Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 December 1993:
Vol. 262. no. 5139, pp. 1580 - 1582
DOI: 10.1126/science.8248808
Prev | Table of Contents | Next

Articles

Science, Vol 262, Issue 5139, 1580-1582
Copyright © 1993 by American Association for the Advancement of Science

articles

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo

AA Vaporciyan, HM DeLisser, HC Yan, Mendiguren II, Thom SR, ML Jones, PA Ward, and SM Albelda

Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.

During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block not only in vivo accumulation of rat neutrophils into the peritoneal cavity and the alveolar compartment of the lung but also neutrophil accumulation in human skin grafts transplanted onto immunodeficient mice. On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neutrophils in cystic fibrosis.
D G Downey, S C Bell, and J S Elborn (2009)
Thorax 64, 81-88
   Abstract »    Full Text »    PDF »
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling.
C. Bergom, C. Paddock, C. Gao, T. Holyst, D. K. Newman, and P. J. Newman (2008)
J. Cell Sci. 121, 1235-1242
   Abstract »    Full Text »    PDF »
RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.
C. Garnacho, V. Shuvaev, A. Thomas, L. McKenna, J. Sun, M. Koval, S. Albelda, V. Muzykantov, and S. Muro (2008)
Blood 111, 3024-3033
   Abstract »    Full Text »    PDF »
CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils.
O. Lou, P. Alcaide, F. W. Luscinskas, and W. A. Muller (2007)
J. Immunol. 178, 1136-1143
   Abstract »    Full Text »    PDF »
The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.
S. Nourshargh, F. Krombach, and E. Dejana (2006)
J. Leukoc. Biol. 80, 714-718
   Abstract »    Full Text »    PDF »
Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.
S. Muro, M. Mateescu, C. Gajewski, M. Robinson, V. R. Muzykantov, and M. Koval (2006)
Am J Physiol Lung Cell Mol Physiol 290, L809-L817
   Abstract »    Full Text »    PDF »
Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS..
E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein, E. E. Schoenbaum, T. M. Calderon, and J. W. Berman (2006)
J. Leukoc. Biol. 79, 444-452
   Abstract »    Full Text »    PDF »
Platelet PECAM-1 inhibits thrombus formation in vivo.
S. Falati, S. Patil, P. L. Gross, M. Stapleton, G. Merrill-Skoloff, N. E. Barrett, K. L. Pixton, H. Weiler, B. Cooley, D. K. Newman, et al. (2006)
Blood 107, 535-541
   Abstract »    Full Text »    PDF »
Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature.
B.-S. Ding, C. Gottstein, A. Grunow, A. Kuo, K. Ganguly, S. M. Albelda, D. B. Cines, and V. R. Muzykantov (2005)
Blood 106, 4191-4198
   Abstract »    Full Text »    PDF »
Neutrophils Lacking Platelet-Endothelial Cell Adhesion Molecule-1 Exhibit Loss of Directionality and Motility in CXCR2-Mediated Chemotaxis.
Y. Wu, P. Stabach, M. Michaud, and J. A. Madri (2005)
J. Immunol. 175, 3484-3491
   Abstract »    Full Text »    PDF »
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase: MOLECULAR MECHANISMS AND ANTI-INFLAMMATORY ACTIVITY IN VIVO.
L. de Garavilla, M. N. Greco, N. Sukumar, Z.-W. Chen, A. O. Pineda, F. S. Mathews, E. Di Cera, E. C. Giardino, G. I. Wells, B. J. Haertlein, et al. (2005)
J. Biol. Chem. 280, 18001-18007
   Abstract »    Full Text »    PDF »
PECAM-1, {alpha}6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration.
S. Wang, J. P. Dangerfield, R. E. Young, and S. Nourshargh (2005)
J. Cell Sci. 118, 2067-2076
   Abstract »    Full Text »    PDF »
Platelet Endothelial Cell Adhesion Molecule Deficiency or Blockade Significantly Reduces Leukocyte Emigration in a Majority of Mouse Strains.
A. R. Schenkel, T. W. Chew, and W. A. Muller (2004)
J. Immunol. 173, 6403-6408
   Abstract »    Full Text »    PDF »
Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration.
C. D. O'Brien, G. Cao, A. Makrigiannakis, and H. M. DeLisser (2004)
Am J Physiol Cell Physiol 287, C1103-C1113
   Abstract »    Full Text »    PDF »
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors.
C. I. Baumann, A. S. Bailey, W. Li, M. J. Ferkowicz, M. C. Yoder, and W. H. Fleming (2004)
Blood 104, 1010-1016
   Abstract »    Full Text »    PDF »
Effect of leukocyte depletion on endothelial cell activation and transendothelial migration of leukocytes during cardiopulmonary bypass.
Y.-F. Chen, W.-C. Tsai, C.-C. Lin, L.-Y. Tsai, C.-S. Lee, C.-H. Huang, P.-C. Pan, and M.-L. Chen (2004)
Ann. Thorac. Surg. 78, 634-642
   Abstract »    Full Text »    PDF »
Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fc{gamma} Receptor Function.
S. M. Albelda, K. C. Lau, P. Chien, Z.-Y. Huang, E. Arguiris, A. Bohen, J. Sun, J. A. Billet, M. Christofidou-Solomidou, Z. K. Indik, et al. (2004)
Am. J. Respir. Cell Mol. Biol. 31, 246-255
   Abstract »    Full Text »    PDF »
Signaling in Leukocyte Transendothelial Migration.
J. D. van Buul and P. L. Hordijk (2004)
Arterioscler Thromb Vasc Biol 24, 824-833
   Abstract »    Full Text »
Embryonic Stem Cells Expressing Both Platelet Endothelial Cell Adhesion Molecule-1 and Stage-Specific Embryonic Antigen-1 Differentiate Predominantly into Epiblast Cells in a Chimeric Embryo.
T. Furusawa, K. Ohkoshi, C. Honda, S. Takahashi, and T. Tokunaga (2004)
Biol Reprod 70, 1452-1457
   Abstract »    Full Text »    PDF »
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury.
J. Vinten-Johansen (2004)
Cardiovasc Res 61, 481-497
   Abstract »    Full Text »    PDF »
Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium.
D. Feng, J. A. Nagy, K. Pyne, H. F. Dvorak, and A. M. Dvorak (2004)
J. Histochem. Cytochem. 52, 87-102
   Abstract »    Full Text »    PDF »
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells.
C. Moog-Lutz, F. Cave-Riant, F. C. Guibal, M. A. Breau, Y. Di Gioia, P. O. Couraud, Y. E. Cayre, S. Bourdoulous, and P. G. Lutz (2003)
Blood 102, 3371-3378
   Abstract »    Full Text »    PDF »
Protective Effect of Chronic Vitamin C Treatment on Endothelial Function of Apolipoprotein E-Deficient Mouse Carotid Artery.
T. Matsumoto, L. V. d'uscio, D. Eguchi, M. Akiyama, L. A. Smith, and Z. S. Katusic (2003)
J. Pharmacol. Exp. Ther. 306, 103-108
   Abstract »    Full Text »    PDF »
PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis.
C. Gao, W. Sun, M. Christofidou-Solomidou, M. Sawada, D. K. Newman, C. Bergom, S. M. Albelda, S. Matsuyama, and P. J. Newman (2003)
Blood 102, 169-179
   Abstract »    Full Text »    PDF »
Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology.
P. J. Newman and D. K. Newman (2003)
Arterioscler Thromb Vasc Biol 23, 953-964
   Abstract »    Full Text »    PDF »
Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice.
D. L. Borjesson, S. I. Simon, E. Hodzic, H. E. V. DeCock, C. M. Ballantyne, and S. W. Barthold (2003)
Blood 101, 3257-3264
   Abstract »    Full Text »    PDF »
Identification of Proteases Involved in the Proteolysis of Vascular Endothelium Cadherin during Neutrophil Transmigration.
B. Hermant, S. Bibert, E. Concord, B. Dublet, M. Weidenhaupt, T. Vernet, and D. Gulino-Debrac (2003)
J. Biol. Chem. 278, 14002-14012
   Abstract »    Full Text »    PDF »
Unique Structural Features That Influence Neutrophil Emigration Into the Lung.
A. R. Burns, C. W. Smith, and D. C. Walker (2003)
Physiol Rev 83, 309-336
   Abstract »    Full Text »    PDF »
PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.
C. D. O'Brien, P. Lim, J. Sun, and S. M. Albelda (2003)
Blood 101, 2816-2825
   Abstract »    Full Text »    PDF »
Platelet Endothelial Cell Adhesion Molecule-1 in Neutrophil Emigration during Acute Bacterial Pneumonia in Mice and Rats.
S. Tasaka, L. Qin, A. Saijo, S. M. Albelda, H. M. DeLisser, and C. M. Doerschuk (2003)
Am. J. Respir. Crit. Care Med. 167, 164-170
   Abstract »    Full Text »    PDF »
Aprotinin inhibits leukocyte-endothelial cell interactions after hemorrhage and reperfusion.
D. Pruefer, J. Makowski, M. Dahm, S. Guth, H. Oelert, H. Darius, and M. Buerke (2003)
Ann. Thorac. Surg. 75, 210-215
   Abstract »    Full Text »    PDF »
Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation.
H. Saito, Y. Minamiya, S. Saito, and J.-i. Ogawa (2002)
J. Leukoc. Biol. 72, 829-836
   Abstract »    Full Text »    PDF »
Effect of endothelial cell polarity on beta -amyloid-induced migration of monocytes across normal and AD endothelium.
R. Giri, S. Selvaraj, C. A. Miller, F. Hofman, S. D. Yan, D. Stern, B. V. Zlokovic, and V. K. Kalra (2002)
Am J Physiol Cell Physiol 283, C895-C904
   Abstract »    Full Text »    PDF »
Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?.
M. Osawa, M. Masuda, K.-i. Kusano, and K. Fujiwara (2002)
J. Cell Biol. 158, 773-785
   Abstract »    Full Text »    PDF »
Absence of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) Leads to Increased Severity of Local and Systemic IgE-Mediated Anaphylaxis and Modulation of Mast Cell Activation.
M.-X. Wong, D. Roberts, P. A. Bartley, and D. E. Jackson (2002)
J. Immunol. 168, 6455-6462
   Abstract »    Full Text »    PDF »
PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells.
G. Ji, C. D. O'Brien, M. Feldman, Y. Manevich, P. Lim, J. Sun, S. M. Albelda, and M. I. Kotlikoff (2002)
J. Cell Biol. 157, 173-184
   Abstract »    Full Text »    PDF »
Vascular Immunotargeting of Glucose Oxidase to the Endothelial Antigens Induces Distinct Forms of Oxidant Acute Lung Injury : Targeting to Thrombomodulin, But Not to PECAM-1, Causes Pulmonary Thrombosis and Neutrophil Transmigration.
M. Christofidou-Solomidou, S. Kennel, A. Scherpereel, R. Wiewrodt, C. C. Solomides, G. G. Pietra, J.-C. Murciano, S. A. Shah, H. Ischiropoulos, S. M. Albelda, et al. (2002)
Am. J. Pathol. 160, 1155-1169
   Abstract »    Full Text »    PDF »
Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells.
R. Wiewrodt, A. P. Thomas, L. Cipelletti, M. Christofidou-Solomidou, D. A. Weitz, S. I. Feinstein, D. Schaffer, S. M. Albelda, M. Koval, and V. R. Muzykantov (2002)
Blood 99, 912-922
   Abstract »    Full Text »    PDF »
Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets.
M. Cicmil, J. M. Thomas, M. Leduc, C. Bon, and J. M. Gibbins (2002)
Blood 99, 137-144
   Abstract »    Full Text »    PDF »
Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo.
A. Dobrina, M. Pausa, F. Fischetti, R. Bulla, E. Vecile, E. Ferrero, A. Mantovani, and F. Tedesco (2002)
Blood 99, 185-192
   Abstract »    Full Text »    PDF »
Vascular Immunotargeting to Endothelial Surface in a Specific Macrodomain in Alveolar Capillaries.
J. C. MURCIANO, D. WIN HARSHAW, L. GHITESCU, S. M. DANILOV, and V. R. MUZYKANTOV (2001)
Am. J. Respir. Crit. Care Med. 164, 1295-1302
   Abstract »    Full Text »    PDF »
Distinct Roles for PECAM-1, ICAM-1, and VCAM-1 in Recruitment of Neutrophils and Eosinophils to the Cornea in Ocular Onchocerciasis (River Blindness).
J. T. Kaifi, E. Diaconu, and E. Pearlman (2001)
J. Immunol. 166, 6795-6801
   Abstract »    Full Text »    PDF »
Elevated plasma endothelial microparticles in multiple sclerosis.
A. Minagar, W. Jy, J. J. Jimenez, W. A. Sheremata, L. M. Mauro, W. W. Mao, L. L. Horstman, and Y. S. Ahn (2001)
Neurology 56, 1319-1324
   Abstract »    Full Text »    PDF »
Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen.
S. Patil, D. K. Newman, and P. J. Newman (2001)
Blood 97, 1727-1732
   Abstract »    Full Text »    PDF »
Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.
R. D. Thompson, K. E. Noble, K. Y. Larbi, A. Dewar, G. S. Duncan, T. W. Mak, and S. Nourshargh (2001)
Blood 97, 1854-1860
   Abstract »    Full Text »    PDF »
PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics.
N. ILAN, A. MOHSENIN, L. CHEUNG, and J. A. MADRI (2001)
FASEB J 15, 362-372
   Abstract »    Full Text »    PDF »
Cell-selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting.
A. SCHERPEREEL, R. WIEWRODT, M. CHRISTOFIDOU-SOLOMIDOU, R. GERVAIS, J.-C. MURCIANO, S. M. ALBELDA, and V. R. MUZYKANTOV (2001)
FASEB J 15, 416-426
   Abstract »    Full Text »    PDF »
Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 from within the Cell.
T. Zhao and P. J. Newman (2001)
J. Cell Biol. 152, 65-74
   Abstract »    Full Text »    PDF »
Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody.
U. Naik, M. Naik, K Eckfeld, P Martin-DeLeon, and J Spychala (2001)
J. Cell Sci. 114, 539-547
   Abstract »    PDF »
Exposure to febrile temperature modifies endothelial cell response to tumor necrosis factor-{alpha}.
J. D. Hasday, D. Bannerman, S. Sakarya, A. S. Cross, I. S. Singh, D. Howard, B.-E. Drysdale, and S. E. Goldblum (2001)
J Appl Physiol 90, 90-98
   Abstract »    Full Text »    PDF »
beta -Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.
R. Giri, Y. Shen, M. Stins, S. Du Yan, A. M. Schmidt, D. Stern, K.-S. Kim, B. Zlokovic, and V. K. Kalra (2000)
Am J Physiol Cell Physiol 279, C1772-C1781
   Abstract »    Full Text »    PDF »
Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice.
K. Zibara, E. Chignier, C. Covacho, R. Poston, G. Canard, P. Hardy, and J. McGregor (2000)
Arterioscler Thromb Vasc Biol 20, 2288-2296
   Abstract »    Full Text »    PDF »
Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions.
J. R. Gamble, J. Drew, L. Trezise, A. Underwood, M. Parsons, L. Kasminkas, J. Rudge, G. Yancopoulos, and M. A. Vadas (2000)
Circ. Res. 87, 603-607
   Abstract »    Full Text »    PDF »
Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature.
J. G. Wagner and R. A. Roth (2000)
Pharmacol. Rev. 52, 349-374
   Abstract »    Full Text »    PDF »
PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo.
S. Mahooti, D. Graesser, S. Patil, P. Newman, G. Duncan, T. Mak, and J. A. Madri (2000)
Am. J. Pathol. 157, 75-81
   Abstract »    Full Text »    PDF »
Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and {beta}3 Integrin Blockade on Leukocyte Transmigration In Vivo.
R. D. Thompson, M. W. Wakelin, K. Y. Larbi, A. Dewar, G. Asimakopoulos, M. A. Horton, M. T. Nakada, and S. Nourshargh (2000)
J. Immunol. 165, 426-434
   Abstract »    Full Text »    PDF »
Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs.
M. Christofidou-Solomidou, G. G. Pietra, C. C. Solomides, E. Arguiris, D. Harshaw, G. A. Fitzgerald, S. M. Albelda, and V. R. Muzykantov (2000)
Am J Physiol Lung Cell Mol Physiol 278, L794-L805
   Abstract »    Full Text »    PDF »
Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization.
J Sun, C Paddock, J Shubert, H. Zhang, K Amin, P. Newman, and S. Albelda (2000)
J. Cell Sci. 113, 1459-1469
   Abstract »    PDF »
Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment.
M. T. Nakada, K. Amin, M. Christofidou-Solomidou, C. D. O'Brien, J. Sun, I. Gurubhagavatula, G. A. Heavner, A. H. Taylor, C. Paddock, Q.-H. Sun, et al. (2000)
J. Immunol. 164, 452-462
   Abstract »    Full Text »    PDF »
Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes.
F. Liao, A. R. Schenkel, and W. A. Muller (1999)
J. Immunol. 163, 5640-5648
   Abstract »    Full Text »    PDF »
Role of the {beta}2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion.
A. M. Lefer (1999)
Ann. Thorac. Surg. 68, 1920-1923
   Abstract »    Full Text »    PDF »
The role of neutrophils in myocardial ischemia-reperfusion injury.
J. E. Jordan, Z.-Q. Zhao, and J. Vinten-Johansen (1999)
Cardiovasc Res 43, 860-878
   Abstract »    Full Text »    PDF »
Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells.
R. Chiba, N. Nakagawa, K. Kurasawa, Y. Tanaka, Y. Saito, and I. Iwamoto (1999)
Blood 94, 1319-1329
   Abstract »    Full Text »    PDF »
Developmental Platelet Endothelial Cell Adhesion Molecule Expression Suggests Multiple Roles for a Vascular Adhesion Molecule.
S. D. Redick and V. L. Bautch (1999)
Am. J. Pathol. 154, 1137-1147
   Abstract »    Full Text »    PDF »
Characterization of the 4C8 Antigen Involved in Transendothelial Migration of CD26hi T Cells after Tight Adhesion to Human Umbilical Vein Endothelial Cell Monolayers.
J.-i. Masuyama, T. Yoshio, K. Suzuki, S. Kitagawa, M. Iwamoto, T. Kamimura, D. Hirata, A. Takeda, S. Kano, and S. Minota (1999)
J. Exp. Med. 189, 979-990
   Abstract »    Full Text »    PDF »
Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs.
V. R. Muzykantov, M. Christofidou-Solomidou, I. Balyasnikova, D. W. Harshaw, L. Schultz, A. B. Fisher, and S. M. Albelda (1999)
PNAS 96, 2379-2384
   Abstract »    Full Text »    PDF »
Irradiation Induces Upregulation of CD31 in Human Endothelial Cells.
S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar (1999)
Arterioscler Thromb Vasc Biol 19, 588-597
   Abstract »    Full Text »    PDF »
Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions.
G. S. Duncan, D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. (1999)
J. Immunol. 162, 3022-3030
   Abstract »    Full Text »    PDF »
PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin.
N Ilan, S Mahooti, D. Rimm, and J. Madri (1999)
J. Cell Sci. 112, 3005-3014
   Abstract »    PDF »
Vascular-endothelial-cadherin modulates endothelial monolayer permeability.
P. Hordijk, E Anthony, F. Mul, R Rientsma, L. Oomen, and D Roos (1999)
J. Cell Sci. 112, 1915-1923
   Abstract »    PDF »
Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction.
V. L. Serebruany and P. A. Gurbel (1999)
Arterioscler Thromb Vasc Biol 19, 153-158
   Abstract »    Full Text »    PDF »
Blood Monocyte Migration to Acute Lung Inflammation Involves Both CD11/CD18 and Very Late Activation Antigen-4-Dependent and Independent Pathways.
X. C. Li, M. Miyasaka, and T. B. Issekutz (1998)
J. Immunol. 161, 6258-6264
   Abstract »    Full Text »    PDF »
Interaction of Sickle Erythrocytes With Endothelial Cells in the Presence of Endothelial Cell Conditioned Medium Induces Oxidant Stress Leading to Transendothelial Migration of Monocytes.
C. Sultana, Y. Shen, V. Rattan, C. Johnson, and V. K. Kalra (1998)
Blood 92, 3924-3935
   Abstract »    Full Text »    PDF »
Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis.
S.-Z. Wang, P. K. Smith, M. Lovejoy, J. J. Bowden, J. H. Alpers, and K. D. Forsyth (1998)
Am J Physiol Lung Cell Mol Physiol 275, L983-L989
   Abstract »    Full Text »    PDF »
The Function of Cell Adhesion Molecules in Lung Inflammation: More Questions Than Answers.
H. M. DeLisser and S. M. Albelda (1998)
Am. J. Respir. Cell Mol. Biol. 19, 533-536
   Full Text »
Increased Endothelial Cell Expression of Platelet-Endothelial Cell Adhesion Molecule-1 during Hyperoxic Lung Injury.
B. Piedboeuf, M. Gamache, J. Frenette, S. Horowitz, H. Scott Baldwin, and P. Petrov (1998)
Am. J. Respir. Cell Mol. Biol. 19, 543-553
   Abstract »    Full Text »
Endotoxin-induced migration of monocytes and PECAM-1 phosphorylation are abrogated by PAF receptor antagonists.
Y. Shen, C. Sultana, M. Arditi, K. S. Kim, and V. K. Kalra (1998)
Am J Physiol Endocrinol Metab 275, E479-E486
   Abstract »    Full Text »    PDF »
Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer.
H. Saito, Y. Minamiya, M. Kitamura, S. Saito, K. Enomoto, K. Terada, and J.-i. Ogawa (1998)
J. Immunol. 161, 1533-1540
   Abstract »    Full Text »    PDF »
Beneficial effects of N,N,N-trimethylsphingosine following ischemia and reperfusion in the isolated perfused rat heart.
B. Campbell, Y. K. Shin, R. Scalia, and A. M. Lefer (1998)
Cardiovasc Res 39, 393-400
   Abstract »    Full Text »    PDF »
A Role for the {alpha}v{beta}3 Integrin in the Transmigration of Monocytes.
D. Weerasinghe, K. P. McHugh, F. P. Ross, E. J. Brown, R. H. Gisler, and B. A. Imhof (1998)
J. Cell Biol. 142, 595-607
   Abstract »    Full Text »    PDF »
Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration.
I. Martin-Padura, S. Lostaglio, M. Schneemann, L. Williams, M. Romano, P. Fruscella, C. Panzeri, A. Stoppacciaro, L. Ruco, A. Villa, et al. (1998)
J. Cell Biol. 142, 117-127
   Abstract »    Full Text »    PDF »
Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN.
Q.-H. Sun, C. Paddock, G. P. Visentin, M. M. Zukowski, W. A. Muller, and P. J. Newman (1998)
J. Biol. Chem. 273, 11483-11490
   Abstract »    Full Text »    PDF »
Requirements for {alpha}d in IgG Immune Complex-Induced Rat Lung Injury.
T. P. Shanley, R. L. Warner, L. D. Crouch, G. N. Dietsch, D. L. Clark, M. M. O'Brien, W. M. Gallatin, and P. A. Ward (1998)
J. Immunol. 160, 1014-1020
   Abstract »    Full Text »    PDF »
Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets.
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman (1998)
Blood 91, 500-507
   Abstract »    Full Text »    PDF »
The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31).
K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian (1997)
J. Biol. Chem. 272, 31086-31091
   Abstract »    Full Text »    PDF »
Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity.
J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda (1997)
J. Cell Biol. 138, 1425-1435
   Abstract »    Full Text »    PDF »
Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31.
J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons (1997)
J. Biol. Chem. 272, 20555-20563
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Monocyte Adhesion to Interleukin-1beta -Stimulated Endothelial Cells Under Physiologic Flow Conditions.
S. Kukreti, K. Konstantopoulos, C. W. Smith, and L. V. McIntire (1997)
Blood 89, 4104-4111
   Abstract »    Full Text »    PDF »
Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31).
K. Sagawa, W. Swaim, J. Zhang, E. Unsworth, and R. P. Siraganian (1997)
J. Biol. Chem. 272, 13412-13418
   Abstract »    Full Text »    PDF »
Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo.
F. Liao, J. Ali, T. Greene, and W. A. Muller (1997)
J. Exp. Med. 185, 1349-1358
   Abstract »    Full Text »    PDF »
The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING.
D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman (1997)
J. Biol. Chem. 272, 6986-6993
   Abstract »    Full Text »    PDF »
Characterization of the Human Platelet/Endothelial Cell Adhesion Molecule-1 Promoter: Identification of a GATA-2 Binding Element Required for Optimal Transcriptional Activity.
R. J. Gumina, N. E. Kirschbaum, K. Piotrowski, and P. J. Newman (1997)
Blood 89, 1260-1269
   Abstract »    Full Text »    PDF »
Administration of a CD31-Derived Peptide Delays the Onset and Significantly Increases Survival From Lethal Graft-Versus-Host Disease.
Y. Chen, P. G. Schlegel, N. Tran, D. Thompson, J. L. Zehnder, and N. J. Chao (1997)
Blood 89, 1452-1268
   Abstract »    Full Text »    PDF »
VE-cadherin antibody accelerates neutrophil recruitment in vivo.
U Gotsch, E Borges, R Bosse, E Boggemeyer, M Simon, H Mossmann, and D Vestweber (1997)
J. Cell Sci. 110, 583-588
   Abstract »    PDF »
Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury.
R. J. Gumina, J. E. Schultz, Z. Yao, D. Kenny, D. C. Warltier, P. J. Newman, and G. J. Gross (1996)
Circulation 94, 3327-3333
   Abstract »    Full Text »
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression.
J. Sun, J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser (1996)
J. Biol. Chem. 271, 18561-18570
   Abstract »    Full Text »    PDF »
Individually Distinct Ig Homology Domains in PECAM-1 Regulate Homophilic Binding and Modulate Receptor Affinity.
Q.-H. Sun, H. M. DeLisser, M. M. Zukowski, C. Paddock, S. M. Albelda, and P. J. Newman (1996)
J. Biol. Chem. 271, 11090-11098
   Abstract »    Full Text »    PDF »
Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1.
C. Buckley, R Doyonnas, J. Newton, S. Blystone, E. Brown, S. Watt, and D. Simmons (1996)
J. Cell Sci. 109, 437-445
   Abstract »    PDF »
Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1).
H.-C. Yan, H. S. Baldwin, J. Sun, C. A. Buck, S. M. Albelda, and H. M. DeLisser (1995)
J. Biol. Chem. 270, 23672-23680
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)