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Science 17 December 1993:
Vol. 262. no. 5141, pp. 1892 - 1895
DOI: 10.1126/science.8018146

Articles

Science, Vol 262, Issue 5141, 1892-1895
Copyright © 1993 by American Association for the Advancement of Science


articles

Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens

T Boren, P Falk, KA Roth, G Larson, and S Normark

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.


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Cancer Epidemiol. Biomarkers Prev. 9, 671-674
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A New Method to Visualize the Helicobacter pylori-associated Lewisb-binding Adhesin Utilizing SDS-digested Freeze-fracture Replica Labeling.
C. Petersson, B. Larsson, J. Mahdavi, T. Borén, and K.-E. Magnusson (2000)
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W. Beil, M. L. Enss, S. Müller, B. Obst, K.-F. Sewing, and S. Wagner (2000)
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H pylori colocalises with MUC5AC in the human stomach.
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Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin.
M. Gerhard, N. Lehn, N. Neumayer, T. Boren, R. Rad, W. Schepp, S. Miehlke, M. Classen, and C. Prinz (1999)
PNAS 96, 12778-12783
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Clinical Course of Acute Gastric Mucosal Lesions Caused by Acute Infection with Helicobacter pylori.
T. Moriai and N. Hirahara (1999)
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Helicobacter pylori-Associated Gastritis in Mice is Host and Strain Specific.
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Secretory Immunoglobulin A Heavy Chain Presents Gal{beta}1-3GalNAc Binding Structures for Actinomyces naeslundii genospecies 1.
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Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology.
P. G. Falk, L. V. Hooper, T. Midtvedt, and J. I. Gordon (1998)
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Characterization of an Acidic-pH-Inducible Stress Protein (hsp70), a Putative Sulfatide Binding Adhesin, from Helicobacter pylori.
M. Huesca, A. Goodwin, A. Bhagwansingh, P. Hoffman, and C. A. Lingwood (1998)
Infect. Immun. 66, 4061-4067
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Epithelial attachment alters the outcome of Helicobacter pylori infection.
J. L. Guruge, P. G. Falk, R. G. Lorenz, M. Dans, H.-P. Wirth, M. J. Blaser, D. E. Berg, and J. I. Gordon (1998)
PNAS 95, 3925-3930
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Neutrophil-Activating Protein Mediates Adhesion of Helicobacter pylori to Sulfated Carbohydrates on High-Molecular-Weight Salivary Mucin.
F. Namavar, M. Sparrius, E. C. I. Veerman, B. J. Appelmelk, and C. M. J. E. Vandenbroucke-Grauls (1998)
Infect. Immun. 66, 444-447
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Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging.
D. Ilver, A. Arnqvist, J. Ögren, I. Frick, D. Kersulyte, E. T. Incecik, D. E. Berg, A. Covacci, L. Engstrand, and T. Borén (1998)
Science 279, 373-377
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Anti-Sia-lb (Anti-Gd) Cold Agglutinins Bind the Domain NeuNAcalpha 2-3Gal in Sialyl Lewisx, Sialyl Lewisa, and Related Carbohydrates on Nucleated Cells and in Soluble Cancer-Associated Mucins.
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Molecular Genetic Analysis of the Human Lewis Histo-blood Group System.
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Production of Human Secretory Component with Dimeric IgA Binding Capacity Using Viral Expression Systems.
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