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Science 10 December 1993:
Vol. 262. no. 5140, pp. 1741 - 1744
DOI: 10.1126/science.8259520
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Articles

Science, Vol 262, Issue 5140, 1741-1744
Copyright © 1993 by American Association for the Advancement of Science

articles

Elements of the yeast pheromone response pathway required for filamentous growth of diploids

H Liu, CA Styles, and GR Fink

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.


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Control of Nitrogen Catabolite Repression Is Not Affected by the tRNAGln-CUU Mutation, Which Results in Constitutive Pseudohyphal Growth of Saccharomyces cerevisiae.
A. E. Beeser and T. G. Cooper (1999)
J. Bacteriol. 181, 2472-2476
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Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity.
D. I. Johnson (1999)
Microbiol. Mol. Biol. Rev. 63, 54-105
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