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Science 28 January 1994:
Vol. 263. no. 5146, pp. 523 - 526
DOI: 10.1126/science.8290961
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Articles

Science, Vol 263, Issue 5146, 523-526
Copyright © 1994 by American Association for the Advancement of Science

articles

Phospholipase D: a downstream effector of ARF in granulocytes

S Cockcroft, GM Thomas, A Fensome, B Geny, E Cunningham, I Gout, I Hiles, NF Totty, O Truong, and JJ Hsuan

Department of Physiology, University College London, United Kingdom.

Activation of the phospholipase D (PLD) pathway is a widespread response when cells are activated by agonists that bind receptors on the cell surface. A 16-kD cytosolic component can reconstitute guanosine triphosphate (GTP)-mediated activation of phospholipase D in HL60 cells depleted of their cytosol by permeabilization. This factor was purified and identified as two small GTP-binding proteins, ARF1 and ARF3. Recombinant ARF1 substituted for purified ARF proteins in the reconstitution assay. These results indicate that phospholipase D is a downstream effector of ARF1 and ARF3. The well-established role of ARF in vesicular traffic would suggest that alterations in lipid content by PLD are an important determinant in vesicular dynamics.


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J. Biol. Chem. 279, 27774-27780
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The GDP-bound form of Arf6 is located at the plasma membrane.
E. Macia, F. Luton, M. Partisani, J. Cherfils, P. Chardin, and M. Franco (2004)
J. Cell Sci. 117, 2389-2398
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W.-I Wu and D. R. Voelker (2004)
J. Biol. Chem. 279, 6635-6642
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Phospholipase D in Cell Proliferation and Cancer.
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Specificity of Rho Insert-mediated Activation of Phospholipase D1.
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J. Leukoc. Biol. 71, 718-728
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R. T. Premont, A. Claing, N. Vitale, S. J. Perry, and R. J. Lefkowitz (2000)
J. Biol. Chem. 275, 22373-22380
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ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA.
R. L. Boshans, S. Szanto, L. van Aelst, and C. D'Souza-Schorey (2000)
Mol. Cell. Biol. 20, 3685-3694
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Effectors Increase the Affinity of ADP-ribosylation Factor for GTP to Increase Binding.
X. Zhu, A. L. Boman, J. Kuai, W. Cieplak, and R. A. Kahn (2000)
J. Biol. Chem. 275, 13465-13475
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Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells.
A. Siddhanta, J. M. Backer, and D. Shields (2000)
J. Biol. Chem. 275, 12023-12031
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Phosphoinositide-dependent Activation of the ADP-ribosylation Factor GTPase-activating Protein ASAP1. EVIDENCE FOR THE PLECKSTRIN HOMOLOGY DOMAIN FUNCTIONING AS AN ALLOSTERIC SITE.
J. L. Kam, K. Miura, T. R. Jackson, J. Gruschus, P. Roller, S. Stauffer, J. Clark, R. Aneja, and P. A. Randazzo (2000)
J. Biol. Chem. 275, 9653-9663
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Similarities in Function and Gene Structure of Cytohesin-4 and Cytohesin-1, Guanine Nucleotide-exchange Proteins for ADP-ribosylation Factors.
M. Ogasawara, S.-C. Kim, R. Adamik, A. Togawa, V. J. Ferrans, K. Takeda, M. Kirby, J. Moss, and M. Vaughan (2000)
J. Biol. Chem. 275, 3221-3230
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Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
N. Thibault, D. Harbour, P. Borgeat, P. H. Naccache, and S. G. Bourgoin (2000)
Blood 95, 519-527
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COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo.
R Pepperkok, J. Whitney, M Gomez, and T. Kreis (2000)
J. Cell Sci. 113, 135-144
   Abstract »    PDF »
Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange.
S. Beraud-Dufour, S. Paris, M. Chabre, and B. Antonny (1999)
J. Biol. Chem. 274, 37629-37636
   Abstract »    Full Text »    PDF »
The ARF-like 2 (ARL2)-binding Protein, BART. PURIFICATION, CLONING, AND INITIAL CHARACTERIZATION.
J. D. Sharer and R. A. Kahn (1999)
J. Biol. Chem. 274, 27553-27561
   Abstract »    Full Text »    PDF »
Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils.
L. M'Rabet, P. J. Coffer, R. M. F. Wolthuis, F. Zwartkruis, L. Koenderman, and J. L. Bos (1999)
J. Biol. Chem. 274, 21847-21852
   Abstract »    Full Text »    PDF »
p125 Is a Novel Mammalian Sec23p-interacting Protein with Structural Similarity to Phospholipid-modifying Proteins.
K. Tani, T. Mizoguchi, A. Iwamatsu, K. Hatsuzawa, and M. Tagaya (1999)
J. Biol. Chem. 274, 20505-20512
   Abstract »    Full Text »    PDF »
Brefeldin A Increases the Quantal Size and Alters the Kinetics of Catecholamine Release from Rat Adrenal Chromaffin Cells.
J. Xu and F. W. Tse (1999)
J. Biol. Chem. 274, 19095-19102
   Abstract »    Full Text »    PDF »
Effect of Rho and ADP-ribosylation Factor GTPases on Phospholipase D Activity in Intact Human Adenocarcinoma A549 Cells.
E. Meacci, V. Vasta, J. P. Moorman, D. A. Bobak, P. Bruni, J. Moss, and M. Vaughan (1999)
J. Biol. Chem. 274, 18605-18612
   Abstract »    Full Text »    PDF »
Brefeldin A Inhibited Activity of the Sec7 Domain of p200, a Mammalian Guanine Nucleotide-exchange Protein for ADP-ribosylation Factors.
N. Morinaga, R. Adamik, J. Moss, and M. Vaughan (1999)
J. Biol. Chem. 274, 17417-17423
   Abstract »    Full Text »    PDF »
GTP-dependent Binding of ADP-ribosylation Factor to Coatomer in Close Proximity to the Binding Site for Dilysine Retrieval Motifs and p23.
L. Zhao, J. B. Helms, J. Brunner, and F. T. Wieland (1999)
J. Biol. Chem. 274, 14198-14203
   Abstract »    Full Text »    PDF »
Purification and Cloning of a Brefeldin A-inhibited Guanine Nucleotide-exchange Protein for ADP-ribosylation Factors.
A. Togawa, N. Morinaga, M. Ogasawara, J. Moss, and M. Vaughan (1999)
J. Biol. Chem. 274, 12308-12315
   Abstract »    Full Text »    PDF »
The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D.
A. Schurmann, M. Schmidt, M. Asmus, S. Bayer, F. Fliegert, S. Koling, S. Massmann, C. Schilf, M. C. Subauste, M. Voss, et al. (1999)
J. Biol. Chem. 274, 9744-9751
   Abstract »    Full Text »    PDF »
Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.
M. Sata, J. Moss, and M. Vaughan (1999)
PNAS 96, 2752-2757
   Abstract »    Full Text »    PDF »
Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1.
M. Yamazaki, Y. Zhang, H. Watanabe, T. Yokozeki, S. Ohno, K. Kaibuchi, H. Shibata, H. Mukai, Y. Ono, M. A. Frohman, et al. (1999)
J. Biol. Chem. 274, 6035-6038
   Abstract »    Full Text »    PDF »
Structural Analysis of Human Phospholipase D1.
T.-C. Sung, Y. Zhang, A. J. Morris, and M. A. Frohman (1999)
J. Biol. Chem. 274, 3659-3666
   Abstract »    Full Text »    PDF »
Characterization of a Novel ADP-ribosylation Factor-like Protein (yARL3) in Saccharomyces cerevisiae.
C.-F. Huang, L.-M. Buu, W.-L. Yu, and F.-J. S. Lee (1999)
J. Biol. Chem. 274, 3819-3827
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EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain.
K Venkateswarlu, F Gunn-Moore, J. Tavare, and P. Cullen (1999)
J. Cell Sci. 112, 1957-1965
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ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements.
H Radhakrishna, O Al-Awar, Z Khachikian, and J. Donaldson (1999)
J. Cell Sci. 112, 855-866
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ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts.
J.C. Norman, D. Jones, S.T. Barry, M.R. Holt, S. Cockcroft, and D.R. Critchley (1998)
J. Cell Biol. 143, 1981-1995
   Abstract »    Full Text »    PDF »
Increased Activity of Oleate-Dependent Type Phospholipase D During Actinomycin D-Induced Apoptosis in Jurkat T Cells.
T. Kasai, K. Ohguchi, S. Nakashima, Y. Ito, T. Naganawa, N. Kondo, and Y. Nozawa (1998)
J. Immunol. 161, 6469-6474
   Abstract »    Full Text »    PDF »
ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src.
M. T. Brown, J. Andrade, H. Radhakrishna, J. G. Donaldson, J. A. Cooper, and P. A. Randazzo (1998)
Mol. Cell. Biol. 18, 7038-7051
   Abstract »    Full Text »    PDF »
ADP-ribosylation Factor Proteins Mediate Agonist-induced Activation of Phospholipase D.
K. Shome, Y. Nie, and G. Romero (1998)
J. Biol. Chem. 273, 30836-30841
   Abstract »    Full Text »    PDF »
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles.
M. Stamnes, G. Schiavo, G. Stenbeck, T. H. Sollner, and J. E. Rothman (1998)
PNAS 95, 13676-13680
   Abstract »    Full Text »    PDF »
Requirement of GM2 ganglioside activator for phospholipase D activation.
S.-i. Nakamura, T. Akisue, H. Jinnai, T. Hitomi, S. Sarkar, N. Miwa, T. Okada, K. Yoshida, S.'i. Kuroda, U. Kikkawa, et al. (1998)
PNAS 95, 12249-12253
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Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects.
Z. Xie, M. Fang, M. P. Rivas, A. J. Faulkner, P. C. Sternweis, J. Engebrecht, and V. A. Bankaitis (1998)
PNAS 95, 12346-12351
   Abstract »    Full Text »    PDF »
Guanine Nucleotide Exchange on ADP-ribosylation Factors Catalyzed by Cytohesin-1 and Its Sec7 Domain.
G. Pacheco-Rodriguez, E. Meacci, N. Vitale, J. Moss, and M. Vaughan (1998)
J. Biol. Chem. 273, 26543-26548
   Abstract »    Full Text »    PDF »
Inhibition of in Vitro Endosomal Vesicle Fusion Activity by Aminoglycoside Antibiotics.
A. T. Jones and M. Wessling-Resnick (1998)
J. Biol. Chem. 273, 25301-25309
   Abstract »    Full Text »    PDF »
Activation of the Small GTPase Rap1 in Human Neutrophils.
L. M'Rabet, P. Coffer, F. Zwartkruis, B. Franke, A. W. Segal, L. Koenderman, and J. L. Bos (1998)
Blood 92, 2133-2140
   Abstract »    Full Text »    PDF »
ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function.
M. Franco, J. Boretto, S. Robineau, S. Monier, B. Goud, P. Chardin, and P. Chavrier (1998)
PNAS 95, 9926-9931
   Abstract »    Full Text »    PDF »
Effects of Arfaptin 1 on Guanine Nucleotide-dependent Activation of Phospholipase D and Cholera Toxin by ADP-ribosylation Factor.
S.-C. Tsai, R. Adamik, J.-X. Hong, J. Moss, M. Vaughan, H. Kanoh, and J. H. Exton (1998)
J. Biol. Chem. 273, 20697-20701
   Abstract »    Full Text »    PDF »
An Essential Role for a Small Synaptic Vesicle-Associated Phosphatidylinositol 4-Kinase in Neurotransmitter Release.
C. Wiedemann, T. Schafer, M. M. Burger, and T. S. Sihra (1998)
J. Neurosci. 18, 5594-5602
   Abstract »    Full Text »    PDF »
ADP-Ribosylation Factors Do Not Activate Yeast Phospholipase Ds but Are Required for Sporulation.
S. A. Rudge, M. M. Cavenagh, R. Kamath, V. A. Sciorra, A. J. Morris, R. A. Kahn, and J. Engebrecht (1998)
Mol. Biol. Cell 9, 2025-2036
   Abstract »    Full Text »
Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels.
A. Siddhanta and D. Shields (1998)
J. Biol. Chem. 273, 17995-17998
   Abstract »    Full Text »    PDF »
Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1.
S. F. Betz, A. Schnuchel, H. Wang, E. T. Olejniczak, R. P. Meadows, B. P. Lipsky, E. A. S. Harris, D. E. Staunton, and S. W. Fesik (1998)
PNAS 95, 7909-7914
   Abstract »    Full Text »    PDF »
Phospholipid- and GTP-dependent Activation of Cholera Toxin and Phospholipase D by Human ADP-ribosylation Factor-like Protein 1 (HARL1).
J.-X. Hong, F.-J. S. Lee, W. A. Patton, C. Y. Lin, J. Moss, and M. Vaughan (1998)
J. Biol. Chem. 273, 15872-15876
   Abstract »    Full Text »    PDF »
ADP-Ribosylation Factor 1 Transiently Activates High-Affinity Adaptor Protein Complex AP-1 Binding Sites On Golgi Membranes.
Y. Zhu, L. M. Traub, and S. Kornfeld (1998)
Mol. Biol. Cell 9, 1323-1337
   Abstract »    Full Text »
Association of the Insulin Receptor with Phospholipase C-gamma (PLCgamma ) in 3T3-L1 Adipocytes Suggests a Role for PLCgamma in Metabolic Signaling by Insulin.
A. G. Kayali, J. Eichhorn, T. Haruta, A. J. Morris, J. G. Nelson, P. Vollenweider, J. M. Olefsky, and N. J. G. Webster (1998)
J. Biol. Chem. 273, 13808-13818
   Abstract »    Full Text »    PDF »
Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2). ADP-RIBOSYLATION FACTOR REGULATES hPLD2.
I. Lopez, R. S. Arnold, and J. D. Lambeth (1998)
J. Biol. Chem. 273, 12846-12852
   Abstract »    Full Text »    PDF »
ADP-ribosylation Factor and Rho Proteins Mediate fMLP-dependent Activation of Phospholipase D in Human Neutrophils.
A. Fensome, J. Whatmore, C. Morgan, D. Jones, and S. Cockcroft (1998)
J. Biol. Chem. 273, 13157-13164
   Abstract »    Full Text »    PDF »
Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D.
C. D. Bae, D. S. Min, I. N. Fleming, and J. H. Exton (1998)
J. Biol. Chem. 273, 11596-11604
   Abstract »    Full Text »    PDF »
Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors.
M. Sata, J. G. Donaldson, J. Moss, and M. Vaughan (1998)
PNAS 95, 4204-4208
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Functional association between Arf and RalA in active phospholipase D complex.
J.-Q. Luo, X. Liu, P. Frankel, T. Rotunda, M. Ramos, J. Flom, H. Jiang, L. A. Feig, A. J. Morris, R. A. Kahn, et al. (1998)
PNAS 95, 3632-3637
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Specific Inhibition of Phorbol Ester-stimulated Phospholipase D by Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B-1470 in HEK-293 Cells. RESTORATION BY Ral GTPases.
M. Schmidt, M. Voss, M. Thiel, B. Bauer, A. Grannass, E. Tapp, R. H. Cool, J. de Gunzburg, C. von Eichel-Streiber, and K. H. Jakobs (1998)
J. Biol. Chem. 273, 7413-7422
   Abstract »    Full Text »    PDF »
Characterization of a Rat Brain Phospholipase D Isozyme.
D. S. Min, S.-K. Park, and J. H. Exton (1998)
J. Biol. Chem. 273, 7044-7051
   Abstract »    Full Text »    PDF »
Reversible dissociation of coatomer: Functional characterization of a beta /delta -coat protein subcomplex.
J. Pavel, C. Harter, and F. T. Wieland (1998)
PNAS 95, 2140-2145
   Abstract »    Full Text »    PDF »
ARF Is Required for Maintenance of Yeast Golgi and Endosome Structure and Function.
E. C. Gaynor, C.-Y. Chen, S. D. Emr, and T. R. Graham (1998)
Mol. Biol. Cell 9, 653-670
   Abstract »    Full Text »
Subcellular Distribution and Differential Expression of Endogenous ADP-ribosylation Factor 6 in Mammalian Cells.
C. Z. Yang, H. Heimberg, C. D'Souza-Schorey, M. M. Mueckler, and P. D. Stahl (1998)
J. Biol. Chem. 273, 4006-4011
   Abstract »    Full Text »    PDF »
ARF6 Targets Recycling Vesicles to the Plasma Membrane: Insights from an Ultrastructural Investigation.
C. D'Souza-Schorey, E. van Donselaar, V. W. Hsu, C. Yang, P. D. Stahl, and P. J. Peters (1998)
J. Cell Biol. 140, 603-616
   Abstract »    Full Text »    PDF »
Molecular Characterization of the GTPase-activating Domain of ADP-ribosylation Factor Domain Protein 1 (ARD1).
N. Vitale, J. Moss, and M. Vaughan (1998)
J. Biol. Chem. 273, 2553-2560
   Abstract »    Full Text »    PDF »
Regulated Exocytosis in Chromaffin Cells. TRANSLOCATION OF ARF6 STIMULATES A PLASMA MEMBRANE-ASSOCIATED PHOSPHOLIPASE D.
A.-S. Caumont, M.-C. Galas, N. Vitale, D. Aunis, and M.-F. Bader (1998)
J. Biol. Chem. 273, 1373-1379
   Abstract »    Full Text »    PDF »
Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading.
J Song, Z Khachikian, H Radhakrishna, and J. Donaldson (1998)
J. Cell Sci. 111, 2257-2267
   Abstract »    PDF »
Different Domains of Mammalian ADP-ribosylation Factor 1 Mediate Interaction with Selected Target Proteins.
J. O. Liang, T.-C. Sung, A. J. Morris, M. A. Frohman, and S. Kornfeld (1997)
J. Biol. Chem. 272, 33001-33008
   Abstract »    Full Text »    PDF »
Activation of ADP-ribosylation Factor 1 GTPase-Activating Protein by Phosphatidylcholine-derived Diacylglycerols.
B. Antonny, I. Huber, S. Paris, M. Chabre, and D. Cassel (1997)
J. Biol. Chem. 272, 30848-30851
   Abstract »    Full Text »    PDF »
Characterization of an ADP-ribosylation Factor-like 1 Protein in Saccharomyces cerevisiae.
F.-J. S. Lee, C.-F. Huang, W.-L. Yu, L.-M. Buu, C.-Y. Lin, M.-C. Huang, J. Moss, and M. Vaughan (1997)
J. Biol. Chem. 272, 30998-31005
   Abstract »    Full Text »    PDF »
Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells.
N. Sciaky, J. Presley, C. Smith, K. J.M. Zaal, N. Cole, J. E. Moreira, M. Terasaki, E. Siggia, and J. Lippincott-Schwartz (1997)
J. Cell Biol. 139, 1137-1155
   Abstract »    Full Text »    PDF »
Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor.
N. Morinaga, J. Moss, and M. Vaughan (1997)
PNAS 94, 12926-12931
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Phospholipase D from Rat Brain.
S.-K. Park, J. J. Provost, C. D. Bae, W.-T. Ho, and J. H. Exton (1997)
J. Biol. Chem. 272, 29263-29271
   Abstract »    Full Text »    PDF »
ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway.
H. Radhakrishna and J. G. Donaldson (1997)
J. Cell Biol. 139, 49-61
   Abstract »    Full Text »    PDF »
The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment.
M. A. West, N. A. Bright, and M. S. Robinson (1997)
J. Cell Biol. 138, 1239-1254
   Abstract »    Full Text »    PDF »
Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno.
S. Paris, S. Beraud-Dufour, S. Robineau, J. Bigay, B. Antonny, M. Chabre, and P. Chardin (1997)
J. Biol. Chem. 272, 22221-22226
   Abstract »    Full Text »    PDF »
Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes.
J. Marcil, D. Harbour, P. H. Naccache, and S. Bourgoin (1997)
J. Biol. Chem. 272, 20660-20664
   Abstract »    Full Text »    PDF »
Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network.
Y.-G. Chen, A. Siddhanta, C. D. Austin, S. M. Hammond, T.-C. Sung, M. A. Frohman, A. J. Morris, and D. Shields (1997)
J. Cell Biol. 138, 495-504
   Abstract »    Full Text »    PDF »
Phosphatase Inhibitors Potentiate 4-Hydroxynonenal-induced Phospholipase D Activation in Vascular Endothelial Cells.
V. Natarajan, W. M. Scribner, and S. Vepa (1997)
Am. J. Respir. Cell Mol. Biol. 17, 251-259
   Abstract »    Full Text »


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