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Science 5 November 1993:
Vol. 262. no. 5135, pp. 909 - 911
DOI: 10.1126/science.7694363
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Articles

Science, Vol 262, Issue 5135, 909-911
Copyright © 1993 by American Association for the Advancement of Science

articles

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

GJ Freeman, JG Gribben, VA Boussiotis, JW Ng, VA Restivo Jr, LA Lombard, GS Gray, and LM Nadler

Division of Hematologic Malignancies, Dana-Farber Cancer Institute.

Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on antigen-presenting cells deliver essential costimulatory signals. T cell activation, in the absence of costimulation, results in T cell anergy. The B7-1 protein is a costimulator molecule that regulates interleukin-2 (IL-2) secretion by signaling through the pathway that uses CD28 and CTLA-4 (hereafter referred to as the CD28 pathway). We have cloned a counter-receptor of CD28 and CTLA-4, termed B7-2. Although only 26 percent identical to B7-1, B7-2 also costimulates IL-2 production and T cell proliferation. Unlike B7-1, B7-2 messenger RNA is constitutively expressed in unstimulated B cells. It is likely that B7-2 provides a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.


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J. Immunol. 162, 2024-2034
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   Abstract »    Full Text »    PDF »
The BB1 Monoclonal Antibody Recognizes Both Cell Surface CD74 (MHC Class II-Associated Invariant Chain) as Well as B7-1 (CD80), Resolving the Question Regarding a Third CD28/CTLA-4 Counterreceptor.
G. J. Freeman, A. A. Cardoso, V. A. Boussiotis, A. Anumanthan, R. W. Groves, T. S. Kupper, E. A. Clark, and L. M. Nadler (1998)
J. Immunol. 161, 2708-2715
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Heterogeneity of Dendritic Cells in Human Superficial Lymph Node : In Vitro Maturation of Immature Dendritic Cells intoMature or Activated Interdigitating Reticulum Cells.
K. Takahashi, K. Asagoe, J. Zaishun, H. Yanai, T. Yoshino, K. Hayashi, and T. Akagi (1998)
Am. J. Pathol. 153, 745-755
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Autoimmunity Without Diabetes in Transgenic Mice Expressing {beta} Cell-Specific CD86, But Not CD80: Parameters that Trigger Progression to Diabetes.
S. Guerder, E. E. Eynon, and R. A. Flavell (1998)
J. Immunol. 161, 2128-2140
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Fas-independent death of activated CD4+ T lymphocytes induced by CTLA-4 crosslinking.
P. Scheipers and H. Reiser (1998)
PNAS 95, 10083-10088
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