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Science 17 December 1993:
Vol. 262. no. 5141, pp. 1877 - 1880
DOI: 10.1126/science.8266077
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Articles

Science, Vol 262, Issue 5141, 1877-1880
Copyright © 1993 by American Association for the Advancement of Science

articles

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

M Noguchi, Y Nakamura, SM Russell, SF Ziegler, M Tsang, X Cao, and WJ Leonard

Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

The interleukin-2 receptor gamma chain (IL-2R gamma) is a necessary component of functional IL-2 receptors. IL-2R gamma mutations result in X-linked severe combined immunodeficiency (XSCID) in humans, a disease characterized by the presence of few or no T cells. In contrast, SCID patients with IL-2 deficiency and IL-2-deficient mice have normal numbers of T cells, suggesting that IL-2R gamma is part of more than one cytokine receptor. By using chemical cross-linking, IL-2R gamma was shown to be physically associated with the IL-7 receptor. The presence of IL-2R gamma augmented both IL-7 binding affinity and the efficiency of internalization of IL-7. These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma.


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Mol. Cell. Biol. 18, 1996-2003
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Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis.
S. J. Sohn, K. A. Forbush, N. Nguyen, B. Witthuhn, T. Nosaka, J. N. Ihle, and R. M. Perlmutter (1998)
J. Immunol. 160, 2130-2138
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Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice.
S. D. McKenna, F. Chen, L. Lai, and I. Goldschneider (1998)
J. Immunol. 160, 2272-2279
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.
K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
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c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3'-Kinase Pathway.
H. Ueno, K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1998)
Blood 91, 46-53
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Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age.
R. P. Stephan, C. R. Reilly, and P. L. Witte (1998)
Blood 91, 75-88
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Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets.
D. David, L. Bani, J.-L. Moreau, C. Demaison, K. Sun, O. Salvucci, T. Nakarai, M. de Montalembert, S. Chouaib, M. Joussemet, et al. (1998)
Blood 91, 165-172
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Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study.
S. Damjanovich, L. Bene, J. Matko, A. Alileche, C. K. Goldman, S. Sharrow, and T. A. Waldmann (1997)
PNAS 94, 13134-13139
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Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency.
P. J. Felsburg, R. L. Somberg, B. J. Hartnett, S. F. Suter, P. S. Henthorn, P. F. Moore, K. I. Weinberg, and H. D. Ochs (1997)
Blood 90, 3214-3221
   Abstract »    Full Text »    PDF »
Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.
M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
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Critical Cytoplasmic Domains of Human Interleukin-9 Receptor alpha  Chain in Interleukin-9-mediated Cell Proliferation and Signal Transduction.
Y. X. Zhu, H. B. Sun, M. L.-S. Tsang, J. McMahel, S. Grigsby, T. Yin, and Y.-C. Yang (1997)
J. Biol. Chem. 272, 21334-21340
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Modulation of Interleukin (IL)-13 Binding and Signaling by the gamma c Chain of the IL-2 Receptor.
N. I. Obiri, T. Murata, W. Debinski, and R. K. Puri (1997)
J. Biol. Chem. 272, 20251-20258
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Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome.
C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al. (1997)
Blood 90, 1115-1123
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Two Discrete Regions of Interleukin-2 (IL2) Receptor beta  Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase.
R. A. Kirken, M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, X. Liu, L. Hennighausen, H. Rui, and W. L. Farrar (1997)
J. Biol. Chem. 272, 15459-15465
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Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.
Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
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Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway.
A. Gonzalez-Garcia, I. Merida, C. Martinez-A, and A. C. Carrera (1997)
J. Biol. Chem. 272, 10220-10226
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Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.
N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
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Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.
B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
   Abstract »    Full Text »    PDF »


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