Science 11 February 1994: Vol. 263. no. 5148, pp. 826 - 828 DOI: 10.1126/science.8303301

Prev | Table of Contents | Next

Articles

Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1beta and Interleukin-18.

A. Sarkar, M. W. Hall, M. Exline, J. Hart, N. Knatz, N. T. Gatson, and M. D. Wewers (2006)
Am. J. Respir. Crit. Care Med. 174, 1003-1010
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Function of Plasminogen Activator Inhibitor-1 in Modulation of the AKT Pathway in Wild-type and Plasminogen Activator Inhibitor-1-deficient Endothelial Cells.

R. D. Balsara, F. J. Castellino, and V. A. Ploplis (2006)
J. Biol. Chem. 281, 22527-22536
 |  Abstract »  |  Full Text »  |  PDF »

Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury..

Q. Sang, M. H. Kim, S. Kumar, N. Bye, M. C. Morganti-Kossman, J. Gunnersen, S. Fuller, J. Howitt, L. Hyde, T. Beissbarth, et al. (2006)
J. Neurosci. 26, 7234-7244
 |  Abstract »  |  Full Text »  |  PDF »

Vaccinia virus induces apoptosis of infected macrophages.

Z. Humlova, M. Vokurka, M. Esteban, and Z. Melkova (2002)
J. Gen. Virol. 83, 2821-2832
 |  Abstract »  |  Full Text »  |  PDF »

Antiviral Actions of Interferons.

C. E. Samuel (2001)
Clin. Microbiol. Rev. 14, 778-809
 |  Abstract »  |  Full Text »  |  PDF »

Activation of NF-{kappa}B by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs.

M. S. Iordanov, J. Wong, J. C. Bell, and B. E. Magun (2001)
Mol. Cell. Biol. 21, 61-72
 |  Abstract »  |  Full Text »

Proteases for Cell Suicide: Functions and Regulation of Caspases.

H. Y. Chang and X. Yang (2000)
Microbiol. Mol. Biol. Rev. 64, 821-846
 |  Abstract »  |  Full Text »  |  PDF »

The Antiangiogenic Factor 16K PRL Induces Programmed Cell Death in Endothelial Cells by Caspase Activation.

J.-F. Martini, C. Piot, L. M. Humeau, I. Struman, J. A. Martial, and R. I. Weiner (2000)
Mol. Endocrinol. 14, 1536-1549
 |  Abstract »  |  Full Text »

Intracellular and Extracellular Leukemia Inhibitory Factor Proteins Have Different Cellular Activities That Are Mediated by Distinct Protein Motifs.

B. P. Haines, R. B. Voyle, and P. D. Rathjen (2000)
Mol. Biol. Cell 11, 1369-1383
 |  Abstract »  |  Full Text »

Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3.

S. Shaham, P. W. Reddien, B. Davies, and H. R. Horvitz (1999)
Genetics 153, 1655-1671
 |  Abstract »  |  Full Text »

SPI-1-Dependent Host Range of Rabbitpox Virus and Complex Formation with Cathepsin G Is Associated with Serpin Motifs.

K. B. Moon, P. C. Turner, and R. W. Moyer (1999)
J. Virol. 73, 8999-9010
 |  Abstract »  |  Full Text »  |  PDF »

Proteolysis of Heat Shock Transcription Factor Is Associated with Apoptosis in Rat Nb2 Lymphoma Cells.

M. Zhang, M. J. Blake, P. W. Gout, D. J. Buckley, and A. R. Buckley (1999)
Cell Growth Differ. 10, 759-767
 |  Abstract »  |  Full Text »

Inhibition of Epidermal Growth Factor-induced Interleukin-1{beta}-converting Enzyme Expression Reduces Proliferation in the Pancreatic Carcinoma Cell Line AsPC-1.

S. Schlosser, F. Gansauge, T. Schnelldorfer, M. Ramadani, A. Schwarz, H.-G. Beger, and S. Gansauge (1999)
Cancer Res. 59, 4551-4554
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation.

M. D. Johnson, Y. Kinoshita, H. Xiang, S. Ghatan, and R. S. Morrison (1999)
J. Neurosci. 19, 2996-3006
 |  Abstract »  |  Full Text »  |  PDF »

The Intracellular Serpin Proteinase Inhibitor 6 Is Expressed in Monocytes and Granulocytes and Is a Potent Inhibitor of the Azurophilic Granule Protease, Cathepsin G.

F. L. Scott, C. E. Hirst, J. Sun, C. H. Bird, S. P. Bottomley, and P. I. Bird (1999)
Blood 93, 2089-2097
 |  Abstract »  |  Full Text »  |  PDF »

Ordering the Cytochrome c-initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9-dependent Manner.

E. A. Slee, M. T. Harte, R. M. Kluck, B. B. Wolf, C. A. Casiano, D. D. Newmeyer, H.-G. Wang, J. C. Reed, D. W. Nicholson, E. S. Alnemri, et al. (1999)
J. Cell Biol. 144, 281-292
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Pathways of Apoptosis in PC12 Cells. CrmA INHIBITS APOPTOSIS INDUCED BY beta -AMYLOID.

K. J. Ivins, J. K. Ivins, J. P. Sharp, and C. W. Cotman (1999)
J. Biol. Chem. 274, 2107-2112
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors.

M. Garcia-Calvo, E. P. Peterson, B. Leiting, R. Ruel, D. W. Nicholson, and N. A. Thornberry (1998)
J. Biol. Chem. 273, 32608-32613
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3'-Kinase/Akt Signal Transduction Pathway. REQUIREMENT FOR Flk-1/KDR ACTIVATION.

H.-P. Gerber, A. McMurtrey, J. Kowalski, M. Yan, B. A. Keyt, V. Dixit, and N. Ferrara (1998)
J. Biol. Chem. 273, 30336-30343
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases.

B. Knepper-Nicolai, J. Savill, and S. B. Brown (1998)
J. Biol. Chem. 273, 30530-30536
 |  Abstract »  |  Full Text »  |  PDF »

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector.

A. J. Krohn, E. Preis, and J. H. M. Prehn (1998)
J. Neurosci. 18, 8186-8197
 |  Abstract »  |  Full Text »  |  PDF »

{blacksquare} REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis.

S. A. Lipton and P. Nicotera (1998)
Neuroscientist 4, 345-352
 |  Abstract »  |  PDF »

Inhibition of CPP32-Like Proteases Rescues Axotomized Retinal Ganglion Cells from Secondary Cell Death In Vivo.

P. Kermer, N. Klocker, M. Labes, and M. Bahr (1998)
J. Neurosci. 18, 4656-4662
 |  Abstract »  |  Full Text »  |  PDF »

Purification of a Multipotent Antideath Activity from Bovine Liver and Its Identification as Arginase: Nitric Oxide-Independent Inhibition of Neuronal Apoptosis.

F. Esch, K.-I Lin, A. Hills, K. Zaman, J. M. Baraban, S. Chatterjee, L. Rubin, D. E. Ash, and R. R. Ratan (1998)
J. Neurosci. 18, 4083-4095
 |  Abstract »  |  Full Text »  |  PDF »

Proteases to die for.

V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
 |  Full Text »

Activation of Caspases in Pig Kidney Cells Infected with Wild-Type and CrmA/SPI-2 Mutants of Cowpox and Rabbitpox Viruses.

J. Macen, A. Takahashi, K. B. Moon, R. Nathaniel, P. C. Turner, and R. W. Moyer (1998)
J. Virol. 72, 3524-3533
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress.

D. S. Park, E. J. Morris, L. Stefanis, C. M. Troy, M. L. Shelanski, H. M. Geller, and L. A. Greene (1998)
J. Neurosci. 18, 830-840
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase.

S. P. Srivastava, K. U. Kumar, and R. J. Kaufman (1998)
J. Biol. Chem. 273, 2416-2423
 |  Abstract »  |  Full Text »  |  PDF »

Caenorhabditis elegans anti-apoptotic gene ced-9 prevents ced-3-induced cell death in Drosophila cells.

S Hisahara, H Kanuka, S Shoji, S Yoshikawa, H Okano, and M Miura (1998)
J. Cell Sci. 111, 667-673
 |  Abstract »  |  PDF »

Sindbis Virus Induces Apoptosis through a Caspase-Dependent, CrmA-Sensitive Pathway.

V. E. Nava, A. Rosen, M. A. Veliuona, R. J. Clem, B. Levine, and J. M. Hardwick (1998)
J. Virol. 72, 452-459
 |  Abstract »  |  Full Text »  |  PDF »

Respiratory Syncytial Virus Infection of Neonatal Monocytes Stimulates Synthesis of Interferon Regulatory Factor 1 and Interleukin-1beta (IL-1beta )-Converting Enzyme and Secretion of IL-1beta.

R. Takeuchi, H. Tsutsumi, M. Osaki, S. Sone, S. Imai, and S. Chiba (1998)
J. Virol. 72, 837-840
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons.

D. S. Park, B. Levine, G. Ferrari, and L. A. Greene (1997)
J. Neurosci. 17, 8975-8983
 |  Abstract »  |  Full Text »  |  PDF »

Dismantling Cell-Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of {beta}-Catenin.

C. Brancolini, D. Lazarevic, J. Rodriguez, and C. Schneider (1997)
J. Cell Biol. 139, 759-771
 |  Abstract »  |  Full Text »  |  PDF »

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.

C. S. Duckett and C. B. Thompson (1997)
Genes & Dev. 11, 2810-2821
 |  Abstract »  |  Full Text »  |  PDF »

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury.

A. G. Yakovlev, S. M. Knoblach, L. Fan, G. B. Fox, R. Goodnight, and A. I. Faden (1997)
J. Neurosci. 17, 7415-7424
 |  Abstract »  |  Full Text »  |  PDF »

Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis.

C. Caulin, G. S. Salvesen, and R. G. Oshima (1997)
J. Cell Biol. 138, 1379-1394
 |  Abstract »  |  Full Text »  |  PDF »

Defining Apoptosis: Players and Systems.

G. F. Erickson (1997)
Reproductive Sciences 4, 219-228
 |  Abstract »  |  PDF »

Activation of Caspase-2 in Apoptosis.

H. Li, L. Bergeron, V. Cryns, M. S. Pasternack, H. Zhu, L. Shi, A. Greenberg, and J. Yuan (1997)
J. Biol. Chem. 272, 21010-21017
 |  Abstract »  |  Full Text »  |  PDF »

TUNEL-Positive Ganglion Cells in Human Primary Open-angle Glaucoma.

L. A. Kerrigan, D. J. Zack, H. A. Quigley, S. D. Smith, and M. E. Pease (1997)
Arch Ophthalmol 115, 1031-1035
 |  Abstract »  |  PDF »

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death.

K. Imaizumi, M. Tsuda, Y. Imai, A. Wanaka, T. Takagi, and M. Tohyama (1997)
J. Biol. Chem. 272, 18842-18848
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Expression of Fas (Apo-1/CD95) Ligand on Multiple Myeloma Cells: A Potential Mechanism of Tumor-Induced Suppression of Immune Surveillance.

A. Villunger, A. Egle, I. Marschitz, M. Kos, G. Bock, H. Ludwig, S. Geley, R. Kofler, and R. Greil (1997)
Blood 90, 12-20
 |  Abstract »  |  Full Text »  |  PDF »

Programmed Cell Death in Neurons: Focus on the Pathway of Nerve Growth Factor Deprivation-Induced Death of Sympathetic Neurons.

M. Deshmukh and E. M. Johnson Jr. (1997)
Mol. Pharmacol. 51, 897-906
 |  Abstract »  |  Full Text »

A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro.

Z. Han, E. A. Hendrickson, T. A. Bremner, and J. H. Wyche (1997)
J. Biol. Chem. 272, 13432-13436
 |  Abstract »  |  Full Text »  |  PDF »

Immunolocalization of the ICE/Ced-3-Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes.

S. Krajewski, R. D. Gascoyne, J. M. Zapata, M. Krajewska, S. Kitada, M. Chhanabhai, D. Horsman, K. Berean, L. D. Piro, I. Fugier-Vivier, et al. (1997)
Blood 89, 3817-3825
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Specificities of Caspase Family Proteases.

R. V. Talanian, C. Quinlan, S. Trautz, M. C. Hackett, J. A. Mankovich, D. Banach, T. Ghayur, K. D. Brady, and W. W. Wong (1997)
J. Biol. Chem. 272, 9677-9682
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway.

E. Goillot, J. Raingeaud, A. Ranger, R. I. Tepper, Roger. J. Davis, E. Harlow, and I. Sanchez (1997)
PNAS 94, 3302-3307
 |  Abstract »  |  Full Text »  |  PDF »

Target Protease Specificity of the Viral Serpin CrmA. ANALYSIS OF FIVE CASPASES.

Q. Zhou, S. Snipas, K. Orth, M. Muzio, V. M. Dixit, and G. S. Salvesen (1997)
J. Biol. Chem. 272, 7797-7800
 |  Abstract »  |  Full Text »  |  PDF »

Substrate and Inhibitor Specificity of Interleukin-1beta -converting Enzyme and Related Caspases.

N. Margolin, S. A. Raybuck, K. P. Wilson, W. Chen, T. Fox, Y. Gu, and D. J. Livingston (1997)
J. Biol. Chem. 272, 7223-7228
 |  Abstract »  |  Full Text »  |  PDF »

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone.

P. R.E. Mittl, S. Di Marco, J. F. Krebs, X. Bai, D. S. Karanewsky, J. P. Priestle, K. J. Tomaselli, and M. G. Grutter (1997)
J. Biol. Chem. 272, 6539-6547
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

H. Hara, R. M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, and M. A. Moskowitz (1997)
PNAS 94, 2007-2012
 |  Abstract »  |  Full Text »  |  PDF »

Expression of a Dominant Negative Mutant of Interleukin-1{beta} Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury.

R. M. Friedlander, V. Gagliardini, H. Hara, K. B. Fink, W. Li, G. MacDonald, M. C. Fishman, A. H. Greenberg, M. A. Moskowitz, and J. Yuan (1997)
J. Exp. Med. 185, 933-940
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-{alpha}: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway.

G. S. Dbaibo, D. K. Perry, C. J. Gamard, R. Platt, G. G. Poirier, L. M. Obeid, and Y. A. Hannun (1997)
J. Exp. Med. 185, 481-490
 |  Abstract »  |  Full Text »  |  PDF »

FLICE Induced Apoptosis in a Cell-free System. CLEAVAGE OF CASPASE ZYMOGENS.

M. Muzio, G. S. Salvesen, and VishvaM. Dixit (1997)
J. Biol. Chem. 272, 2952-2956
 |  Abstract »  |  Full Text »  |  PDF »

Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis.

R. Datta, H. Kojima, D. Banach, N. J. Bump, R. V. Talanian, E. S. Alnemri, R. R. Weichselbaum, W. W. Wong, and D. W. Kufe (1997)
J. Biol. Chem. 272, 1965-1969
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis.

R. C. Armstrong, T. J. Aja, K. D. Hoang, S. Gaur, X. Bai, E. S. Alnemri, G. Litwack, D. S. Karanewsky, L. C. Fritz, and K. J. Tomaselli (1997)
J. Neurosci. 17, 553-562
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak.

N. J. McCarthy, M. K.B. Whyte, C. S. Gilbert, and G. I. Evan (1997)
J. Cell Biol. 136, 215-227
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of caspases in sympathetic neuron apoptosis.

M. McCarthy, L. Rubin, and K. Philpott (1997)
J. Cell Sci. 110, 2165-2173
 |  Abstract »  |  PDF »

Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

K Vekrellis, M. McCarthy, A Watson, J Whitfield, L. Rubin, and J Ham (1997)
Development 124, 1239-1249
 |  Abstract »  |  PDF »

CrmA/SPI-2 Inhibition of an Endogenous ICE-related Protease Responsible for Lamin A Cleavage and Apoptotic Nuclear Fragmentation.

A. Takahashi, P.-Y. Musy, L. M. Martins, G. G. Poirier, R. W. Moyer, and W. C. Earnshaw (1996)
J. Biol. Chem. 271, 32487-32490
 |  Abstract »  |  Full Text »  |  PDF »

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

S. M. Srinivasula, M. Ahmad, T. Fernandes-Alnemri, G. Litwack, and E. S. Alnemri (1996)
PNAS 93, 14486-14491
 |  Abstract »  |  Full Text »  |  PDF »

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis.

D. M. Vanags, M. I. Porn-Ares, S. Coppola, D. H. Burgess, and S. Orrenius (1996)
J. Biol. Chem. 271, 31075-31085
 |  Abstract »  |  Full Text »  |  PDF »

Specific Cleavage of alpha -Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1beta -converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease.

V. L. Cryns, L. Bergeron, H. Zhu, H. Li, and J. Yuan (1996)
J. Biol. Chem. 271, 31277-31282
 |  Abstract »  |  Full Text »  |  PDF »

A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes.

J. Sun, C. H. Bird, V. Sutton, L. McDonald, P. B. Coughlin, T. A. De Jong, J. A. Trapani, and P. I. Bird (1996)
J. Biol. Chem. 271, 27802-27809
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 Expression in Neural Cells Blocks Activation of ICE/CED-3 Family Proteases during Apoptosis.

A. Srinivasan, L. M. Foster, M.-P. Testa, T. Ord, R. W. Keane, D. E. Bredesen, and C. Kayalar (1996)
J. Neurosci. 16, 5654-5660
 |  Abstract »  |  Full Text »  |  PDF »

Ordering the Cell Death Pathway. DIFFERENTIAL EFFECTS OF BCL2, AN INTERLEUKIN-1-CONVERTING ENZYME FAMILY PROTEASE INHIBITOR, AND OTHER SURVIVAL AGENTS ON JNK ACTIVATION IN SERUM/NERVE GROWTH FACTOR-DEPRIVED PC12 CELLS.

D. S. Park, L. Stefanis, C. Y. I. Yan, S. E. Farinelli, and L. A. Greene (1996)
J. Biol. Chem. 271, 21898-21905
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Ich-3, a Member of the Interleukin-1beta Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE.

S. Wang, M. Miura, Y.-k. Jung, H. Zhu, V. Gagliardini, L. Shi, A. H. Greenberg, and J. Yuan (1996)
J. Biol. Chem. 271, 20580-20587
 |  Abstract »  |  Full Text »  |  PDF »

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors.

R. C. Armstrong, T. Aja, J. Xiang, S. Gaur, J. F. Krebs, K. Hoang, X. Bai, S. J. Korsmeyer, D. S. Karanewsky, L. C. Fritz, et al. (1996)
J. Biol. Chem. 271, 16850-16855
 |  Abstract »  |  Full Text »  |  PDF »

Purification and Characterization of an Interleukin-1beta -converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32).

X. Liu, C. N. Kim, J. Pohl, and X. Wang (1996)
J. Biol. Chem. 271, 13371-13376
 |  Abstract »  |  Full Text »  |  PDF »

Processing and Activation of CMH-1 by Granzyme B.

Y. Gu, C. Sarnecki, M. A. Fleming, J. A. Lippke, R. C. Bleackley, and M. S.-S. Su (1996)
J. Biol. Chem. 271, 10816-10820
 |  Abstract »  |  Full Text »  |  PDF »

REVIEW {blacksquare} : Keeping Neurons Alive: The Molecular Control of Apoptosis (Part I.

D. E. Bredesen (1996)
Neuroscientist 2, 181-190
 |  Abstract »  |  PDF »

Suppression of Interleukin-1beta-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor.

Y.-K. Jung, M. Miura, and J. Yuan (1996)
J. Biol. Chem. 271, 5112-5117
 |  Abstract »  |  Full Text »  |  PDF »

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities..

S Shaham and H R Horvitz (1996)
Genes & Dev. 10, 578-591
 |  Abstract »  |  PDF »

DNA Damage and Repair in Central Nervous System Injury : National Institute of Neurological Disorders and Stroke Workshop Summary.

M. Chopp, P. H. Chan, C. Y. Hsu, M. E. Cheung, and T. P. Jacobs (1996)
Stroke 27, 363-369
 |  Abstract »  |  Full Text »

Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32.

J. A. Lippke, Y. Gu, C. Sarnecki, P. R. Caron, and M. S.-S. Su (1996)
J. Biol. Chem. 271, 1825-1828
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.

V. Weaver, C. Carson, P. Walker, N Chaly, B Lach, Y Raymond, D. Brown, and M Sikorska (1996)
J. Cell Sci. 109, 45-56
 |  Abstract »  |  PDF »

Programmed cell death in the absence of c-Fos and c-Jun.

S Roffler-Tarlov, J. Brown, E Tarlov, J Stolarov, D. Chapman, M Alexiou, and V. Papaioannou (1996)
Development 122, 1-9
 |  Abstract »  |  PDF »

Life, death, and the pursuit of apoptosis..

E White (1996)
Genes & Dev. 10, 1-15
 |  PDF »

Molecular Cloning of Bomapin (Protease Inhibitor 10), a Novel Human Serpin That Is Expressed Specifically in the Bone Marrow.

M. Riewald and R. R. Schleef (1995)
J. Biol. Chem. 270, 26754-26757
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Toxicity and Carcinogenesis.

B. F. Trump (1995)
Toxicol Pathol 23, 775-827
 |  PDF »

CrmA, a Poxvirus-encoded Serpin, Inhibits Cytotoxic T-lymphocyte-mediated Apoptosis.

M. Tewari, W. G. Telford, R. A. Miller, and V. M. Dixit (1995)
J. Biol. Chem. 270, 22705-22708
 |  Abstract »  |  Full Text »  |  PDF »

Gene Structure, Chromosomal Localization, and Expression of the Murine Homologue of Human Proteinase Inhibitor 6 (PI-6) Suggests Divergence of PI-6 from the Ovalbumin Serpins.

J. Sun, J. B. Rose, and P. Bird (1995)
J. Biol. Chem. 270, 16089-16096
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Pro-apoptotic Activity of ICE[IMAGE]II and ICE[IMAGE]III, Members of the ICE/CED-3 Family of Cysteine Proteases.

N. A. Munday, J. P. Vaillancourt, A. Ali, F. J. Casano, D. K. Miller, S. M. Molineaux, T.-T. Yamin, V. L. Yu, and D. W. Nicholson (1995)
J. Biol. Chem. 270, 15870-15876
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1[IMAGE]-converting Enzyme Family of Cysteine Proteases.

J. Kamens, M. Paskind, M. Hugunin, R. V. Talanian, H. Allen, D. Banach, N. Bump, M. Hackett, C. G. Johnston, P. Li, et al. (1995)
J. Biol. Chem. 270, 15250-15256
 |  Abstract »  |  Full Text »  |  PDF »

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A.

L. T. Quan, A. Caputo, R. C. Bleackley, D. J. Pickup, and G. S. Salvesen (1995)
J. Biol. Chem. 270, 10377-10379
 |  Abstract »  |  Full Text »  |  PDF »

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

K Kuida, J. Lippke, G Ku, M. Harding, D. Livingston, M. Su, and R. Flavell (1995)
Science 267, 2000-2003
 |  Abstract »  |  PDF »

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis.

S. J. Martin, G. A. O'Brien, W. K. Nishioka, A. J. McGahon, A. Mahboubi, T. C. Saido, and D. R. Green (1995)
J. Biol. Chem. 270, 6425-6428
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms and genes of cellular suicide.

H Steller (1995)
Science 267, 1445-1449
 |  Abstract »  |  PDF »

Apoptosis in the pathogenesis and treatment of disease.

C. Thompson (1995)
Science 267, 1456-1462
 |  Abstract »  |  PDF »

Cloning and Expression of Four Novel Isoforms of Human Interleukin-1beta Converting Enzyme with Different Apoptotic Activities.

E. S. Alnemri, T. Fernandes-Alnemri, and G. Litwack (1995)
J. Biol. Chem. 270, 4312-4317
 |  Abstract »  |  Full Text »  |  PDF »

Review : Apoptosis: regulation and relevance to toxicology.

M. R Alison and C. E Sarraf (1995)
Human and Experimental Toxicology 14, 234-247
 |  Abstract »  |  PDF »

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product.

M. Tewari and V. M. Dixit (1995)
J. Biol. Chem. 270, 3255-3260
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.

N Boudreau, C. Sympson, Z Werb, and M. Bissell (1995)
Science 267, 891-893
 |  Abstract »  |  PDF »

The induction of multiple cell cycle events precedes target-related neuronal death.

K Herrup and J. Busser (1995)
Development 121, 2385-2395
 |  Abstract »  |  PDF »

Cell cycle control and cancer.

L. Hartwell and M. Kastan (1994)
Science 266, 1821-1828
 |  Abstract »  |  PDF »

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme..

S Kumar, M Kinoshita, M Noda, N G Copeland, and N A Jenkins (1994)
Genes & Dev. 8, 1613-1626
 |  Abstract »  |  PDF »

Cell death genes: Drosophila enters the field.

M. Raff (1994)
Science 264, 668-669
 |  PDF »

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans.

H.R. Horvitz, S. Shaham, and M.O. Hengartner (1994)
Cold Spring Harb Symp Quant Biol 59, 377-385
 |  Abstract »  |  PDF »

Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative Agent N-alpha -tosyl-L-phenylalanyl Chloromethyl Ketone.

B. A. Ballif, A. Shimamura, E. Pae, and J. Blenis (2001)
J. Biol. Chem. 276, 12466-12475
 |  Abstract »  |  Full Text »  |  PDF »

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.

H. Mochizuki, H. Hayakawa, M. Migita, M. Shibata, R. Tanaka, A. Suzuki, Y. Shimo-Nakanishi, T. Urabe, M. Yamada, K. Tamayose, et al. (2001)
PNAS 98, 10918-10923
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products