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Science 28 January 1994: Vol. 263. no. 5146, pp. 515 - 518 DOI: 10.1126/science.8290959
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Articles
Science, Vol 263, Issue 5146, 515-518
Copyright © 1994 by American Association for the Advancement of Science
Meiosis-induced double-strand break sites determined by yeast chromatin structure
TC Wu
and
M Lichten
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Double-strand DNA breaks (DSBs) occur at recombination hotspots during Saccharomyces cerevisiae meiosis and are thought to initiate exchange at these loci. Analysis of DSB sites in three regions of the yeast genome indicated that breaks occur at or near many potential transcription promoters and that DSBs initiate most, if not all, meiotic recombination. DSB sites displayed deoxyribonuclease I hypersensitivity in chromatin from mitotic and meiotic cells, and changes in chromatin structure produced parallel changes in the occurrence of DSBs. Thus, features of chromatin structure that are established before meiosis play a role in determining where meiotic recombination events initiate.
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94, 8681-8685
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- The hotspot conversion paradox and the evolution of meiotic recombination.
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PNAS
94, 8058-8063
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- Position- and orientation-independent activity of the Schizosaccharomyces pombe meiotic recombination hot spot M26.
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PNAS
94, 7446-7451
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- Clustering of meiotic double-strand breaks on yeast chromosome III.
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PNAS
94, 5213-5218
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- The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast..
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Genes & Dev.
11, 876-886
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- Expression of Human RAD52 Confers Resistance to Ionizing Radiation in Mammalian Cells.
- M. S. Park and M. S. Park (1995)
J. Biol. Chem.
270, 15467-15470
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- A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity..
- W P Wahls and G R Smith (1994)
Genes & Dev.
8, 1693-1702
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- Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast.
- C. Jankowski, F. Nasar, and D. K. Nag (2000)
PNAS
97, 2134-2139
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- From the Cover: Molecular characterization of meiotic recombination across the 140-kb multigenic a1-sh2 interval of maize.
- H. Yao, Q. Zhou, J. Li, H. Smith, M. Yandeau, B. J. Nikolau, and P. S. Schnable (2002)
PNAS
99, 6157-6162
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