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Science 12 November 1993: Vol. 262. no. 5136, pp. 1011 - 1018 DOI: 10.1126/science.8235617
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Articles
Science, Vol 262, Issue 5136, 1011-1018
Copyright © 1993 by American Association for the Advancement of Science
Multifactorial nature of human immunodeficiency virus disease: implications for therapy
AS Fauci
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
The immunopathogenic mechanisms underlying human immunodeficiency virus (HIV) disease are extremely complex; the disease process is multifactorial with multiple overlapping phases. Viral burden is substantial and viral replication occurs throughout the entire course of HIV infection. Inappropriate immune activation and elevated secretion of certain cytokines compound the pathogenic process. Profound immunosuppression ultimately occurs together with a disruption of the microenvironment of the immune system, which is probably unable to regenerate spontaneously. Thus, therapeutic strategies in HIV disease must not be unidimensional, but rather must be linked to the complex pathogenic components of the disease and must address where feasible each of the recognized pathogenic processes for the possibility of therapeutic intervention.
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| Full Text »
| PDF »
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| Abstract »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
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| Full Text »
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| Abstract »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
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283, 381-390
| Abstract »
| Full Text »
| PDF »
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J. Virol.
73, 7132-7137
| Abstract »
| Full Text »
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- M. Mata and Y. Paterson (1999)
J. Immunol.
163, 1449-1456
| Abstract »
| Full Text »
| PDF »
- T Cell-Tropic HIV gp120 Mediates CD4 and CD8 Cell Chemotaxis through CXCR4 Independent of CD4: Implications for HIV Pathogenesis.
- S. Iyengar, D. H. Schwartz, and J. E. K. Hildreth (1999)
J. Immunol.
162, 6263-6267
| Abstract »
| Full Text »
| PDF »
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- J. Leserman, E. D. Jackson, J. M. Petitto, R. N. Golden, S. G. Silva, D. O. Perkins, J. Cai, J. D. Folds, and D. L. Evans (1999)
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61, 397-406
| Abstract »
| Full Text »
| PDF »
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- E. Y. Denkers and R. T. Gazzinelli (1998)
Clin. Microbiol. Rev.
11, 569-588
| Abstract »
| Full Text »
| PDF »
- Restoration of Immune Response by a Cationic Amphiphilic Drug (AY 9944) In Vitro: A New Approach To Chemotherapy against Human Immunodeficiency Virus Type 1.
- A. Achour, J.-C. Landureau, R. Salerno-Concalves, J.-C. Mazière, and D. Zagury (1998)
Antimicrob. Agents Chemother.
42, 2482-2491
| Abstract »
| Full Text »
- Effect of Immune Activation on the Dynamics of Human Immunodeficiency Virus Replication and on the Distribution of Viral Quasispecies.
- M. A. Ostrowski, D. C. Krakauer, Y. Li, S. J. Justement, G. Learn, L. A. Ehler, S. K. Stanley, M. Nowak, and A. S. Fauci (1998)
J. Virol.
72, 7772-7784
| Abstract »
| Full Text »
| PDF »
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- M. Costner and C. J. Cockerell (1998)
Arch Dermatol
134, 1290-1292
| Full Text »
| PDF »
- Expression of Chemokine Receptors CXCR4 and CCR5 in HIV-1-Infected and Uninfected Individuals.
- M. A. Ostrowski, S. J. Justement, A. Catanzaro, C. A. Hallahan, L. A. Ehler, S. B. Mizell, P. N. Kumar, J. A. Mican, T.-W. Chun, and A. S. Fauci (1998)
J. Immunol.
161, 3195-3201
| Abstract »
| Full Text »
| PDF »
- Cytokines, Plasma Immune Activation Markers, and Clinically Relevant Surrogate Markers in Human Immunodeficiency Virus Infection.
- J. L. Fahey (1998)
Clin. Vaccine Immunol.
5, 597-603
| Full Text »
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- W. Popik, J. E. Hesselgesser, and P. M. Pitha (1998)
J. Virol.
72, 6406-6413
| Abstract »
| Full Text »
| PDF »
- HIV-1 Antigen-specific and -nonspecific B Cell Responses Are Sensitive to Combination Antiretroviral Therapy.
- L. Morris, J. M. Binley, B. A. Clas, S. Bonhoeffer, T. P. Astill, R. Kost, A. Hurley, Y. Cao, M. Markowitz, D. D. Ho, et al. (1998)
J. Exp. Med.
188, 233-245
| Abstract »
| Full Text »
| PDF »
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- T.-W. Chun, D. Engel, S. B. Mizell, L. A. Ehler, and A. S. Fauci (1998)
J. Exp. Med.
188, 83-91
| Abstract »
| Full Text »
| PDF »
- Costimulatory Pathways in Lymphocyte Proliferation Induced by the Simian Immunodeficiency Virus SIVsmmPBj14.
- L. Whetter, F. J. Novembre, M. Saucier, S. Gummuluru, and S. Dewhurst (1998)
J. Virol.
72, 6155-6158
| Abstract »
| Full Text »
| PDF »
- Inhibition of Phosphodiesterase Type IV Suppresses Human Immunodeficiency Virus Type 1 Replication and Cytokine Production in Primary T Cells: Involvement of NF-kappa B and NFAT.
- J. Navarro, C. Punzon, J. L. Jimenez, E. Fernandez-Cruz, A. Pizarro, M. Fresno, and M. A. Munoz-Fernandez (1998)
J. Virol.
72, 4712-4720
| Abstract »
| Full Text »
| PDF »
- Inhibition of Human Immunodeficiency Virus Type 1 Replication and Cytokine Production by Fluoroquinoline Derivatives.
- M. Baba, M. Okamoto, M. Kawamura, M. Makino, T. Higashida, T. Takashi, Y. Kimura, T. Ikeuchi, T. Tetsuka, and T. Okamoto (1998)
Mol. Pharmacol.
53, 1097-1103
| Abstract »
| Full Text »
- Superinduction of IL-8 in T Cells by HIV-1 Tat Protein Is Mediated Through NF-{kappa}B Factors.
- M. Ott, J. L. Lovett, L. Mueller, and E. Verdin (1998)
J. Immunol.
160, 2872-2880
| Abstract »
| Full Text »
| PDF »
- A Lymph Node-Derived Cytopathic Simian Immunodeficiency Virus Mne Variant Replicates in Nonstimulated Peripheral Blood Mononuclear Cells.
- J. T. Kimata, A. Mozaffarian, and J. Overbaugh (1998)
J. Virol.
72, 245-256
| Abstract »
| Full Text »
| PDF »
- Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes.
- G. Herbein, C. Van Lint, J. L. Lovett, and E. Verdin (1998)
J. Virol.
72, 660-670
| Abstract »
| Full Text »
| PDF »
- Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.
- T.-W. Chun, L. Stuyver, S. B. Mizell, L. A. Ehler, J. A. M. Mican, M. Baseler, A. L. Lloyd, M. A. Nowak, and A. S. Fauci (1997)
PNAS
94, 13193-13197
| Abstract »
| Full Text »
| PDF »
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- P. D. Katsikis, M. E. Garcia-Ojeda, J. F. Torres-Roca, I. M. Tijoe, C. A. Smith, L. A. Herzenberg, and L. A. Herzenberg (1997)
J. Exp. Med.
186, 1365-1372
| Abstract »
| Full Text »
| PDF »
- CD4 Cross-Linking (CD4XL) Induces RAS Activation and Tumor Necrosis Factor-alpha Secretion in CD4+ T Cells.
- S. M. L. Tamma, N. Chirmule, H. Yagura, N. Oyaizu, V. Kalyanaraman, and S. Pahwa (1997)
Blood
90, 1588-1593
| Abstract »
| Full Text »
| PDF »
- CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4+ T cells.
- A. J. Henderson and K. L. Calame (1997)
PNAS
94, 8714-8719
| Abstract »
| Full Text »
| PDF »
- Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.
- C. J. Li, Y. Ueda, B. Shi, L. Borodyansky, L. Huang, Y.-Z. Li, and A. B. Pardee (1997)
PNAS
94, 8116-8120
| Abstract »
| Full Text »
| PDF »
- Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome.
- R. Forster, G. Schweigard, S. Johann, T. Emrich, E. Kremmer, C. Nerl, and M. Lipp (1997)
Blood
90, 520-525
| Abstract »
| Full Text »
| PDF »
- Differential Effects of Interleukin-13 on Cytomegalovirus and Human Immunodeficiency Virus Infection in Human Alveolar Macrophages.
- W. C. Hatch, A. R. Freedman, D. M. Boldt-Houle, J. E. Groopman, and E. F. Terwilliger (1997)
Blood
89, 3443-3450
| Abstract »
| Full Text »
| PDF »
- Hematopoietic Stem Cell-Based Gene Therapy for Acquired Immunodeficiency Syndrome: Efficient Transduction and Expression of RevM10 in Myeloid Cells In Vivo and In Vitro.
- L. Su, R. Lee, M. Bonyhadi, H. Matsuzaki, S. Forestell, S. Escaich, E. Bohnlein, and H. Kaneshima (1997)
Blood
89, 2283-2290
| Abstract »
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- Severe Stress, Depressive Symptoms, and Changes in Lymphocyte Subsets in Human Immunodeficiency Virus--Infected Men: A 2-Year Follow-up Study.
- J. Leserman, J. M. Petitto, D. O. Perkins, J. D. Folds, R. N. Golden, and D. L. Evans (1997)
Arch Gen Psychiatry
54, 279-285
| Abstract »
| PDF »
- Upregulation of c-Fos in Activated T Lymphoid and Monocytic Cells by Human Immunodeficiency Virus-1 Tat Protein.
- D. Gibellini, A. Caputo, S. Capitani, M. La Placa, and G. Zauli (1997)
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89, 1654-1664
| Abstract »
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- Y. Yang, Z.-H. Liu, C. F. Ware, and J. D. Ashwell (1997)
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89, 550-557
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- P. Accornero, M. Radrizzani, D. Delia, F. Gerosa, R. Kurrle, and M. P. Colombo (1997)
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- M.-L. Wong, P. B. Bongiorno, V. Rettori, S. M. McCann, and J. Licinio (1997)
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- A. D. Badley, D. Dockrell, M. Simpson, R. Schut, D. H. Lynch, P. Leibson, and C. V. Paya (1997)
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- J. K. Lazdins, M. Grell, M. R. Walker, K. Woods-Cook, P. Scheurich, and K. Pfizenmaier (1997)
J. Exp. Med.
185, 81-90
| Abstract »
| Full Text »
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- E. Vicenzi, P. Bagnarelli, E. Santagostino, S. Ghezzi, M. Alfano, M. S. Sinnone, G. Fabio, L. Turchetto, G. Moretti, A. Lazzarin, et al. (1997)
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- A. S. Fauci (1996)
JAMA
276, 155-156
| Abstract »
| PDF »
- Primary HIV-1 infection: a new medical emergency?.
- S. Jolles, S. K. De Loes, M. A Johnson, and G. Janossy (1996)
BMJ
312, 1243-1244
| Full Text »
- Effect of Immunization with a Common Recall Antigen on Viral Expression in Patients Infected with Human Immunodeficiency Virus Type 1.
- S. K. Stanley, M. A. Ostrowski, J. S. Justement, K. Gantt, S. Hedayati, M. Mannix, K. Roche, D. J. Schwartzentruber, C. H. Fox, and A. S. Fauci (1996)
N. Engl. J. Med.
334, 1222-1229
| Abstract »
| Full Text »
| PDF »
- Carnitine in Human Immunodeficiency Virus Type 1 Infection/Acquired Immune Deficiency Syndrome.
- M. Mintz (1995)
J Child Neurol
10, 2S40-2S44
| Abstract »
| PDF »
- A Controlled Trial of Zidovudine in Primary Human Immunodeficiency Virus Infection.
- S. Kinloch-de Loes, B. J. Hirschel, B. Hoen, D. A. Cooper, B. Tindall, A. Carr, J.-H. Saurat, N. Clumeck, A. Lazzarin, L. Mathiesen, et al. (1995)
N. Engl. J. Med.
333, 408-413
| Abstract »
| Full Text »
| PDF »
- Stimulation of HIV Expression by Intracellular Calcium Pump Inhibition.
- Bél. Papp and R. A. Byrn (1995)
J. Biol. Chem.
270, 10278-10283
| Abstract »
| Full Text »
| PDF »
- Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
- C. Li, D. Friedman, C Wang, V Metelev, and A. Pardee (1995)
Science
268, 429-431
| Abstract »
| PDF »
- TH2 downregulation of macrophage HIV-1 replication.
- L. Montaner and S Gordon (1995)
Science
267, 538-539
| PDF »
- What to Do When Zidovudine Fails.
- M. S. Saag (1994)
N. Engl. J. Med.
330, 706-707
| Full Text »
|
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