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Science 7 January 1994:
Vol. 263. no. 5143, pp. 87 - 89
DOI: 10.1126/science.8272871
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Articles

Science, Vol 263, Issue 5143, 87-89
Copyright © 1994 by American Association for the Advancement of Science

articles

A transforming growth factor beta type I receptor that signals to activate gene expression

CH Bassing, JM Yingling, DJ Howe, T Wang, WW He, ML Gustafson, P Shah, PK Donahoe, and XF Wang

Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.


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Cooperative Binding of Transforming Growth Factor (TGF)-[IMAGE]2 to the Types I and II TGF-[IMAGE] Receptors.
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J. Biol. Chem. 270, 15919-15922
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Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-[IMAGE] Receptors.
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J. Biol. Chem. 270, 12235-12241
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Inactive Type II and Type I Receptors for TGFbeta Are Dominant Inhibitors of TGFbeta-dependent Transcription.
T. Brand and M. D. Schneider (1995)
J. Biol. Chem. 270, 8274-8284
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Transforming Growth Factor beta Activation of p44[IMAGE] in Proliferating Cultures of Epithelial Cells.
M. T. Hartsough and K. M. Mulder (1995)
J. Biol. Chem. 270, 7117-7124
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Signaling Activity of Homologous and Heterologous Transforming Growth Factor-beta Receptor Kinase Complexes.
D. Vivien, L. Attisano, and J. Massagué (1995)
J. Biol. Chem. 270, 7134-7141
   Abstract »    Full Text »    PDF »
Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-beta Receptor.
M. Kawabata, A. Chytil, and H. L. Moses (1995)
J. Biol. Chem. 270, 5625-5630
   Abstract »    Full Text »    PDF »
Requirements for Transforming Growth Factor-beta Regulation of the Pro-alpha2(I) Collagen and Plasminogen Activator Inhibitor-1 Promoters.
E. Chang and H. Goldberg (1995)
J. Biol. Chem. 270, 4473-4477
   Abstract »    Full Text »    PDF »
The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-beta Receptor.
H. Y. Lin, A. Moustakas, P. Knaus, R. G. Wells, Y. I. Henis, and H. F. Lodish (1995)
J. Biol. Chem. 270, 2747-2754
   Abstract »    Full Text »    PDF »
GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor beta and Activin-A.
A. Moustakas, T. Takumi, H. Y. Lin, and H. F. Lodish (1995)
J. Biol. Chem. 270, 765-769
   Abstract »    Full Text »    PDF »
A Rat Pituitary Tumor Cell Line (GH(3)) Expresses Type I and Type II Receptors and Other Cell Surface Binding Protein(s) for Transforming Growth Factor-beta.
H. Yamashita, T. Okadome, P. Franzén, P. t. Dijke, C.-H. Heldin, and K. Miyazono (1995)
J. Biol. Chem. 270, 770-774
   Abstract »    Full Text »    PDF »
Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12.
T Wang, P. Donahoe, and A. Zervos (1994)
Science 265, 674-676
   Abstract »    PDF »
Characterization of type I receptors for transforming growth factor-beta and activin.
P ten Dijke, H Yamashita, H Ichijo, P Franzen, M Laiho, K Miyazono, and C. Heldin (1994)
Science 264, 101-104
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The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily.
T Xie, A. Finelli, and R. Padgett (1994)
Science 263, 1756-1759
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Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.
E. Filvaroff, R Ebner, and R Derynck (1994)
Development 120, 1085-1095
   Abstract »    PDF »
Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor beta Receptor in Regulating Transforming Growth Factor beta Signaling.
G. C. Blobe, W. P. Schiemann, M.-C. Pepin, M. Beauchemin, A. Moustakas, H. F. Lodish, and M. D. O'Connor-McCourt (2001)
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