Science 17 December 1993: Vol. 262. no. 5141, pp. 1877 - 1880 DOI: 10.1126/science.8266077

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Articles

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection.

I. Sereti, R. M. Dunham, J. Spritzler, E. Aga, M. A. Proschan, K. Medvik, C. A. Battaglia, A. L. Landay, S. Pahwa, M. A. Fischl, et al. (2009)
Blood 113, 6304-6314
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Biochemical Characterization of Human Plasma Soluble IL-7R: Lower Concentrations in HIV-1-Infected Patients.

T. Rose, O. Lambotte, C. Pallier, J.-F. Delfraissy, and J.-H. Colle (2009)
J. Immunol. 182, 7389-7397
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.

M. Zhang, Z. Yao, S. Dubois, W. Ju, J. R. Muller, and T. A. Waldmann (2009)
PNAS 106, 7513-7518
 |  Abstract »  |  Full Text »  |  PDF »

IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.

E. Faller, J. Kakal, R. Kumar, and P. MacPherson (2009)
Int. Immunol. 21, 203-216
 |  Abstract »  |  Full Text »  |  PDF »

The "Bubble Boy" Paradox: An Answer That Led to a Question.

L. J. Berg (2008)
J. Immunol. 181, 5815-5816
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Development of regulatory T cells requires IL-7R{alpha} stimulation by IL-7 or TSLP.

R. Mazzucchelli, J. A. Hixon, R. Spolski, X. Chen, W. Q. Li, V. L. Hall, J. Willette-Brown, A. A. Hurwitz, W. J. Leonard, and S. K. Durum (2008)
Blood 112, 3283-3292
 |  Abstract »  |  Full Text »  |  PDF »

Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation.

L. S. de Paiva, A. Nobrega, G. O. De Melo, E. A. Hayashi, V. Carvalho, P. M. Rodrigues e Silva, M. Bellio, G. P. Teixeira, V. Rumjanek, S. S. Costa, et al. (2008)
J. Leukoc. Biol. 83, 1038-1048
 |  Abstract »  |  Full Text »  |  PDF »

Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.

S. Chappaz, L. Flueck, A. G. Farr, A. G. Rolink, and D. Finke (2007)
Blood 110, 3862-3870
 |  Abstract »  |  Full Text »  |  PDF »

Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.

C.-L. Hsu, K. Kikuchi, and M. Kondo (2007)
Blood 110, 1420-1428
 |  Abstract »  |  Full Text »  |  PDF »

Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function.

X. Dai, Y. Chen, L. Di, A. Podd, G. Li, K. D. Bunting, L. Hennighausen, R. Wen, and D. Wang (2007)
J. Immunol. 179, 1068-1079
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits.

S. L. Kalis, S.-K. Zhai, P.-C. Yam, P. L. Witte, and K. L. Knight (2007)
Int. Immunol. 19, 801-811
 |  Abstract »  |  Full Text »  |  PDF »

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.

A. Frohlich, B. J. Marsland, I. Sonderegger, M. Kurrer, M. R. Hodge, N. L. Harris, and M. Kopf (2007)
Blood 109, 2023-2031
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Cellular Intermediates and Molecular Pathways Induced by IL-21 in Human B Cells.

D. Konforte and C. J. Paige (2006)
J. Immunol. 177, 8381-8392
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory Effects of the Anionic Alkali Mineral Complex BARODON on Equine Lymphocytes.

H. Koo, S.-H. Ryu, H. J. Ahn, W. K. Jung, Y. K. Park, N. H. Kwon, S. H. Kim, J. M. Kim, B. W. Yoo, S. I. Choi, et al. (2006)
Clin. Vaccine Immunol. 13, 1255-1266
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of STAT5 Supersedes the Requirement for Cytokine and TCR Engagement of CD4+ T Cells in Steady-State Homeostasis.

D. K. Taylor, P. T. Walsh, D. F. LaRosa, J. Zhang, M. A. Burchill, M. A. Farrar, and L. A. Turka (2006)
J. Immunol. 177, 2216-2223
 |  Abstract »  |  Full Text »  |  PDF »

HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro.

M. Zhang, J. Drenkow, C. S. R. Lankford, D. M. Frucht, R. L. Rabin, T. R. Gingeras, C. Venkateshan, F. Schwartzkopff, K. A. Clouse, and A. I. Dayton (2006)
J. Leukoc. Biol. 79, 1328-1338
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells.

N. J. Poindexter, E. T. Walch, S. Chada, and E. A. Grimm (2005)
J. Leukoc. Biol. 78, 745-752
 |  Abstract »  |  Full Text »  |  PDF »

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice.

F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada (2005)
Blood 106, 1565-1573
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of the Mouse IL-7 Receptor {alpha} Promoter by Glucocorticoid Receptor.

H.-C. Lee, H. Shibata, S. Ogawa, K. Maki, and K. Ikuta (2005)
J. Immunol. 174, 7800-7806
 |  Abstract »  |  Full Text »  |  PDF »

Suppressive Effect of IL-4 on IL-13-Induced Genes in Mouse Lung.

F. D. Finkelman, M. Yang, C. Perkins, K. Schleifer, A. Sproles, J. Santeliz, J. A. Bernstein, M. E. Rothenberg, S. C. Morris, and M. Wills-Karp (2005)
J. Immunol. 174, 4630-4638
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor-deficient Mice.

M. Pellegrini, P. Bouillet, M. Robati, G. T. Belz, G. M. Davey, and A. Strasser (2004)
J. Exp. Med. 200, 1189-1195
 |  Abstract »  |  Full Text »  |  PDF »

Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.

C. A. J. Vosshenrich, A. Cumano, W. Muller, J. P. Di Santo, and P. Vieira (2004)
PNAS 101, 11070-11075
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development.

A. Al-Shami, R. Spolski, J. Kelly, T. Fry, P. L. Schwartzberg, A. Pandey, C. L. Mackall, and W. J. Leonard (2004)
J. Exp. Med. 200, 159-168
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members.

Q. Jiang, W. Q. Li, R. R. Hofmeister, H. A. Young, D. R. Hodge, J. R. Keller, A. R. Khaled, and S. K. Durum (2004)
Mol. Cell. Biol. 24, 6501-6513
 |  Abstract »  |  Full Text »  |  PDF »

Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines.

L. Cosmi, F. Liotta, R. Angeli, B. Mazzinghi, V. Santarlasci, R. Manetti, L. Lasagni, V. Vanini, P. Romagnani, E. Maggi, et al. (2004)
Blood 103, 3117-3121
 |  Abstract »  |  Full Text »  |  PDF »

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.

M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med. 350, 913-922
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Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis.

S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo (2003)
Endocrinology 144, 3524-3531
 |  Abstract »  |  Full Text »  |  PDF »

In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals.

C. S. McCauslin, J. Wine, L. Cheng, K. D. Klarmann, F. Candotti, P. A. Clausen, S. E. Spence, and J. R. Keller (2003)
Blood 102, 843-848
 |  Abstract »  |  Full Text »  |  PDF »

Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential.

J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen (2003)
Pharmacol. Rev. 55, 133-166
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

Mac-1 (CD11b/CD18) as Accessory Molecule for Fc{alpha}R (CD89) Binding of IgA.

A. B. van Spriel, J. H. W. Leusen, H. Vile, and J. G. J. van de Winkel (2002)
J. Immunol. 169, 3831-3836
 |  Abstract »  |  Full Text »  |  PDF »

Partial restoration of B cell development in Jak-3-/- mice achieved by co-expression of IgH and E{micro}-myc transgenes.

S. R. Dillon and M. S. Schlissel (2002)
Int. Immunol. 14, 893-904
 |  Abstract »  |  Full Text »  |  PDF »

Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein.

M. Iwata, L. Graf, N. Awaya, and B. Torok-Storb (2002)
Blood 100, 1318-1325
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7: from bench to clinic.

T. J. Fry and C. L. Mackall (2002)
Blood 99, 3892-3904
 |  Full Text »  |  PDF »

Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy.

S. Hacein-Bey-Abina, F. Le Deist, F. Carlier, C. Bouneaud, C. Hue, J.-P. De Villartay, A. J. Thrasher, N. Wulffraat, R. Sorensen, S. Dupuis-Girod, et al. (2002)
N. Engl. J. Med. 346, 1185-1193
 |  Abstract »  |  Full Text »  |  PDF »

Effects of exogenous interleukin-7 on human thymus function.

Y. Okamoto, D. C. Douek, R. D. McFarland, and R. A. Koup (2002)
Blood 99, 2851-2858
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis for Binding Multiple Ligands by the Common Cytokine Receptor gamma -Chain.

F. Olosz and T. R. Malek (2002)
J. Biol. Chem. 277, 12047-12052
 |  Abstract »  |  Full Text »  |  PDF »

Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor {alpha}.

D. Franchimont, J. Galon, M. S. Vacchio, S. Fan, R. Visconti, D. M. Frucht, V. Geenen, G. P. Chrousos, J. D. Ashwell, and J. J. O'Shea (2002)
J. Immunol. 168, 2212-2218
 |  Abstract »  |  Full Text »  |  PDF »

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.

S. M. Stepkowski, R. A. Erwin-Cohen, F. Behbod, M.-E. Wang, X. Qu, N. Tejpal, Z. S. Nagy, B. D. Kahan, and R. A. Kirken (2002)
Blood 99, 680-689
 |  Abstract »  |  Full Text »  |  PDF »

Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays.

H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman (2002)
Blood 99, 282-289
 |  Abstract »  |  Full Text »  |  PDF »

Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7-/- Mice.

T. L. Carvalho, T. Mota-Santos, A. Cumano, J. Demengeot, and P. Vieira (2001)
J. Exp. Med. 194, 1141-1150
 |  Abstract »  |  Full Text »  |  PDF »

Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.

O. Alpdogan, C. Schmaltz, S. J. Muriglan, B. J. Kappel, M.-A. Perales, J. A. Rotolo, J. A. Halm, B. E. Rich, and M. R. M. van den Brink (2001)
Blood 98, 2256-2265
 |  Abstract »  |  Full Text »  |  PDF »

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells.

P. A. Reche, V. Soumelis, D. M. Gorman, T. Clifford, M.-r. Liu, M. Travis, S. M. Zurawski, J. Johnston, Y.-J. Liu, H. Spits, et al. (2001)
J. Immunol. 167, 336-343
 |  Abstract »  |  Full Text »  |  PDF »

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts.

F. Behbod, R. A. Erwin-Cohen, M.-E. Wang, B. W. Trawick, X. Qu, R. Verani, B. D. Kahan, S. M. Stepkowski, and R. A. Kirken (2001)
J. Immunol. 166, 3724-3732
 |  Abstract »  |  Full Text »  |  PDF »

A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
 |  Abstract »  |  Full Text »

Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin.

C.-H. Yen, Y.-C. Yang, S. K. Ruscetti, R. A. Kirken, R. M. Dai, and C.-C. H. Li (2000)
J. Immunol. 165, 6372-6380
 |  Abstract »  |  Full Text »  |  PDF »

Memory-Type CD8+ T Cells Protect IL-2 Receptor {alpha}-Deficient Mice from Systemic Infection with Herpes Simplex Virus Type 2.

H. Tsunobuchi, H. Nishimura, F. Goshima, T. Daikoku, Y. Nishiyama, and Y. Yoshikai (2000)
J. Immunol. 165, 4552-4560
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of the Murine Thymic Stromal Lymphopoietin (TSLP) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor.

L. S. Park, U. Martin, K. Garka, B. Gliniak, J. P. Di Santo, W. Muller, D. A. Largaespada, N. G. Copeland, N. A. Jenkins, A. G. Farr, et al. (2000)
J. Exp. Med. 192, 659-670
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-3 Expression Promotes Cell Survival following Interleukin-4 Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors.

A. Rebollo, L. Dumoutier, J.-C. Renauld, A. Zaballos, V. Ayllón, and C. Martínez-A. (2000)
Mol. Cell. Biol. 20, 3407-3416
 |  Abstract »  |  Full Text »

{kappa}-Opioid Regulation of Thymocyte IL-7 Receptor and C-C Chemokine Receptor 2 Expression.

L. Zhang and T. J. Rogers (2000)
J. Immunol. 164, 5088-5093
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Ralpha.

N. Benbernou, K. Muegge, and S. K. Durum (2000)
J. Biol. Chem. 275, 7060-7065
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly.

F. M. Smart and A. R. Venkitaraman (2000)
J. Exp. Med. 191, 737-742
 |  Abstract »  |  Full Text »  |  PDF »

Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7R{alpha}, Terminal Deoxynucleotidyltransferase, and c{micro} Expression.

C. Wei, R. Zeff, and I. Goldschneider (2000)
J. Immunol. 164, 1961-1970
 |  Abstract »  |  Full Text »  |  PDF »

The First {alpha} Helix of Interleukin (IL)-2 Folds as a Homotetramer, Acts as an Agonist of the IL-2 Receptor {beta} Chain, and Induces Lymphokine-activated Killer Cells.

R. Eckenberg, T. Rose, J.-L. Moreau, R. Weil, F. Gesbert, S. Dubois, D. Tello, M. Bossus, H. Gras, A. Tartar, et al. (2000)
J. Exp. Med. 191, 529-540
 |  Abstract »  |  Full Text »  |  PDF »

Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor {alpha}-Chain.

H. Huang and W. E. Paul (2000)
J. Immunol. 164, 1211-1215
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of Natural Killer Cytotoxic Activity and Interferon {gamma} Production in CCAAT/Enhancer Binding Protein {gamma}-deficient Mice.

T. Kaisho, H. Tsutsui, T. Tanaka, T. Tsujimura, K. Takeda, T. Kawai, N. Yoshida, K. Nakanishi, and S. Akira (1999)
J. Exp. Med. 190, 1573-1582
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction.

D. E. Isaksen, H. Baumann, P. A. Trobridge, A. G. Farr, S. D. Levin, and S. F. Ziegler (1999)
J. Immunol. 163, 5971-5977
 |  Abstract »  |  Full Text »  |  PDF »

Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach.

M. Lo, M. L. Bloom, K. Imada, M. Berg, J. M. Bollenbacher, E. T. Bloom, B. L. Kelsall, and W. J. Leonard (1999)
Blood 94, 3027-3036
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of Early Lymphoid Proliferation and Immune Function in Jak3-Deficient Mice by Interleukin-3.

M. P. Brown, T. Nosaka, R. A. Tripp, J. Brooks, J. M.A. van Deursen, M. K. Brenner, P. C. Doherty, and J. N. Ihle (1999)
Blood 94, 1906-1914
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors.

C. Rusterholz, P. C. Henrioud, and M. Nabholz (1999)
Mol. Cell. Biol. 19, 2681-2689
 |  Abstract »  |  Full Text »  |  PDF »

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism.

S. D. Levin, R. M. Koelling, S. L. Friend, D. E. Isaksen, S. F. Ziegler, R. M. Perlmutter, and A. G. Farr (1999)
J. Immunol. 162, 677-683
 |  Abstract »  |  Full Text »  |  PDF »

IgE Hyperproduction Through Enhanced Tyrosine Phosphorylation of Janus Kinase 3 in NC/Nga Mice, a Model for Human Atopic Dermatitis.

M. Matsumoto, C. Ra, K. Kawamoto, H. Sato, A. Itakura, J. Sawada, H. Ushio, H. Suto, K. Mitsuishi, Y. Hikasa, et al. (1999)
J. Immunol. 162, 1056-1063
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
 |  Abstract »  |  Full Text »  |  PDF »

Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
 |  Abstract »  |  PDF »

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins: Development of a Recombinant Interleukin-4-Pseudomonas Exotoxin for Therapy of Glioblastoma.

R. K. Puri (1999)
Toxicol Pathol 27, 53-57
 |  Abstract »  |  PDF »

Interleukin 7 Receptor Control of  T Cell Receptor gamma  Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility.

S. K. Durum, S. Candeias, H. Nakajima, W. J. Leonard, A. M. Baird, L. J. Berg, and K. Muegge (1998)
J. Exp. Med. 188, 2233-2241
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression.

A. J. Marshall, H. E. Fleming, G. E. Wu, and C. J. Paige (1998)
J. Immunol. 161, 6038-6045
 |  Abstract »  |  Full Text »  |  PDF »

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation.

A. Cerezo, C. Martínez-A, D. Lanzarot, S. Fischer, T. F. Franke, and A. Rebollo (1998)
Mol. Biol. Cell 9, 3107-3118
 |  Abstract »  |  Full Text »

Role of JAK3 in CD40-Mediated Signaling.

H. H. Jabara, R. H. Buckley, J. L. Roberts, G. Lefranc, J. Loiselet, G. Khalil, and R. S. Geha (1998)
Blood 92, 2435-2440
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Regions of Interleukin-2 (IL-2) Receptor beta  Chain Important for Association of Jak1 and Jak3. Jak1-INDEPENDENT FUNCTIONAL RECRUITMENT OF Jak3 TO IL-2Rbeta.

M.-h. Zhu, J. A. Berry, S. M. Russell, and W. J. Leonard (1998)
J. Biol. Chem. 273, 10719-10725
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells.

H. Huang and W. E. Paul (1998)
J. Exp. Med. 187, 1305-1313
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes.

H. Ogata, D. Ford, N. Kouttab, T. C. King, N. Vita, A. Minty, J. Stoeckler, D. Morgan, C. Girasole, J. W. Morgan, et al. (1998)
J. Biol. Chem. 273, 9864-9871
 |  Abstract »  |  Full Text »  |  PDF »

Heteromerization of the gamma c Chain with the Interleukin-9 Receptor alpha  Subunit Leads to STAT Activation and Prevention of Apoptosis.

J. H. Bauer, K. D. Liu, Y. You, S. Y. Lai, and M. A. Goldsmith (1998)
J. Biol. Chem. 273, 9255-9260
 |  Abstract »  |  Full Text »  |  PDF »

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
 |  Abstract »  |  Full Text »

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis.

S. J. Sohn, K. A. Forbush, N. Nguyen, B. Witthuhn, T. Nosaka, J. N. Ihle, and R. M. Perlmutter (1998)
J. Immunol. 160, 2130-2138
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice.

S. D. McKenna, F. Chen, L. Lai, and I. Goldschneider (1998)
J. Immunol. 160, 2272-2279
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3'-Kinase Pathway.

H. Ueno, K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1998)
Blood 91, 46-53
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age.

R. P. Stephan, C. R. Reilly, and P. L. Witte (1998)
Blood 91, 75-88
 |  Abstract »  |  Full Text »  |  PDF »

Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets.

D. David, L. Bani, J.-L. Moreau, C. Demaison, K. Sun, O. Salvucci, T. Nakarai, M. de Montalembert, S. Chouaib, M. Joussemet, et al. (1998)
Blood 91, 165-172
 |  Abstract »  |  Full Text »  |  PDF »

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study.

S. Damjanovich, L. Bene, J. Matko, A. Alileche, C. K. Goldman, S. Sharrow, and T. A. Waldmann (1997)
PNAS 94, 13134-13139
 |  Abstract »  |  Full Text »  |  PDF »

Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency.

P. J. Felsburg, R. L. Somberg, B. J. Hartnett, S. F. Suter, P. S. Henthorn, P. F. Moore, K. I. Weinberg, and H. D. Ochs (1997)
Blood 90, 3214-3221
 |  Abstract »  |  Full Text »  |  PDF »

Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
 |  Abstract »  |  Full Text »  |  PDF »

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
 |  Abstract »  |  Full Text »  |  PDF »

Critical Cytoplasmic Domains of Human Interleukin-9 Receptor alpha  Chain in Interleukin-9-mediated Cell Proliferation and Signal Transduction.

Y. X. Zhu, H. B. Sun, M. L.-S. Tsang, J. McMahel, S. Grigsby, T. Yin, and Y.-C. Yang (1997)
J. Biol. Chem. 272, 21334-21340
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Interleukin (IL)-13 Binding and Signaling by the gamma c Chain of the IL-2 Receptor.

N. I. Obiri, T. Murata, W. Debinski, and R. K. Puri (1997)
J. Biol. Chem. 272, 20251-20258
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome.

C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al. (1997)
Blood 90, 1115-1123
 |  Abstract »  |  Full Text »  |  PDF »

Coexpression of Kit and the Receptors for Erythropoietin, Interleukin 6 and GM-CSF on Hemopoietic Cells.

M. O. de Jong, Y. Westerman, G. Wagemaker, and A. W. Wognum (1997)
Stem Cells 15, 275-285
 |  Abstract »  |  Full Text »

Two Discrete Regions of Interleukin-2 (IL2) Receptor beta  Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase.

R. A. Kirken, M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, X. Liu, L. Hennighausen, H. Rui, and W. L. Farrar (1997)
J. Biol. Chem. 272, 15459-15465
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.

Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
 |  Abstract »  |  Full Text »  |  PDF »

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway.

A. Gonzalez-Garcia, I. Merida, C. Martinez-A, and A. C. Carrera (1997)
J. Biol. Chem. 272, 10220-10226
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.

N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.

B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor alpha Enhances the Expression of the Interleukin (IL)-4 Receptor alpha -Chain on Endothelial Cells Increasing IL-4 or IL-13-induced Stat6 Activation.

S. M. Lugli, N. Feng, M. H. Heim, M. Adam, B. Schnyder, H. Etter, M. Yamage, H.-P. Eugster, R. A. Lutz, G. Zurawski, et al. (1997)
J. Biol. Chem. 272, 5487-5494
 |  Abstract »  |  Full Text »  |  PDF »

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