Related Content
Search Google Scholar for:
|
|
Science 26 November 1993: Vol. 262. no. 5138, pp. 1401 - 1407 DOI: 10.1126/science.8248779
|
|
Articles
Science, Vol 262, Issue 5138, 1401-1407
Copyright © 1993 by American Association for the Advancement of Science
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
PB Harbury,
T Zhang,
PS Kim,
and
T Alber
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Coiled-coil sequences in proteins consist of heptad repeats containing two characteristic hydrophobic positions. The role of these buried hydrophobic residues in determining the structures of coiled coils was investigated by studying mutants of the GCN4 leucine zipper. When sets of buried residues were altered, two-, three-, and four-helix structures were formed. The x-ray crystal structure of the tetramer revealed a parallel, four-stranded coiled coil. In the tetramer conformation, the local packing geometry of the two hydrophobic positions in the heptad repeat is reversed relative to that in the dimer. These studies demonstrate that conserved, buried residues in the GCN4 leucine zipper direct dimer formation. In contrast to proposals that the pattern of hydrophobic and polar amino acids in a protein sequence is sufficient to determine three-dimensional structure, the shapes of buried side chains in coiled coils are essential determinants of the global fold.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Functional Characterization of SsaE, a Novel Chaperone Protein of the Type III Secretion System Encoded by Salmonella Pathogenicity Island 2.
- T. Miki, Y. Shibagaki, H. Danbara, and N. Okada (2009)
J. Bacteriol.
191, 6843-6854
| Abstract »
| Full Text »
| PDF »
- A coiled-coil motif that sequesters ions to the hydrophobic core.
- M. D. Hartmann, O. Ridderbusch, K. Zeth, R. Albrecht, O. Testa, D. N. Woolfson, G. Sauer, S. Dunin-Horkawicz, A. N. Lupas, and B. H. Alvarez (2009)
PNAS
106, 16950-16955
| Abstract »
| Full Text »
| PDF »
- The Expression of N-Terminal Deletion DNA Pilot Proteins Inhibits the Early Stages of {phi}X174 Replication.
- M. V. Ruboyianes, M. Chen, M. S. Dubrava, J. E. Cherwa Jr., and B. A. Fane (2009)
J. Virol.
83, 9952-9956
| Abstract »
| Full Text »
| PDF »
- Challenges in the computational design of proteins.
- M. Suarez and A. Jaramillo (2009)
J R Soc Interface
6, S477-S491
| Abstract »
| Full Text »
| PDF »
- Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
- D. V. Rozanov, A. Y. Savinov, V. S. Golubkov, O. L. Rozanova, T. I. Postnova, E. A. Sergienko, S. Vasile, A. E. Aleshin, M. F. Rega, M. Pellecchia, et al. (2009)
Mol. Cancer Ther.
8, 1515-1525
| Abstract »
| Full Text »
| PDF »
- Crystallographic structure of the {alpha}-helical triple coiled-coil domain of avian reovirus S1133 fibre.
- P. Guardado-Calvo, G. C. Fox, A. L. Llamas-Saiz, and M. J. van Raaij (2009)
J. Gen. Virol.
90, 672-677
| Abstract »
| Full Text »
| PDF »
- Assembly Properties of Human Immunodeficiency Virus Type 1 Gag-Leucine Zipper Chimeras: Implications for Retrovirus Assembly.
- R. M. Crist, S. A. K. Datta, A. G. Stephen, F. Soheilian, J. Mirro, R. J. Fisher, K. Nagashima, and A. Rein (2009)
J. Virol.
83, 2216-2225
| Abstract »
| Full Text »
| PDF »
- An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks.
- O. Zgheib, K. Pataky, J. Brugger, and T. D. Halazonetis (2009)
Mol. Cell. Biol.
29, 1050-1058
| Abstract »
| Full Text »
| PDF »
- CC+: a relational database of coiled-coil structures.
- O. D. Testa, E. Moutevelis, and D. N. Woolfson (2009)
Nucleic Acids Res.
37, D315-D322
| Abstract »
| Full Text »
| PDF »
- An FTS/Hook/p107FHIP Complex Interacts with and Promotes Endosomal Clustering by the Homotypic Vacuolar Protein Sorting Complex.
- L. Xu, M. E. Sowa, J. Chen, X. Li, S. P. Gygi, and J. W. Harper (2008)
Mol. Biol. Cell
19, 5059-5071
| Abstract »
| Full Text »
| PDF »
- Probing the Interaction between the Coiled Coil Leucine Zipper of cGMP-dependent Protein Kinase I{alpha} and the C Terminus of the Myosin Binding Subunit of the Myosin Light Chain Phosphatase.
- A. K. Sharma, G.-P. Zhou, J. Kupferman, H. K. Surks, E. N. Christensen, J. J. Chou, M. E. Mendelsohn, and A. C. Rigby (2008)
J. Biol. Chem.
283, 32860-32869
| Abstract »
| Full Text »
| PDF »
- Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines.
- M. M. Islam, S. Sohya, K. Noguchi, M. Yohda, and Y. Kuroda (2008)
PNAS
105, 15334-15339
| Abstract »
| Full Text »
| PDF »
- Self-assembling multimeric integrin {alpha}5{beta}1 ligands for cell attachment and spreading.
- M. Kreiner, Z. Li, J. Beattie, S.M. Kelly, H.J. Mardon, and C.F. van der Walle (2008)
Protein Eng. Des. Sel.
21, 553-560
| Abstract »
| Full Text »
| PDF »
- Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly.
- W. S. Horne, J. L. Price, and S. H. Gellman (2008)
PNAS
105, 9151-9156
| Abstract »
| Full Text »
| PDF »
- Saccharomyces cerevisiae septins: Supramolecular organization of heterooligomers and the mechanism of filament assembly.
- A. Bertin, M. A. McMurray, P. Grob, S.-S. Park, G. Garcia III, I. Patanwala, H.-l. Ng, T. Alber, J. Thorner, and E. Nogales (2008)
PNAS
105, 8274-8279
| Abstract »
| Full Text »
| PDF »
- Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.
- K. Nakajo and Y. Kubo (2008)
J. Physiol.
586, 2827-2840
| Abstract »
| Full Text »
| PDF »
- An Influenza A Vaccine Based on Tetrameric Ectodomain of Matrix Protein 2.
- M. De Filette, W. Martens, K. Roose, T. Deroo, F. Vervalle, M. Bentahir, J. Vandekerckhove, W. Fiers, and X. Saelens (2008)
J. Biol. Chem.
283, 11382-11387
| Abstract »
| Full Text »
| PDF »
- The KCNQ1 (Kv7.1) COOH Terminus, a Multitiered Scaffold for Subunit Assembly and Protein Interaction.
- R. Wiener, Y. Haitin, L. Shamgar, M. C. Fernandez-Alonso, A. Martos, O. Chomsky-Hecht, G. Rivas, B. Attali, and J. A. Hirsch (2008)
J. Biol. Chem.
283, 5815-5830
| Abstract »
| Full Text »
| PDF »
- Preferred side-chain constellations at antiparallel coiled-coil interfaces.
- E. B. Hadley, O. D. Testa, D. N. Woolfson, and S. H. Gellman (2008)
PNAS
105, 530-535
| Abstract »
| Full Text »
| PDF »
- A new expression system for protein crystallization using trimeric coiled-coil adaptors.
- B. Hernandez Alvarez, M. D. Hartmann, R. Albrecht, A. N. Lupas, K. Zeth, and D. Linke (2008)
Protein Eng. Des. Sel.
| Abstract »
| Full Text »
| PDF »
- Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
- K. Chattopadhyay, U. A. Ramagopal, A. Mukhopadhaya, V. N. Malashkevich, T. P. DiLorenzo, M. Brenowitz, S. G. Nathenson, and S. C. Almo (2007)
PNAS
104, 19452-19457
| Abstract »
| Full Text »
| PDF »
- Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils.
- D. S. Touw, C. E. Nordman, J. A. Stuckey, and V. L. Pecoraro (2007)
PNAS
104, 11969-11974
| Abstract »
| Full Text »
| PDF »
- Structural Basis for the Conformational Integrity of the Arabidopsis thaliana HY5 Leucine Zipper Homodimer.
- M.-K. Yoon, H.-M. Kim, G. Choi, J.-O. Lee, and B.-S. Choi (2007)
J. Biol. Chem.
282, 12989-13002
| Abstract »
| Full Text »
| PDF »
- Helix-Helix Interactions between Homo- and Heterodimeric {gamma}-Carboxyglutamate-containing Conantokin Peptides and Their Derivatives.
- Q. Dai, Z. Sheng, J. H. Geiger, F. J. Castellino, and M. Prorok (2007)
J. Biol. Chem.
282, 12641-12649
| Abstract »
| Full Text »
| PDF »
- Different Mechanisms Are Involved in the Transcriptional Activation by Yeast Heat Shock Transcription Factor through Two Different Types of Heat Shock Elements.
- N. Hashikawa, N. Yamamoto, and H. Sakurai (2007)
J. Biol. Chem.
282, 10333-10340
| Abstract »
| Full Text »
| PDF »
- A seven-helix coiled coil.
- J. Liu, Q. Zheng, Y. Deng, C.-S. Cheng, N. R. Kallenbach, and M. Lu (2006)
PNAS
103, 15457-15462
| Abstract »
| Full Text »
| PDF »
- Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.
- K. Heusser, H. Yuan, I. Neagoe, A. I. Tarasov, F. M. Ashcroft, and B. Schwappach (2006)
J. Cell Sci.
119, 4353-4363
| Abstract »
| Full Text »
| PDF »
- Tetrameric Hub Structure of Postsynaptic Scaffolding Protein Homer..
- M. K. Hayashi, H. M. Ames, and Y. Hayashi (2006)
J. Neurosci.
26, 8492-8501
| Abstract »
| Full Text »
| PDF »
- Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design.
- J. M. Mason, M. A. Schmitz, K. M. Muller, and K. M. Arndt (2006)
PNAS
103, 8989-8994
| Abstract »
| Full Text »
| PDF »
- Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase.
- P. Garcia, Z. Ucurum, R. Bucher, D. I. Svergun, T. Huber, A. Lustig, P. V. Konarev, M. Marino, and O. Mayans (2006)
FASEB J
20, 1142-1151
| Abstract »
| Full Text »
| PDF »
- The Effects of the Side Chains of Hydrophobic Aliphatic Amino Acid Residues in an Amphipathic Polypeptide on the Formation of {alpha} Helix and Its Association.
- T. Takei, A. Okonogi, K. Tateno, A. Kimura, S. Kojima, K. Yazaki, and K.-i. Miura (2006)
J. Biochem.
139, 271-278
| Abstract »
| Full Text »
| PDF »
- Addition of N-Glycans in the Stalk of the Newcastle Disease Virus HN Protein Blocks Its Interaction with the F Protein and Prevents Fusion.
- V. R. Melanson and R. M. Iorio (2006)
J. Virol.
80, 623-633
| Abstract »
| Full Text »
| PDF »
- Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription.
- P. Moller, N. Pariente, H.-D. Klenk, and S. Becker (2005)
J. Virol.
79, 14876-14886
| Abstract »
| Full Text »
| PDF »
- Redundant Roles for Nucleocapsid and Matrix RNA-Binding Sequences in Human Immunodeficiency Virus Type 1 Assembly.
- D. E. Ott, L. V. Coren, and T. D. Gagliardi (2005)
J. Virol.
79, 13839-13847
| Abstract »
| Full Text »
| PDF »
- Retroviral Restriction Factor TRIM5{alpha} Is a Trimer.
- C. C. Mische, H. Javanbakht, B. Song, F. Diaz-Griffero, M. Stremlau, B. Strack, Z. Si, and J. Sodroski (2005)
J. Virol.
79, 14446-14450
| Abstract »
| Full Text »
| PDF »
- A conserved trimerization motif controls the topology of short coiled coils.
- R. A. Kammerer, D. Kostrewa, P. Progias, S. Honnappa, D. Avila, A. Lustig, F. K. Winkler, J. Pieters, and M. O. Steinmetz (2005)
PNAS
102, 13891-13896
| Abstract »
| Full Text »
| PDF »
- Toward the development of peptide nanofilaments and nanoropes as smart materials.
- D. E. Wagner, C. L. Phillips, W. M. Ali, G. E. Nybakken, E. D. Crawford, A. D. Schwab, W. F. Smith, and R. Fairman (2005)
PNAS
102, 12656-12661
| Abstract »
| Full Text »
| PDF »
- Stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75NTR receptor.
- L. Sissoeff, M. Mousli, P. England, and C. Tuffereau (2005)
J. Gen. Virol.
86, 2543-2552
| Abstract »
| Full Text »
| PDF »
- Soluble Mimetics of Human Immunodeficiency Virus Type 1 Viral Spikes Produced by Replacement of the Native Trimerization Domain with a Heterologous Trimerization Motif: Characterization and Ligand Binding Analysis.
- M. Pancera, J. Lebowitz, A. Schon, P. Zhu, E. Freire, P. D. Kwong, K. H. Roux, J. Sodroski, and R. Wyatt (2005)
J. Virol.
79, 9954-9969
| Abstract »
| Full Text »
| PDF »
- Roles of the N-terminal Domain on the Function and Quaternary Structure of the Ionotropic Glutamate Receptor.
- S. Matsuda, Y. Kamiya, and M. Yuzaki (2005)
J. Biol. Chem.
280, 20021-20029
| Abstract »
| Full Text »
| PDF »
- Solution Structure of Enzyme IIAChitobiose from the N,N'-Diacetylchitobiose Branch of the Escherichia coli Phosphotransferase System.
- C. Tang, D. C. Williams Jr., R. Ghirlando, and G. M. Clore (2005)
J. Biol. Chem.
280, 11770-11780
| Abstract »
| Full Text »
| PDF »
- Favorable scaffolds: proteins with different sequence, structure and function may associate in similar ways.
- O. Keskin and R. Nussinov (2005)
Protein Eng. Des. Sel.
18, 11-24
| Abstract »
| Full Text »
| PDF »
- The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.
- K. Kuhnel, T. Jarchau, E. Wolf, I. Schlichting, U. Walter, A. Wittinghofer, and S. V. Strelkov (2004)
PNAS
101, 17027-17032
| Abstract »
| Full Text »
| PDF »
- Atomic structure of a tryptophan-zipper pentamer.
- J. Liu, W. Yong, Y. Deng, N. R. Kallenbach, and M. Lu (2004)
PNAS
101, 16156-16161
| Abstract »
| Full Text »
| PDF »
- Conservation of the Biochemical Properties of IncA from Chlamydia trachomatis and Chlamydia caviae: OLIGOMERIZATION OF IncA MEDIATES INTERACTION BETWEEN FACING MEMBRANES.
- C. Delevoye, M. Nilges, A. Dautry-Varsat, and A. Subtil (2004)
J. Biol. Chem.
279, 46896-46906
| Abstract »
| Full Text »
| PDF »
- From The Cover: De novo design of defined helical bundles in membrane environments.
- B. Bilgicer and K. Kumar (2004)
PNAS
101, 15324-15329
| Abstract »
| Full Text »
| PDF »
- Biophysical and Mutational Analysis of the Putative bZIP Domain of Epstein-Barr Virus EBNA 3C.
- M. J. West, H. M. Webb, A. J. Sinclair, and D. N. Woolfson (2004)
J. Virol.
78, 9431-9445
| Abstract »
| Full Text »
| PDF »
- X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture.
- M. H. Ali, E. Peisach, K. N. Allen, and B. Imperiali (2004)
PNAS
101, 12183-12188
| Abstract »
| Full Text »
| PDF »
- Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs.
- C. D. Deppmann, A. Acharya, V. Rishi, B. Wobbes, S. Smeekens, E. J. Taparowsky, and C. Vinson (2004)
Nucleic Acids Res.
32, 3435-3445
| Abstract »
| Full Text »
| PDF »
- Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail.
- D. L. Waning, C. J. Russell, T. S. Jardetzky, and R. A. Lamb (2004)
PNAS
101, 9217-9222
| Abstract »
| Full Text »
| PDF »
- Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus.
- P. Ingallinella, E. Bianchi, M. Finotto, G. Cantoni, D. M. Eckert, V. M. Supekar, C. Bruckmann, A. Carfi, and A. Pessi (2004)
PNAS
101, 8709-8714
| Abstract »
| Full Text »
| PDF »
- Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core.
- B. Tripet, M. W. Howard, M. Jobling, R. K. Holmes, K. V. Holmes, and R. S. Hodges (2004)
J. Biol. Chem.
279, 20836-20849
| Abstract »
| Full Text »
| PDF »
- Stabilizing and Destabilizing Clusters in the Hydrophobic Core of Long Two-stranded {alpha}-Helical Coiled-coils.
- S. C. Kwok and R. S. Hodges (2004)
J. Biol. Chem.
279, 21576-21588
| Abstract »
| Full Text »
| PDF »
- From The Cover: Automated protein crystal structure determination using ELVES.
- J. Holton and T. Alber (2004)
PNAS
101, 1537-1542
| Abstract »
| Full Text »
| PDF »
- Dimerization of cGMP-dependent Protein Kinase I{beta} Is Mediated by an Extensive Amino-terminal Leucine Zipper Motif, and Dimerization Modulates Enzyme Function.
- R. Richie-Jannetta, S. H. Francis, and J. D. Corbin (2003)
J. Biol. Chem.
278, 50070-50079
| Abstract »
| Full Text »
| PDF »
- Shift of fibril-forming ability of the designed {alpha}-helical coiled-coil peptides into the physiological pH region.
- T.N. Melnik, V. Villard, V. Vasiliev, G. Corradin, A.V. Kajava, and S.A. Potekhin (2003)
Protein Eng. Des. Sel.
16, 1125-1130
| Abstract »
| Full Text »
| PDF »
- A Heterologous Coiled Coil Can Substitute for Helix I of the Sindbis Virus Capsid Protein.
- R. Perera, C. Navaratnarajah, and R. J. Kuhn (2003)
J. Virol.
77, 8345-8353
| Abstract »
| Full Text »
| PDF »
- Variable Sensitivity to Substitutions in the N-Terminal Heptad Repeat of Mason-Pfizer Monkey Virus Transmembrane Protein.
- C. Song and E. Hunter (2003)
J. Virol.
77, 7779-7785
| Abstract »
| Full Text »
| PDF »
- Homotetrameric Structure of the SNAP-23 N-terminal Coiled-coil Domain.
- S. J. Freedman, H. K. Song, Y. Xu, Z.-Y. J. Sun, and M. J. Eck (2003)
J. Biol. Chem.
278, 13462-13467
| Abstract »
| Full Text »
| PDF »
- Consensus-derived structural determinants of the ankyrin repeat motif.
- L. K. Mosavi, D. L. Minor Jr., and Z.-y. Peng (2002)
PNAS
99, 16029-16034
| Abstract »
| Full Text »
| PDF »
- Trimerization of the Amino Propeptide of Type IIA Procollagen Using a 14-Amino Acid Sequence Derived from the Coiled-Coil Neck Domain of Surfactant Protein D.
- A. McAlinden, E. C. Crouch, J. G. Bann, P. Zhang, and L. J. Sandell (2002)
J. Biol. Chem.
277, 41274-41281
| Abstract »
| Full Text »
| PDF »
- Designing Heterodimeric Two-stranded alpha -Helical Coiled-coils. EFFECTS OF HYDROPHOBICITY AND alpha -HELICAL PROPENSITY ON PROTEIN FOLDING, STABILITY, AND SPECIFICITY.
- J. R. Litowski and R. S. Hodges (2002)
J. Biol. Chem.
277, 37272-37279
| Abstract »
| Full Text »
| PDF »
- Classification of Human B-ZIP Proteins Based on Dimerization Properties.
- C. Vinson, M. Myakishev, A. Acharya, A. A. Mir, J. R. Moll, and M. Bonovich (2002)
Mol. Cell. Biol.
22, 6321-6335
| Full Text »
| PDF »
- B-ZIP Proteins Encoded by the Drosophila Genome: Evaluation of Potential Dimerization Partners.
- J. Fassler, D. Landsman, A. Acharya, J. R. Moll, M. Bonovich, and C. Vinson (2002)
Genome Res.
12, 1190-1200
| Abstract »
| Full Text »
| PDF »
- A de Novo Designed Template for Generating Conformation-specific Antibodies That Recognize alpha -Helices in Proteins.
- S. M. Lu and R. S. Hodges (2002)
J. Biol. Chem.
277, 23515-23524
| Abstract »
| Full Text »
| PDF »
- Characterization of the Matrilin Coiled-coil Domains Reveals Seven Novel Isoforms.
- S. Frank, T. Schulthess, R. Landwehr, A. Lustig, T. Mini, P. Jeno, J. Engel, and R. A. Kammerer (2002)
J. Biol. Chem.
277, 19071-19079
| Abstract »
| Full Text »
| PDF »
- A Designed System for Assessing How Sequence Affects alpha to beta Conformational Transitions in Proteins.
- B. Ciani, E. G. Hutchinson, R. B. Sessions, and D. N. Woolfson (2002)
J. Biol. Chem.
277, 10150-10155
| Abstract »
| Full Text »
| PDF »
- Targeting Adenoviral Vectors by Using the Extracellular Domain of the Coxsackie-Adenovirus Receptor: Improved Potency via Trimerization.
- J. Kim, T. Smith, N. Idamakanti, K. Mulgrew, M. Kaloss, H. Kylefjord, P. C. Ryan, M. Kaleko, and S. C. Stevenson (2002)
J. Virol.
76, 1892-1903
| Abstract »
| Full Text »
| PDF »
- Role of Interfacial Hydrophobic Residues in the Stabilization of the Leucine Zipper Structures of the Transcription Factors c-Fos and c-Jun.
- R. I. Boysen, A. J. O. Jong, J. A. Wilce, G. F. King, and M. T. W. Hearn (2002)
J. Biol. Chem.
277, 23-31
| Abstract »
| Full Text »
- Structure-Function Analysis of the Heat Shock Factor-binding Protein Reveals a Protein Composed Solely of a Highly Conserved and Dynamic Coiled-coil Trimerization Domain.
- L.-J. Tai, S. M. McFall, K. Huang, B. Demeler, S. G. Fox, K. Brubaker, I. Radhakrishnan, and R. I. Morimoto (2002)
J. Biol. Chem.
277, 735-745
| Abstract »
| Full Text »
- Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils.
- A. E. Keating, V. N. Malashkevich, B. Tidor, and P. S. Kim (2001)
PNAS
98, 14825-14830
| Abstract »
| Full Text »
| PDF »
- Polyionic fusion peptides function as specific dimerization motifs.
- S. A. Richter, K. Stubenrauch, H. Lilie, and R. Rudolph (2001)
Protein Eng. Des. Sel.
14, 775-783
| Abstract »
| Full Text »
| PDF »
- Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region.
- D. M. Eckert and P. S. Kim (2001)
PNAS
98, 11187-11192
| Abstract »
| Full Text »
| PDF »
- Tetramerization Is a Conserved Feature of the Virion-Associated Protein in Plant Pararetroviruses.
- L. Stavolone, E. Herzog, D. Leclerc, and T. Hohn (2001)
J. Virol.
75, 7739-7743
| Abstract »
| Full Text »
| PDF »
- Functional Analysis of Adenovirus Protein IX Identifies Domains Involved in Capsid Stability, Transcriptional Activity, and Nuclear Reorganization.
- M. Rosa-Calatrava, L. Grave, F. Puvion-Dutilleul, B. Chatton, and C. Kedinger (2001)
J. Virol.
75, 7131-7141
| Abstract »
| Full Text »
- Phosphorylation-Dependent Regulation of Ryanodine Receptors: A Novel Role for Leucine/Isoleucine Zippers.
- S. O. Marx, S. Reiken, Y. Hisamatsu, M. Gaburjakova, J. Gaburjakova, Y.-M. Yang, N. Rosemblit, and A. R. Marks (2001)
J. Cell Biol.
153, 699-708
| Abstract »
| Full Text »
| PDF »
- Rap1p Requires Gcr1p and Gcr2p Homodimers to Activate Ribosomal Protein and Glycolytic Genes, Respectively.
- S. J. Deminoff and G. M. Santangelo (2001)
Genetics
158, 133-143
| Abstract »
| Full Text »
- In Vitro Assembly of Sindbis Virus Core-Like Particles from Cross-Linked Dimers of Truncated and Mutant Capsid Proteins.
- T. L. Tellinghuisen, R. Perera, and R. J. Kuhn (2001)
J. Virol.
75, 2810-2817
| Abstract »
| Full Text »
- Adenovirus Type 5 Viral Particles Pseudotyped with Mutagenized Fiber Proteins Show Diminished Infectivity of Coxsackie B-Adenovirus Receptor-Bearing Cells.
- J. L. Jakubczak, M. L. Rollence, D. A. Stewart, J. D. Jafari, D. J. Von Seggern, G. R. Nemerow, S. C. Stevenson, and P. L. Hallenbeck (2001)
J. Virol.
75, 2972-2981
| Abstract »
| Full Text »
- Breaking open a protein barrel.
- N. Kallenbach (2001)
PNAS
98, 2958-2960
| Full Text »
| PDF »
- Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.
- N. Zerangue, M. J. Malan, S. R. Fried, P. F. Dazin, Y. N. Jan, L. Y. Jan, and B. Schwappach (2001)
PNAS
98, 2431-2436
| Abstract »
| Full Text »
| PDF »
- Improved Elicitation of Neutralizing Antibodies against Primary Human Immunodeficiency Viruses by Soluble Stabilized Envelope Glycoprotein Trimers.
- X. Yang, R. Wyatt, and J. Sodroski (2001)
J. Virol.
75, 1165-1171
| Abstract »
| Full Text »
- Polar side chains drive the association of model transmembrane peptides.
- H. Gratkowski, J. D. Lear, and W. F. DeGrado (2001)
PNAS
98, 880-885
| Abstract »
| Full Text »
| PDF »
- Alphavirus Nucleocapsid Protein Contains a Putative Coiled Coil {alpha}-Helix Important for Core Assembly.
- R. Perera, K. E. Owen, T. L. Tellinghuisen, A. E. Gorbalenya, and R. J. Kuhn (2001)
J. Virol.
75, 1-10
| Abstract »
| Full Text »
- The location and type of mutation predict malformation severity in isolated lissencephaly caused by abnormalities within the LIS1 gene.
- C. Cardoso, R. J. Leventer, N. Matsumoto, J. A. Kuc, M. B. Ramocki, S. K. Mewborn, L. L. Dudlicek, L. F. May, P. L. Mills, S. Das, et al. (2000)
Hum. Mol. Genet.
9, 3019-3028
| Abstract »
| Full Text »
| PDF »
- A guided tour in protein interaction space: Coiled coils from the yeast proteome.
- J. C. Hu (2000)
PNAS
97, 12935-12936
| Full Text »
| PDF »
- The Skn7 Response Regulator of Saccharomyces cerevisiae Interacts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress.
- D. C. Raitt, A. L. Johnson, A. M. Erkine, K. Makino, B. Morgan, D. S. Gross, and L. H. Johnston (2000)
Mol. Biol. Cell
11, 2335-2347
| Abstract »
| Full Text »
- Efficient Particle Production by Minimal Gag Constructs Which Retain the Carboxy-Terminal Domain of Human Immunodeficiency Virus Type 1 Capsid-p2 and a Late Assembly Domain.
- M. A. Accola, B. Strack, and H. G. Göttlinger (2000)
J. Virol.
74, 5395-5402
| Abstract »
| Full Text »
- Characterization of Stable, Soluble Trimers Containing Complete Ectodomains of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins.
- X. Yang, M. Farzan, R. Wyatt, and J. Sodroski (2000)
J. Virol.
74, 5716-5725
| Abstract »
| Full Text »
- Modifications That Stabilize Human Immunodeficiency Virus Envelope Glycoprotein Trimers in Solution.
- X. Yang, L. Florin, M. Farzan, P. Kolchinsky, P. D. Kwong, J. Sodroski, and R. Wyatt (2000)
J. Virol.
74, 4746-4754
| Abstract »
| Full Text »
- A Distinct Seven-residue Trigger Sequence Is Indispensable for Proper Coiled-coil Formation of the Human Macrophage Scavenger Receptor Oligomerization Domain.
- S. Frank, A. Lustig, T. Schulthess, J. Engel, and R. A. Kammerer (2000)
J. Biol. Chem.
275, 11672-11677
| Abstract »
| Full Text »
| PDF »
- The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.
- P. R. E. Mittl, C. Deillon, D. Sargent, N. Liu, S. Klauser, R. M. Thomas, B. Gutte, and M. G. Grutter (2000)
PNAS
97, 2562-2566
| Abstract »
| Full Text »
| PDF »
- A Chimeric Protein Containing the N Terminus of the Adeno-Associated Virus Rep Protein Recognizes Its Target Site in an In Vivo Assay.
- T. Cathomen, D. Collete, and M. D. Weitzman (2000)
J. Virol.
74, 2372-2382
| Abstract »
| Full Text »
- Diabetes-associated mutations in a beta -cell transcription factor destabilize an antiparallel "mini-zipper" in a dimerization interface.
- Q.-X. Hua, M. Zhao, N. Narayana, S. H. Nakagawa, W. Jia, and M. A. Weiss (2000)
PNAS
97, 1999-2004
| Abstract »
| Full Text »
| PDF »
- Linker Scanning Analysis of TBP Promoter Binding Factor DNA Binding, Activation, and Repression Domains.
- L. Chen and E. Bateman (2000)
J. Biol. Chem.
275, 2771-2776
| Abstract »
| Full Text »
| PDF »
|
|