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Science 12 November 1993:
Vol. 262. no. 5136, pp. 1072 - 1074
DOI: 10.1126/science.8093125
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Articles

Science, Vol 262, Issue 5136, 1072-1074
Copyright © 1993 by American Association for the Advancement of Science

articles

Unidirectional coupling of gap junctions between neuroglia

Robinson SR, EC Hampson, MN Munro, and DI Vaney

Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.

Gap junctions permit the passage of ions and small molecules between cells, thereby providing a basis for direct intercellular communication. In the rabbit retina, the low molecular weight dyes Lucifer yellow and biocytin passed readily from astrocytes into adjacent astrocytes, oligodendrocytes, and Muller cells. However, the dyes rarely passed from either oligodendrocytes or Muller cells into astrocytes. Unidirectional passage of dye suggests the presence of an asymmetric barrier to the movement of molecules through heterologous gap junctions and indicates the potential for a hierarchy of command between interconnected cells.


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The Permeability of Gap Junction Channels to Probes of Different Size Is Dependent on Connexin Composition and Permeant-Pore Affinities.
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Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells.
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Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures.
M. M. Froes, A. H. P. Correia, J. Garcia-Abreu, D. C. Spray, A. C. Campos de Carvalho, and V. M. Neto (1999)
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Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node.
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Cloning and Expression of Two Related Connexins from the Perch Retina Define a Distinct Subgroup of the Connexin Family.
J. O'Brien, R. Bruzzone, T. W. White, M. R. Al-Ubaidi, and H. Ripps (1998)
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Direct Recording of Nicotinic Responses in Presynaptic Nerve Terminals.
J. S. Coggan, J. Paysan, W. G. Conroy, and D. K. Berg (1997)
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Selectivity of Connexin-Specific Gap Junctions Does Not Correlate With Channel Conductance.
R. D. Veenstra, H.-Z. Wang, D. A. Beblo, M. G. Chilton, A. L. Harris, E. C. Beyer, and P. R. Brink (1995)
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L-Arginine–Induced Conducted Signals Alter Upstream Arteriolar Responsivity to L-Arginine.
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Response.
S. R. Robinson and E. C. G. M. Hampson (1994)
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Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.
M Nedergaard (1994)
Science 263, 1768-1771
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Science. ISSN 0036-8075 (print), 1095-9203 (online)