satriano, M. Isome, R. A. Casero Jr., S. C. Thomson, and R. C. Blantz (2001)
Am J Physiol Cell Physiol 281, C329-C334
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Ornithine Decarboxylase Activity and Polyamine Transport by Agmatine in Rat Pulmonary Artery Endothelial Cells.

P. Babál, M. Ruchko, C. C. Campbell, S. P. Gilmour, J. L. Mitchell, J. W. Olson, and M. N. Gillespie (2001)
J. Pharmacol. Exp. Ther. 296, 372-377
 |  Abstract »  |  Full Text »

The Effect of Agmatine Administration on Ischemic-Reperfused Isolated Rat Heart.

S. Greenberg, J. George, Y. Wollman, I. Shapira, S. Laniado, and G. Keren (2001)
Journal of Cardiovascular Pharmacology and Therapeutics 6, 37-45
 |  Abstract »  |  PDF »

Nitric Oxide and Central Antihypertensive Drugs : One More Difference Between Catecholamines and Imidazolines.

G. Y. Sy, V. Bruban, P. Bousquet, and J. Feldman (2001)
Hypertension 37, 246-249
 |  Abstract »  |  Full Text »  |  PDF »

Agmatine Inhibits Cell Proliferation and Improves Renal Function in Anti--Thy-1 Glomerulonephritis.

S. ISHIZUKA, R. CUNARD, S. POUCELL-HATTON, L. WEAD, M. LORTIE, S. C. THOMSON, F. B. GABBAI, J. SATRIANO, and R. C. BLANTZ (2000)
J. Am. Soc. Nephrol. 11, 2256-2264
 |  Abstract »  |  Full Text »

Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.

C. A. Fairbanks, K. L. Schreiber, K. L. Brewer, C.-G. Yu, L. S. Stone, K. F. Kitto, H. O. Nguyen, B. M. Grocholski, D. W. Shoeman, L. J. Kehl, et al. (2000)
PNAS 97, 10584-10589
 |  Abstract »  |  Full Text »  |  PDF »

Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon.

D. O'Sullivan, J. T. Brosnan, and M. E. Brosnan (2000)
Am J Physiol Endocrinol Metab 278, E516-E521
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacologic Characterization of Imidazoline Receptor Proteins Identified by Immunologic Techniques and Other Methods.

P. V. ESCRIBA, A. OZAITA, and J. A. GARCIA-SEVILLA (1999)
Ann. N.Y. Acad. Sci. 881, 8-25
 |  Abstract »  |  Full Text »  |  PDF »

The I1-Imidazoline Receptor and Its Cellular Signaling Pathways.

P. ERNSBERGER (1999)
Ann. N.Y. Acad. Sci. 881, 35-53
 |  Abstract »  |  Full Text »  |  PDF »

Agmatine: An Endogenous Ligand at Imidazoline Receptors Is a Novel Neurotransmitter.

D. J. REIS and S. REGUNATHAN (1999)
Ann. N.Y. Acad. Sci. 881, 65-80
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Crude Methanolic CDS Extracts from Various Tissues.

C. A. PARKER, A. L. HUDSON, D. J. NUTT, M. P. DILLON, R. M. EGLEN, and J. CROSBY (1999)
Ann. N.Y. Acad. Sci. 881, 92-96
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Effects of Agmatine on the Cardiovascular System of Spontaneously Hypertensive Rats.

U. SCHAFER, W. RAASCH, F. QADRI, J. CHUN, and P. DOMINIAK (1999)
Ann. N.Y. Acad. Sci. 881, 97-101
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Pharmacologic and Molecular Discrimination of I2-Imidazoline Receptor Subtypes.

G. OLMOS, R. ALEMANY, M. A. BORONAT, and J. A. GARCIA-SEVILLA (1999)
Ann. N.Y. Acad. Sci. 881, 144-160
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Imidazoline-Receptor Binding Sites in Cortex and Medulla of the Bovine Adrenal Gland: Colocalization with MAO-A and MAO-B.

P. R. KING, A. L GUNDLACH, and W. J. LOUIS (1999)
Ann. N.Y. Acad. Sci. 881, 161-170
 |  Abstract »  |  Full Text »  |  PDF »

Imidazoline (I2) Binding Sites in Chicken Brain.

T. C. DANBURY, B. RUBAN, A. L. HUDSON, A. E. WATERMAN-PEARSON, and S. C. KESTIN (1999)
Ann. N.Y. Acad. Sci. 881, 189-192
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Modulation of MAO Activity by Imidazoline and Guanidine Derivatives.

W. RAASCH, H. MUHLE, and P. DOMINIAK (1999)
Ann. N.Y. Acad. Sci. 881, 313-331
 |  Abstract »  |  Full Text »  |  PDF »

Imidazoline Recognition Sites and Stomach Function.

G. J. MOLDERINGS, M. BURIAN, S. MENZEL, K. DONECKER, J. HOMANN, M. NILIUS, and M. GOTHERT (1999)
Ann. N.Y. Acad. Sci. 881, 332-343
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Agmatine and Platelet Imidazoline Receptors in Depression.

A. HALARIS, H. ZHU, Y. FENG, and J. E. PILETZ (1999)
Ann. N.Y. Acad. Sci. 881, 445-451
 |  Abstract »  |  Full Text »  |  PDF »

Preface.

M. GOTHERT, G. J. MOLDERINGS, and D. J. REIS (1999)
Ann. N.Y. Acad. Sci. 881, xiii
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Agmatine Selectively Blocks the N-Methyl-D-Aspartate Subclass of Glutamate Receptor Channels in Rat Hippocampal Neurons.

X.-C. Yang and D. J. Reis (1999)
J. Pharmacol. Exp. Ther. 288, 544-549
 |  Abstract »  |  Full Text »

The Effect of Agmatine on Ischemic and Nonischemic Isolated Rat Heart.

S. Greenberg, A. Finkelstein, J. Gurevich, E. Brazowski, F. Rosenfeld, I. Shapira, J. George, S. Laniado, and G. Keren (1999)
Journal of Cardiovascular Pharmacology and Therapeutics 4, 151-158
 |  Abstract »  |  PDF »

Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanisms.

J. BUSCIGLIO, J. K. ANDERSEN, H. M. SCHIPPER, G. M. GILAD, R. McCARTY, F. MARZATICO, and O. TOUSSAINT (1998)
Ann. N.Y. Acad. Sci. 851, 429-443
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Agmatine Suppresses Proliferation by Frameshift Induction of Antizyme and Attenuation of Cellular Polyamine Levels.

J. Satriano, S. Matsufuji, Y. Murakami, M. J. Lortie, D. Schwartz, C. J. Kelly, S.-i. Hayashi, and R. C. Blantz (1998)
J. Biol. Chem. 273, 15313-15316
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of I2 Imidazoline and sigma  Binding Sites in the Rat and Human Stomach.

G. J. Molderings, K. Donecker, M. Burian, W. A. Simon, D. W. Schröder, and M. Göthert (1998)
J. Pharmacol. Exp. Ther. 285, 170-177
 |  Abstract »  |  Full Text »

Tyramine and Vanadate Synergistically Stimulate Glucose Transport in Rat Adipocytes by Amine Oxidase-Dependent Generation of Hydrogen Peroxide.

L. Marti, N. Morin, G. Enrique-Tarancon, D. Prevot, M. Lafontan, X. Testar, A. Zorzano, and C. Carpéné (1998)
J. Pharmacol. Exp. Ther. 285, 342-349
 |  Abstract »  |  Full Text »

Intracellular Signaling Pathways Confer Specificity of Transactivation by Mineralocorticoid and Glucocorticoid Receptors.

S. S. Lim-Tio and P. J. Fuller (1998)
Endocrinology 139, 1653-1661
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Alpha-2 Adrenoceptors in the Effects of Moxonidine on Intestinal Motility and Fluid Transport.

L. Liu and I. M. Coupar (1997)
J. Pharmacol. Exp. Ther. 283, 1367-1374
 |  Abstract »  |  Full Text »

The imidazoline receptor in control of blood pressure by clonidine and allied drugs.

D. J. Reis and J. E. Piletz (1997)
Am J Physiol Regulatory Integrative Comp Physiol 273, R1569-R1571
 |  Abstract »  |  Full Text »  |  PDF »

Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?.

P. G. Guyenet (1997)
Am J Physiol Regulatory Integrative Comp Physiol 273, R1580-R1584
 |  Abstract »  |  Full Text »  |  PDF »

Acute Tolerance To Spinally Administered Morphine Compares Mechanistically with Chronically Induced Morphine Tolerance.

C. A. Fairbanks and G. L. Wilcox (1997)
J. Pharmacol. Exp. Ther. 282, 1408-1417
 |  Abstract »  |  Full Text »

Stimulation of Imidazoline Receptors Inhibits Proliferation of Human Coronary Artery Vascular Smooth Muscle Cells.

S. Regunathan and D. J. Reis (1997)
Hypertension 30, 295-300
 |  Abstract »  |  Full Text »

Clonidine and ST-91 May Activate Imidazoline Binding Sites in the Heart to Release Atrial Natriuretic Peptide.

S. Mukaddam-Daher, C. Lambert, and J. Gutkowska (1997)
Hypertension 30, 83-87
 |  Abstract »  |  Full Text »

Aminoguanidine Ameliorates and L-Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion.

F. Zhang, R. M. Casey, M. E. Ross, and C. Iadecola (1996)
Stroke 27, 317-323
 |  Abstract »  |  Full Text »

Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI.

S. Jordan, H.C. Jackson, D.J. Nutt, and S.L. Handley (1996)
J Psychopharmacol 10, 273-278
 |  Abstract »  |  PDF »

Imidazoline/Guanidinium Binding Domains on Monoamine Oxidases.

R. Raddatz, A. Parini, and S. M. Lanier (1995)
J. Biol. Chem. 270, 27961-27968
 |  Abstract »  |  Full Text »  |  PDF »

Localization of I[IMAGE]-Imidazoline Binding Sites on Monoamine Oxidases.

F.édér. Tesson, I. Limon-Boulez, P. Urban, M. Puype, J. Vandekerckhove, I. Coupry, D. Pompon, and A. Parini (1995)
J. Biol. Chem. 270, 9856-9861
 |  Abstract »  |  Full Text »  |  PDF »

Identifying clonidine-displacing substance.

D Atlas (1994)
Science 266, 462-464
 |  PDF »

Response.

D. J. Reis, G. Li, S. Regunathan, C. J. Barrow, and R. Cooper (1994)
Science 266, 463-464
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