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Science 5 November 1993:
Vol. 262. no. 5135, pp. 914 - 917
DOI: 10.1126/science.8235615
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Articles

Science, Vol 262, Issue 5135, 914-917
Copyright © 1993 by American Association for the Advancement of Science

articles

Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

ST Nichol, CF Spiropoulou, S Morzunov, PE Rollin, TG Ksiazek, H Feldmann, A Sanchez, J Childs, S Zaki, and CJ Peters

Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.

A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.


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   Abstract »    Full Text »    PDF »
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J. Virol. 77, 12203-12210
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Y.-K. CHU, R. D. OWEN, L. M. GONZALEZ, and C. B. JONSSON (2003)
Am J Trop Med Hyg 69, 263-268
   Abstract »    Full Text »    PDF »
Improvement of binding of Puumala virus neutralization site resembling peptide with a second-generation phage library.
T. Heiskanen, X.-D. Li, J. Hepojoki, E. Gustafsson, A. Lundkvist, A. Vaheri, and H. Lankinen (2003)
Protein Eng. Des. Sel. 16, 443-450
   Abstract »    Full Text »    PDF »
Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States.
G. E. Glass, T. L. Yates, J. B. Fine, T. M. Shields, J. B. Kendall, A. G. Hope, C. A. Parmenter, C. J. Peters, T. G. Ksiazek, C.-S. Li, et al. (2002)
PNAS 99, 16817-16822
   Abstract »    Full Text »    PDF »
The Multimerization of Hantavirus Nucleocapsid Protein Depends on Type-Specific Epitopes.
K. Yoshimatsu, B.-H. Lee, K. Araki, M. Morimatsu, M. Ogino, H. Ebihara, and J. Arikawa (2002)
J. Virol. 77, 943-952
   Abstract »    Full Text »    PDF »
Hantavirus Infection of Dendritic Cells.
M. J. Raftery, A. A. Kraus, R. Ulrich, D. H. Kruger, and G. Schonrich (2002)
J. Virol. 76, 10724-10733
   Abstract »    Full Text »    PDF »
Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus).
M. Bharadwaj, K. Mirowsky, C. Ye, J. Botten, B. Masten, J. Yee, C. R. Lyons, and B. Hjelle (2002)
J. Gen. Virol. 83, 1745-1751
   Abstract »    Full Text »    PDF »
Characterization of HLA-A2.1-restricted epitopes, conserved in both Hantaan and Sin Nombre viruses, in Hantaan virus-infected patients.
K.-Y. Lee, E. Chun, N.-Y. Kim, and B. L. Seong (2002)
J. Gen. Virol. 83, 1131-1136
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Analysis of Hantavirus Genetic Diversity in Argentina: S Segment-Derived Phylogeny.
M. C. Bohlman, S. P. Morzunov, J. Meissner, M. B. Taylor, K. Ishibashi, J. Rowe, S. Levis, D. Enria, and S. C. St. Jeor (2002)
J. Virol. 76, 3765-3773
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Hantavirus Pulmonary Syndrome--Vermont, 2000.
(2001)
JAMA 286, 912-913
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Hantavirus Pulmonary Syndrome Due to Andes Virus in Temuco, Chile : Clinical Experience With 16 Adults.
C. Castillo, J. Naranjo, A. Sepulveda, G. Ossa, and H. Levy (2001)
Chest 120, 548-554
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Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells.
J. B. Sundstrom, L. K. McMullan, C. F. Spiropoulou, W. C. Hooper, A. A. Ansari, C. J. Peters, and P. E. Rollin (2001)
J. Virol. 75, 6070-6085
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T-helper and humoral responses to Puumala hantavirus nucleocapsid protein: identification of T-helper epitopes in a mouse model.
C. de Carvalho Nicacio, M. Sällberg, C. Hultgren, and A. Lundkvist (2001)
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Pathogenicity of Hantaan Virus in Newborn Mice: Genetic Reassortant Study Demonstrating that a Single Amino Acid Change in Glycoprotein G1 Is Related to Virulence.
H. Ebihara, K. Yoshimatsu, M. Ogino, K. Araki, Y. Ami, H. Kariwa, I. Takashima, D. Li, and J. Arikawa (2000)
J. Virol. 74, 9245-9255
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Genetic Diversity, Distribution, and Serological Features of Hantavirus Infection in Five Countries in South America.
P. J. Padula, S. B. Colavecchia, V. P. Martínez, M. O. Gonzalez Della Valle, A. Edelstein, S. D. L. Miguel, J. Russi, J. M. Riquelme, N. Colucci, M. Almirón, et al. (2000)
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   Abstract »    Full Text »
Hantaviruses.
C. McCAUGHEY and C.A. HART (2000)
J. Med. Microbiol. 49, 587-599
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Role of Maternal Antibody in Natural Infection of Peromyscus maniculatus with Sin Nombre Virus.
M. K. Borucki, J. D. Boone, J. E. Rowe, M. C. Bohlman, E. A. Kuhn, R. DeBaca, and S. C. St. Jeor (2000)
J. Virol. 74, 2426-2429
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Development and evaluation of a solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein.
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Temporal and Spatial Analysis of Sin Nombre Virus Quasispecies in Naturally Infected Rodents.
R. Feuer, J. D. Boone, D. Netski, S. P. Morzunov, and S. C. St. Jeor (1999)
J. Virol. 73, 9544-9554
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Human Memory Cytotoxic T-Lymphocyte (CTL) Responses to Hantaan Virus Infection: Identification of Virus-Specific and Cross-Reactive CD8+ CTL Epitopes on Nucleocapsid Protein.
H. L. Van Epps, C. S. Schmaljohn, and F. A. Ennis (1999)
J. Virol. 73, 5301-5308
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The Search for Unrecognized Pathogens.
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Science 284, 1308-1310
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Cellular Entry of Hantaviruses Which Cause Hemorrhagic Fever with Renal Syndrome Is Mediated by beta 3 Integrins.
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J. Virol. 73, 3951-3959
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Practicing participatory research in American Indian communities.
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Am. J. Clinical Nutrition 69 , 755S-759S
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New York 1 and Sin Nombre Viruses Are Serotypically Distinct Viruses Associated with Hantavirus Pulmonary Syndrome.
I. Gavrilovskaya, R. LaMonica, M.-E. Fay, B. Hjelle, C. Schmaljohn, R. Shaw, and E. R. Mackow (1999)
J. Clin. Microbiol. 37, 122-126
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Sin Nombre Virus Pathogenesis in Peromyscus maniculatus.
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J. Virol. 73, 585-591
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Recombination in Tula Hantavirus Evolution: Analysis of Genetic Lineages from Slovakia.
C. Sibold, H. Meisel, D. H. Kruger, M. Labuda, J. Lysy, O. Kozuch, M. Pejcoch, A. Vaheri, and A. Plyusnin (1999)
J. Virol. 73, 667-675
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beta 3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure.
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PNAS 95, 7074-7079
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Role of Actin Microfilaments in Black Creek Canal Virus Morphogenesis.
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Genetic Analysis of the Diversity and Origin of Hantaviruses in Peromyscus leucopus Mice in North America.
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J. Virol. 72, 57-64
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Molecular diagnostics of infectious diseases.
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Clin. Chem. 43, 2021-2038
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The Public Health Threat of Emerging Viral Disease.
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J. Nutr. 127 , 951S
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PNAS 93, 15400-15404
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Hantaviruses in the United States.
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Arch Intern Med 156, 705-707
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Human and Rodent Hantavirus Infection in New York State: Public Health Significance of an Emerging Infectious Disease.
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Arch Intern Med 156, 722-726
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Utility of Emergency, Telephone-Based National Surveillance for Hantavirus Pulmonary Syndrome.
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JAMA 275, 398-400
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World Health Organization Strategy for Emerging Infectious Diseases.
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JAMA 275, 318-320
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Infectious diseases: an ecological perspective.
M. E Wilson (1995)
BMJ 311, 1681-1684
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Xenotransplantation and Xenogeneic Infections.
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N. Engl. J. Med. 333, 1498-1501
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Has Trench Fever Returned?.
D. A. Relman (1995)
N. Engl. J. Med. 332, 463-464
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More on Hantavirus in New England and New York.
S. R. Telford, J.-W. Song, R. Yanagihara, E. R. Mackow, B. J. Luft, E. Bosler, D. Goldgaber, and I. N. Gavrilovskaya (1995)
N. Engl. J. Med. 332, 337-338
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Hantavirus Infection in the Domestic Cat.
N. Nowotny, H. Weissenboeck, S. Aberle, and F. Hinterdorfer (1994)
JAMA 272, 1100-1101
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Hantavirus Pulmonary Syndrome in New England and Europe.
L. E. Brackett, J. Rotenberg, C. B. Sherman, J. Clement, P. Colson, P. McKenna, T. H. Denetclaw, W. F. Denetclaw, J. S. Duchin, R. F. Breiman, et al. (1994)
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Hantavirus Pulmonary Syndrome: A Clinical Description of 17 Patients with a Newly Recognized Disease.
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N. Engl. J. Med. 330, 949-955
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A New Hantavirus Infection in North America.
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N. Engl. J. Med. 330, 1004-1005
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