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Science 11 February 1994:
Vol. 263. no. 5148, pp. 814 - 817
DOI: 10.1126/science.8303299
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Articles

Science, Vol 263, Issue 5148, 814-817
Copyright © 1994 by American Association for the Advancement of Science

articles

Mapping the lectin-like activity of tumor necrosis factor

R Lucas, S Magez, R De Leys, L Fransen, JP Scheerlinck, M Rampelberg, E Sablon, and P De Baetselier

Laboratory of Cellular Immunology, University of Brussels, Sint-Genesius-Rode, Belgium.

Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian trypanosomes. This activity was not blocked by soluble 55-kilodalton and 75-kilodalton TNF receptors, but was potently inhibited by N,N'-diacetylchitobiose, an oligosaccharide that binds TNF. Comparative sequence analysis of TNF and LT localized the trypanocidal region, and synthetic peptides were trypanolytic. TNF molecules in which the trypanocidal region was mutated or deleted retained tumoricidal activity. Thus, trypanosome-TNF interactions occur via a TNF domain, probably with lectin-like affinity, which is functionally and spatially distinct from the mammalian TNF receptor binding sites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. Latta, G. Kunstle, R. Lucas, H. Hentze, and A. Wendel (2007)
J. Pharmacol. Exp. Ther. 321, 875-883
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An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels.
M. Bilej, R. Joskova, R. Van den Bergh, P. Prochazkova, M. Silerova, P. Ameloot, P. De Baetselier, and A. Beschin (2006)
Int. Immunol. 18, 1663-1670
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Dichotomal Role of TNF in Experimental Pulmonary Edema Reabsorption.
C. Braun, J. Hamacher, D. R. Morel, A. Wendel, and R. Lucas (2005)
J. Immunol. 175, 3402-3408
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Quercetin Induces Apoptosis of Trypanosoma brucei gambiense and Decreases the Proinflammatory Response of Human Macrophages.
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Antimicrob. Agents Chemother. 48, 924-929
   Abstract »    Full Text »    PDF »
Functional Identification of the Alveolar Edema Reabsorption Activity of Murine Tumor Necrosis Factor-{alpha}.
N. Elia, M. Tapponnier, M. A. Matthay, J. Hamacher, J.-C. Pache, M.-A. Brundler, M. Totsch, P. De Baetselier, L. Fransen, N. Fukuda, et al. (2003)
Am. J. Respir. Crit. Care Med. 168, 1043-1050
   Abstract »    Full Text »    PDF »
Recombinant Tumor Necrosis Factor Alpha Does Not Inhibit the Growth of African Trypanosomes in Axenic Cultures.
H. Kitani, S. J. Black, Y. Nakamura, J. Naessens, N. B. Murphy, Y. Yokomizo, J. Gibson, and F. Iraqi (2002)
Infect. Immun. 70, 2210-2214
   Abstract »    Full Text »    PDF »
Control of Experimental Trypanosoma brucei Infections Occurs Independently of Lymphotoxin-{alpha} Induction.
S. Magez, B. Stijlemans, G. Caljon, H.-P. Eugster, and P. De Baetselier (2002)
Infect. Immun. 70, 1342-1351
   Abstract »    Full Text »    PDF »
Mechanisms of TNF-{alpha} stimulation of amiloride-sensitive sodium transport across alveolar epithelium.
N. Fukuda, C. Jayr, A. Lazrak, Y. Wang, R. Lucas, S. Matalon, and M. A. Matthay (2001)
Am J Physiol Lung Cell Mol Physiol 280, L1258-L1265
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Alternative versus classical macrophage activation during experimental African trypanosomosis.
B. Namangala, P. De Baetselier, W. Noël, L. Brys, and A. Beschin (2001)
J. Leukoc. Biol. 69, 387-396
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Tumor Necrosis Factor Alpha Is a Key Mediator in the Regulation of Experimental Trypanosoma brucei Infections.
S. Magez, M. Radwanska, A. Beschin, K. Sekikawa, and P. De Baetselier (1999)
Infect. Immun. 67, 3128-3132
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Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) alpha  Differentially Modulate Cellular Sensitivity to TNF/LT-alpha Cytotoxicity in L929 Cells.
E. Decoster, S. Cornelis, B. Vanhaesebroeck, and W. Fiers (1998)
J. Cell Biol. 143, 2057-2065
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Resistance to the African Trypanosomes Is IFN-{gamma} Dependent.
C. J. Hertz, H. Filutowicz, and J. M. Mansfield (1998)
J. Immunol. 161, 6775-6783
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Experimental Murine Trypanosoma congolense Infections. I. Administration of Anti-IFN-{gamma} Antibodies Alters Trypanosome-Susceptible Mice to a Resistant-Like Phenotype.
J. E. Uzonna, R. S. Kaushik, J. R. Gordon, and H. Tabel (1998)
J. Immunol. 161, 5507-5515
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Effects of Granulocyte-Macrophage Colony-Stimulating Factor and Tumor Necrosis Factor Alpha on Trypanosoma cruzi Trypomastigotes.
E. O. Fontt, P. De Baetselier, C. Heirman, K. Thielemans, R. Lucas, and B. Vray (1998)
Infect. Immun. 66, 2722-2727
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The Glycosyl-Inositol-Phosphate and Dimyristoylglycerol Moieties of the Glycosylphosphatidylinositol Anchor of the Trypanosome Variant-Specific Surface Glycoprotein Are Distinct Macrophage-Activating Factors.
S. Magez, B. Stijlemans, M. Radwanska, E. Pays, M. A. J. Ferguson, and P. De Baetselier (1998)
J. Immunol. 160, 1949-1956
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Induction of Unresponsiveness to Tumor Necrosis Factor (TNF) after Autocrine TNF Expression Requires TNF Membrane Retention.
E. Decoster, B. Vanhaesebroeck, E. Boone, S. Plaisance, K. De Vos, G. Haegeman, J. Grooten, and W. Fiers (1998)
J. Biol. Chem. 273, 3271-3277
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Specific Uptake of Tumor Necrosis Factor-alpha Is Involved in Growth Control of Trypanosoma brucei.
S. Magez, M. Geuskens, A. Beschin, H. d. Favero, H. Verschueren, R. Lucas, E. Pays, and P. d. Baetselier (1997)
J. Cell Biol. 137, 715-727
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Lectin-like Characteristics of Recombinant Human Interleukin-1beta Recognizing Glycans of the Glycosylphosphatidylinositol Anchor.
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J. Biol. Chem. 272, 10579-10584
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Generation and Biological Characterization of Membrane-bound, Uncleavable Murine Tumor Necrosis Factor.
E. Decoster, B. Vanhaesebroeck, P. Vandenabeele, J. Grooten, and W. Fiers (1995)
J. Biol. Chem. 270, 18473-18478
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Mapping the Domain(s) Critical for the Binding of Human Tumor Necrosis Factor-alpha to Its Two Receptors.
P. C.-H. Chen, G. C. DuBois, and M.-J. Chen (1995)
J. Biol. Chem. 270, 2874-2878
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A Conserved Flagellar Pocket Exposed High Mannose Moiety Is Used by African Trypanosomes as a Host Cytokine Binding Molecule.
S. Magez, M. Radwanska, B. Stijlemans, H. Van Xong, E. Pays, and P. De Baetselier (2001)
J. Biol. Chem. 276, 33458-33464
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