Science 14 January 1994: Vol. 263. no. 5144, pp. 235 - 237 DOI: 10.1126/science.7904381

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Articles

Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process.

I. Okwor, D. Liu, S. M. Beverley, and J. E. Uzonna (2009)
PNAS 106, 13951-13956
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Effector T Cells in Dry Eye Disease.

J. El Annan, S. K. Chauhan, T. Ecoiffier, Q. Zhang, D. R. Saban, and R. Dana (2009)
Invest. Ophthalmol. Vis. Sci. 50, 3802-3807
 |  Abstract »  |  Full Text »  |  PDF »

CytoPred: a server for prediction and classification of cytokines.

S. Lata and G.P.S. Raghava (2008)
Protein Eng. Des. Sel. 21, 279-282
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Susceptible BALB/c Mice from Challenge with Leishmania major by Nucleoside Hydrolase, a Soluble Exo-antigen of Leishmania.

M. A. Al-Wabel, W. K. Tonui, L. Cui, S. K. Martin, and R. G. Titus (2007)
Am J Trop Med Hyg 77, 1060-1065
 |  Abstract »  |  Full Text »  |  PDF »

LIGHT Is Critical for IL-12 Production by Dendritic Cells, Optimal CD4+ Th1 Cell Response, and Resistance to Leishmania major.

G. Xu, D. Liu, I. Okwor, Y. Wang, H. Korner, S. K. P. Kung, Y.-X. Fu, and J. E. Uzonna (2007)
J. Immunol. 179, 6901-6909
 |  Abstract »  |  Full Text »  |  PDF »

Generation of CD8 T Cell Memory Is Regulated by IL-12.

E. L. Pearce and H. Shen (2007)
J. Immunol. 179, 2074-2081
 |  Abstract »  |  Full Text »  |  PDF »

Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.

M. D. Chiesa, C. Romagnani, A. Thiel, L. Moretta, and A. Moretta (2006)
Blood 108, 3851-3858
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell Expression Cloning of Porphyromonas gingivalis Genes Coding for T Helper-Biased Immune Responses during Infection.

R. B. Goncalves, O. Leshem, K. Bernards, J. R. Webb, P. P. Stashenko, and A. Campos-Neto (2006)
Infect. Immun. 74, 3958-3966
 |  Abstract »  |  Full Text »  |  PDF »

The Novel Cytokine p43 Induces IL-12 Production in Macrophages via NF-{kappa}B Activation, Leading to Enhanced IFN-{gamma} Production in CD4+ T Cells.

E. Kim, S. H. Kim, S. Kim, and T. S. Kim (2006)
J. Immunol. 176, 256-264
 |  Abstract »  |  Full Text »  |  PDF »

IL-12 Is Required for Induction but Not Maintenance of Protective, Memory Responses to Blastomyces dermatitidis: Implications for Vaccine Development in Immune-Deficient Hosts.

M. Wuthrich, T. Warner, and B. S. Klein (2005)
J. Immunol. 175, 5288-5297
 |  Abstract »  |  Full Text »  |  PDF »

Control of Infection with Leishmania major in Susceptible BALB/c Mice Lacking the Common {gamma}-Chain for FcR Is Associated with Reduced Production of IL-10 and TGF-{beta} by Parasitized Cells.

U. M. Padigel and J. P. Farrell (2005)
J. Immunol. 174, 6340-6345
 |  Abstract »  |  Full Text »  |  PDF »

The Reciprocal Interaction of NK Cells with Plasmacytoid or Myeloid Dendritic Cells Profoundly Affects Innate Resistance Functions.

F. Gerosa, A. Gobbi, P. Zorzi, S. Burg, F. Briere, G. Carra, and G. Trinchieri (2005)
J. Immunol. 174, 727-734
 |  Abstract »  |  Full Text »  |  PDF »

Immunization with Leishmania major Exogenous Antigens Protects Susceptible BALB/c Mice against Challenge Infection with L. major.

W. K. Tonui, J. S. Mejia, L. Hochberg, M. L. Mbow, J. R. Ryan, A. S. T. Chan, S. K. Martin, and R. G. Titus (2004)
Infect. Immun. 72, 5654-5661
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by Leishmania mexicana Amastigotes: The Role of Cysteine Peptidases and the NF-{kappa}B Signaling Pathway.

P. Cameron, A. McGachy, M. Anderson, A. Paul, G. H. Coombs, J. C. Mottram, J. Alexander, and R. Plevin (2004)
J. Immunol. 173, 3297-3304
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Immunoglobulin G and Its Subclass Response to Indian Kala-Azar Infection before and after Chemotherapy.

R. Ravindran, K. Anam, B. C. Bairagi, B. Saha, N. Pramanik, S. K. Guha, R. P. Goswami, D. Banerjee, and N. Ali (2004)
Infect. Immun. 72, 863-870
 |  Abstract »  |  Full Text »  |  PDF »

TRANCE-RANK Costimulation is Required for IL-12 Production and the Initiation of a Th1-Type Response to Leishmania major Infection in CD40L-Deficient Mice.

U. M. Padigel, N. Kim, Y. Choi, and J. P. Farrell (2003)
J. Immunol. 171, 5437-5441
 |  Abstract »  |  Full Text »  |  PDF »

Virulent Toxoplasma gondii strain RH promotes T-cell-independent overproduction of proinflammatory cytokines IL12 and {gamma}-interferon.

T. D. Nguyen, G. Bigaignon, D. Markine-Goriaynoff, H. Heremans, T. N. Nguyen, G. Warnier, M. Delmee, M. Warny, S. F. Wolf, C. Uyttenhove, et al. (2003)
J. Med. Microbiol. 52, 869-876
 |  Abstract »  |  Full Text »  |  PDF »

Coinjection with CpG-Containing Immunostimulatory Oligodeoxynucleotides Reduces the Pathogenicity of a Live Vaccine against Cutaneous Leishmaniasis but Maintains Its Potency and Durability.

S. Mendez, K. Tabbara, Y. Belkaid, S. Bertholet, D. Verthelyi, D. Klinman, R. A. Seder, and D. L. Sacks (2003)
Infect. Immun. 71, 5121-5129
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination with Novel Immunostimulatory Adjuvants against Blood-Stage Malaria in Mice.

Z. Su, M.-F. Tam, D. Jankovic, and M. M. Stevenson (2003)
Infect. Immun. 71, 5178-5187
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 1{alpha} Promotes Th1 Differentiation and Inhibits Disease Progression in Leishmania major-susceptible BALB/c Mice.

E. von Stebut, J. M. Ehrchen, Y. Belkaid, S. L. Kostka, K. Molle, J. Knop, C. Sunderkotter, and M. C. Udey (2003)
J. Exp. Med. 198, 191-199
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides to Act as an Adjuvant for Protective Vaccine Immunity Against Leishmania major in Mice.

J. A. Shah, P. A. Darrah, D. R. Ambrozak, T. N. Turon, S. Mendez, J. Kirman, C.-Y. Wu, N. Glaichenhaus, and R. A. Seder (2003)
J. Exp. Med. 198, 281-291
 |  Abstract »  |  Full Text »  |  PDF »

Intranasal Immunization with Recombinant Lactococcus lactis Secreting Murine Interleukin-12 Enhances Antigen-Specific Th1 Cytokine Production.

L. G. Bermudez-Humaran, P. Langella, N. G. Cortes-Perez, A. Gruss, R. S. Tamez-Guerra, S. C. Oliveira, O. S. Cardenas, R. Montes de Oca-Luna, and Y. Le Loir (2003)
Infect. Immun. 71, 1887-1896
 |  Abstract »  |  Full Text »

CD40-CD40 Ligand Costimulation Is Not Required for Initiation and Maintenance of a Th1-Type Response to Leishmania major Infection.

U. M. Padigel and J. P. Farrell (2003)
Infect. Immun. 71, 1389-1395
 |  Abstract »  |  Full Text »  |  PDF »

The Leishmania mexicana Cysteine Protease, CPB2.8, Induces Potent Th2 Responses.

K. G. J. Pollock, K. S. McNeil, J. C. Mottram, R. E. Lyons, J. M. Brewer, P. Scott, G. H. Coombs, and J. Alexander (2003)
J. Immunol. 170, 1746-1753
 |  Abstract »  |  Full Text »  |  PDF »

Identification of IFN Regulatory Factor-1 Binding Site in IL-12 p40 Gene Promoter.

S. Maruyama, K. Sumita, H. Shen, M. Kanoh, X. Xu, M. Sato, M. Matsumoto, H. Shinomiya, and Y. Asano (2003)
J. Immunol. 170, 997-1001
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Role of p38 Mitogen-Activated Protein Kinase in Mediating the Anti-inflammatory Effects of CpG Oligodeoxynucleotide in Murine Asthma.

B. K. Choudhury, J. S. Wild, R. Alam, D. M. Klinman, I. Boldogh, N. Dharajiya, W. J. Mileski, and S. Sur (2002)
J. Immunol. 169, 5955-5961
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability.

M. Rodriguez-Sosa, A. R. Satoskar, R. Calderon, L. Gomez-Garcia, R. Saavedra, R. Bojalil, and L. I. Terrazas (2002)
Infect. Immun. 70, 3656-3664
 |  Abstract »  |  Full Text »  |  PDF »

Cellular and Molecular Regulation of Vaccination with Heat Shock Protein 60 from Histoplasma capsulatum.

G. S. Deepe, Jr., and R. S. Gibbons (2002)
Infect. Immun. 70, 3759-3767
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-Term Memory CD4+and CD8+T Cell Responses and Protection Against Leishmania major Infection.

E. G. Rhee, S. Mendez, J. A. Shah, C.-y. Wu, J. R. Kirman, T. N. Turon, D. F. Davey, H. Davis, D. M. Klinman, R. N. Coler, et al. (2002)
J. Exp. Med. 195, 1565-1573
 |  Abstract »  |  Full Text »  |  PDF »

The Role of IL-12 in Maintaining Resistance to Leishmania major.

A. Y. Park, B. Hondowicz, M. Kopf, and P. Scott (2002)
J. Immunol. 168, 5771-5777
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Immunity within the Central Nervous System Stimulated by Recombinant Listeria monocytogenes Vaccination.

L. M. Liau, E. R. Jensen, T. J. Kremen, S. K. Odesa, S. N. Sykes, M. C. Soung, J. F. Miller, and J. M. Bronstein (2002)
Cancer Res. 62, 2287-2293
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation and Parasite Dose Combine to Influence the Susceptibility of BALB/c Mice to Infection with Leishmania major.

H. L. Compton and J. P. Farrell (2002)
J. Immunol. 168, 1302-1308
 |  Abstract »  |  Full Text »  |  PDF »

KM+, a lectin from Artocarpus integrifolia, induces IL-12 p40 production by macrophages and switches from type 2 to type 1 cell-mediated immunity against Leishmania major antigens, resulting in BALB/c mice resistance to infection.

A. Panunto-Castelo, M. A. Souza, M.-C. Roque-Barreira, and J. S. Silva (2001)
Glycobiology 11, 1035-1042
 |  Abstract »  |  Full Text »  |  PDF »

The Development of a Th1-Type Response and Resistance to Leishmania major Infection in the Absence of CD40-CD40L Costimulation.

U. M. Padigel, P. J. Perrin, and J. P. Farrell (2001)
J. Immunol. 167, 5874-5879
 |  Abstract »  |  Full Text »  |  PDF »

Leishmania donovani p36(LACK) DNA Vaccine Is Highly Immunogenic but Not Protective against Experimental Visceral Leishmaniasis.

P. C. Melby, J. Yang, W. Zhao, L. E. Perez, and J. Cheng (2001)
Infect. Immun. 69, 4719-4725
 |  Abstract »  |  Full Text »  |  PDF »

IL-12 Decreases Activation-Induced Cell Death in Human Naive Th Cells Costimulated by Intercellular Adhesion Molecule-1. I. IL-12 Alters Caspase Processing and Inhibits Enzyme Function.

E. M. Palmer, L. Farrokh-Siar, J. Maguire van Seventer, and G. A. van Seventer (2001)
J. Immunol. 167, 749-758
 |  Abstract »  |  Full Text »  |  PDF »

A Role for IL-12 Receptor Expression and Signal Transduction in Host Defense in Leprosy.

J. Kim, K. Uyemura, M. K. Van Dyke, A. J. Legaspi, T. H. Rea, K. Shuai, and R. L. Modlin (2001)
J. Immunol. 167, 779-786
 |  Abstract »  |  Full Text »  |  PDF »

Down-Regulation of IL-12 p40 Gene in Plasmodium berghei-Infected Mice.

X. Xu, K. Sumita, C. Feng, X. Xiong, H. Shen, S. Maruyama, M. Kanoh, and Y. Asano (2001)
J. Immunol. 167, 235-241
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Cutaneous Leishmaniasis Induced by Recombinant Antigens in Murine and Nonhuman Primate Models of the Human Disease.

A. Campos-Neto, R. Porrozzi, K. Greeson, R. N. Coler, J. R. Webb, Y. A. W. Seiky, S. G. Reed, and G. Grimaldi Jr. (2001)
Infect. Immun. 69, 4103-4108
 |  Abstract »  |  Full Text »  |  PDF »

Myelin/Axonal Pathology in Interleukin-12 Induced Serial Relapses of Experimental Allergic Encephalomyelitis in the Lewis Rat.

Z. Ahmed, D. Gveric, G. Pryce, D. Baker, J. P. Leonard, and M. L. Cuzner (2001)
Am. J. Pathol. 158, 2127-2138
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination against the Intracellular Pathogens Leishmania major and L. amazonensis by Directing CD40 Ligand to Macrophages.

G. Chen, P. A. Darrah, and D. M. Mosser (2001)
Infect. Immun. 69, 3255-3263
 |  Abstract »  |  Full Text »  |  PDF »

The Potency and Durability of DNA- and Protein-Based Vaccines Against Leishmania major Evaluated Using Low-Dose, Intradermal Challenge.

S. Mendez, S. Gurunathan, S. Kamhawi, Y. Belkaid, M. A. Moga, Y. A. W. Skeiky, A. Campos-Neto, S. Reed, R. A. Seder, and D. Sacks (2001)
J. Immunol. 166, 5122-5128
 |  Abstract »  |  Full Text »  |  PDF »

Successful Therapy of Lethal Murine Visceral Leishmaniasis with Cystatin Involves Up-Regulation of Nitric Oxide and a Favorable T Cell Response.

L. Das, N. Datta, S. Bandyopadhyay, and P. K. Das (2001)
J. Immunol. 166, 4020-4028
 |  Abstract »  |  Full Text »  |  PDF »

Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Mycobacterium smegmatis-Induced Cytokine Production by Human Macrophages In Vitro.

F. A. Post, C. Manca, O. Neyrolles, B. Ryffel, D. B. Young, and G. Kaplan (2001)
Infect. Immun. 69, 1433-1439
 |  Abstract »  |  Full Text »  |  PDF »

Protective Immunity Against the Protozoan Leishmania chagasi Is Induced by Subclinical Cutaneous Infection with Virulent But Not Avirulent Organisms.

J. A. Streit, T. J. Recker, F. G. Filho, S. M. Beverley, and M. E. Wilson (2001)
J. Immunol. 166, 1921-1929
 |  Abstract »  |  Full Text »  |  PDF »

Vervet Monkeys Vaccinated with Killed Leishmania major Parasites and Interleukin-12 Develop a Type 1 Immune Response but Are Not Protected against Challenge Infection.

M. M. Gicheru, J. O. Olobo, C. O. Anjili, A. S. Orago, F. Modabber, and P. Scott (2001)
Infect. Immun. 69, 245-251
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 12 as an Adjuvant to WI-1 Adhesin Immunization Augments Delayed-Type Hypersensitivity, Shifts the Subclass Distribution of Immunoglobulin G Antibodies, and Enhances Protective Immunity to Blastomyces dermatitidis Infection.

M. Wuthrich, B. E. Finkel-Jiminez, and B. S. Klein (2000)
Infect. Immun. 68, 7172-7174
 |  Abstract »  |  Full Text »  |  PDF »

Immunization of Cats against Feline Immunodeficiency Virus (FIV) Infection by Using Minimalistic Immunogenic Defined Gene Expression Vector Vaccines Expressing FIV gp140 Alone or with Feline Interleukin-12 (IL-12), IL-16, or a CpG Motif.

C. M. Leutenegger, F. S. Boretti, C. N. Mislin, J. N. Flynn, M. Schroff, A. Habel, C. Junghans, S. A. Koenig-Merediz, B. Sigrist, A. Aubert, et al. (2000)
J. Virol. 74, 10447-10457
 |  Abstract »  |  Full Text »

Salmonella Infection Does Not Increase Expression and Activity of the High Affinity IL-12 Receptor.

A. Elhofy, I. Marriott, and K. L. Bost (2000)
J. Immunol. 165, 3324-3332
 |  Abstract »  |  Full Text »  |  PDF »

A Role for CD40-CD40 Ligand Interactions in the Generation of Type 1 Cytokine Responses in Human Leprosy.

P. S. Yamauchi, J. R. Bleharski, K. Uyemura, J. Kim, P. A. Sieling, A. Miller, H. Brightbill, K. Schlienger, T. H. Rea, and R. L. Modlin (2000)
J. Immunol. 165, 1506-1512
 |  Abstract »  |  Full Text »  |  PDF »

IL-12 Is Required to Maintain a Th1 Response During Leishmania major Infection.

A. Y. Park, B. D. Hondowicz, and P. Scott (2000)
J. Immunol. 165, 896-902
 |  Abstract »  |  Full Text »  |  PDF »

Requirements for the Maintenance of Th1 Immunity In Vivo Following DNA Vaccination: A Potential Immunoregulatory Role for CD8+ T Cells.

S. Gurunathan, L. Stobie, C. Prussin, D. L. Sacks, N. Glaichenhaus, D. J. Fowell, R. M. Locksley, J. T. Chang, C.-Y. Wu, and R. A. Seder (2000)
J. Immunol. 165, 915-924
 |  Abstract »  |  Full Text »  |  PDF »

Beryllium, an Adjuvant That Promotes Gamma Interferon Production.

J. Y. Lee, O. Atochina, B. King, L. Taylor, M. Elloso, P. Scott, and M. D. Rossman (2000)
Infect. Immun. 68, 4032-4039
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Effects of Mycobacterium tuberculosis Ag38 Gene Transduction and Interleukin 12 in Vaccination against Spontaneous Tumor Development in Proto-neu Transgenic Mice.

L. Sfondrini, M. Rodolfo, M. Singh, M. P. Colombo, M. I. Colnaghi, S. Ménard, and A. Balsari (2000)
Cancer Res. 60, 3777-3781
 |  Abstract »  |  Full Text »

A Dose-Escalation and Pharmacokinetic Study of Subcutaneously Administered Recombinant Human Interleukin 12 and Its Biological Effects in Japanese Patients with Advanced Malignancies.

R. Ohno, Y. Yamaguchi, T. Toge, T. Kinouchi, T. Kotake, M. Shibata, Y. Kiyohara, S. Ikeda, I. Fukui, A. Gohchi, et al. (2000)
Clin. Cancer Res. 6, 2661-2669
 |  Abstract »  |  Full Text »

Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention of Leishmania major Infection.

K. Ohkusu, T. Yoshimoto, K. Takeda, T. Ogura, S.-i. Kashiwamura, Y. Iwakura, S. Akira, H. Okamura, and K. Nakanishi (2000)
Infect. Immun. 68, 2449-2456
 |  Abstract »  |  Full Text »  |  PDF »

Primary Role for GI Protein Signaling in the Regulation of Interleukin 12 Production and the Induction of T Helper Cell Type 1 Responses.

J. He, S. Gurunathan, A. Iwasaki, B. Ash-Shaheed, and B. L. Kelsall (2000)
J. Exp. Med. 191, 1605-1610
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cytokine Profiles by the Mycoplasma Superantigen Mycoplasma arthritidis Mitogen Parallels Susceptibility to Arthritis Induced by M. arthritidis.

H.-H. Mu, A. D. Sawitzke, and B. C. Cole (2000)
Infect. Immun. 68, 1142-1149
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Vaccination of Mice against New World Cutaneous Leishmaniasis: Comparison of Three Proteins Expressed in Amastigotes and Six Adjuvants.

T. Aebischer, M. Wolfram, S. I. Patzer, T. Ilg, M. Wiese, and P. Overath (2000)
Infect. Immun. 68, 1328-1336
 |  Abstract »  |  Full Text »  |  PDF »

Listeria monocytogenes as a Short-Lived Delivery System for the Induction of Type 1 Cell-Mediated Immunity against the p36/LACK Antigen of Leishmania major.

N. Soussi, G. Milon, J.-H. Colle, E. Mougneau, N. Glaichenhaus, and P. L. Goossens (2000)
Infect. Immun. 68, 1498-1506
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-12 as an Adjuvant Promotes Immunoglobulin G and Type 1 Cytokine Recall Responses to Major Surface Protein 2 of the Ehrlichial Pathogen Anaplasma marginale.

W. Tuo, G. H. Palmer, T. C. McGuire, D. Zhu, and W. C. Brown (2000)
Infect. Immun. 68, 270-280
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination with Heat-Killed Listeria as Adjuvant Reverses Established Allergen-Induced Airway Hyperreactivity and Inflammation: Role of CD8+ T Cells and IL-18.

G. Hansen, V. P. Yeung, G. Berry, D. T. Umetsu, and R. H. DeKruyff (2000)
J. Immunol. 164, 223-230
 |  Abstract »  |  Full Text »  |  PDF »

Coadministration of Interleukin 12 Expression Vector with Antigen 2 cDNA Enhances Induction of Protective Immunity against Coccidioides immitis.

C. Jiang, D. M. Magee, and R. A. Cox (1999)
Infect. Immun. 67, 5848-5853
 |  Abstract »  |  Full Text »  |  PDF »

Protective Immunity Using Recombinant Human IL-12 and Alum as Adjuvants in a Primate Model of Cutaneous Leishmaniasis.

R. T. Kenney, D. L. Sacks, J. P. Sypek, L. Vilela, A. A. Gam, and K. Evans-Davis (1999)
J. Immunol. 163, 4481-4488
 |  Abstract »  |  Full Text »  |  PDF »

Limited Interleukin-18 Response in Salmonella-Infected Murine Macrophages and in Salmonella-Infected Mice.

A. Elhofy and K. L. Bost (1999)
Infect. Immun. 67, 5021-5026
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-{{gamma}} and CXC Chemokine Induction by Interleukin 12 in Renal Cell Carcinoma.

R. M. Bukowski, P. Rayman, L. Molto, C. S. Tannenbaum, T. Olencki, D. Peereboom, R. Tubbs, D. McLain, G. T. Budd, T. Griffin, et al. (1999)
Clin. Cancer Res. 5, 2780-2789
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory DNA as an Adjuvant in Vaccination against Leishmania major.

K. J. Stacey and J. M. Blackwell (1999)
Infect. Immun. 67, 3719-3726
 |  Abstract »  |  Full Text »  |  PDF »

An alternate pathway for type 1 T cell differentiation.

C. Feng, S. Watanabe, S. Maruyama, G. Suzuki, M. Sato, T. Furuta, S. Kojima, S. Taki, and Y. Asano (1999)
Int. Immunol. 11, 1185-1194
 |  Abstract »  |  Full Text »  |  PDF »

IL-18 Inhibits Diabetes Development in Nonobese Diabetic Mice by Counterregulation of Th1-Dependent Destructive Insulitis.

H. Rothe, A. Hausmann, K. Casteels, H. Okamura, M. Kurimoto, V. Burkart, C. Mathieu, and H. Kolb (1999)
J. Immunol. 163, 1230-1236
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma -dependent mechanisms.

P. S. Walker, T. Scharton-Kersten, A. M. Krieg, L. Love-Homan, E. D. Rowton, M. C. Udey, and J. C. Vogel (1999)
PNAS 96, 6970-6975
 |  Abstract »  |  Full Text »  |  PDF »

Mice Lacking NK Cells Develop an Efficient Th1 Response and Control Cutaneous Leishmania major Infection.

A. R. Satoskar, L. M. Stamm, X. Zhang, A. A. Satoskar, M. Okano, C. Terhorst, J. R. David, and B. Wang (1999)
J. Immunol. 162, 6747-6754
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of the IL-12 p40 Promoter and of p40 Secretion by CpG DNA and Lipopolysaccharide.

J. S. Cowdery, N. J. Boerth, L. A. Norian, P. S. Myung, and G. A. Koretzky (1999)
J. Immunol. 162, 6770-6775
 |  Abstract »  |  Full Text »  |  PDF »

Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides.

S. Sur, J. S. Wild, B. K. Choudhury, N. Sur, R. Alam, and D. M. Klinman (1999)
J. Immunol. 162, 6284-6293
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Interleukin-12 Is Capable of Generating an Antigen-Specific Th1-Type Response in the Presence of an Ongoing Infection-Driven Th2-Type Response.

L. R. Schopf, J. L. Bliss, L. M. Lavigne, C. L. Chung, S. F. Wolf, and J. P. Sypek (1999)
Infect. Immun. 67, 2166-2171
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Different Doses of Adenoviral Vector Expressing IL-12 Enhance or Depress the Immune Response to a Coadministered Antigen: the Role of Nitric Oxide.

J. J. Lasarte, F. J. Corrales, N. Casares, A. Lopez-Diaz de Cerio, C. Qian, X. Xie, F. Borras-Cuesta, and J. Prieto (1999)
J. Immunol. 162, 5270-5277
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The Natural Killer T (NKT) Cell Ligand {alpha}-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells.

H. Kitamura, K. Iwakabe, T. Yahata, S.-i. Nishimura, A. Ohta, Y. Ohmi, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, et al. (1999)
J. Exp. Med. 189, 1121-1128
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Interleukin 12 Protects from a T Helper Type 1-mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon {gamma}, Nitric Oxide, and Apoptosis.

T. K. Tarrant, P. B. Silver, J. L. Wahlsten, L. V. Rizzo, C.-C. Chan, B. Wiggert, and R. R. Caspi (1999)
J. Exp. Med. 189, 219-230
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A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice Against Leishmania major Infection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice.

C. R. Gabaglia, B. Pedersen, M. Hitt, N. Burdin, E. E. Sercarz, F. L. Graham, J. Gauldie, and T. A. Braciak (1999)
J. Immunol. 162, 753-760
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IL-12 Is a Heparin-Binding Cytokine.

M. Hasan, S. Najjam, M. Y. Gordon, R. V. Gibbs, and C. C. Rider (1999)
J. Immunol. 162, 1064-1070
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Leishmania species: models of intracellular parasitism.

J Alexander, A. Satoskar, and D. Russell (1999)
J. Cell Sci. 112, 2993-3002
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Leishmania mexicana Cysteine Proteinase-Deficient Mutants Have Attenuated Virulence for Mice and Potentiate a Th1 Response.

J. Alexander, G. H. Coombs, and J. C. Mottram (1998)
J. Immunol. 161, 6794-6801
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LeIF: A Recombinant Leishmania Protein That Induces an IL-12-Mediated Th1 Cytokine Profile.

Y. A. W. Skeiky, M. Kennedy, D. Kaufman, M. M. Borges, J. A. Guderian, J. K. Scholler, P. J. Ovendale, K. S. Picha, P. J. Morrissey, K. H. Grabstein, et al. (1998)
J. Immunol. 161, 6171-6179
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Evaluation of IL-12 in Immunotherapy and Vaccine Design in Experimental Mycobacterium avium Infections.

R. A. Silva, T. F. Pais, and R. Appelberg (1998)
J. Immunol. 161, 5578-5585
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Activation of Natural Killer Cells in Arthritis-Susceptible but Not Arthritis-Resistant Mouse Strains following Borrelia burgdorferi Infection.

C. R. Brown and S. L. Reiner (1998)
Infect. Immun. 66, 5208-5214
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Immunogenicity and Protective Efficacy of the WI-1 Adhesin of Blastomyces dermatitidis.

M. Wuthrich, W.-l. Chang, and B. S. Klein (1998)
Infect. Immun. 66, 5443-5449
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CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge.

S. Gurunathan, K. R. Irvine, C.-Y. Wu, J. I. Cohen, E. Thomas, C. Prussin, N. P. Restifo, and R. A. Seder (1998)
J. Immunol. 161, 4563-4571
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Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile.

H.-M. Hu, W. J. Urba, and B. A. Fox (1998)
J. Immunol. 161, 3033-3041
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Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae.

H. Su, R. Messer, W. Whitmire, E. Fischer, J. C. Portis, and H. D. Caldwell (1998)
J. Exp. Med. 188, 809-818
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Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice.

V. Letscher-Bru, O. Villard, B. Risse, M. Zauke, J.-P. Klein, and T. T. Kien (1998)
Infect. Immun. 66, 4503-4506
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Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes.

B. Dubois, C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux (1998)
J. Immunol. 161, 2223-2231
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Differential Regulation of the Interleukin-12 Receptor during the Innate Immune Response to Leishmania major.

D. Jones, M. M. Elloso, L. Showe, D. Williams, G. Trinchieri, and P. Scott (1998)
Infect. Immun. 66, 3818-3824
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Human and Murine Immune Responses to a Novel Leishmania major Recombinant Protein Encoded by Members of a Multicopy Gene Family.

J. R. Webb, A. Campos-Neto, P. J. Ovendale, T. I. Martin, E. J. Stromberg, R. Badaro, and S. G. Reed (1998)
Infect. Immun. 66, 3279-3289
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Endogenous IL-12 Is Required for Induction and Expression of Experimental Autoimmune Uveitis.

T. K. Tarrant, P. B. Silver, C.-C. Chan, B. Wiggert, and R. R. Caspi (1998)
J. Immunol. 161, 122-127
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Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis.

S. L. Baldwin, C. D'Souza, A. D. Roberts, B. P. Kelly, A. A. Frank, M. A. Lui, J. B. Ulmer, K. Huygen, D. M. McMurray, and I. M. Orme (1998)
Infect. Immun. 66, 2951-2959
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Acute and Chronic Phases of Toxoplasma gondii Infection in Mice Modulate the Host Immune Responses.

T. D. Nguyen, G. Bigaignon, J. Van Broeck, M. Vercammen, T. N. Nguyen, M. Delmee, M. Turneer, S. F. Wolf, and J. P. Coutelier (1998)
Infect. Immun. 66, 2991-2995
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Modulation of T Cell Cytokine Profiles and Peptide-MHC Complex Availability In Vivo by Delivery to Scavenger Receptors via Antigen Maleylation.

N. Singh, S. Bhatia, R. Abraham, S. K. Basu, A. George, V. Bal, and S. Rath (1998)
J. Immunol. 160, 4869-4880
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Recombinant Vaccine-Induced Protection against the Highly Pathogenic Simian Immunodeficiency Virus SIVmac251: Dependence on Route of Challenge Exposure.

J. Benson, C. Chougnet, M. Robert-Guroff, D. Montefiori, P. Markham, G. Shearer, R. C. Gallo, M. Cranage, E. Paoletti, K. Limbach, et al. (1998)
J. Virol. 72, 4170-4182
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