Science 21 January 1994: Vol. 263. no. 5145, pp. 384 - 387 DOI: 10.1126/science.8278813

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Articles

Hsp90 Regulates the Function of Argonaute 2 and Its Recruitment to Stress Granules and P-Bodies.

J. M. Pare, N. Tahbaz, J. Lopez-Orozco, P. LaPointe, P. Lasko, and T. C. Hobman (2009)
Mol. Biol. Cell 20, 3273-3284
 |  Abstract »  |  Full Text »  |  PDF »

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator.

X.-b. Chang, A. Mengos, Y.-x. Hou, L. Cui, T. J. Jensen, A. Aleksandrov, J. R. Riordan, and M. Gentzsch (2008)
J. Cell Sci. 121, 2814-2823
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D1 and D2 Dopamine Receptor Expression Is Regulated by Direct Interaction with the Chaperone Protein Calnexin.

R. B. Free, L. A. Hazelwood, D. M. Cabrera, H. N. Spalding, Y. Namkung, M. L. Rankin, and D. R. Sibley (2007)
J. Biol. Chem. 282, 21285-21300
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Bap31 Enhances the Endoplasmic Reticulum Export and Quality Control of Human Class I MHC Molecules.

J. J. Ladasky, S. Boyle, M. Seth, H. Li, T. Pentcheva, F. Abe, S. J. Steinberg, and M. Edidin (2006)
J. Immunol. 177, 6172-6181
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Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.

D. B. Williams (2006)
J. Cell Sci. 119, 615-623
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ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity.

I. Ron and M. Horowitz (2005)
Hum. Mol. Genet. 14, 2387-2398
 |  Abstract »  |  Full Text »  |  PDF »

Inefficient Cross-Presentation Limits the CD8+ T Cell Response to a Subdominant Tumor Antigen Epitope.

P. Otahal, S. C. Hutchinson, L. M. Mylin, M. J. Tevethia, S. S. Tevethia, and T. D. Schell (2005)
J. Immunol. 175, 700-712
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Calnexin and ERp57 Facilitate the Assembly of the Neonatal Fc Receptor for IgG with {beta}2-Microglobulin in the Endoplasmic Reticulum.

X. Zhu, J. Peng, D. Chen, X. Liu, L. Ye, H. Iijima, K. Kadavil, W. I. Lencer, and R. S. Blumberg (2005)
J. Immunol. 175, 967-976
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Glycoprotein Tertiary and Quaternary Structures Are Monitored by the Same Quality Control Mechanism.

N. Keith, A. J. Parodi, and J. J. Caramelo (2005)
J. Biol. Chem. 280, 18138-18141
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PrPC Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its Cellular Conformation.

D. Sarnataro, V. Campana, S. Paladino, M. Stornaiuolo, L. Nitsch, and C. Zurzolo (2004)
Mol. Biol. Cell 15, 4031-4042
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Bap29/31 Influences the Intracellular Traffic of MHC Class I Molecules.

M.-E. Paquet, M. Cohen-Doyle, G. C. Shore, and D. B. Williams (2004)
J. Immunol. 172, 7548-7555
 |  Abstract »  |  Full Text »  |  PDF »

Lectin-deficient Calnexin Is Capable of Binding Class I Histocompatibility Molecules in Vivo and Preventing Their Degradation.

M. R. Leach and D. B. Williams (2004)
J. Biol. Chem. 279, 9072-9079
 |  Abstract »  |  Full Text »  |  PDF »

Calreticulin Promotes Folding/Dimerization of Human Lipoprotein Lipase Expressed in Insect Cells (Sf21).

L. Zhang, G. Wu, C. G. Tate, A. Lookene, and G. Olivecrona (2003)
J. Biol. Chem. 278, 29344-29351
 |  Abstract »  |  Full Text »  |  PDF »

An Essential Function of Tapasin in Quality Control of HLA-G Molecules.

B. Park and K. Ahn (2003)
J. Biol. Chem. 278, 14337-14345
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Identification of Specific Glycoforms of Major Histocompatibility Complex Class I Heavy Chains Suggests That Class I Peptide Loading Is an Adaptation of the Quality Control Pathway Involving Calreticulin and ERp57.

C. M. Radcliffe, G. Diedrich, D. J. Harvey, R. A. Dwek, P. Cresswell, and P. M. Rudd (2002)
J. Biol. Chem. 277, 46415-46423
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Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation by Inhibitor of 90-kDa Heat-Shock Protein Family: Endoplasmic Reticulum Retention of Monomeric Insulin Receptor Precursor with Calnexin in Adrenal Chromaffin Cells.

T. Saitoh, T. Yanagita, S. Shiraishi, H. Yokoo, H. Kobayashi, S.-i. Minami, T. Onitsuka, and A. Wada (2002)
Mol. Pharmacol. 62, 847-855
 |  Abstract »  |  Full Text »  |  PDF »

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.

M.-E. Paquet and D. B. Williams (2002)
Int. Immunol. 14, 347-358
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Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum.

A. D. De Silva, J.-J. Park, N. Matsuki, A. K. Stanic, R. R. Brutkiewicz, M. E. Medof, and S. Joyce (2002)
J. Immunol. 168, 723-733
 |  Abstract »  |  Full Text »  |  PDF »

The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases.

B. Lankat-Buttgereit and R. Tampe (2002)
Physiol Rev 82, 187-204
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between Calnexin and BiP in Suppressing Aggregation and Promoting Refolding of Protein and Glycoprotein Substrates.

V. S. Stronge, Y. Saito, Y. Ihara, and D. B. Williams (2001)
J. Biol. Chem. 276, 39779-39787
 |  Abstract »  |  Full Text »  |  PDF »

Distinct differences in association of MHC class I with endoplasmic reticulum proteins in wild-type, and {beta}2-microglobulin- and TAP-deficient cell lines.

K. M. Paulsson, P. Wang, P. O. Anderson, S. Chen, R. F. Pettersson, and S. Li (2001)
Int. Immunol. 13, 1063-1073
 |  Abstract »  |  Full Text »  |  PDF »

Processing of Exogenous Antigens for Presentation by Class I MHC Molecules Involves Post-Golgi Peptide Exchange Influenced by Peptide-MHC Complex Stability and Acidic pH.

P. J. Chefalo and C. V. Harding (2001)
J. Immunol. 167, 1274-1282
 |  Abstract »  |  Full Text »  |  PDF »

CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface.

H. W. Sohn, Y. K. Shin, I.-S. Lee, Y. M. Bae, Y. H. Suh, M. K. Kim, T. J. Kim, K. C. Jung, W. S. Park, C.-S. Park, et al. (2001)
J. Immunol. 166, 787-794
 |  Abstract »  |  Full Text »  |  PDF »

Infection with an H2 recombinant herpes simplex virus vector results in expression of MHC class I antigens on the surfaces of human neuroblastoma cells in vitro and mouse sensory neurons in vivo.

A. Abendroth, A. Simmons, S. Efstathiou, and R. A. Pereira (2000)
J. Gen. Virol. 81, 2375-2383
 |  Abstract »  |  Full Text »

Blocked transport of soluble Kb molecules containing connecting peptide segment involved in calnexin association.

S.-B. Qian and S.-S. Chen (2000)
Int. Immunol. 12, 1409-1416
 |  Abstract »  |  Full Text »  |  PDF »

Functional Relationship between Calreticulin, Calnexin, and the Endoplasmic Reticulum Luminal Domain of Calnexin.

U. G. Danilczyk, M. F. Cohen-Doyle, and D. B. Williams (2000)
J. Biol. Chem. 275, 13089-13097
 |  Abstract »  |  Full Text »  |  PDF »

cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum.

V. Briquet-Laugier, O. Ben-Zeev, A. White, and M. H. Doolittle (1999)
J. Lipid Res. 40, 2044-2058
 |  Abstract »  |  Full Text »

Thermolabile H-2Kb Molecules Expressed by Transporter Associated with Antigen Processing-Deficient RMA-S Cells Are Occupied by Low-Affinity Peptides.

A. D. De Silva, A. Boesteanu, R. Song, N. Nagy, E. Harhaj, C. V. Harding, and S. Joyce (1999)
J. Immunol. 163, 4413-4420
 |  Abstract »  |  Full Text »  |  PDF »

The Majority of H2-M3 Is Retained Intracellularly in a Peptide-Receptive State and Traffics to the Cell Surface in the Presence of N-Formylated Peptides.

N. M. Chiu, T. Chun, M. Fay, M. Mandal, and C.-R. Wang (1999)
J. Exp. Med. 190, 423-434
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Molecular Chaperones Stimulate the Functional Expression of the Cocaine-sensitive Serotonin Transporter.

C. G. Tate, E. Whiteley, and M. J. Betenbaugh (1999)
J. Biol. Chem. 274, 17551-17558
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Calnexin Interaction with N-Glycosylation Mutants of a Polytopic Membrane Glycoprotein, the Human Erythrocyte Anion Exchanger 1 (Band 3).

M. Popov and R. A. F. Reithmeier (1999)
J. Biol. Chem. 274, 17635-17642
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Specific Proteolytic Cleavages Limit the Diversity of the Pool of Peptides Available to MHC Class I Molecules in Living Cells.

T. Serwold and N. Shastri (1999)
J. Immunol. 162, 4712-4719
 |  Abstract »  |  Full Text »  |  PDF »

Peptide-bound Major Histocompatibility Complex Class I Molecules Associate with Tapasin before Dissociation from Transporter Associated with Antigen Processing.

S. Li, K. M. Paulsson, H.-O. Sjogren, and P. Wang (1999)
J. Biol. Chem. 274, 8649-8654
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Murine MHC Class I Molecules with Tapasin and TAP Enhances Peptide Loading and Involves the Heavy Chain {alpha}3 Domain.

W.-K. Suh, M. A. Derby, M. F. Cohen-Doyle, G. J. Schoenhals, K. Fruh, J. A. Berzofsky, and D. B. Williams (1999)
J. Immunol. 162, 1530-1540
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Differential role of mannose and glucose trimming in the ER degradation of asialoglycoprotein receptor subunits.

M Ayalon-Soffer, M Shenkman, and G. Lederkremer (1999)
J. Cell Sci. 112, 3309-3318
 |  Abstract »  |  PDF »

In vitro reconstitution of calreticulin-substrate interactions.

J. Peterson and A Helenius (1999)
J. Cell Sci. 112, 2775-2784
 |  Abstract »  |  PDF »

Characterization of Domains in Mice of Calnexin-t, a Putative Molecular Chaperone Required in Sperm Fertility, with Use of Glutathione S-Transferase-Fusion Proteins.

S. Ohsako, L. Janulis, Y. Hayashi, and D. Bunick (1998)
Biol Reprod 59, 1214-1223
 |  Abstract »  |  Full Text »

Assembly of MHC Class I Molecules with Biosynthesized Endoplasmic Reticulum-Targeted Peptides Is Inefficient in Insect Cells and Can Be Enhanced by Protease Inhibitors.

Y. Deng, J. Gibbs, I. Bacik, A. Porgador, J. Copeman, P. Lehner, B. Ortmann, P. Cresswell, J. R. Bennink, and J. W. Yewdell (1998)
J. Immunol. 161, 1677-1685
 |  Abstract »  |  Full Text »  |  PDF »

Herpes Simplex Virus Type 1 Glycoprotein B Requires a Cysteine Residue at Position 633 for Folding, Processing, and Incorporation into Mature Infectious Virus Particles.

S. Laquerre, D. B. Anderson, R. Argnani, and J. C. Glorioso (1998)
J. Virol. 72, 4940-4949
 |  Abstract »  |  Full Text »  |  PDF »

Calreticulin and Calnexin Interact with Different Protein and Glycan Determinants During the Assembly of MHC Class I.

M. R. Harris, Y. Y. L. Yu, C. S. Kindle, T. H. Hansen, and J. C. Solheim (1998)
J. Immunol. 160, 5404-5409
 |  Abstract »  |  Full Text »  |  PDF »

Folding of Insulin Receptor Monomers Is Facilitated by the Molecular Chaperones Calnexin and Calreticulin and Impaired by Rapid Dimerization.

J. Bass, G. Chiu, Y. Argon, and D. F. Steiner (1998)
J. Cell Biol. 141, 637-646
 |  Abstract »  |  Full Text »  |  PDF »

Differential Interaction of Coagulation Factor VIII and Factor V with Protein Chaperones Calnexin and Calreticulin.

S. W. Pipe, J. A. Morris, J. Shah, and R. J. Kaufman (1998)
J. Biol. Chem. 273, 8537-8544
 |  Abstract »  |  Full Text »  |  PDF »

Endocrinopathies in the Family of Endoplasmic Reticulum (ER) Storage Diseases: Disorders of Protein Trafficking and the Role of ER Molecular Chaperones.

P. S. Kim and P. Arvan (1998)
Endocr. Rev. 19, 173-202
 |  Abstract »  |  Full Text »

Direct Binding of the MHC Class I Molecule H-2Ld to CD8: Interaction with the Amino Terminus of a Mature Cell Surface Protein.

M. T. Jelonek, B. J. Classon, P. J. Hudson, and D. H. Margulies (1998)
J. Immunol. 160, 2809-2814
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Patterns of Folding and Interactions with Calnexin and Calreticulin in Human Class I MHC Proteins with Altered N-Glycosylation.

Q. Zhang and R. D. Salter (1998)
J. Immunol. 160, 831-837
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic reticulum quality control of asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval.

M. Shenkman, M. Ayalon, and G. Z. Lederkremer (1997)
PNAS 94, 11363-11368
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Translation and Assembly of a Complete T Cell Receptor-CD3 Complex.

J. B. Huppa and H. L. Ploegh (1997)
J. Exp. Med. 186, 393-403
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Disposal of Incompletely Folded Human alpha 1-Antitrypsin Involves Release from Calnexin and Post-translational Trimming of Asparagine-linked Oligosaccharides.

Y. Liu, P. Choudhury, C. M. Cabral, and R. N. Sifers (1997)
J. Biol. Chem. 272, 7946-7951
 |  Abstract »  |  Full Text »  |  PDF »

Delta F508 in cystic fibrosis: willing but not able.

K. W Southern (1997)
Arch. Dis. Child. 76, 278-282
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Interactions between Newly Synthesized Glycoproteins, Calnexin and a Network of Resident Chaperones in the Endoplasmic Reticulum.

U. Tatu and A. Helenius (1997)
J. Cell Biol. 136, 555-565
 |  Abstract »  |  Full Text »  |  PDF »

Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes.

J. E. M. Van Leeuwen and K. P. Kearse (1996)
PNAS 93, 13997-14001
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of a Mutant Secretory Protein, alpha 1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity.

D. Qu, J. H. Teckman, S. Omura, and D. H. Perlmutter (1996)
J. Biol. Chem. 271, 22791-22795
 |  Abstract »  |  Full Text »  |  PDF »

The Glut 1Glucose Transporter Interacts with Calnexin and Calreticulin.

J. D. Oliver, R. C. Hresko, M. Mueckler, and S. High (1996)
J. Biol. Chem. 271, 13691-13696
 |  Abstract »  |  Full Text »  |  PDF »

Unique Expression of Major Histocompatibility Complex Class I Proteins in the Absence of Glucose Trimming and Calnexin Association.

J. P. Balow, J. D. Weissman, and K. P. Kearse (1995)
J. Biol. Chem. 270, 29025-29029
 |  Abstract »  |  Full Text »  |  PDF »

Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail.

H. T. Leung, J. Bradshaw, J. S. Cleaveland, and P. S. Linsley (1995)
J. Biol. Chem. 270, 25107-25114
 |  Abstract »  |  Full Text »  |  PDF »

Chaperone Function of Calreticulin When Expressed in the Endoplasmic Reticulum as the Membrane-anchored and Soluble Forms.

I. Wada, S.-i. Imai, M. Kai, F. Sakane, and H. Kanoh (1995)
J. Biol. Chem. 270, 20298-20304
 |  Abstract »  |  Full Text »  |  PDF »

Calnexin Influences Folding of Human Class I Histocompatibility Proteins but Not Their Assembly with beta(2)-Microglobulin.

M. Tector and R. D. Salter (1995)
J. Biol. Chem. 270, 19638-19642
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Endoplasmic Reticulum Chaperone Calnexin in Subunit Folding and Assembly of Nicotinic Acetylcholine Receptors.

M. S. Gelman, W. Chang, D. Y. Thomas, J. J. M. Bergeron, and J. M. Prives (1995)
J. Biol. Chem. 270, 15085-15092
 |  Abstract »  |  Full Text »  |  PDF »

Transient Aggregation of Major Histocompatibility Complex Class II Chains during Assembly in Normal Spleen Cells.

M. S. Marks, R. N. Germain, and J. S. Bonifacino (1995)
J. Biol. Chem. 270, 10475-10481
 |  Abstract »  |  Full Text »  |  PDF »

Presentation without Proteolytic Cleavage of Endogenous Precursors in the MHC Class I Antigen Processing Pathway.

D. Buchholz, P. Scott, and N. Shastri (1995)
J. Biol. Chem. 270, 6515-6522
 |  Abstract »  |  Full Text »  |  PDF »

The Molecular Chaperone Calnexin Binds Glc(1)Man(9)GlcNAc(2) Oligosaccharide as an Initial Step in Recognizing Unfolded Glycoproteins.

F. E. Ware, A. Vassilakos, P. A. Peterson, M. R. Jackson, M. A. Lehrman, and D. B. Williams (1995)
J. Biol. Chem. 270, 4697-4704
 |  Abstract »  |  Full Text »  |  PDF »

Calnexin Recognizes Carbohydrate and Protein Determinants of Class I Major Histocompatibility Complex Molecules.

Q. Zhang, M. Tector, and R. D. Salter (1995)
J. Biol. Chem. 270, 3944-3948
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin.

B. Arunachalam and P. Cresswell (1995)
J. Biol. Chem. 270, 2784-2790
 |  Abstract »  |  Full Text »  |  PDF »

Saccharomyces cerevisiae CNE1 Encodes an Endoplasmic Reticulum (ER) Membrane Protein with Sequence Similarity to Calnexin and Calreticulin and Functions as a Constituent of the ER Quality Control Apparatus.

F. Parlati, M. Dominguez, J. J. M. Bergeron, and D. Y. Thomas (1995)
J. Biol. Chem. 270, 244-253
 |  Abstract »  |  Full Text »  |  PDF »

Assembly and Intracellular Transport of MHC Class I and Class II Molecules.

M.R. Jackson, K. Fruh, L. Karlsson, L. Teyton, Y. Yang, and P.A. Peterson (1995)
Cold Spring Harb Symp Quant Biol 60, 249-261
 |  Abstract »  |  PDF »

Folding of VSV G protein: sequential interaction with BiP and calnexin.

C Hammond and A Helenius (1994)
Science 266, 456-458
 |  Abstract »  |  PDF »

Interaction of MHC class I molecules with the transporter associated with antigen processing.

W. Suh, M. Cohen-Doyle, K Fruh, K Wang, P. Peterson, and D. Williams (1994)
Science 264, 1322-1326
 |  Abstract »  |  PDF »

The Lectin Chaperone Calnexin Utilizes Polypeptide-based Interactions to Associate with Many of Its Substrates in Vivo.

U. G. Danilczyk and D. B. Williams (2001)
J. Biol. Chem. 276, 25532-25540
 |  Abstract »  |  Full Text »  |  PDF »

An Endoplasmic Reticulum Protein Implicated in Chaperoning Peptides to Major Histocompatibility of Class I Is an Aminopeptidase.

A. Menoret, Z. Li, M. L. Niswonger, A. Altmeyer, and P. K. Srivastava (2001)
J. Biol. Chem. 276, 33313-33318
 |  Abstract »  |  Full Text »  |  PDF »

Oligosaccharide-based Information in Endoplasmic Reticulum Quality Control and Other Biological Systems.

M. A. Lehrman (2001)
J. Biol. Chem. 276, 8623-8626
 |  Full Text »  |  PDF »

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