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Science 4 February 1994:
Vol. 263. no. 5147, pp. 681 - 684
DOI: 10.1126/science.7508143
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Articles

Science, Vol 263, Issue 5147, 681-684
Copyright © 1994 by American Association for the Advancement of Science

articles

Magnetic resonance microscopy of embryonic cell lineages and movements

RE Jacobs and SE Fraser

Division of Biology, Beckman Institute, California Institute of Technology, Pasadena 91125.

Key events in vertebrate embryogenesis are difficult to observe in many species. High-resolution magnetic resonance imaging was used to follow cell movements and lineages in developing frog embryos. A single cell was injected at the 16-cell stage with a contrast agent, based on the gadolinium chelate gadolinium-diethylenetriamine pentaacetic acid-dextran. The labeled progeny cells could be followed uniquely in three-dimensional magnetic resonance images, acquired from the embryo over several days. The results show that external ectodermal and internal mesodermal tissues extend at different rates during amphibian gastrulation and neurulation.


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