Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 December 1993:
Vol. 262. no. 5139, pp. 1572 - 1575
DOI: 10.1126/science.8248807

Articles

Science, Vol 262, Issue 5139, 1572-1575
Copyright © 1993 by American Association for the Advancement of Science


articles

A link between cyclin A expression and adhesion-dependent cell cycle progression

TM Guadagno, M Ohtsubo, JM Roberts, and RK Assoian

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.

Cell adhesion has an essential role in regulating proliferation during the G1 phase of the cell cycle, and loss of this adhesion requirement is a classic feature of oncogenic transformation. The appearance of cyclin A messenger RNA and protein in late G1 was dependent on cell adhesion in both NRK and NIH 3T3 fibroblasts. In contrast, the expression of Cdc2, Cdk2, cyclin D1, and cyclin E was independent of adhesion in both cell lines. Transfection of NRK cells with a cyclin A complementary DNA resulted in adhesion-independent accumulation of cyclin A protein and cyclin A-associated kinase activity. These transfected cells also entered S phase and complete multiple rounds of cell division in the absence of cell adhesion. Thus, cyclin A is a target of the adhesion-dependent signals that control cell proliferation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polymerized Collagen Inhibits Fibroblast Proliferation via a Mechanism Involving the Formation of a {beta}1 Integrin-Protein Phosphatase 2A-Tuberous Sclerosis Complex 2 Complex That Suppresses S6K1 Activity.
H. Xia, R. Nho, J. Kleidon, J. Kahm, and C. A. Henke (2008)
J. Biol. Chem. 283, 20350-20360
   Abstract »    Full Text »    PDF »
Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation.
R. D. Coletta, K. L. Christensen, D. S. Micalizzi, P. Jedlicka, M. Varella-Garcia, and H. L. Ford (2008)
Cancer Res. 68, 2204-2213
   Abstract »    Full Text »    PDF »
Cyclin A Is a c-Jun Target Gene and Is Necessary for c-Jun-induced Anchorage-independent Growth in RAT1a Cells.
M. Katabami, H. Donninger, F. Hommura, V. D. Leaner, I. Kinoshita, J. F. B. Chick, and M. J. Birrer (2005)
J. Biol. Chem. 280, 16728-16738
   Abstract »    Full Text »    PDF »
Cyclin A expression and growth in suspension can be uncoupled from p27 deregulation and extracellular signal-regulated kinase activity in cells transformed by bovine papillomavirus type 4 E5.
M. Zago, M. S. Campo, and V. O'Brien (2004)
J. Gen. Virol. 85, 3585-3595
   Abstract »    Full Text »    PDF »
Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling.
M. A. Westhoff, B. Serrels, V. J. Fincham, M. C. Frame, and N. O. Carragher (2004)
Mol. Cell. Biol. 24, 8113-8133
   Abstract »    Full Text »    PDF »
Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex.
S. Diederichs, N. Baumer, P. Ji, S. K. Metzelder, G. E. Idos, T. Cauvet, W. Wang, M. Moller, S. Pierschalski, J. Gromoll, et al. (2004)
J. Biol. Chem. 279, 33727-33741
   Abstract »    Full Text »    PDF »
Overexpression of the C-terminal PG-M/versican domain impairs growth of tumor cells by intervening in the interaction between epidermal growth factor receptor and {beta}1-integrin.
Y. Wu, L. Chen, L. Cao, W. Sheng, and B. B. Yang (2004)
J. Cell Sci. 117, 2227-2237
   Abstract »    Full Text »    PDF »
Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution.
M. T. Tetzlaff, C. Bai, M. Finegold, J. Wilson, J. W. Harper, K. A. Mahon, and S. J. Elledge (2004)
Mol. Cell. Biol. 24, 2487-2498
   Abstract »    Full Text »    PDF »
Efficient Down-Regulation of Cyclin A-Associated Activity and Expression in Suspended Primary Keratinocytes Requires p21Cip1.
P. Hauser, L. Ma, D. Agrawal, E. Haura, W. D. Cress, and W. J. Pledger (2004)
Mol. Cancer Res. 2, 96-104
   Abstract »    Full Text »    PDF »
Loss of Cables, a Cyclin-Dependent Kinase Regulatory Protein, Is Associated with the Development of Endometrial Hyperplasia and Endometrial Cancer.
L. R. Zukerberg, R. L. DeBernardo, S. D. Kirley, M. D'Apuzzo, M. P. Lynch, R. D. Littell, L. R. Duska, L. Boring, and B. R. Rueda (2004)
Cancer Res. 64, 202-208
   Abstract »    Full Text »    PDF »
Activation of c-Myc Contributes to Bovine Papillomavirus Type 1 E7-induced Cell Proliferation.
X. Fan, Y. Liu, and J. J. Chen (2003)
J. Biol. Chem. 278, 43163-43168
   Abstract »    Full Text »    PDF »
Transient induction of cyclin A in loaded chicken skeletal muscle.
M. Fluck, M. Kitzmann, C. Dapp, M. Chiquet, F. W. Booth, and A. Fernandez (2003)
J Appl Physiol 95, 1664-1671
   Abstract »    Full Text »    PDF »
Cdc42 Promotes G1 Progression through p70 S6 Kinase-mediated Induction of Cyclin E Expression.
M. M. Chou, J. M. Masuda-Robens, and M. L. Gupta (2003)
J. Biol. Chem. 278, 35241-35247
   Abstract »    Full Text »    PDF »
The Role of Collagen Structure in Mitogen Stimulation of ERK, Cyclin D1 Expression, and G1-S Progression in Rat Hepatocytes.
J. T. Fassett, D. Tobolt, C. J. Nelsen, J. H. Albrecht, and L. K. Hansen (2003)
J. Biol. Chem. 278, 31691-31700
   Abstract »    Full Text »    PDF »
MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-{alpha}.
D. Marshall, J. P. Dangerfield, V. K. Bhatia, K. Y. Larbi, S. Nourshargh, and D. O. Haskard (2003)
Rheumatology 42, 929-934
   Abstract »    Full Text »    PDF »
YB-1 as a Cell Cycle-regulated Transcription Factor Facilitating Cyclin A and Cyclin B1 Gene Expression.
K. Jurchott, S. Bergmann, U. Stein, W. Walther, M. Janz, I. Manni, G. Piaggio, E. Fietze, M. Dietel, and H.-D. Royer (2003)
J. Biol. Chem. 278, 27988-27996
   Abstract »    Full Text »    PDF »
Functions of Pulmonary Epithelial Integrins: From Development to Disease.
D. SHEPPARD (2003)
Physiol Rev 83, 673-686
   Abstract »    Full Text »    PDF »
{alpha}v{beta}3 integrin expression up-regulates cdc2, which modulates cell migration.
T. Manes, D.-Q. Zheng, S. Tognin, A. S. Woodard, P. C. Marchisio, and L. R. Languino (2003)
J. Cell Biol. 161, 817-826
   Abstract »    Full Text »    PDF »
Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts.
S. Uttamsingh, C. S. Zong, and L.-H. Wang (2003)
J. Biol. Chem. 278, 18798-18810
   Abstract »    Full Text »    PDF »
CEMENTUM AND PERIODONTAL WOUND HEALING AND REGENERATION.
W. J. Grzesik and A.S. Narayanan (2002)
Crit. Rev. Oral. Biol. Med. 13, 474-484
   Abstract »    Full Text »    PDF »
Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase.
L. Zhang, M. Bewick, and R. M. Lafrenie (2002)
Carcinogenesis 23, 1251-1258
   Abstract »    Full Text »    PDF »
Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation.
F. Jiang, Y. Jia, and I. Cohen (2002)
Blood 99, 3579-3584
   Abstract »    Full Text »    PDF »
v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation.
N. O. Carragher, M. A. Westhoff, D. Riley, D. A. Potter, P. Dutt, J. S. Elce, P. A. Greer, and M. C. Frame (2002)
Mol. Cell. Biol. 22, 257-269
   Abstract »    Full Text »    PDF »
Role of the F-Box Protein Skp2 in Adhesion-dependent Cell Cycle Progression.
A. C. Carrano and M. Pagano (2001)
J. Cell Biol. 153, 1381-1390
   Abstract »    Full Text »    PDF »
Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
I. Spyridopoulos, P. Mayer, K. S. Shook, D. I. Axel, R. Viebahn, and K. R. Karsch (2001)
Cardiovasc Res 50, 97-107
   Abstract »    Full Text »    PDF »
A Modest Reduction in c-Myc Expression Has Minimal Effects on Cell Growth and Apoptosis But Dramatically Reduces Susceptibility to Ras and Raf Transformation.
A. V. Bazarov, S. Adachi, S.-F. Li, M. K. Mateyak, S. Wei, and J. M. Sedivy (2001)
Cancer Res. 61, 1178-1186
   Abstract »    Full Text »
Anoikis and Metastatic Potential of Cloudman S91 Melanoma Cells.
Z. Zhu, O. Sanchez-Sweatman, X. Huang, R. Wiltrout, R. Khokha, Q. Zhao, and E. Gorelik (2001)
Cancer Res. 61, 1707-1716
   Abstract »    Full Text »
A Role for the Integrin {{alpha}}v{beta}8 in the Negative Regulation of Epithelial Cell Growth.
S. Cambier, D.-z. Mu, D. O’Connell, K. Boylen, W. Travis, W.-h. Liu, V. C. Broaddus, and S. L. Nishimura (2000)
Cancer Res. 60, 7084-7093
   Abstract »    Full Text »
Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions.
J.-H. Dannenberg, A. van Rossum, L. Schuijff, and H. te Riele (2000)
Genes & Dev. 14, 3051-3064
   Abstract »    Full Text »
Induction of Anchorage-independent Growth by Transforming Growth Factor-beta Linked to Anchorage-independent Expression of Cyclin D1.
X. Zhu, E. Scharf, and R. K. Assoian (2000)
J. Biol. Chem. 275, 6703-6706
   Abstract »    Full Text »    PDF »
Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts.
A. Philips, P. Roux, V. Coulon, J.-M. Bellanger, A. Vie, M.-L. Vignais, and J. M. Blanchard (2000)
J. Biol. Chem. 275, 5911-5917
   Abstract »    Full Text »    PDF »
Thyrotropin Prevents Apoptosis by Promoting Cell Adhesion and Cell Cycle Progression in FRTL-5 Cells.
X. Li, S. Lu, E. Miyagi, R. Katoh, and A. Kawaoi (1999)
Endocrinology 140, 5962-5970
   Abstract »    Full Text »
PTEN Gene and Integrin Signaling in Cancer.
M. Tamura, J. Gu, H. Tran, and K. M. Yamada (1999)
J Natl Cancer Inst 91, 1820-1828
   Abstract »    Full Text »    PDF »
Loss of Insulin-like Growth Factor I Receptor-dependent Expression of p107 and Cyclin A in Cells That Lack the Extracellular Matrix Protein Secreted Protein Acidic and Rich in Cysteine.
A. Basu, U. Rodeck, G. C. Prendergast, and C. C. Howe (1999)
Cell Growth Differ. 10, 721-728
   Abstract »    Full Text »
Loss of Cell Cycle Control by Deregulation of Cyclin-dependent Kinase 2 Kinase Activity in Evi-1 Transformed Fibroblasts.
A. Kilbey, V. Stephens, and C. Bartholomew (1999)
Cell Growth Differ. 10, 601-610
   Abstract »    Full Text »
A Novel Disintegrin Salmosin Inhibits Tumor Angiogenesis.
I.-C. Kang, Y.-D. Lee, and D.-S. Kim (1999)
Cancer Res. 59, 3754-3760
   Abstract »    Full Text »    PDF »
Possible Role of Calponin h1 as a Tumor Suppressor in Human Uterine Leiomyosarcoma.
A. Horiuchi, T. Nikaido, S. Taniguchi, and S. Fujii (1999)
J Natl Cancer Inst 91, 790-796
   Abstract »    Full Text »    PDF »
Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells.
A. Kramer, S. Horner, A. Willer, S. Fruehauf, A. Hochhaus, M. Hallek, and R. Hehlmann (1999)
PNAS 96, 2087-2092
   Abstract »    Full Text »    PDF »
Reduced expression of (alpha)5(beta)1 integrin prevents spreading-dependent cell proliferation.
G Davey, M Buzzai, and R. Assoian (1999)
J. Cell Sci. 112, 4663-4672
   Abstract »    PDF »
The amino-terminal matrix assembly domain of fibronectin stabilizes cell shape and prevents cell cycle progression.
R. Christopher, S. Judge, P. Vincent, P. Higgins, and P. McKeown-Longo (1999)
J. Cell Sci. 112, 3225-3235
   Abstract »    PDF »
Regulation of the hepatocyte cell cycle by type I collagen matrix: role of cyclin D1.
L. Hansen and J. Albrecht (1999)
J. Cell Sci. 112, 2971-2981
   Abstract »    PDF »
Functional Cooperation of Cyclin C and c-Myc in Mediating Homotypic Cell Adhesion Via Very Late Antigen-4 Activation and Vascular Cell Adhesion Molecule-1 Induction.
Z.-J. Liu, Y. Tanaka, S. Mine, A. Morinobu, H. Yagita, K. Okumura, T. Taniguchi, H. Yamamura, and Y. Minami (1998)
Blood 92, 4700-4711
   Abstract »    Full Text »    PDF »
Role of the ß3 Integrin Subunit in Human Primary Melanoma Progression : Multifunctional Activities Associated with{alpha}vß3 Integrin Expression.
R. E. B. Seftor (1998)
Am. J. Pathol. 153, 1347-1351
   Full Text »    PDF »
Control of Cell Cycle Progression by Fibronectin Matrix Architecture.
J. L. Sechler and J. E. Schwarzbauer (1998)
J. Biol. Chem. 273, 25533-25536
   Abstract »    Full Text »    PDF »
Airway Epithelial Integrins: Why So Many?.
D. Sheppard (1998)
Am. J. Respir. Cell Mol. Biol. 19, 349-351
   Full Text »
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins.
A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano (1998)
Pharmacol. Rev. 50, 197-264
   Abstract »    Full Text »    PDF »
Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control.
F. Di Cunto, G. Topley, E. Calautti, J. Hsiao, L. Ong, P. K. Seth, and G. P. Dotto (1998)
Science 280, 1069-1072
   Abstract »    Full Text »
Ras Signals to the Cell Cycle Machinery via Multiple Pathways To Induce Anchorage-Independent Growth.
J.-J. Yang, J.-S. Kang, and R. S. Krauss (1998)
Mol. Cell. Biol. 18, 2586-2595
   Abstract »    Full Text »
The Effect of alpha 4beta 1-Integrin Binding Sequences of Fibronectin on Growth of Cells From Human Hematopoietic Progenitors.
K. P. Schofield, M. J. Humphries, E. de Wynter, N. Testa, and J. T. Gallagher (1998)
Blood 91, 3230-3238
   Abstract »    Full Text »    PDF »
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells.
J. Brugarolas, R. T. Bronson, and T. Jacks (1998)
J. Cell Biol. 141, 503-514
   Abstract »    Full Text »    PDF »
Anchorage-Independent Transcription of the Cyclin A Gene Induced by the E7 Oncoprotein of Human Papillomavirus Type 16.
A. Schulze, B. Mannhardt, K. Zerfass-Thome, W. Zwerschke, and P. Jansen-Durr (1998)
J. Virol. 72, 2323-2334
   Abstract »    Full Text »    PDF »
Disruption of Fibronectin Binding to the alpha 5beta 1 Integrin Stimulates the Expression of Cyclin-dependent Kinases and DNA Synthesis through Activation of Extracellular Signal-regulated Kinase.
J. Gong, T. C. Ko, and M. G. Brattain (1998)
J. Biol. Chem. 273, 1662-1669
   Abstract »    Full Text »    PDF »
Role of Proteasomes in T Cell Activation and Proliferation.
X. Wang, H. Luo, H. Chen, W. Duguid, and J. Wu (1998)
J. Immunol. 160, 788-801
   Abstract »    Full Text »    PDF »
Fibronectin matrix assembly enhances adhesion-dependent cell growth.
J Sottile, D. Hocking, and P. Swiatek (1998)
J. Cell Sci. 111, 2933-2943
   Abstract »    PDF »
Integrins, Adhesion, and Cardiac Remodeling.
W. A. Hsueh, R. E. Law, and Y. S. Do (1998)
Hypertension 31, 176-180
   Abstract »    Full Text »    PDF »
The MDM2 C-terminal Region Binds to TAFII250 and Is Required for MDM2 Regulation of the Cyclin A Promoter.
T. Leveillard and B. Wasylyk (1997)
J. Biol. Chem. 272, 30651-30661
   Abstract »    Full Text »    PDF »
Activation of p53-p21waf1 Pathway in Response to Disruption of Cell-Matrix Interactions.
R.-C. Wu and A. H. Schonthal (1997)
J. Biol. Chem. 272, 29091-29098
   Abstract »    Full Text »    PDF »
beta 1 Integrin Is Essential for Teratoma Growth and Angiogenesis.
W. Bloch, E. Forsberg, S. Lentini, C. Brakebusch, K. Martin, H. W. Krell, U. H. Weidle, K. Addicks, and R. Fassler (1997)
J. Cell Biol. 139, 265-278
   Abstract »    Full Text »    PDF »
Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells.
J. S. Levine, J. S. Koh, V. Triaca, and W. Lieberthal (1997)
Am J Physiol Renal Physiol 273, F575-F585
   Abstract »    Full Text »    PDF »
Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex.
J. M. Trowbridge, I. Rogatsky, and M. J. Garabedian (1997)
PNAS 94, 10132-10137
   Abstract »    Full Text »    PDF »
Ectopic ICER Expression in Pituitary Corticotroph AtT20 Cells: Effects on Morphology, Cell Cycle, and Hormonal Production.
M. Lamas, C. Molina, N. S. Foulkes, E. Jansen, and P. Sassone-Corsi (1997)
Mol. Endocrinol. 11, 1425-1434
   Abstract »    Full Text »
Down-regulation of the Cyclin A Promoter by Transforming Growth Factor-beta 1 Is Associated with a Reduction in Phosphorylated Activating Transcription Factor-1 and Cyclic AMP-responsive Element-binding Protein.
M. Yoshizumi, H. Wang, C.-M. Hsieh, N. E. S. Sibinga, M. A. Perrella, and M.-E. Lee (1997)
J. Biol. Chem. 272, 22259-22264
   Abstract »    Full Text »    PDF »
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
J. L. Arbiser, M. A. Moses, C. A. Fernandez, N. Ghiso, Y. Cao, N. Klauber, D. Frank, M. Brownlee, E. Flynn, S. Parangi, et al. (1997)
PNAS 94, 861-866
   Abstract »    Full Text »    PDF »
Extracellular ATP Induces Anchorage-independent Expression of Cyclin A and Rescues the Transformed Phenotype of a Ras-resistant Mutant Cell Line.
J.-J. Yang and R. S. Krauss (1997)
J. Biol. Chem. 272, 3103-3108
   Abstract »    Full Text »    PDF »
Anchorage-dependent Cell Cycle Progression.
R. K. Assoian (1997)
J. Cell Biol. 136, 1-4
   Full Text »    PDF »
Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport.
J. M. Lewis, R. Baskaran, S. Taagepera, M. A. Schwartz, and J. Y. J. Wang (1996)
PNAS 93, 15174-15179
   Abstract »    Full Text »    PDF »
Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway.
R. K. Malik and J. T. Parsons (1996)
J. Biol. Chem. 271, 29785-29791
   Abstract »    Full Text »    PDF »
The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion..
M A Lilly and A C Spradling (1996)
Genes & Dev. 10, 2514-2526
   Abstract »    PDF »
Differential Effects of the Integrins alpha 9beta 1, alpha vbeta 3, and alpha vbeta 6 on Cell Proliferative Responses to Tenascin. ROLES OF THE beta SUBUNIT EXTRACELLULAR AND CYTOPLASMIC DOMAINS.
Y. Yokosaki, H. Monis, J. Chen, and D. Sheppard (1996)
J. Biol. Chem. 271, 24144-24150
   Abstract »    Full Text »    PDF »
Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras.
Q. Chen, T. H. Lin, C. J. Der, and R. L. Juliano (1996)
J. Biol. Chem. 271, 18122-18127
   Abstract »    Full Text »    PDF »
ADP-ribosylation of the G Protein Rho Inhibits Integrin Regulation of Tumor Cell Growth.
T. Udagawa and B. W. McIntyre (1996)
J. Biol. Chem. 271, 12542-12548
   Abstract »    Full Text »    PDF »
A Novel CCAAT-binding Protein Necessary for Adhesion-dependent Cyclin A Transcription at the G(1)/S Boundary Is Sequestered by a Retinoblastoma-like Protein in G(0).
A. Krämer, C.-P. Carstens, and W. E. Fahl (1996)
J. Biol. Chem. 271, 6579-6582
   Abstract »    Full Text »    PDF »
Paradoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells.
F Depoortere, J. Dumont, and P. Roger (1996)
J. Cell Sci. 109, 1759-1764
   Abstract »    PDF »
Activation of the p21 Pathway of Growth Arrest and Apoptosis by the beta(4) Integrin Cytoplasmic Domain.
A. S. Clarke, M. M. Lotz, C. Chao, and A. M. Mercurio (1995)
J. Biol. Chem. 270, 22673-22676
   Abstract »    Full Text »    PDF »
Stat5 as a Target for Regulation by Extracellular Matrix.
C. H. Streuli, G. M. Edwards, M. Delcommenne, C. B. A. Whitelaw, T. G. Burdon, C. Schindler, and C. J. Watson (1995)
J. Biol. Chem. 270, 21639-21644
   Abstract »    Full Text »    PDF »
Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality..
L E Stephens, A E Sutherland, I V Klimanskaya, A Andrieux, J Meneses, R A Pedersen, and C H Damsky (1995)
Genes & Dev. 9, 1883-1895
   Abstract »    PDF »
Cyclin A Links c-Myc to Adhesion-independent Cell Proliferation.
J. F. Barrett, B. C. Lewis, A. T. Hoang, R. J. Alvarez , Jr., and C. V. Dang (1995)
J. Biol. Chem. 270, 15923-15925
   Abstract »    Full Text »    PDF »
Cell spreading and the regulation of ornithine decarboxylase.
R. Morrison and E. Seidel (1995)
J. Cell Sci. 108, 3787-3794
   Abstract »    PDF »
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts..
M Pagano, A M Theodoras, S W Tam, and G F Draetta (1994)
Genes & Dev. 8, 1627-1639
   Abstract »    PDF »
Perturbing cell surface beta-(1,4)-galactosyltransferase on F9 embryonal carcinoma cells arrests cell growth and induces laminin synthesis.
C. Maillet and B. Shur (1994)
J. Cell Sci. 107, 1713-1724
   Abstract »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)