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Science 28 January 1994:
Vol. 263. no. 5146, pp. 532 - 536
DOI: 10.1126/science.8290963
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Articles

Science, Vol 263, Issue 5146, 532-536
Copyright © 1994 by American Association for the Advancement of Science

articles

Locally distributed synaptic potentiation in the hippocampus

EM Schuman and DV Madison

Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford Medical School, CA 94305.

The long-lasting increase in synaptic strength known as long-term potentiation has been advanced as a potential physiological mechanism for many forms of both developmental and adult neuronal plasticity. In many models of plasticity, intercellular communication has been proposed to account for observations in which simultaneously active neurons are strengthened together. The data presented here indicate that long-term potentiation can be communicated between synapses on neighboring neurons by means of a diffusible messenger. This distributed potentiation provides a mechanism for the cooperative strengthening of proximal synapses and may underlie a variety of plastic processes in the nervous system.


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