Science 10 December 1993: Vol. 262. no. 5140, pp. 1731 - 1734 DOI: 10.1126/science.8259518

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Articles

{beta}-Catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours.

E. M. Kohler, S. H. V. Chandra, J. Behrens, and J. Schneikert (2009)
Hum. Mol. Genet. 18, 213-226
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Functional Screen in Human Cells Identifies MOCA as a Negative Regulator of Wnt Signaling.

E. Caspi and R. Rosin-Arbesfeld (2008)
Mol. Biol. Cell 19, 4660-4674
 |  Abstract »  |  Full Text »  |  PDF »

Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology.

B. M. Boman and E. Huang (2008)
J. Clin. Oncol. 26, 2828-2838
 |  Abstract »  |  Full Text »  |  PDF »

Anchoring Junctions As Drug Targets: Role in Contraceptive Development.

D. D. Mruk, B. Silvestrini, and C. Y. Cheng (2008)
Pharmacol. Rev. 60, 146-180
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Frequent nuclear expression of {beta}-catenin protein but rare {beta}-catenin mutation in pulmonary sclerosing haemangioma.

P-M Chiang, R-H Yuan, H-C Hsu, T-L Mao, R-H Hu, P-L Lai, and Y-M Jeng (2008)
J. Clin. Pathol. 61, 268-271
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The Intercalated Disc Protein, mXin{alpha}, Is Capable of Interacting with -Catenin and Bundling Actin Filaments.

S. Choi, E. A. Gustafson-Wagner, Q. Wang, S. M. Harlan, H. W. Sinn, J. L.-C. Lin, and J. J.-C. Lin (2007)
J. Biol. Chem. 282, 36024-36036
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Modifier Loci of ApcMin Affecting Mammary Tumor Development.

H. Wang, D. Teske, A. Tess, R. Kohlhepp, Y. Choi, C. Kendziorski, and A. R. Moser (2007)
Cancer Res. 67, 11226-11233
 |  Abstract »  |  Full Text »  |  PDF »

Sox17 and Sox4 Differentially Regulate {beta}-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells.

D. Sinner, J. J. Kordich, J. R. Spence, R. Opoka, S. Rankin, S.-C. J. Lin, D. Jonatan, A. M. Zorn, and J. M. Wells (2007)
Mol. Cell. Biol. 27, 7802-7815
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Inhibits beta-Catenin through Suppression of Cox-2: A ROLE FOR TRUNCATED ADENOMATOUS POLYPOSIS COLI.

A. L. Eisinger, L. D. Nadauld, D. N. Shelton, S. M. Prescott, D. M. Stafforini, and D. A. Jones (2007)
J. Biol. Chem. 282, 29394-29400
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.

K. Aoki and M. M. Taketo (2007)
J. Cell Sci. 120, 3327-3335
 |  Abstract »  |  Full Text »  |  PDF »

Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.

N. Suraweera, A. Latchford, A. McCart, P. Rogers, S. Spain, O. Sieber, R. Phillips, I. Tomlinson, and A. Silver (2007)
J. Med. Genet. 44, 541-544
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Translocation of {beta}-Catenin Protein but Absence of {beta}-Catenin and APC Mutation in Gastrointestinal Carcinoid Tumor.

M.-C. Su, C.-C. Wang, C.-C. Chen, R.-H. Hu, T.-H. Wang, H.-L. Kao, Y.-M. Jeng, and R.-H. Yuan (2006)
Ann. Surg. Oncol. 13, 1604-1609
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Antitumor Response in C57BL/6J-Min/+ Mice during Long-term Administration of a Selective Cyclooxygenase-2 Inhibitor..

A. M. Carothers, A. E. Moran, N. L. Cho, M. Redston, and M. M. Bertagnolli (2006)
Cancer Res. 66, 6432-6438
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression Patterns of Wnt and {beta}-Catenin/TCF Target Genes in the Uterus of Immature Female Rats Exposed to 17{alpha}-Ethynyl Estradiol.

S. Katayama, K. Ashizawa, T. Fukuhara, M. Hiroyasu, Y. Tsuzuki, H. Tatemoto, T. Nakada, and K. Nagai (2006)
Toxicol. Sci. 91, 419-430
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Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB1.

K. Kita, T. Wittmann, I. S. Nathke, and C. M. Waterman-Storer (2006)
Mol. Biol. Cell 17, 2331-2345
 |  Abstract »  |  Full Text »  |  PDF »

Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention..

E. Krieghoff, J. Behrens, and B. Mayr (2006)
J. Cell Sci. 119, 1453-1463
 |  Abstract »  |  Full Text »  |  PDF »

MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3{beta}-Mediated Phosphorylation and Degradation of {beta}-Catenin.

L. Huang, D. Chen, D. Liu, L. Yin, S. Kharbanda, and D. Kufe (2005)
Cancer Res. 65, 10413-10422
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (-)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea.

J. Ju, J. Hong, J.-n. Zhou, Z. Pan, M. Bose, J. Liao, G.-y. Yang, Y. Y. Liu, Z. Hou, Y. Lin, et al. (2005)
Cancer Res. 65, 10623-10631
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Pathway and Its Role in Cancer.

A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
 |  Abstract »  |  Full Text »  |  PDF »

Wnt signaling in the intestinal epithelium: from endoderm to cancer.

A. Gregorieff and H. Clevers (2005)
Genes & Dev. 19, 877-890
 |  Abstract »  |  Full Text »  |  PDF »

Self-Renewal and Cancer of the Gut: Two Sides of a Coin.

F. Radtke and H. Clevers (2005)
Science 307, 1904-1909
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Peptide Array-based Delineation of the Differential {beta}-Catenin Interaction with Tcf4, E-Cadherin, and Adenomatous Polyposis Coli.

R. Gail, R. Frank, and A. Wittinghofer (2005)
J. Biol. Chem. 280, 7107-7117
 |  Abstract »  |  Full Text »  |  PDF »

Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.

K. C. Slep, S. L. Rogers, S. L. Elliott, H. Ohkura, P. A. Kolodziej, and R. D. Vale (2005)
J. Cell Biol. 168, 587-598
 |  Abstract »  |  Full Text »  |  PDF »

The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro.

K. Steigerwald, G. K. Behbehani, K. A. Combs, M. C. Barton, and J. Groden (2005)
Mol. Cancer Res. 3, 78-89
 |  Abstract »  |  Full Text »  |  PDF »

Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.

R. Gonzalez-Quevedo, M. Shoffer, L. Horng, and A. E. Oro (2005)
J. Cell Biol. 168, 453-463
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.

J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells.

M. Bordonaro, D. L. Lazarova, and A. C. Sartorelli (2004)
Nucleic Acids Res. 32, 2660-2674
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor, c-MET, {beta}-Catenin, and p53 Expression as Prognostic Indicators in Stage II Colon Cancer: A Tissue Microarray Study.

M. B. Resnick, J. Routhier, T. Konkin, E. Sabo, and V. E. Pricolo (2004)
Clin. Cancer Res. 10, 3069-3075
 |  Abstract »  |  Full Text »  |  PDF »

Acetylation of {beta}-Catenin by p300 Regulates {beta}-Catenin-Tcf4 Interaction.

L. Levy, Y. Wei, C. Labalette, Y. Wu, C.-A. Renard, M. A. Buendia, and C. Neuveut (2004)
Mol. Cell. Biol. 24, 3404-3414
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Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes.

R. K. Louie, S. Bahmanyar, K. A. Siemers, V. Votin, P. Chang, T. Stearns, W. J. Nelson, and A. I. M. Barth (2004)
J. Cell Sci. 117, 1117-1128
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Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-{beta} Signaling, as a Target of the {beta}-Catenin Pathway in Colorectal Tumor Cells.

T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura, K. Tashiro, S. Kuhara, et al. (2004)
J. Biol. Chem. 279, 6840-6846
 |  Abstract »  |  Full Text »  |  PDF »

GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs.

C. Weaver, G. H. Farr III, W. Pan, B. A. Rowning, J. Wang, J. Mao, D. Wu, L. Li, C. A. Larabell, and D. Kimelman (2003)
Development 130, 5425-5436
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Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse.

N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino (2003)
Physiol Genomics 15, 228-235
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Eradication of pathogenic {beta}-catenin by Skp1/Cullin/F box ubiquitination machinery.

Y. Su, S. Ishikawa, M. Kojima, and B. Liu (2003)
PNAS 100, 12729-12734
 |  Abstract »  |  Full Text »  |  PDF »

Sulindac metabolites induce caspase- and proteasome-dependent degradation of {beta}-catenin protein in human colon cancer cells.

P. L. Rice, J. Kelloff, H. Sullivan, L. J. Driggers, K. S. Beard, S. Kuwada, G. Piazza, and D. J. Ahnen (2003)
Mol. Cancer Ther. 2, 885-892
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Cooperation between the {beta}-Catenin Signaling Pathway and Steroidogenic Factor 1 in the Activation of the Mullerian Inhibiting Substance Type II Receptor.

A. Hossain and G. F. Saunders (2003)
J. Biol. Chem. 278, 26511-26516
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin Regulation during the Cell Cycle: Implications in G2/M and Apoptosis.

D. Olmeda, S. Castel, S. Vilaro, and A. Cano (2003)
Mol. Biol. Cell 14, 2844-2860
 |  Abstract »  |  Full Text »  |  PDF »

Novel Candidate Targets of {beta}-Catenin/T-cell Factor Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas.

D. R. Schwartz, R. Wu, S. L. R. Kardia, A. M. Levin, C.-C. Huang, K. A. Shedden, R. Kuick, D. E. Misek, S. M. Hanash, J. M. G. Taylor, et al. (2003)
Cancer Res. 63, 2913-2922
 |  Abstract »  |  Full Text »  |  PDF »

The Human T-Cell Factor-4 Gene Splicing Isoforms, Wnt Signal Pathway, and Apoptosis in Renal Cell Carcinoma.

H. Shiina, M. Igawa, J. Breault, L. Ribeiro-Filho, D. Pookot, S. Urakami, M. Terashima, M. Deguchi, M. Yamanaka, M. Shirai, et al. (2003)
Clin. Cancer Res. 9, 2121-2132
 |  Abstract »  |  Full Text »  |  PDF »

Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization.

T. Husoy, V. Cruciani, H. K. Knutsen, S.-O. Mikalsen, H. B. Olstorn, and J. Alexander (2003)
Carcinogenesis 24, 643-650
 |  Abstract »  |  Full Text »  |  PDF »

Clinical, Cellular, and Molecular Aspects of Cancer Invasion.

M. Mareel and A. Leroy (2003)
Physiol Rev 83, 337-376
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the LIM Protein FHL2 as a Coactivator of beta -Catenin.

Y. Wei, C.-A. Renard, C. Labalette, Y. Wu, L. Levy, C. Neuveut, X. Prieur, M. Flajolet, S. Prigent, and M.-A. Buendia (2003)
J. Biol. Chem. 278, 5188-5194
 |  Abstract »  |  Full Text »  |  PDF »

APC-dependent suppression of colon carcinogenesis by PPARgamma.

G. D. Girnun, W. M. Smith, S. Drori, P. Sarraf, E. Mueller, C. Eng, P. Nambiar, D. W. Rosenberg, R. T. Bronson, W. Edelmann, et al. (2002)
PNAS 99, 13771-13776
 |  Abstract »  |  Full Text »  |  PDF »

A novel aberrant splice site mutation in the APC gene.

G S Charames, H Cheng, C A Gilpin, A G W Hunter, T Berk, and B Bapat (2002)
J. Med. Genet. 39, 754-757
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A yeast model system for functional analysis of {beta}-catenin signaling.

M. S. Lee, K. A. D'Amour, and J. Papkoff (2002)
J. Cell Biol. 158, 1067-1078
 |  Abstract »  |  Full Text »  |  PDF »

Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells.

L. Fischer, G. Boland, and R. S. Tuan (2002)
J. Biol. Chem. 277, 30870-30878
 |  Abstract »  |  Full Text »  |  PDF »

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta -catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

T. Schwarz-Romond, C. Asbrand, J. Bakkers, M. Kuhl, H.-J. Schaeffer, J. Huelsken, J. Behrens, M. Hammerschmidt, and W. Birchmeier (2002)
Genes & Dev. 16, 2073-2084
 |  Abstract »  |  Full Text »  |  PDF »

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the {beta}-catenin signaling cascade.

C. Albuquerque, C. Breukel, R. van der Luijt, P. Fidalgo, P. Lage, F. J.M. Slors, C. N. Leitao, R. Fodde, and R. Smits (2002)
Hum. Mol. Genet. 11, 1549-1560
 |  Abstract »  |  Full Text »  |  PDF »

Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation.

T. A. Chan, Z. Wang, L. H. Dang, B. Vogelstein, and K. W. Kinzler (2002)
PNAS 99, 8265-8270
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.

Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
 |  Abstract »  |  Full Text »  |  PDF »

High-Throughput Tissue Microarray Analysis Used to Evaluate Biology and Prognostic Significance of the E-Cadherin Pathway in Non-Small-Cell Lung Cancer.

R. M. Bremnes, R. Veve, E. Gabrielson, F. R. Hirsch, A. Baron, L. Bemis, R. M. Gemmill, H. A. Drabkin, and W. A. Franklin (2002)
J. Clin. Oncol. 20, 2417-2428
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C delta Regulates Function of the DF3/MUC1 Carcinoma Antigen in beta -Catenin Signaling.

J. Ren, Y. Li, and D. Kufe (2002)
J. Biol. Chem. 277, 17616-17622
 |  Abstract »  |  Full Text »  |  PDF »

Characteristics of the peroxisome proliferator activated receptor {gamma} (PPAR{gamma}) ligand induced apoptosis in colon cancer cells.

T Shimada, K Kojima, K Yoshiura, H Hiraishi, and A Terano (2002)
Gut 50, 658-664
 |  Abstract »  |  Full Text »  |  PDF »

Expression status of E-cadherin and {alpha}-, {beta}-, and {gamma}-catenins in thymoma.

I. Yoshino, S. Kase, T. Yano, K. Sugio, and K. Sugimachi (2002)
Ann. Thorac. Surg. 73, 933-937
 |  Abstract »  |  Full Text »  |  PDF »

IQGAP1-mediated Stimulation of Transcriptional Co-activation by beta -Catenin Is Modulated by Calmodulin.

M. W. Briggs, Z. Li, and D. B. Sacks (2002)
J. Biol. Chem. 277, 7453-7465
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin--A Linchpin in Colorectal Carcinogenesis?.

N. A. C. S. Wong and M. Pignatelli (2002)
Am. J. Pathol. 160, 389-401
 |  Abstract »  |  Full Text »  |  PDF »

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein.

F. Zhang, R. L. White, and K. L. Neufeld (2001)
Mol. Cell. Biol. 21, 8143-8156
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Microarray Analysis of {beta}-Catenin in Colorectal Cancer Shows Nuclear Phospho-{beta}-catenin Is Associated with a Better Prognosis.

G. G. Chung, E. Provost, E. P. Kielhorn, L. A. Charette, B. L. Smith, and D. L. Rimm (2001)
Clin. Cancer Res. 7, 4013-4020
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Catenin Function by the Ikappa B Kinases.

C. Lamberti, K.-M. Lin, Y. Yamamoto, U. Verma, I. M. Verma, S. Byers, and R. B. Gaynor (2001)
J. Biol. Chem. 276, 42276-42286
 |  Abstract »  |  Full Text »  |  PDF »

Genetics of Nonmelanoma Skin Cancer.

H. Tsao (2001)
Arch Dermatol 137, 1486-1492
 |  Abstract »  |  Full Text »  |  PDF »

Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1epsilon.

B. Rubinfeld, D. A. Tice, and P. Polakis (2001)
J. Biol. Chem. 276, 39037-39045
 |  Abstract »  |  Full Text »  |  PDF »

Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice.

A. M. Carothers, K. A. Melstrom Jr., J. D. Mueller, M. J. Weyant, and M. M. Bertagnolli (2001)
J. Biol. Chem. 276, 39094-39102
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of {beta}- and {gamma}-Catenin in N-Butyl-N-(-4-hydroxybutyl)nitrosamine-induced Murine Bladder Cancer.

H. Shiina, M. Igawa, S. Urakami, K. Shigeno, T. Yoneda, M. Terashima, M. Deguchi, L. Ribeiro-Filho, and R. Dahiya (2001)
Cancer Res. 61, 7101-7109
 |  Abstract »  |  Full Text »  |  PDF »

Cyclooxygenase-independent actions of cyclooxygenase inhibitors.

I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER (2001)
FASEB J 15, 2057-2072
 |  Abstract »  |  Full Text »  |  PDF »

Where is APC going?.

Y. Mimori-Kiyosue and S. Tsukita (2001)
J. Cell Biol. 154, 1105-1110
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of {beta}-Catenin Inhibits the Neoplastic Growth of APC-Mutant Colon Cancer Cells.

H. Roh, D. W. Green, C. B. Boswell, J. A. Pippin, and J. A. Drebin (2001)
Cancer Res. 61, 6563-6568
 |  Abstract »  |  Full Text »  |  PDF »

The Divergent Caenorhabditis elegans {beta}-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy in Vivo.

L. Natarajan, N. E. Witwer, and D. M. Eisenmann (2001)
Genetics 159, 159-172
 |  Abstract »  |  Full Text »  |  PDF »

What we could do now: molecular pathology of colorectal cancer.

R S Houlston (2001)
Mol. Pathol. 54, 206-214
 |  Abstract »  |  Full Text »  |  PDF »

Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth.

E Hidaka, A Yanagisawa, M Seki, T Setoguchi, and Y Kato (2001)
Gut 48, 656-659
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of the Retinoic Acid-responsive Gene Stra6 in Human Cancers and Its Synergistic Induction by Wnt-1 and Retinoic Acid.

W. Szeto, W. Jiang, D. A. Tice, B. Rubinfeld, P. G. Hollingshead, S. E. Fong, D. L. Dugger, T. Pham, D. G. Yansura, T. A. Wong, et al. (2001)
Cancer Res. 61, 4197-4205
 |  Abstract »  |  Full Text »

The ABC of APC.

N. S. Fearnhead, M. P. Britton, and W. F. Bodmer (2001)
Hum. Mol. Genet. 10, 721-733
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin Mutations in Biliary Tract Cancers: A Population-based Study in China.

A. Rashid, Y.-T. Gao, S. Bhakta, M.-C. Shen, B.-S. Wang, J. Deng, J. F. Fraumeni Jr., and A. W. Hsing (2001)
Cancer Res. 61, 3406-3409
 |  Abstract »  |  Full Text »

Down-Regulation of {beta}-Catenin TCF Signaling Is Linked to Colonic Epithelial Cell Differentiation.

J. M. Mariadason, M. Bordonaro, F. Aslam, L. Shi, M. Kuraguchi, A. Velcich, and L. H. Augenlicht (2001)
Cancer Res. 61, 3465-3471
 |  Abstract »  |  Full Text »

A distinct splice form of APC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours.

K. STEIGERWALD, I. M SANTORO, J. J KORDICH, V. GISMONDI, C. TRZEPACZ, M. BADIALI, F GIANGASPERO, M G. BALKO, J. S GRAHAM, N. RATNER, et al. (2001)
J. Med. Genet. 38, 257-262
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Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer.

J M D Wheeler, H C Kim, J A Efstathiou, M Ilyas, N J M. Mortensen, and W F Bodmer (2001)
Gut 48, 367-371
 |  Abstract »  |  Full Text »  |  PDF »

Gas6 Induces Growth, {beta}-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells.

S. Goruppi, C. Chiaruttini, M. E. Ruaro, B. Varnum, and C. Schneider (2001)
Mol. Cell. Biol. 21, 902-915
 |  Abstract »  |  Full Text »

Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the {beta}-Catenin Destruction Complex in Polarized Epithelial Cells.

A. Reinacher-Schick and B. M. Gumbiner (2001)
J. Cell Biol. 152, 491-502
 |  Abstract »  |  Full Text »  |  PDF »

Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.

R HOULSTON, M CRABTREE, R PHILLIPS, M CRABTREE, and I TOMLINSON (2001)
Gut 48, 1-5
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A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis.

L. Lo Muzio (2001)
Critical Reviews in Oral Biology & Medicine 12, 152-165
 |  Abstract »  |  Full Text »  |  PDF »

Mutant E-cadherin Breast Cancer Cells Do Not Display Constitutive Wnt Signaling.

M. van de Wetering, N. Barker, I. C. Harkes, M. van der Heyden, N. J. Dijk, A. Hollestelle, J. G. M. Klijn, H. Clevers, and M. Schutte (2001)
Cancer Res. 61, 278-284
 |  Abstract »  |  Full Text »

Expression of E-cadherin and {beta}-Catenin in Human Non-Small Cell Lung Cancer and the Clinical Significance.

S. Kase, K. Sugio, K. Yamazaki, T. Okamoto, T. Yano, and K. Sugimachi (2000)
Clin. Cancer Res. 6, 4789-4796
 |  Abstract »  |  Full Text »

{beta}-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis.

H.-C. Hsu, Y.-M. Jeng, T.-L. Mao, J.-S. Chu, P.-L. Lai, and S.-Y. Peng (2000)
Am. J. Pathol. 157, 763-770
 |  Abstract »  |  Full Text »  |  PDF »

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling.

Y. Kawasaki, T. Senda, T. Ishidate, R. Koyama, T. Morishita, Y. Iwayama, O. Higuchi, and T. Akiyama (2000)
Science 289, 1194-1197
 |  Abstract »  |  Full Text »

Wnt signaling and cancer.

P. Polakis (2000)
Genes & Dev. 14, 1837-1851
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Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.

C. R. Goding (2000)
Genes & Dev. 14, 1712-1728
 |  Full Text »

Altered expression of {beta}-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.

M. Takahashi, M. Mutoh, T. Kawamori, T. Sugimura, and K. Wakabayashi (2000)
Carcinogenesis 21, 1319-1327
 |  Abstract »  |  Full Text »  |  PDF »

Differential Formation of {beta}-Catenin/Lymphoid Enhancer Factor-1 DNA Binding Complex Induced by Nitric Oxide in Mouse Colonic Epithelial Cells Differing in Adenomatous Polyposis Coli (Apc) Genotype.

J. M. Mei, N. G. Hord, D. F. Winterstein, S. P. Donald, and J. M. Phang (2000)
Cancer Res. 60, 3379-3383
 |  Abstract »  |  Full Text »

The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines.

A. Duval, S. Rolland, E. Tubacher, H. Bui, G. Thomas, and R. Hamelin (2000)
Cancer Res. 60, 3872-3879
 |  Abstract »  |  Full Text »

Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells.

J. M. MEI, N. G. HORD, D. F. WINTERSTEIN, S. P. DONALD, and J. M. PHANG (2000)
FASEB J 14, 1188-1201
 |  Abstract »  |  Full Text »

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.

N. N. Mahmoud, A. M. Carothers, D. Grunberger, R. T. Bilinski, M. R. Churchill, C. Martucci, H. L. Newmark, and M. M. Bertagnolli (2000)
Carcinogenesis 21, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Protein-tyrosine Phosphatase RPTP{micro} Binds to and Dephosphorylates the Catenin p120ctn.

G. C. M. Zondag, A. B. Reynolds, and W. H. Moolenaar (2000)
J. Biol. Chem. 275, 11264-11269
 |  Abstract »  |  Full Text »  |  PDF »

The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression.

E. F. Hoier, W. A. Mohler, S. K. Kim, and A. Hajnal (2000)
Genes & Dev. 14, 874-886
 |  Abstract »  |  Full Text »

Down-regulation of beta -Catenin by the Colorectal Tumor Suppressor APC Requires Association with Axin and beta -Catenin.

K. Kawahara, T. Morishita, T. Nakamura, F. Hamada, K. Toyoshima, and T. Akiyama (2000)
J. Biol. Chem. 275, 8369-8374
 |  Abstract »  |  Full Text »  |  PDF »

The {beta}-Catenin Binding Domain of Adenomatous Polyposis Coli Is Sufficient for Tumor Suppression.

I.-M. Shih, J. Yu, T.-C. He, B. Vogelstein, and K. W. Kinzler (2000)
Cancer Res. 60, 1671-1676
 |  Abstract »  |  Full Text »

Interaction among GSK-3, GBP, Axin, and APC in Xenopus Axis Specification.

G. H. Farr , III, D. M. Ferkey, C. Yost, S. B. Pierce, C. Weaver, and D. Kimelman (2000)
J. Cell Biol. 148, 691-702
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells.

Y. Mimori-Kiyosue, N. Shiina, and S. Tsukita (2000)
J. Cell Biol. 148, 505-518
 |  Abstract »  |  Full Text »  |  PDF »

The Relationship Between Frequencies of Extracolonic Manifestations and the Position of APC Germline Mutation in Patients with Familial Adenomatous Polyposis.

M. Enomoto, M. Konishi, T. Iwama, J. Utsunomiya, K.-i. Sugihara, and M. Miyaki (2000)
Jpn. J. Clin. Oncol. 30, 82-88
 |  Abstract »  |  Full Text »  |  PDF »

Altered Expression of {beta}-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of {beta}-catenin Gene Mutations.

V. Bilim, T. Kawasaki, A. Katagiri, S.-j. Wakatsuki, K. Takahashi, and Y. Tomita (2000)
Clin. Cancer Res. 6, 460-466
 |  Abstract »  |  Full Text »

Plakoglobin and beta-catenin: protein interactions, regulation and biological roles.

J Zhurinsky, M Shtutman, and A Ben-Ze'ev (2000)
J. Cell Sci. 113, 3127-3139
 |  Abstract »  |  PDF »

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