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Science 14 January 1994:
Vol. 263. no. 5144, pp. 237 - 240
DOI: 10.1126/science.8284676
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Articles

Science, Vol 263, Issue 5144, 237-240
Copyright © 1994 by American Association for the Advancement of Science

articles

Phase shifting of the circadian clock by induction of the Drosophila period protein

I Edery, JE Rutila, and M Rosbash

Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02254.

Virtually all organisms manifest circadian (24-hour) rhythms, governed by an ill-defined endogenous pacemaker or clock. Several lines of evidence suggest that the Drosophila melanogaster period gene product PER is a clock component. If PER were central to the time-keeping mechanism, a transient increase in its concentration would cause a stable shift in the phase of the clock. Therefore, transgenic flies bearing a heat-inducible copy of PER were subjected to temperature pulses. This treatment caused long-lasting phase shifts in the locomotor activity circadian rhythm, a result that supports the contention that PER is a bona fide clock component.


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