Science 17 December 1993: Vol. 262. no. 5141, pp. 1874 - 1877 DOI: 10.1126/science.8266076

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Articles

The "Bubble Boy" Paradox: An Answer That Led to a Question.

L. J. Berg (2008)
J. Immunol. 181, 5815-5816
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Development of regulatory T cells requires IL-7R{alpha} stimulation by IL-7 or TSLP.

R. Mazzucchelli, J. A. Hixon, R. Spolski, X. Chen, W. Q. Li, V. L. Hall, J. Willette-Brown, A. A. Hurwitz, W. J. Leonard, and S. K. Durum (2008)
Blood 112, 3283-3292
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte Cell Surface Glycosaminoglycans Positively Modulate IL-4-Induced Differentiation toward Dendritic Cells.

E. den Dekker, S. Grefte, T. Huijs, G. B. ten Dam, E. M. M. Versteeg, L. C. J. van den Berk, B. A. Bladergroen, T. H. van Kuppevelt, C. G. Figdor, and R. Torensma (2008)
J. Immunol. 180, 3680-3688
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Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function.

X. Dai, Y. Chen, L. Di, A. Podd, G. Li, K. D. Bunting, L. Hennighausen, R. Wen, and D. Wang (2007)
J. Immunol. 179, 1068-1079
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Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors.

C. M Smyth, S. L Ginn, C. T Deakin, G. J Logan, and I. E Alexander (2007)
Blood 110, 91-98
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IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.

A. Frohlich, B. J. Marsland, I. Sonderegger, M. Kurrer, M. R. Hodge, N. L. Harris, and M. Kopf (2007)
Blood 109, 2023-2031
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Expansion of CD4+CD25+and FOXP3+ Regulatory T Cells during the Follicular Phase of the Menstrual Cycle: Implications for Human Reproduction.

L. Arruvito, M. Sanz, A. H. Banham, and L. Fainboim (2007)
J. Immunol. 178, 2572-2578
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IL-4R{alpha} polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus.

W. Shiroiwa, K. Tsukamoto, M. Ohtsuji, Q. Lin, A. Ida, S. Kodera, N. Ohtsuji, K. Nakamura, H. Tsurui, K. Kinoshita, et al. (2007)
Int. Immunol. 19, 175-183
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Constitutive Activation of STAT5 Supersedes the Requirement for Cytokine and TCR Engagement of CD4+ T Cells in Steady-State Homeostasis.

D. K. Taylor, P. T. Walsh, D. F. LaRosa, J. Zhang, M. A. Burchill, M. A. Farrar, and L. A. Turka (2006)
J. Immunol. 177, 2216-2223
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IL-4 Receptor {alpha} Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets..

A.-L. Andrews, J. W. Holloway, S. T. Holgate, and D. E. Davies (2006)
J. Immunol. 176, 7456-7461
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Interleukin-13-regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis.

P. Sinha, V. K. Clements, and S. Ostrand-Rosenberg (2005)
Cancer Res. 65, 11743-11751
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Induction of Uteroglobin-Related Protein 2 (Ugrp2) Gene Expression by the Th2 Cytokines IL-4 and IL-13.

A. Yamada, F. Sheikh, T. Niimi, F. J. DeMayo, A. D. Keegan, R. P. Donnelly, and S. Kimura (2005)
J. Immunol. 175, 5708-5715
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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chainnull mice.

F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada (2005)
Blood 106, 1565-1573
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IFN-{gamma} Suppresses STAT6 Phosphorylation by Inhibiting Its Recruitment to the IL-4 Receptor.

Z. Huang, J. Xin, J. Coleman, and H. Huang (2005)
J. Immunol. 174, 1332-1337
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Upregulation of Interleukin-4 Receptor by Interferon-{gamma}: Enhanced Interleukin-4-Induced Eotaxin-3 Production in Airway Epithelium.

S. Yamamoto, I. Kobayashi, K. Tsuji, N. Nishi, E. Muro, M. Miyazaki, M. Zaitsu, S. Inada, T. Ichimaru, and Y. Hamasaki (2004)
Am. J. Respir. Cell Mol. Biol. 31, 456-462
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Interleukin-7 and Transforming Growth Factor-{beta} Play Counter-regulatory Roles in Protein Kinase C-{delta}-dependent Control of Fibroblast Collagen Synthesis in Pulmonary Fibrosis.

L. Zhang, M. P. Keane, L. X. Zhu, S. Sharma, E. Rozengurt, R. M. Strieter, S. M. Dubinett, and M. Huang (2004)
J. Biol. Chem. 279, 28315-28319
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Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines.

L. Cosmi, F. Liotta, R. Angeli, B. Mazzinghi, V. Santarlasci, R. Manetti, L. Lasagni, V. Vanini, P. Romagnani, E. Maggi, et al. (2004)
Blood 103, 3117-3121
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Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
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Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.

M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med. 350, 913-922
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Identification of the Interleukin 4 Receptor {alpha} Gene as a Direct Target for p73.

Y. Sasaki, H. Mita, M. Toyota, S. Ishida, I. Morimoto, T. Yamashita, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino (2003)
Cancer Res. 63, 8145-8152
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Inactivation of the IL-4 Receptor {alpha} Chain I4R Motif Promotes Allergic Airway Inflammation.

F. Blaeser, P. J. Bryce, N. Ho, V. Raman, F. Dedeoglu, D. D. Donaldson, R. S. Geha, H. C. Oettgen, and T. A. Chatila (2003)
J. Exp. Med. 198, 1189-1200
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Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis.

S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo (2003)
Endocrinology 144, 3524-3531
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Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
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Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.

Y.-i. Seki, K. Hayashi, A. Matsumoto, N. Seki, J. Tsukada, J. Ransom, T. Naka, T. Kishimoto, A. Yoshimura, and M. Kubo (2002)
PNAS 99, 13003-13008
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Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling.

A. G. King, M. Kondo, D. C. Scherer, and I. L. Weissman (2002)
PNAS 99, 4508-4513
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Structural Basis for Binding Multiple Ligands by the Common Cytokine Receptor gamma -Chain.

F. Olosz and T. R. Malek (2002)
J. Biol. Chem. 277, 12047-12052
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IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT.

E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs (2002)
J. Immunol. 168, 597-603
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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.

S. M. Stepkowski, R. A. Erwin-Cohen, F. Behbod, M.-E. Wang, X. Qu, N. Tejpal, Z. S. Nagy, B. D. Kahan, and R. A. Kirken (2002)
Blood 99, 680-689
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Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays.

H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman (2002)
Blood 99, 282-289
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Interleukin-4 Receptor-Stat6 Signaling in Murine Infections with a Tissue-Dwelling Nematode Parasite.

L. Spencer, L. Shultz, and T. V. Rajan (2001)
Infect. Immun. 69, 7743-7752
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Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation.

M. Kashiwada, C. C. Giallourakis, P.-Y. Pan, and P. B. Rothman (2001)
J. Immunol. 167, 6382-6387
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{beta}c Cytokine Receptor-Induced Stimulation of cAMP Response Element Binding Protein Phosphorylation Requires Protein Kinase C In Myeloid Cells: A Novel Cytokine Signal Transduction Cascade.

E. Gubina, X. Luo, E. Kwon, K. Sakamoto, Y. F. Shi, and R. A. Mufson (2001)
J. Immunol. 167, 4303-4310
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11{{beta}}-Hydroxysteroid Dehydrogenase Type 1 Is Induced in Human Monocytes upon Differentiation to Macrophages.

R. Thieringer, C. B. Le Grand, L. Carbin, T.-Q. Cai, B. Wong, S. D. Wright, and A. Hermanowski-Vosatka (2001)
J. Immunol. 167, 30-35
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Sulfhydryl-2 domain-containing protein tyrosine phosphatase-1 is not a negative regulator of interleukin-4 signaling in murine mast cells.

E. D. White, R. P. Andrews, and G. K. K. Hershey (2001)
J. Leukoc. Biol. 69, 825-830
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Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts.

F. Behbod, R. A. Erwin-Cohen, M.-E. Wang, B. W. Trawick, X. Qu, R. Verani, B. D. Kahan, S. M. Stepkowski, and R. A. Kirken (2001)
J. Immunol. 166, 3724-3732
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Lack of dominant-negative effects of a truncated {gamma}c on retroviral-mediated gene correction of immunodeficient mice.

M. Otsu, K. Sugamura, and F. Candotti (2001)
Blood 97, 1618-1624
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A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1{beta}2.

N. L. Monson, T. J. Fenske, S. Wei, A. J. Okragly, J. L.O. de Jong, M. Haak-Frendscho, J. O’Shea, J. Djeu, and P. M. Sondel (2001)
J. Leukoc. Biol. 69, 419-425
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NF-{{kappa}}B/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells.

A. L. Mora, J. Youn, A. D. Keegan, and M. Boothby (2001)
J. Immunol. 166, 2218-2227
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Memory-Type CD8+ T Cells Protect IL-2 Receptor {alpha}-Deficient Mice from Systemic Infection with Herpes Simplex Virus Type 2.

H. Tsunobuchi, H. Nishimura, F. Goshima, T. Daikoku, Y. Nishiyama, and Y. Yoshikai (2000)
J. Immunol. 165, 4552-4560
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Bcl-3 Expression Promotes Cell Survival following Interleukin-4 Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors.

A. Rebollo, L. Dumoutier, J.-C. Renauld, A. Zaballos, V. Ayllon, and C. Martinez-A. (2000)
Mol. Cell. Biol. 20, 3407-3416
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Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo.

D. T. M. Leung, S. Morefield, and D. M. Willerford (2000)
J. Immunol. 164, 3527-3534
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Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor {alpha}-Chain.

H. Huang and W. E. Paul (2000)
J. Immunol. 164, 1211-1215
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Soluble IL-4 Receptor Inhibits Airway Inflammation Following Allergen Challenge in a Mouse Model of Asthma.

W. R. Henderson Jr., E. Y. Chi, and C. R. Maliszewski (2000)
J. Immunol. 164, 1086-1095
 |  Abstract »  |  Full Text »  |  PDF »

Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach.

M. Lo, M. L. Bloom, K. Imada, M. Berg, J. M. Bollenbacher, E. T. Bloom, B. L. Kelsall, and W. J. Leonard (1999)
Blood 94, 3027-3036
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Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly (1999)
PNAS 96, 10800-10805
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Cytokines in asthma.

K F Chung and P J Barnes (1999)
Thorax 54, 825-857
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Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-alpha.

P. L. Orchansky, R. Kwan, F. Lee, and J. W. Schrader (1999)
J. Biol. Chem. 274, 20818-20825
 |  Abstract »  |  Full Text »  |  PDF »

No Association between Atopy/Asthma and the Ile50val Polymorphism of IL-4 Receptor.

E. NOGUCHI, M. SHIBASAKI, T. ARINAMI, K. TAKEDA, Y. YOKOUCHI, K. KOBAYASHI, N. IMOTO, S. NAKAHARA, A. MATSUI, and H. HAMAGUCHI (1999)
Am. J. Respir. Crit. Care Med. 160, 342-345
 |  Abstract »  |  Full Text »

Pharmacology of the Eosinophil.

M. A. Giembycz and M. A. Lindsay (1999)
Pharmacol. Rev. 51, 213-340
 |  Abstract »  |  Full Text »  |  PDF »

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains.

N. Noben-Trauth, W. E. Paul, and D. L. Sacks (1999)
J. Immunol. 162, 6132-6140
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Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors.

C. Rusterholz, P. C. Henrioud, and M. Nabholz (1999)
Mol. Cell. Biol. 19, 2681-2689
 |  Abstract »  |  Full Text »  |  PDF »

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of JAK3 Protein Levels in T Lymphocytes by Prostaglandin E2 and Other Cyclic Adenosine Monophosphate-Elevating Agents: Impact on Interleukin-2 Receptor Signaling Pathway.

V. Kolenko, P. Rayman, B. Roy, M. K. Cathcart, J. O'Shea, R. Tubbs, L. Rybicki, R. Bukowski, and J. Finke (1999)
Blood 93, 2308-2318
 |  Abstract »  |  Full Text »  |  PDF »

Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism.

S. D. Levin, R. M. Koelling, S. L. Friend, D. E. Isaksen, S. F. Ziegler, R. M. Perlmutter, and A. G. Farr (1999)
J. Immunol. 162, 677-683
 |  Abstract »  |  Full Text »  |  PDF »

IgE Hyperproduction Through Enhanced Tyrosine Phosphorylation of Janus Kinase 3 in NC/Nga Mice, a Model for Human Atopic Dermatitis.

M. Matsumoto, C. Ra, K. Kawamoto, H. Sato, A. Itakura, J. Sawada, H. Ushio, H. Suto, K. Mitsuishi, Y. Hikasa, et al. (1999)
J. Immunol. 162, 1056-1063
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
 |  Abstract »  |  Full Text »  |  PDF »

Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
 |  Abstract »  |  PDF »

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins: Development of a Recombinant Interleukin-4-Pseudomonas Exotoxin for Therapy of Glioblastoma.

R. K. Puri (1999)
Toxicol Pathol 27, 53-57
 |  Abstract »  |  PDF »

Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction.

S. J. Haque, P. Harbor, M. Tabrizi, T. Yi, and B. R. G. Williams (1998)
J. Biol. Chem. 273, 33893-33896
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators of Asthma: An Update.

P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
 |  Abstract »  |  Full Text »  |  PDF »

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation.

A. Cerezo, C. Martínez-A, D. Lanzarot, S. Fischer, T. F. Franke, and A. Rebollo (1998)
Mol. Biol. Cell 9, 3107-3118
 |  Abstract »  |  Full Text »

Human Eosinophils Constitutively Express a Functional Interleukin-4 Receptor: Interleukin-4 -Induced Priming of Chemotactic Responses and Induction of PI-3 Kinase Activity.

G. R. Dubois, R. C. Schweizer, C. Versluis, C. A. F. M. Bruijnzeel-Koomen, and P. L. B. Bruijnzeel (1998)
Am. J. Respir. Cell Mol. Biol. 19, 691-699
 |  Abstract »  |  Full Text »

Specific Antagonism of Type I IL-4 Receptor with a Mutated Form of Murine IL-4.

M. Schnare, H. Blum, S. Juttner, M. Rollinghoff, and A. Gessner (1998)
J. Immunol. 161, 3484-3492
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis of the Common Cytokine Receptor gamma c Chain. IDENTIFICATION OF SEQUENCES INVOLVED IN INTERNALIZATION AND DEGRADATION.

E. Morelon and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 22044-22051
 |  Abstract »  |  Full Text »  |  PDF »

An immune cell-selective interleukin 4 agonist.

A. B. Shanafelt, C. P. Forte, J. J. Kasper, L. Sanchez-Pescador, M. Wetzel, R. Gundel, and J. M. Greve (1998)
PNAS 95, 9454-9458
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13 Receptor alpha ' But Not alpha  Chain: A Functional Component of Interleukin-4 Receptors.

T. Murata, J. Taguchi, and R. K. Puri (1998)
Blood 91, 3884-3891
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells.

H. Huang and W. E. Paul (1998)
J. Exp. Med. 187, 1305-1313
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Interleukin-13 Receptor Constituents on Mature Human B Lymphocytes.

H. Ogata, D. Ford, N. Kouttab, T. C. King, N. Vita, A. Minty, J. Stoeckler, D. Morgan, C. Girasole, J. W. Morgan, et al. (1998)
J. Biol. Chem. 273, 9864-9871
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the IL-2 Receptor {gamma}-Chain ({gamma}c) in the Control by IL-4 of Human Monocyte and Macrophage Proinflammatory Mediator Production.

C. S. Bonder, H. L. Dickensheets, J. J. Finlay-Jones, R. P. Donnelly, and P. H. Hart (1998)
J. Immunol. 160, 4048-4056
 |  Abstract »  |  Full Text »  |  PDF »

Heteromerization of the gamma c Chain with the Interleukin-9 Receptor alpha  Subunit Leads to STAT Activation and Prevention of Apoptosis.

J. H. Bauer, K. D. Liu, Y. You, S. Y. Lai, and M. A. Goldsmith (1998)
J. Biol. Chem. 273, 9255-9260
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7 (IL-7) Enhances Class Switching to IgE and IgG4 in the Presence of T Cells Via IL-9 and sCD23.

P. Jeannin, Y. Delneste, S. Lecoanet-Henchoz, D. Gretener, and J.-Y. Bonnefoy (1998)
Blood 91, 1355-1361
 |  Abstract »  |  Full Text »  |  PDF »

The Association of Atopy with a Gain-of-Function Mutation in the {alpha} Subunit of the Interleukin-4 Receptor.

G. K. K. Hershey, M. F. Friedrich, L. A. Esswein, M. L. Thomas, and T. A. Chatila (1997)
N. Engl. J. Med. 337, 1720-1725
 |  Abstract »  |  Full Text »  |  PDF »

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study.

S. Damjanovich, L. Bene, J. Matko, A. Alileche, C. K. Goldman, S. Sharrow, and T. A. Waldmann (1997)
PNAS 94, 13134-13139
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization and Functional Analysis of Murine Interleukin 4 Receptor Allotypes.

T. Schulte, R. Kurrle, M. Rollinghoff, and A. Gessner (1997)
J. Exp. Med. 186, 1419-1429
 |  Abstract »  |  Full Text »  |  PDF »

Full Immunologic Reconstitution Following Nonconditioned Bone Marrow Transplantation for Canine X-Linked Severe Combined Immunodeficiency.

P. J. Felsburg, R. L. Somberg, B. J. Hartnett, S. F. Suter, P. S. Henthorn, P. F. Moore, K. I. Weinberg, and H. D. Ochs (1997)
Blood 90, 3214-3221
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Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
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HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor.

D. Wang, J. Zamorano, A. D. Keegan, and M. Boothby (1997)
J. Biol. Chem. 272, 25083-25090
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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

N. Noben-Trauth, L. D. Shultz, F. Brombacher, J. F. Urban Jr., H. Gu, and W. E. Paul (1997)
PNAS 94, 10838-10843
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An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4.

P. L. Orchansky, S. D. Ayres, D. J. Hilton, and J. W. Schrader (1997)
J. Biol. Chem. 272, 22940-22947
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Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome.

C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al. (1997)
Blood 90, 1115-1123
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Two Discrete Regions of Interleukin-2 (IL2) Receptor beta  Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase.

R. A. Kirken, M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, X. Liu, L. Hennighausen, H. Rui, and W. L. Farrar (1997)
J. Biol. Chem. 272, 15459-15465
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Clonal Proliferation and Cytokine Requirement of Murine Progenitors for Natural Killer Cells.

Y. Aiba, F. Hirayama, and M. Ogawa (1997)
Blood 89, 4005-4012
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Homodimerization of the human interleukin 4 receptor alpha  chain induces Cvarepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma  chain.

H. Fujiwara, S. H. Hanissian, A. Tsytsykova, and R. S. Geha (1997)
PNAS 94, 5866-5871
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Activation of Phosphatidylinositol 3-Kinase by Interleukin-13. AN INHIBITORY SIGNAL FOR INDUCIBLE NITRIC-OXIDE SYNTHASE EXPRESSION IN EPITHELIAL CELL LINE HT-29.

K. Wright, S. G. Ward, G. Kolios, and J. Westwick (1997)
J. Biol. Chem. 272, 12626-12633
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Interleukin-4 (IL-4) Induces Phosphatidylinositol 3-Kinase (p85) Dephosphorylation. IMPLICATIONS FOR THE ROLE OF SHP-1 IN THE IL-4-INDUCED SIGNALS IN HUMAN B CELLS.

F. Imani, K. J. Rager, B. Catipovic, and D. G. Marsh (1997)
J. Biol. Chem. 272, 7927-7931
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Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.

N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
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Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules.

X. H. Chen, B. K.R. Patel, L.-M. Wang, M. Frankel, N. Ellmore, R. A. Flavell, W. J. LaRochelle, and J. H. Pierce (1997)
J. Biol. Chem. 272, 6556-6560
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A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha  chain.

Y. Wang, B.-J. Shen, and W. Sebald (1997)
PNAS 94, 1657-1662
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Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.

B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
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Tumor Necrosis Factor alpha Enhances the Expression of the Interleukin (IL)-4 Receptor alpha -Chain on Endothelial Cells Increasing IL-4 or IL-13-induced Stat6 Activation.

S. M. Lugli, N. Feng, M. H. Heim, M. Adam, B. Schnyder, H. Etter, M. Yamage, H.-P. Eugster, R. A. Lutz, G. Zurawski, et al. (1997)
J. Biol. Chem. 272, 5487-5494
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Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function.

D. C. Thomis and L. J. Berg (1997)
J. Exp. Med. 185, 197-206
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Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells.

K. Saijo, S. Y. Park, Y. Ishida, H. Arase, and T. Saito (1997)
J. Exp. Med. 185, 351-356
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A Murine Interleukin-4 Antagonistic Mutant Protein Completely Inhibits Interleukin-4-induced Cell Proliferation, Differentiation, and Signal Transduction.

S. M. Grunewald, S. Kunzmann, B. Schnarr, J. Ezernieks, W. Sebald, and A. Duschl (1997)
J. Biol. Chem. 272, 1480-1483
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Activating Mutations in Cytokine Receptors: Implications for Receptor Function and Role in Disease.

T. J. Gonda and R. J. D'Andrea (1997)
Blood 89, 355-369
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Evidence for the Participation of Interleukin-2 (IL-2) and IL-4 in the Regulation of Autonomous Growth and Tumorigenesis of Transformed Cells of Lymphoid Origin.

M. R. Hassuneh, P. S. Nagarkatti, and M. Nagarkatti (1997)
Blood 89, 610-620
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