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Science 26 November 1993:
Vol. 262. no. 5138, pp. 1448 - 1451
DOI: 10.1126/science.8248784
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Articles

Science, Vol 262, Issue 5138, 1448-1451
Copyright © 1993 by American Association for the Advancement of Science

articles

The influence of antigen organization on B cell responsiveness

MF Bachmann, UH Rohrer, TM Kundig, K Burki, H Hengartner, and RM Zinkernagel

Department of Pathology, University of Zurich, Switzerland.

The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.


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