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Science 3 December 1993:
Vol. 262. no. 5139, pp. 1580 - 1582
DOI: 10.1126/science.8248808
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Articles

Science, Vol 262, Issue 5139, 1580-1582
Copyright © 1993 by American Association for the Advancement of Science

articles

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo

AA Vaporciyan, HM DeLisser, HC Yan, Mendiguren II, Thom SR, ML Jones, PA Ward, and SM Albelda

Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.

During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block not only in vivo accumulation of rat neutrophils into the peritoneal cavity and the alveolar compartment of the lung but also neutrophil accumulation in human skin grafts transplanted onto immunodeficient mice. On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target.


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S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 588-597
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Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions.
G. S. Duncan, D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. (1999)
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Vascular-endothelial-cadherin modulates endothelial monolayer permeability.
P. Hordijk, E Anthony, F. Mul, R Rientsma, L. Oomen, and D Roos (1999)
J. Cell Sci. 112, 1915-1923
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Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction.
V. L. Serebruany and P. A. Gurbel (1999)
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Cardiovasc Res 39, 393-400
   Abstract »    Full Text »    PDF »
A Role for the alpha vbeta 3 Integrin in the Transmigration of Monocytes.
D. Weerasinghe, K. P. McHugh, F. P. Ross, E. J. Brown, R. H. Gisler, and B. A. Imhof (1998)
J. Cell Biol. 142, 595-607
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Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration.
I. Martin-Padura, S. Lostaglio, M. Schneemann, L. Williams, M. Romano, P. Fruscella, C. Panzeri, A. Stoppacciaro, L. Ruco, A. Villa, et al. (1998)
J. Cell Biol. 142, 117-127
   Abstract »    Full Text »    PDF »
Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN.
Q.-H. Sun, C. Paddock, G. P. Visentin, M. M. Zukowski, W. A. Muller, and P. J. Newman (1998)
J. Biol. Chem. 273, 11483-11490
   Abstract »    Full Text »    PDF »
Requirements for {alpha}d in IgG Immune Complex-Induced Rat Lung Injury.
T. P. Shanley, R. L. Warner, L. D. Crouch, G. N. Dietsch, D. L. Clark, M. M. O'Brien, W. M. Gallatin, and P. A. Ward (1998)
J. Immunol. 160, 1014-1020
   Abstract »    Full Text »    PDF »
Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets.
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman (1998)
Blood 91, 500-507
   Abstract »    Full Text »    PDF »
The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31).
K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian (1997)
J. Biol. Chem. 272, 31086-31091
   Abstract »    Full Text »    PDF »
Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity.
J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda (1997)
J. Cell Biol. 138, 1425-1435
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Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31.
J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons (1997)
J. Biol. Chem. 272, 20555-20563
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Monocyte Adhesion to Interleukin-1beta -Stimulated Endothelial Cells Under Physiologic Flow Conditions.
S. Kukreti, K. Konstantopoulos, C. W. Smith, and L. V. McIntire (1997)
Blood 89, 4104-4111
   Abstract »    Full Text »    PDF »
Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31).
K. Sagawa, W. Swaim, J. Zhang, E. Unsworth, and R. P. Siraganian (1997)
J. Biol. Chem. 272, 13412-13418
   Abstract »    Full Text »    PDF »
Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo.
F. Liao, J. Ali, T. Greene, and W. A. Muller (1997)
J. Exp. Med. 185, 1349-1358
   Abstract »    Full Text »    PDF »
The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING.
D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman (1997)
J. Biol. Chem. 272, 6986-6993
   Abstract »    Full Text »    PDF »
Characterization of the Human Platelet/Endothelial Cell Adhesion Molecule-1 Promoter: Identification of a GATA-2 Binding Element Required for Optimal Transcriptional Activity.
R. J. Gumina, N. E. Kirschbaum, K. Piotrowski, and P. J. Newman (1997)
Blood 89, 1260-1269
   Abstract »    Full Text »    PDF »
Administration of a CD31-Derived Peptide Delays the Onset and Significantly Increases Survival From Lethal Graft-Versus-Host Disease.
Y. Chen, P. G. Schlegel, N. Tran, D. Thompson, J. L. Zehnder, and N. J. Chao (1997)
Blood 89, 1452-1268
   Abstract »    Full Text »    PDF »
VE-cadherin antibody accelerates neutrophil recruitment in vivo.
U Gotsch, E Borges, R Bosse, E Boggemeyer, M Simon, H Mossmann, and D Vestweber (1997)
J. Cell Sci. 110, 583-588
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Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury.
R. J. Gumina, J. E. Schultz, Z. Yao, D. Kenny, D. C. Warltier, P. J. Newman, and G. J. Gross (1996)
Circulation 94, 3327-3333
   Abstract »    Full Text »
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression.
J. Sun, J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser (1996)
J. Biol. Chem. 271, 18561-18570
   Abstract »    Full Text »    PDF »
Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity.
Q.-H. Sun, H. M. DeLisser, M. M. Zukowski, C. Paddock, S. M. Albelda, and P. J. Newman (1996)
J. Biol. Chem. 271, 11090-11098
   Abstract »    Full Text »    PDF »
Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1.
C. Buckley, R Doyonnas, J. Newton, S. Blystone, E. Brown, S. Watt, and D. Simmons (1996)
J. Cell Sci. 109, 437-445
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Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1).
H.-C. Yan, H. S. Baldwin, J. Sun, C. A. Buck, S. M. Albelda, and H. M. DeLisser (1995)
J. Biol. Chem. 270, 23672-23680
   Abstract »    Full Text »    PDF »


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