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Science 4 February 1994:
Vol. 263. no. 5147, pp. 689 - 692
DOI: 10.1126/science.8303279
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Articles

Science, Vol 263, Issue 5147, 689-692
Copyright © 1994 by American Association for the Advancement of Science

articles

Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal

DG Rainnie, HC Grunze, RW McCarley, and RW Greene

Department of Psychiatry, Harvard University, Brockton, MA.

Increased discharge activity of mesopontine cholinergic neurons participates in the production of electroencephalographic (EEG) arousal; such arousal diminishes as a function of the duration of prior wakefulness or of brain hyperthermia. Whole-cell and extracellular recordings in a brainstem slice show that mesopontine cholinergic neurons are under the tonic inhibitory control of endogenous adenosine, a neuromodulator released during brain metabolism. This inhibitory tone is mediated postsynaptically by an inwardly rectifying potassium conductance and by an inhibition of the hyperpolarization-activated current. These data provide a coupling mechanism linking neuronal control of EEG arousal with the effects of prior wakefulness, brain hyperthermia, and the use of the adenosine receptor blockers caffeine and theophylline.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)