Science 12 November 1993: Vol. 262. no. 5136, pp. 1019 - 1024 DOI: 10.1126/science.7694365

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Articles

Engineered GPCRs as Tools to Modulate Signal Transduction.

Y. Pei, S. C. Rogan, F. Yan, and B. L. Roth (2008)
Physiology 23, 313-321
 |  Abstract »  |  Full Text »  |  PDF »

Oligomerization Regulates the Localization of Cdc24, the Cdc42 Activator in Saccharomyces cerevisiae.

C. Mionnet, S. Bogliolo, and R. A. Arkowitz (2008)
J. Biol. Chem. 283, 17515-17530
 |  Abstract »  |  Full Text »  |  PDF »

Cell expansion and maintenance of stemness.

K. Kaushansky (2008)
Blood 111, 3920-3921
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Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint.

J. Kang, Y. Chen, Y. Zhao, and H. Yu (2007)
PNAS 104, 20232-20237
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Activation of Human Dendritic Cells by Inducible CD40 and Toll-like Receptor-4 Ligation.

N. Lapteva, M. R. Seethammagari, B. A. Hanks, J. Jiang, J. M. Levitt, K. M. Slawin, and D. M. Spencer (2007)
Cancer Res. 67, 10528-10537
 |  Abstract »  |  Full Text »  |  PDF »

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.

C. Quintarelli, J. F. Vera, B. Savoldo, G. M. P. Giordano Attianese, M. Pule, A. E. Foster, H. E. Heslop, C. M. Rooney, M. K. Brenner, and G. Dotti (2007)
Blood 110, 2793-2802
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy.

A. Varshavsky (2007)
PNAS 104, 14935-14940
 |  Abstract »  |  Full Text »  |  PDF »

Exploiting protein destruction for constructive use.

K. Stankunas and G. R. Crabtree (2007)
PNAS 104, 11511-11512
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Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.

Z. Hayouka, J. Rosenbluh, A. Levin, S. Loya, M. Lebendiker, D. Veprintsev, M. Kotler, A. Hizi, A. Loyter, and A. Friedler (2007)
PNAS 104, 8316-8321
 |  Abstract »  |  Full Text »  |  PDF »

Activation of MTK1/MEKK4 by GADD45 through Induced N-C Dissociation and Dimerization-Mediated trans Autophosphorylation of the MTK1 Kinase Domain.

Z. Miyake, M. Takekawa, Q. Ge, and H. Saito (2007)
Mol. Cell. Biol. 27, 2765-2776
 |  Abstract »  |  Full Text »  |  PDF »

Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.

R. Zoncu, R. M. Perera, R. Sebastian, F. Nakatsu, H. Chen, T. Balla, G. Ayala, D. Toomre, and P. V. De Camilli (2007)
PNAS 104, 3793-3798
 |  Abstract »  |  Full Text »  |  PDF »

Translational Research in Academia and Industry.

T. Clackson (2006)
Experimental Biology and Medicine 231, 1685-1689
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Chemically Induced Changes of PtdIns(4,5)P2 Gate KCNQ Ion Channels.

B.-C. Suh, T. Inoue, T. Meyer, and B. Hille (2006)
Science 314, 1454-1457
 |  Abstract »  |  Full Text »  |  PDF »

The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple beta Importins.

L. Goffin, S. Vodala, C. Fraser, J. Ryan, M. Timms, S. Meusburger, B. Catimel, E. C. Nice, P. A. Silver, C.-Y. Xiao, et al. (2006)
Mol. Biol. Cell 17, 5309-5323
 |  Abstract »  |  Full Text »  |  PDF »

Growth factor receptors as regulators of hematopoiesis.

M. A. Weinreich, I. Lintmaer, L. Wang, H. D. Liggitt, M. A. Harkey, and C. A. Blau (2006)
Blood 108, 3713-3721
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals.

M. Sun, K. T. Ames, I. Suzuki, and P. J. Fink (2006)
J. Immunol. 177, 1481-1491
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic IRE1{alpha}-mediated XBP1 mRNA Splicing in the Absence of Nuclear Processing and Endoplasmic Reticulum Stress.

S. H. Back, K. Lee, E. Vink, and R. J. Kaufman (2006)
J. Biol. Chem. 281, 18691-18706
 |  Abstract »  |  Full Text »  |  PDF »

Controlled Activation of ErbB1/ErbB2 Heterodimers Promote Invasion of Three-Dimensional Organized Epithelia in an ErbB1-Dependent Manner: Implications for Progression of ErbB2-Overexpressing Tumors..

L. Zhan, B. Xiang, and S. K. Muthuswamy (2006)
Cancer Res. 66, 5201-5208
 |  Abstract »  |  Full Text »  |  PDF »

Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.

Y.-j. Xu, M. Davenport, and T. J. Kelly (2006)
Genes & Dev. 20, 990-1003
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of a Cell Model Based on FKBP12 Dimerization for Screening of FK506-like Neurotrophic Small Molecular Compounds.

H. Xiao, L.-L. Wang, C.-L. Shu, M. Yu, S. Li, B.-F. Shen, and Y. Li (2006)
J Biomol Screen 11, 225-235
 |  Abstract »  |  PDF »

Anatomical Compartments Modify the Response of Human Hematopoietic Cells to a Mitogenic Signal.

Y. Nagasawa, B. L. Wood, L. Wang, I. Lintmaer, W. Guo, T. Papayannopoulou, M. A. Harkey, C. Nourigat, and C. A. Blau (2006)
Stem Cells 24, 908-917
 |  Abstract »  |  Full Text »  |  PDF »

An AOA Critical Issue. The Future of the Orthopaedic Surgeon-Proceduralist or Keeper of the Musculoskeletal System?.

S. D. Boden, T. A. Einhorn, T. S. Morgan, L. L. Tosi, and J. N. Weinstein (2005)
J. Bone Joint Surg. Am. 87, 2812-2821
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{gamma}-Globin Gene Expression in Chemical Inducer of Dimerization (CID)-dependent Multipotential Cells Established from Human {beta}-Globin Locus Yeast Artificial Chromosome ({beta}-YAC) Transgenic Mice.

C. A. Blau, C. F. Barbas III, A. L. Bomhoff, R. Neades, J. Yan, P. A. Navas, and K. R. Peterson (2005)
J. Biol. Chem. 280, 36642-36647
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Dimerization of the Thyrotropin-Releasing Hormone Receptor Affects Receptor Trafficking But Not Signaling.

G. J. Song and P. M. Hinkle (2005)
Mol. Endocrinol. 19, 2859-2870
 |  Abstract »  |  Full Text »  |  PDF »

Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation.

D. Friedmann-Morvinski, A. Bendavid, T. Waks, D. Schindler, and Z. Eshhar (2005)
Blood 105, 3087-3093
 |  Abstract »  |  Full Text »  |  PDF »

Dimerization through the Catalytic Domain Is Essential for MEKK2 Activation.

J. Cheng, L. Yu, D. Zhang, Q. Huang, D. Spencer, and B. Su (2005)
J. Biol. Chem. 280, 13477-13482
 |  Abstract »  |  Full Text »  |  PDF »

Forcing interactions as a genetic screen to identify proteins that exert a defined activity.

M. DeVit, P. J. Cullen, M. Branson, G. F. Sprague Jr., and S. Fields (2005)
Genome Res. 15, 560-565
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: A small-molecule switch for Golgi sulfotransferases.

C. L. de Graffenried, S. T. Laughlin, J. J. Kohler, and C. R. Bertozzi (2004)
PNAS 101, 16715-16720
 |  Abstract »  |  Full Text »  |  PDF »

Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid {beta} Aggregation.

J. E. Gestwicki, G. R. Crabtree, and I. A. Graef (2004)
Science 306, 865-869
 |  Abstract »  |  Full Text »  |  PDF »

Modulating erythrocyte chimerism in a mouse model of pyruvate kinase deficiency.

R. E. Richard, M. Weinreich, K.-H. Chang, J. Ieremia, M. M. Stevenson, and C. A. Blau (2004)
Blood 103, 4432-4439
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity.

C. E. Tognon, C. D. Mackereth, A. M. Somasiri, L. P. McIntosh, and P. H. B. Sorensen (2004)
Mol. Cell. Biol. 24, 4636-4650
 |  Abstract »  |  Full Text »  |  PDF »

Localization to the Proteasome Is Sufficient for Degradation.

D. M. Janse, B. Crosas, D. Finley, and G. M. Church (2004)
J. Biol. Chem. 279, 21415-21420
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction.

D. E. BREDESEN, P. MEHLEN, and S. RABIZADEH (2004)
Physiol Rev 84, 411-430
 |  Abstract »  |  Full Text »  |  PDF »

A Highly Conserved NTRK3 C-terminal Sequence in the ETV6-NTRK3 Oncoprotein Binds the Phosphotyrosine Binding Domain of Insulin Receptor Substrate-1: AN ESSENTIAL INTERACTION FOR TRANSFORMATION.

C. L. Lannon, M. J. Martin, C. E. Tognon, W. Jin, S.-J. Kim, and P. H. B. Sorensen (2004)
J. Biol. Chem. 279, 6225-6234
 |  Abstract »  |  Full Text »  |  PDF »

Meeting Report: Cellular Dependence--Old Concept, New Mechanisms.

P. Mehlen and D. E. Bredesen (2003)
Science Signaling 2003 , pe55
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Signal Transducer and Activator of Transcription 5 is Required for Progression of Autochthonous Prostate Cancer: Evidence from the Transgenic Adenocarcinoma of the Mouse Prostate System.

A. V. Kazansky, D. M. Spencer, and N. M. Greenberg (2003)
Cancer Res. 63, 8757-8762
 |  Abstract »  |  Full Text »  |  PDF »

Inducible Prostate Intraepithelial Neoplasia with Reversible Hyperplasia in Conditional FGFR1-Expressing Mice.

K. W. Freeman, B. E. Welm, R. D. Gangula, J. M. Rosen, M. Ittmann, N. M. Greenberg, and D. M. Spencer (2003)
Cancer Res. 63, 8256-8263
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Chemical Disruption of Clathrin Function in Living Cells.

H. S. Moskowitz, J. Heuser, T. E. McGraw, and T. A. Ryan (2003)
Mol. Biol. Cell 14, 4437-4447
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Activation of Fibroblast Growth Factor Receptor (FGFR) 1, but not FGFR2, in Prostate Cancer Cells Leads to Increased Osteopontin Induction, Extracellular Signal-regulated Kinase Activation, and in Vivo Proliferation.

K. W. Freeman, R. D. Gangula, B. E. Welm, M. Ozen, B. A. Foster, J. M. Rosen, M. Ittmann, N. M. Greenberg, and D. M. Spencer (2003)
Cancer Res. 63, 6237-6243
 |  Abstract »  |  Full Text »  |  PDF »

Computational design of a Zn2+ receptor that controls bacterial gene expression.

M. A. Dwyer, L. L. Looger, and H. W. Hellinga (2003)
PNAS 100, 11255-11260
 |  Abstract »  |  Full Text »  |  PDF »

Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors.

T. E. Boursalian and P. J. Fink (2003)
J. Exp. Med. 198, 349-360
 |  Abstract »  |  Full Text »  |  PDF »

Androgen Stimulates Matrix Metalloproteinase-2 Expression in Human Prostate Cancer.

X. Liao, J. B. Thrasher, J. Pelling, J. Holzbeierlein, Q.-X. A. Sang, and B. Li (2003)
Endocrinology 144, 1656-1663
 |  Abstract »  |  Full Text »  |  PDF »

Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition.

T. Scheibel, R. Parthasarathy, G. Sawicki, X.-M. Lin, H. Jaeger, and S. L. Lindquist (2003)
PNAS 100, 4527-4532
 |  Abstract »  |  Full Text »  |  PDF »

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.

C. R. Sinars, J. Cheung-Flynn, R. A. Rimerman, J. G. Scammell, D. F. Smith, and J. Clardy (2003)
PNAS 100, 868-873
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Gene function: Getting specific, generally speaking.

S. W. Michnick and F.-X. C. Valois (2002)
PNAS 99, 16513-16515
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The D0 Domain of KIR3D Acts as a Major Histocompatibility Complex Class I Binding Enhancer.

S. I. Khakoo, R. Geller, S. Shin, J. A. Jenkins, and P. Parham (2002)
J. Exp. Med. 196, 911-921
 |  Abstract »  |  Full Text »  |  PDF »

The Nucleophosmin-Anaplastic Lymphoma Kinase Fusion Protein Induces c-Myc Expression in Pediatric Anaplastic Large Cell Lymphomas.

E. A. Raetz, S. L. Perkins, M. A. Carlson, K. P. Schooler, W. L. Carroll, and D. M. Virshup (2002)
Am. J. Pathol. 161, 875-883
 |  Abstract »  |  Full Text »  |  PDF »

The CXC Chemokine Murine Monokine Induced by IFN-{gamma} (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo.

M. K. Park, D. Amichay, P. Love, E. Wick, F. Liao, A. Grinberg, R. L. Rabin, H. H. Zhang, S. Gebeyehu, T. M. Wright, et al. (2002)
J. Immunol. 169, 1433-1443
 |  Abstract »  |  Full Text »  |  PDF »

Chk2 Activation and Phosphorylation-Dependent Oligomerization.

X. Xu, L. M. Tsvetkov, and D. F. Stern (2002)
Mol. Cell. Biol. 22, 4419-4432
 |  Abstract »  |  Full Text »  |  PDF »

Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.

B. E. Welm, K. W. Freeman, M. Chen, A. Contreras, D. M. Spencer, and J. M. Rosen (2002)
J. Cell Biol. 157, 703-714
 |  Abstract »  |  Full Text »  |  PDF »

Lateral Clustering of Platelet GP Ib-IX Complexes Leads to Up-regulation of the Adhesive Function of Integrin alpha IIbbeta 3.

A. Kasirer-Friede, J. Ware, L. Leng, P. Marchese, Z. M. Ruggeri, and S. J. Shattil (2002)
J. Biol. Chem. 277, 11949-11956
 |  Abstract »  |  Full Text »  |  PDF »

Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2.

D. N. Chadee, T. Yuasa, and J. M. Kyriakis (2002)
Mol. Cell. Biol. 22, 737-749
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Therapies for Myocardial Infarct Repair.

C.E. MURRY, M.L. WHITNEY, M.A. LAFLAMME, H. REINECKE, and L.J. FIELD (2002)
Cold Spring Harb Symp Quant Biol 67, 519-526
 |  Abstract »  |  PDF »

Membrane localization is not required for Mpl function in normal hematopoietic cells.

K. G. Otto, V. C. Broudy, N. L. Lin, E. Parganas, J. N. Luthi, J. G. Drachman, J. N. Ihle, and C. A. Blau (2001)
Blood 98, 2077-2083
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-mediated Tissue-targeted Expression of a Caspase-9-based Artificial Death Switch for the Treatment of Prostate Cancer.

X. Xie, X. Zhao, Y. Liu, J. Zhang, R. J. Matusik, K. M. Slawin, and D. M. Spencer (2001)
Cancer Res. 61, 6795-6804
 |  Abstract »  |  Full Text »  |  PDF »

Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells.

H. Zeng, M. Masuko, L. Jin, T. Neff, K. G. Otto, and C. A. Blau (2001)
Blood 98, 328-334
 |  Abstract »  |  Full Text »  |  PDF »

Cell proliferation through forced engagement of c-Kit and Flt-3.

K. G. Otto, L. Jin, D. M. Spencer, and C. A. Blau (2001)
Blood 97, 3662-3664
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacologically regulated cell therapy.

T. Neff and C. A. Blau (2001)
Blood 97, 2535-2540
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Adenovirus-mediated Transfer of Inducible Caspases: A Novel "Death Switch" Gene Therapeutic Approach to Prostate Cancer.

S. F. Shariat, S. Desai, W. Song, T. Khan, J. Zhao, C. Nguyen, B. A. Foster, N. Greenberg, D. M. Spencer, and K. M. Slawin (2001)
Cancer Res. 61, 2562-2571
 |  Abstract »  |  Full Text »

Streptogramin- and tetracycline-responsive dual regulated expression of p27Kip1 sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.

C. Fux, S. Moser, S. Schlatter, M. Rimann, J. E. Bailey, and M. Fussenegger (2001)
Nucleic Acids Res. 29, e19
 |  Abstract »  |  Full Text »  |  PDF »

Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 from Within the Cell.

T. Zhao and P. J. Newman (2001)
J. Cell Biol. 152, 65-74
 |  Abstract »  |  Full Text »  |  PDF »

Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking.

Z. Intody, B. D. Perkins, J. H. Wilson, and T. G. Wensel (2000)
Nucleic Acids Res. 28, 4283-4290
 |  Abstract »  |  Full Text »  |  PDF »

Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice.

C. ALBANESE, A. T. REUTENS, B. BOUZAHZAH, M. FU, M. D’AMICO, T. LINK, R. NICHOLSON, R. A. DEPINHO, and R. G. PESTELL (2000)
FASEB J 14, 877-884
 |  Abstract »  |  Full Text »

CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand.

C.-R. Yu, K. W. C. Peden, M. B. Zaitseva, H. Golding, and J. M. Farber (2000)
J. Immunol. 164, 1293-1305
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade.

S. C. Bunnell, M. Diehn, M. B. Yaffe, P. R. Findell, L. C. Cantley, and L. J. Berg (2000)
J. Biol. Chem. 275, 2219-2230
 |  Abstract »  |  Full Text »  |  PDF »

Expansion of genetically modified primary human hemopoietic cells using chemical inducers of dimerization.

R. E. Richard, B. Wood, H. Zeng, L. Jin, T. Papayannopoulou, and C. A. Blau (2000)
Blood 95, 430-436
 |  Abstract »  |  Full Text »  |  PDF »

Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells.

X. Wen, H. H. Lin, H.-M. Shih, H.-J. Kung, and D. K. Ann (1999)
J. Biol. Chem. 274, 38204-38210
 |  Abstract »  |  Full Text »  |  PDF »

TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction.

X. Ye, P. Mehlen, S. Rabizadeh, T. VanArsdale, H. Zhang, H. Shin, J. J. L. Wang, E. Leo, J. Zapata, C. A. Hauser, et al. (1999)
J. Biol. Chem. 274, 30202-30208
 |  Abstract »  |  Full Text »  |  PDF »

The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells.

J. E. M. van Leeuwen, P. K. Paik, and L. E. Samelson (1999)
Mol. Cell. Biol. 19, 6652-6664
 |  Abstract »  |  Full Text »  |  PDF »

Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers.

S. K. Muthuswamy, M. Gilman, and J. S. Brugge (1999)
Mol. Cell. Biol. 19, 6845-6857
 |  Abstract »  |  Full Text »  |  PDF »

CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-kappa B Activation and Apoptosis.

S. M. Srinivasula, M. Ahmad, J.-h. Lin, J.-L. Poyet, T. Fernandes-Alnemri, P. N. Tsichlis, and E. S. Alnemri (1999)
J. Biol. Chem. 274, 17946-17954
 |  Abstract »  |  Full Text »  |  PDF »

Oligomerization State Influences the Degradation Rate of 3-Hydroxy-3-methylglutaryl-CoA Reductase.

H. H. Cheng, L. Xu, H. Kumagai, and R. D. Simoni (1999)
J. Biol. Chem. 274, 17171-17178
 |  Abstract »  |  Full Text »  |  PDF »

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.

V. Baud, Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin (1999)
Genes & Dev. 13, 1297-1308
 |  Abstract »  |  Full Text »

Tyrphostin B42 Inhibits IL-12-Induced Tyrosine Phosphorylation and Activation of Janus Kinase-2 and Prevents Experimental Allergic Encephalomyelitis.

J. J. Bright, C. Du, and S. Sriram (1999)
J. Immunol. 162, 6255-6262
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic RNA modulators of an inside-out signal-transduction cascade.

M. Blind, W. Kolanus, and M. Famulok (1999)
PNAS 96, 3606-3610
 |  Abstract »  |  Full Text »  |  PDF »

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces.

R. Briesewitz, G. T. Ray, T. J. Wandless, and G. R. Crabtree (1999)
PNAS 96, 1953-1958
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Nuclear Factor of Activated T Cells-(NFAT) and Activating Protein 1 (AP-1) by Oncogenic 70Z Cbl Requires an Intact Phosphotyrosine Binding Domain but Not Crk(L) or p85 Phosphatidylinositol 3-Kinase Association.

J. E. M. van Leeuwen, P. K. Paik, and L. E. Samelson (1999)
J. Biol. Chem. 274, 5153-5162
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A Inhibits Inositol 1,4,5-Trisphosphate Binding to Its Receptors and Release of Calcium from Intracellular Stores in Peritoneal Macrophages.

U. K. Misra, G. Gawdi, and S. V. Pizzo (1998)
J. Immunol. 161, 6122-6127
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain.

A. Kawahara, Y. Ohsawa, H. Matsumura, Y. Uchiyama, and S. Nagata (1998)
J. Cell Biol. 143, 1353-1360
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Activation of Janus Kinase (JAK) Confers Factor Independence upon Interleukin-3-dependent Cells. ESSENTIAL ROLE OF Ras IN JAK-TRIGGERED MITOGENESIS.

R. Mizuguchi and M. Hatakeyama (1998)
J. Biol. Chem. 273, 32297-32303
 |  Abstract »  |  Full Text »  |  PDF »

IL-2R{alpha} on One Cell Can Present IL-2 to IL-2R{beta}/{gamma}c on Another Cell to Augment IL-2 Signaling.

D. M. Eicher and T. A. Waldmann (1998)
J. Immunol. 161, 5430-5437
 |  Abstract »  |  Full Text »  |  PDF »

PRIM: Proximity imaging of green fluorescent protein-tagged polypeptides.

D. A. De Angelis, G. Miesenbock, B. V. Zemelman, and J. E. Rothman (1998)
PNAS 95, 12312-12316
 |  Abstract »  |  Full Text »  |  PDF »

Controlling Gene Expression in Living Cells Through Small Molecule-RNA Interactions.

G. Werstuck and M. R. Green (1998)
Science 282, 296-298
 |  Abstract »  |  Full Text »

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity.

T. Clackson, W. Yang, L. W. Rozamus, M. Hatada, J. F. Amara, C. T. Rollins, L. F. Stevenson, S. R. Magari, S. A. Wood, N. L. Courage, et al. (1998)
PNAS 95, 10437-10442
 |  Abstract »  |  Full Text »  |  PDF »

Targeted expansion of genetically modified bone marrow cells.

L. Jin, N. Siritanaratkul, D. W. Emery, R. E. Richard, K. Kaushansky, T. Papayannopoulou, and C. A. Blau (1998)
PNAS 95, 8093-8097
 |  Abstract »  |  Full Text »  |  PDF »

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt.

A. D. Kohn, A. Barthel, K. S. Kovacina, A. Boge, B. Wallach, S. A. Summers, M. J. Birnbaum, P. H. Scott, J. C. Lawrence Jr., and R. A. Roth (1998)
J. Biol. Chem. 273, 11937-11943
 |  Abstract »  |  Full Text »  |  PDF »

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn.

A. S. Yap, C. M. Niessen, and B. M. Gumbiner (1998)
J. Cell Biol. 141, 779-789
 |  Abstract »  |  Full Text »  |  PDF »

A Trivalent System from Vancomycin·D-Ala-D-Ala with Higher Affinity Than Avidin·Biotin.

J. Rao, J. Lahiri, L. Isaacs, R. M. Weis, and G. M. Whitesides (1998)
Science 280, 708-711
 |  Abstract »  |  Full Text »

Synthetic activation of caspases: Artificial death switches.

R. A. MacCorkle, K. W. Freeman, and D. M. Spencer (1998)
PNAS 95, 3655-3660
 |  Abstract »  |  Full Text »  |  PDF »

Stimulating Cell Proliferation Through the Pharmacologic Activation of c-kit.

L. Jin, H. Asano, and C. Anthony Blau (1998)
Blood 91, 890-897
 |  Abstract »  |  Full Text »  |  PDF »

An Induced Proximity Model for Caspase-8 Activation.

M. Muzio, B. R. Stockwell, H. R. Stennicke, G. S. Salvesen, and V. M. Dixit (1998)
J. Biol. Chem. 273, 2926-2930
 |  Abstract »  |  Full Text »  |  PDF »

Controlling signaling with a specifically designed Gi-coupled receptor.

P. Coward, H. G. Wada, M. S. Falk, S. D. H. Chan, F. Meng, H. Akil, and B. R. Conklin (1998)
PNAS 95, 352-357
 |  Abstract »  |  Full Text »  |  PDF »

A nonnatural transcriptional coactivator.

O. Nyanguile, M. Uesugi, D. J. Austin, and G. L. Verdine (1997)
PNAS 94, 13402-13406
 |  Abstract »  |  Full Text »  |  PDF »

Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells.

T. Kondo, T. Yokokura, and S. Nagata (1997)
PNAS 94, 11951-11956
 |  Abstract »  |  Full Text »  |  PDF »

A versatile synthetic dimerizer for the regulation of protein-protein interactions.

J. F. Amara, T. Clackson, V. M. Rivera, T. Guo, T. Keenan, S. Natesan, R. Pollock, W. Yang, N. L. Courage, D. A. Holt, et al. (1997)
PNAS 94, 10618-10623
 |  Abstract »  |  Full Text »  |  PDF »

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen.

S. D. Liberles, S. T. Diver, D. J. Austin, and S. L. Schreiber (1997)
PNAS 94, 7825-7830
 |  Abstract »  |  Full Text »  |  PDF »

A proliferation switch for genetically modified cells.

C. A. Blau, K. R. Peterson, J. G. Drachman, and D. M. Spencer (1997)
PNAS 94, 3076-3081
 |  Abstract »  |  Full Text »  |  PDF »

Assembly of an active enzyme by the linkage of two protein modules.

A. E. Nixon, M. S. Warren, and S. J. Benkovic (1997)
PNAS 94, 1069-1073
 |  Abstract »  |  Full Text »  |  PDF »

A three-hybrid system for detecting small ligand-protein receptor interactions.

E. J. Licitra and J. O. Liu (1996)
PNAS 93, 12817-12821
 |  Abstract »  |  Full Text »  |  PDF »

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