Science 19 November 1993: Vol. 262. no. 5137, pp. 1265 - 1267 DOI: 10.1126/science.7694370

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Articles

Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells.

R. Hrdlickova, J. Nehyba, and H. R. Bose Jr. (2009)
Mol. Cell. Biol. 29, 929-941
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6.

S. Sehra, H. A. Bruns, A.-N. N. Ahyi, E. T. Nguyen, N. W. Schmidt, E. G. Michels, G.-U. von Bulow, and M. H. Kaplan (2008)
J. Immunol. 180, 3551-3559
 |  Abstract »  |  Full Text »  |  PDF »

Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6.

D. K. Fritz, C. Kerr, L. Tong, D. Smyth, and C. D. Richards (2006)
J. Immunol. 176, 4352-4360
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Induction of Uteroglobin-Related Protein 2 (Ugrp2) Gene Expression by the Th2 Cytokines IL-4 and IL-13.

A. Yamada, F. Sheikh, T. Niimi, F. J. DeMayo, A. D. Keegan, R. P. Donnelly, and S. Kimura (2005)
J. Immunol. 175, 5708-5715
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NF-{kappa}B elements associated with the Stat6 site in the germline {gamma}1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.

M. T. Berton, L. A. Linehan, K. R. Wick, and W. A. Dunnick (2004)
Int. Immunol. 16, 1741-1749
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Interferon-{gamma} Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial Cells.

N. M. Heller, S. Matsukura, S. N. Georas, M. R. Boothby, P. B. Rothman, C. Stellato, and R. P. Schleimer (2004)
Am. J. Respir. Cell Mol. Biol. 31, 573-582
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Germline Transcription and Switch Recombination of a Transgene Containing the Entire H Chain Constant Region Locus: Effect of a Mutation in a STAT6 Binding Site in the {gamma}1 Promoter.

W. A. Dunnick, J. Shi, K. A. Graves, and J. T. Collins (2004)
J. Immunol. 173, 5531-5539
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Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells.

H. A. Bruns, U. Schindler, and M. H. Kaplan (2003)
J. Immunol. 170, 3478-3487
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Regulation of the Dephosphorylation of Stat6. PARTICIPATION OF TYR-713 IN THE INTERLEUKIN-4 RECEPTOR alpha , THE TYROSINE PHOSPHATASE SHP-1, AND THE PROTEASOME.

E. M. Hanson, H. Dickensheets, C.-K. Qu, R. P. Donnelly, and A. D. Keegan (2003)
J. Biol. Chem. 278, 3903-3911
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1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor.

J. B. Cordero, M. Cozzolino, Y. Lu, M. Vidal, E. Slatopolsky, P. D. Stahl, M. A. Barbieri, and A. Dusso (2002)
J. Biol. Chem. 277, 38965-38971
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Induces the Proteolytic Processing of Mast Cell STAT6.

M. A. Sherman, D. R. Powell, and M. A. Brown (2002)
J. Immunol. 169, 3811-3818
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms.

A. Finnegan, M. J. Grusby, C. D. Kaplan, S. K. O'Neill, H. Eibel, T. Koreny, M. Czipri, K. Mikecz, and J. Zhang (2002)
J. Immunol. 169, 3345-3352
 |  Abstract »  |  Full Text »  |  PDF »

Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription.

M. Vidal, C. V. Ramana, and A. S. Dusso (2002)
Mol. Cell. Biol. 22, 2777-2787
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40.

C.-s. Mao and J. Stavnezer (2001)
J. Immunol. 167, 1522-1534
 |  Abstract »  |  Full Text »  |  PDF »

Stage-Specific Modulation of IFN-Regulatory Factor 4 Function by Kruppel-Type Zinc Finger Proteins.

S. Gupta, A. Anthony, and A. B. Pernis (2001)
J. Immunol. 166, 6104-6111
 |  Abstract »  |  Full Text »  |  PDF »

Fes Mediates the IL-4 Activation of Insulin Receptor Substrate-2 and Cellular Proliferation.

H. Jiang, K. Foltenyi, M. Kashiwada, L. Donahue, B. Vuong, B. Hehn, and P. Rothman (2001)
J. Immunol. 166, 2627-2634
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A DNase I hypersensitive site near the murine {gamma}1 switch region contributes to insertion site independence of transgenes and modulates the amount of transcripts induced by CD40 ligation.

K. Adams, H. Ackerly, K. Cunningham, and W. Dunnick (2000)
Int. Immunol. 12, 1705-1713
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IL-4-Activated STAT-6 Inhibits IFN-{gamma}-Induced CD40 Gene Expression in Macrophages/Microglia.

V. T. Nguyen and E. N. Benveniste (2000)
J. Immunol. 165, 6235-6243
 |  Abstract »  |  Full Text »  |  PDF »

STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells.

E. J. Davey, G. Greicius, J. Thyberg, and E. Severinson (2000)
Int. Immunol. 12, 995-1003
 |  Abstract »  |  Full Text »  |  PDF »

Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.

L. H. Wang, R. A. Kirken, X. Y. Yang, R. A. Erwin, L. DaSilva, C.-R. Yu, and W. L. Farrar (2000)
Blood 95, 3816-3822
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Mediates Cell Growth Inhibition through Activation of Stat1.

T. L.-Y. Chang, X. Peng, and X.-Y. Fu (2000)
J. Biol. Chem. 275, 10212-10217
 |  Abstract »  |  Full Text »  |  PDF »

Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven TH2 cell response.

L. H. Wang, X. Y. Yang, R. A. Kirken, J. H. Resau, and W. L. Farrar (2000)
Blood 95, 1249-1257
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6.

M. Pesu, K. Takaluoma, S. Aittomaki, A. Lagerstedt, K. Saksela, P. E. Kovanen, and O. Silvennoinen (2000)
Blood 95, 494-502
 |  Abstract »  |  Full Text »  |  PDF »

Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein.

B Chen, E Harms, T Chu, G Henrion, and S Strickland (2000)
Development 127, 1243-1251
 |  Abstract »  |  PDF »

Lineage-specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4.

S. Gupta, M. Jiang, A. Anthony, and A. B. Pernis (1999)
J. Exp. Med. 190, 1837-1848
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Paired Stat6 C-Terminal Transcription Activation Domains Required Both for Inhibition of an IFN-Responsive Promoter and Trans-Activation.

S. Goenka, J. Youn, L. M. Dzurek, U. Schindler, L.-y. Yu-Lee, and M. Boothby (1999)
J. Immunol. 163, 4663-4672
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Induction of 3{beta}-Hydroxysteroid Dehydrogenase/ Isomerase Type 1 Expression by Interleukin-4 in Human Normal Prostate Epithelial Cells, Immortalized Keratinocytes, Colon, and Cervix Cancer Cell Lines.

S. Gingras and J. Simard (1999)
Endocrinology 140, 4573-4584
 |  Abstract »  |  Full Text »

IFN-{alpha} Activates Stat6 and Leads to the Formation of Stat2:Stat6 Complexes in B Cells.

S. Gupta, M. Jiang, and A. B. Pernis (1999)
J. Immunol. 163, 3834-3841
 |  Abstract »  |  Full Text »  |  PDF »

Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly (1999)
PNAS 96, 10800-10805
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation.

M. Kubo, M. Yamashita, R. Abe, T. Tada, K. Okumura, J. T. Ransom, and T. Nakayama (1999)
J. Immunol. 163, 2432-2442
 |  Abstract »  |  Full Text »  |  PDF »

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.

K. Friedrich, W. Kammer, I. Erhardt, S. Brandlein, W. Sebald, and R. Moriggl (1999)
Int. Immunol. 11, 1283-1294
 |  Abstract »  |  Full Text »  |  PDF »

Repression of IL-4-Induced Gene Expression by IFN-{gamma} Requires Stat1 Activation.

C. Venkataraman, S. Leung, A. Salvekar, H. Mano, and U. Schindler (1999)
J. Immunol. 162, 4053-4061
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Preferentially Activates a Novel STAT6 Isoform in Mast Cells.

M. A. Sherman, V. H. Secor, and M. A. Brown (1999)
J. Immunol. 162, 2703-2708
 |  Abstract »  |  Full Text »  |  PDF »

Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.

K. Schnurr, A. Borchert, and H. Kuhn (1999)
FASEB J 13, 143-154
 |  Abstract »  |  Full Text »

Signaling Pathways Mediated by the TNF- and Cytokine-Receptor Families Target a Common cis-Element of the IFN Regulatory Factor 1 Promoter.

S. Gupta, D. Xia, M. Jiang, S. Lee, and A. B. Pernis (1998)
J. Immunol. 161, 5997-6004
 |  Abstract »  |  Full Text »  |  PDF »

The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common gamma -Chain.

A. Lischke, R. Moriggl, S. Brandlein, S. Berchtold, W. Kammer, W. Sebald, B. Groner, X. Liu, L. Hennighausen, and K. Friedrich (1998)
J. Biol. Chem. 273, 31222-31229
 |  Abstract »  |  Full Text »  |  PDF »

STAT6 Is Required for the Anti-inflammatory Activity of Interleukin-4 in Mouse Peritoneal Macrophages.

Y. Ohmori and T. A. Hamilton (1998)
J. Biol. Chem. 273, 29202-29209
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Activation of the Germline {epsilon} Promoter Mediated by Stat6 and C/EBP{beta}.

T. Mikita, M. Kurama, and U. Schindler (1998)
J. Immunol. 161, 1822-1828
 |  Abstract »  |  Full Text »  |  PDF »

Antagonistic Action of IFN-{beta} and IFN-{gamma} on High Affinity Fc{gamma} Receptor Expression in Healthy Controls and Multiple Sclerosis Patients.

J. Van Weyenbergh, P. Lipinski, A. Abadie, D. Chabas, U. Blank, R. Liblau, and J. Wietzerbin (1998)
J. Immunol. 161, 1568-1574
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
 |  Abstract »  |  Full Text »  |  PDF »

STAT6 Is Required for IL-4-Induced Germline Ig Gene Transcription and Switch Recombination.

L. A. Linehan, W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton (1998)
J. Immunol. 161, 302-310
 |  Abstract »  |  Full Text »  |  PDF »

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
 |  Abstract »  |  Full Text »

Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production.

K. Siemasko, A. S-F. Chong, H.-M. Jack, H. Gong, J. W. Williams, and A. Finnegan (1998)
J. Immunol. 160, 1581-1588
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.

B. K. R. Patel, J. H. Pierce, and W. J. LaRochelle (1998)
PNAS 95, 172-177
 |  Abstract »  |  Full Text »  |  PDF »

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.

S. T. Smiley, S. N. Boyer, M. J. Heeb, J. H. Griffin, and M. J. Grusby (1997)
PNAS 94, 11484-11489
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of Soluble and Transmembrane Isoforms of a Novel Component of the Murine Type I Interferon Receptor, IFNAR 2.

C. M. Owczarek, S. Y. Hwang, K. A. Holland, L. M. Gulluyan, M. Tavaria, B. Weaver, N. C. Reich, I. Kola, and P. J. Hertzog (1997)
J. Biol. Chem. 272, 23865-23870
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.

N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
 |  Abstract »  |  Full Text »  |  PDF »

Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules.

X. H. Chen, B. K.R. Patel, L.-M. Wang, M. Frankel, N. Ellmore, R. A. Flavell, W. J. LaRochelle, and J. H. Pierce (1997)
J. Biol. Chem. 272, 6556-6560
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor alpha Enhances the Expression of the Interleukin (IL)-4 Receptor alpha -Chain on Endothelial Cells Increasing IL-4 or IL-13-induced Stat6 Activation.

S. M. Lugli, N. Feng, M. H. Heim, M. Adam, B. Schnyder, H. Etter, M. Yamage, H.-P. Eugster, R. A. Lutz, G. Zurawski, et al. (1997)
J. Biol. Chem. 272, 5487-5494
 |  Abstract »  |  Full Text »  |  PDF »

P210 and P190BCR/ABL Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members.

R. L. Ilaria Jr. and R. A. Van Etten (1996)
J. Biol. Chem. 271, 31704-31710
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain.

R. M. Weber-Nordt, J. K. Riley, A. C. Greenlund, K. W. Moore, J. E. Darnell, and R. D. Schreiber (1996)
J. Biol. Chem. 271, 27954-27961
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene.

H. Kotanides and N. C. Reich (1996)
J. Biol. Chem. 271, 25555-25561
 |  Abstract »  |  Full Text »  |  PDF »

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts.

B. K.R. Patel, L.-M. Wang, C.-C. Lee, W. G. Taylor, J. H. Pierce, and W. J. LaRochelle (1996)
J. Biol. Chem. 271, 22175-22182
 |  Abstract »  |  Full Text »  |  PDF »

Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon-alpha.

X. Li, S. Leung, S. Qureshi, J. E. Darnell Jr., and G. R. Stark (1996)
J. Biol. Chem. 271, 5790-5794
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients.

K. Izuhara, T. Heike, T. Otsuka, K. Yamaoka, M. Mayumi, T. Imamura, Y. Niho, and N. Harada (1996)
J. Biol. Chem. 271, 619-622
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin.

D.-Z. Wang, P. Ray, and M. Boothby (1995)
J. Biol. Chem. 270, 22924-22932
 |  Abstract »  |  Full Text »  |  PDF »

Mapping of the Cytoplasmic Domain of the Human Growth Hormone Receptor Required for the Activation of Jak2 and Stat Proteins.

R. H. Hackett, Y.-D. Wang, and A. C. Larner (1995)
J. Biol. Chem. 270, 21326-21330
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins.

H. Kotanides, M. Moczygemba, M. F. White, and N. C. Reich (1995)
J. Biol. Chem. 270, 19481-19486
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Stat-like DNA Binding Activity in Drosophila melanogaster.

S. M. Sweitzer, S. Calvo, M. H. Kraus, D. S. Finbloom, and A. C. Larner (1995)
J. Biol. Chem. 270, 16510-16513
 |  Abstract »  |  Full Text »  |  PDF »

Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells.

A Pernis, S Gupta, K. Gollob, E Garfein, R. Coffman, C Schindler, and P Rothman (1995)
Science 269, 245-247
 |  Abstract »  |  PDF »

[IMAGE]Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors.

A. Pernis, S. Gupta, J. Yopp, E. Garfein, H. Kashleva, C. Schindler, and P. Rothman (1995)
J. Biol. Chem. 270, 14517-14522
 |  Abstract »  |  Full Text »  |  PDF »

Growth Hormone Signaling Leading to CYP2C12 Gene Expression in Rat Hepatocytes Involves Phospholipase A[IMAGE].

P. Tollet, M. Hamberg, J. Gustafsson, and A. Mode (1995)
J. Biol. Chem. 270, 12569-12577
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells.

M. J. Welham, L. Learmonth, H. Bone, and J. W. Schrader (1995)
J. Biol. Chem. 270, 12286-12296
 |  Abstract »  |  Full Text »  |  PDF »

The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts.

K. K. Morella, C.-f. Lai, S. Kumaki, N. Kumaki, Y. Wang, E. M. Bluman, B. A. Witthuhn, J. N. Ihle, J. Giri, D. P. Gearing, et al. (1995)
J. Biol. Chem. 270, 8298-8310
 |  Abstract »  |  Full Text »  |  PDF »

Both Interleukin 4 and Interleukin 13 Induce Tyrosine Phosphorylation of the 140-kDa Subunit of the Interleukin 4 Receptor.

C. Smerz-Bertling and A. Duschl (1995)
J. Biol. Chem. 270, 966-970
 |  Abstract »  |  Full Text »  |  PDF »

An interleukin-4-induced transcription factor: IL-4 Stat.

J Hou, U Schindler, W. Henzel, T. Ho, M Brasseur, and S. McKnight (1994)
Science 265, 1701-1706
 |  Abstract »  |  PDF »

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

J. Darnell Jr, I. Kerr, and G. Stark (1994)
Science 264, 1415-1421
 |  Abstract »  |  PDF »

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.

Z Zhong, Z Wen, and J. Darnell Jr (1994)
Science 264, 95-98
 |  Abstract »  |  PDF »

DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES.

G. B. Ehret, P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher (2001)
J. Biol. Chem. 276, 6675-6688
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4/STAT6 Represses STAT1 and NF-kappa B-dependent Transcription through Distinct Mechanisms.

Y. Ohmori and T. A. Hamilton (2000)
J. Biol. Chem. 275, 38095-38103
 |  Abstract »  |  Full Text »  |  PDF »

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