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Science 5 November 1993:
Vol. 262. no. 5135, pp. 902 - 905
DOI: 10.1126/science.8235613
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Articles

Science, Vol 262, Issue 5135, 902-905
Copyright © 1993 by American Association for the Advancement of Science

articles

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

KS Ravichandran, KK Lee, Z Songyang, LC Cantley, P Burn, and SJ Burakoff

Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.

The shc oncogene product is tyrosine-phosphorylated by Src family kinases and after its phosphorylation interacts with the adapter protein Grb2 (growth factor receptor-bound protein 2). In turn, Grb2 interacts with the guanine nucleotide exchange factor for Ras, mSOS. Because several Src family kinases participate in T cell activation and Shc functions upstream of Ras, the role of Shc in T cell signaling was examined. Shc was phosphorylated on tyrosine after activation through the T cell receptor (TCR), and subsequently interacted with Grb2 and mSOS. The Src homology region 2 (SH2) domain of Shc directly interacted with the tyrosine-phosphorylated zeta chain of the TCR. Thus, Shc may couple TCR activation to the Ras signaling pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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T. L. Geiger, D. Leitenberg, and R. A. Flavell (1999)
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K. Sakaguchi, Y. Okabayashi, Y. Kido, S. Kimura, Y. Matsumura, K. Inushima, and M. Kasuga (1998)
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M. K. Jones and J. H. Jackson (1998)
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N. S. C. van Oers, P. E. Love, E. W. Shores, and A. Weiss (1998)
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V. A. Boussiotis, G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler (1997)
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T Cell Receptor-induced Phosphorylation of Sos Requires Activity of CD45, Lck, and Protein Kinase C, but Not ERK.
H. Zhao, Y.-Y. Li, R. V. Fucini, S. E. Ross, J. E. Pessin, and G. A. Koretzky (1997)
J. Biol. Chem. 272, 21625-21634
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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
A. J. da Silva, Z. Li, C. de Vera, E. Canto, P. Findell, and C. E. Rudd (1997)
PNAS 94, 7493-7498
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Characterization of Lnk. AN ADAPTOR PROTEIN EXPRESSED IN LYMPHOCYTES.
S. Takaki, J. D. Watts, K. A. Forbush, N. T. Nguyen, J. Hayashi, J. Alberola-Ila, R. Aebersold, and R. M. Perlmutter (1997)
J. Biol. Chem. 272, 14562-14570
   Abstract »    Full Text »    PDF »
Shc Interaction with Src Homology 2Domain Containing Inositol Phosphatase (SHIP) in Vivo Requires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP.
T. D. Lamkin, S. F. Walk, L. Liu, J. E. Damen, G. Krystal, and K. S. Ravichandran (1997)
J. Biol. Chem. 272, 10396-10401
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Purification and Molecular Cloning of SH2- and SH3-Containing Inositol Polyphosphate-5-Phosphatase, Which Is Involved in the Signaling Pathway of Granulocyte-Macrophage Colony-Stimulating Factor, Erythropoietin, and Bcr-Abl.
H. Odai, K. Sasaki, A. Iwamatsu, T. Nakamoto, H. Ueno, T. Yamagata, K. Mitani, Y. Yazaki, and H. Hirai (1997)
Blood 89, 2745-2756
   Abstract »    Full Text »    PDF »
The Src Homology 2(SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis.
L. Liu, J. E. Damen, M. R. Hughes, I. Babic, F. R. Jirik, and G. Krystal (1997)
J. Biol. Chem. 272, 8983-8988
   Abstract »    Full Text »    PDF »
RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes.
R. K. Ganju, W. C. Hatch, H. Avraham, M. A. Ona, B. Druker, S. Avraham, and J. E. Groopman (1997)
J. Exp. Med. 185, 1055-1064
   Abstract »    Full Text »    PDF »
The Human SHIP Gene Is Differentially Expressed in Cell Lineages of the Bone Marrow and Blood.
S. J. Geier, P. A. Algate, K. Carlberg, D. Flowers, C. Friedman, B. Trask, and L. R. Rohrschneider (1997)
Blood 89, 1876-1885
   Abstract »    Full Text »    PDF »
Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling.
N. Fusaki, A. Iwamatsu, M. Iwashima, and J.-i. Fujisawa (1997)
J. Biol. Chem. 272, 6214-6219
   Abstract »    Full Text »    PDF »
Mutation of Tyrosines 492/493 in the Kinase Domain of ZAP-70 Affects Multiple T-cell Receptor Signaling Pathways.
D. Mege, V. Di Bartolo, V. Germain, L. Tuosto, F. Michel, and O. Acuto (1996)
J. Biol. Chem. 271, 32644-32652
   Abstract »    Full Text »    PDF »
The Inositol 5'-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation.
M. A. Osborne, G. Zenner, M. Lubinus, X. Zhang, Z. Songyang, L. C. Cantley, P. Majerus, P. Burn, and J. P. Kochan (1996)
J. Biol. Chem. 271, 29271-29278
   Abstract »    Full Text »    PDF »
beta -Tubulin Binds Src Homology 2Domains through a Region Different from the Tyrosine-phosphorylated Protein-recognizing Site.
T. Itoh, K. Miura, H. Miki, and T. Takenawa (1996)
J. Biol. Chem. 271, 27931-27935
   Abstract »    Full Text »    PDF »
Downstream Signaling Molecules Bind to Different Phosphorylated Immunoreceptor Tyrosine-based Activation Motif (ITAM) Peptides of the High Affinity IgE Receptor.
T. Kimura, H. Kihara, S. Bhattacharyya, H. Sakamoto, E. Appella, and R. P. Siraganian (1996)
J. Biol. Chem. 271, 27962-27968
   Abstract »    Full Text »    PDF »
Role of the Lck Src Homology 2and 3Domains in Protein Tyrosine Phosphorylation.
K. K. Lee-Fruman, T. L. Collins, and S. J. Burakoff (1996)
J. Biol. Chem. 271, 25003-25010
   Abstract »    Full Text »    PDF »
Normal T Cells Express Two T Cell Antigen Receptor Populations, One of Which Is Linked to the Cytoskeleton via zeta Chain and Displays a Unique Activation-dependent Phosphorylation Pattern.
S. Caplan and M. Baniyash (1996)
J. Biol. Chem. 271, 20705-20712
   Abstract »    Full Text »    PDF »
Syk-dependent Phosphorylation of Shc. A POTENTIAL LINK BETWEEN Fc&egr;RI AND THE Ras/MITOGEN-ACTIVATED PROTEIN KINASE SIGNALING PATHWAY THROUGH SOS AND Grb2.
B. Jabril-Cuenod, C. Zhang, A. M. Scharenberg, R. Paolini, R. Numerof, M. A. Beaven, and J.-P. Kinet (1996)
J. Biol. Chem. 271, 16268-16272
   Abstract »    Full Text »    PDF »
A Role for Shc, Grb2, and Raf-1 in Fcgamma RI Signal Relay.
R. K. Park, Y. Liu, and D. L. Durden (1996)
J. Biol. Chem. 271, 13342-13348
   Abstract »    Full Text »    PDF »
Evidence for a Physical Association between the Shc-PTB Domain and the beta(c) Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor.
J. C. Pratt, M. Weiss, C. A. Sieff, S. E. Shoelson, S. J. Burakoff, and K. S. Ravichandran (1996)
J. Biol. Chem. 271, 12137-12140
   Abstract »    Full Text »    PDF »
Outside-in Integrin Signal Transduction.
D. A. Law, L. Nannizzi-Alaimo, and D. R. Phillips (1996)
J. Biol. Chem. 271, 10811-10815
   Abstract »    Full Text »    PDF »
SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction.
D. B. Straus, A. C. Chan, B. Patai, and A. Weiss (1996)
J. Biol. Chem. 271, 9976-9981
   Abstract »    Full Text »    PDF »
Association between Mitogen-activated Protein Kinase and the [IMAGE] Chain of the T Cell Receptor (TcR) with the SH2,3 Domain of p56[IMAGE].
A. August and B. Dupont (1996)
J. Biol. Chem. 271, 10054-10059
   Abstract »    Full Text »    PDF »
Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors.
L. Smit, G. van der Horst, and J. Borst (1996)
J. Biol. Chem. 271, 8564-8569
   Abstract »    Full Text »    PDF »
Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G.
K. A. Reedquist, T. Fukazawa, G. Panchamoorthy, W. Y. Langdon, S. E. Shoelson, B. J. Druker, and H. Band (1996)
J. Biol. Chem. 271, 8435-8442
   Abstract »    Full Text »    PDF »
Interactions of Cbl with Two Adaptor Proteins, Grb2 and Crk, upon T Cell Activation.
Lás. Buday, A. Khwaja, S. Sipeki, A. Faragó, and J. Downward (1996)
J. Biol. Chem. 271, 6159-6163
   Abstract »    Full Text »    PDF »
Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif.
V. Mandiyan, R. O'Brien, M. Zhou, B. Margolis, M. A. Lemmon, J. M. Sturtevant, and J. Schlessinger (1996)
J. Biol. Chem. 271, 4770-4775
   Abstract »    Full Text »    PDF »
Interaction of Shc with Adaptor Protein Adaptins.
Y. Okabayashi, Y. Sugimoto, N. F. Totty, J. Hsuan, Y. Kido, K. Sakaguchi, I. Gout, M. D. Waterfield, and M. Kasuga (1996)
J. Biol. Chem. 271, 5265-5269
   Abstract »    Full Text »    PDF »
p120[IMAGE] Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase.
G. Panchamoorthy, T. Fukazawa, S. Miyake, S. Soltoff, K. Reedquist, B. Druker, S. Shoelson, L. Cantley, and H. Band (1996)
J. Biol. Chem. 271, 3187-3194
   Abstract »    Full Text »    PDF »
Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages.
M. T. Crowley, S. L. Harmer, and A. L. DeFranco (1996)
J. Biol. Chem. 271, 1145-1152
   Abstract »    Full Text »    PDF »
Src Homologous and Collagen (Shc) Protein Binds to F-actin and Translocates to the Cytoskeleton upon Nerve Growth Factor Stimulation in PC12 Cells.
D. Thomas, S. D. Patterson, and R. A. Bradshaw (1995)
J. Biol. Chem. 270, 28924-28931
   Abstract »    Full Text »    PDF »
Association of Activated Phosphatidylinositol 3-Kinase with p120[IMAGE] in Antigen Receptor-ligated B Cells.
T. J. Kim, Y.-T. Kim, and S. Pillai (1995)
J. Biol. Chem. 270, 27504-27509
   Abstract »    Full Text »    PDF »
Ras Is Not Required for the Interleukin 3-induced Proliferation of a Mouse Pro-B Cell Line, BaF3.
K. Terada, Y. Kaziro, and T. Satoh (1995)
J. Biol. Chem. 270, 27880-27886
   Abstract »    Full Text »    PDF »
Binding of Shc to the NPXY Motif Is Mediated by Its N-terminal Domain.
S. A. Prigent, T. S. Pillay, K. S. Ravichandran, and W. J. Gullick (1995)
J. Biol. Chem. 270, 22097-22100
   Abstract »    Full Text »    PDF »
An Epidermal Growth Factor Receptor-Leukocyte Tyrosine Kinase Chimeric Receptor Generates Ligand-dependent Growth Signals through the Ras Signaling Pathway.
H. Ueno, N. Hirano, H. Kozutsumi, K. Sasaki, T. Tanaka, Y. Yazaki, and H. Hirai (1995)
J. Biol. Chem. 270, 20135-20142
   Abstract »    Full Text »    PDF »
T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-[IMAGE]1-binding Phosphotyrosyl Protein pp36/38.
T. Fukazawa, K. A. Reedquist, G. Panchamoorthy, S. Soltoff, T. Trub, B. Druker, L. Cantley, S. E. Shoelson, and H. Band (1995)
J. Biol. Chem. 270, 20177-20182
   Abstract »    Full Text »    PDF »
The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120.
T. Fukazawa, K. A. Reedquist, T. Trub, S. Soltoff, G. Panchamoorthy, B. Druker, L. Cantley, S. E. Shoelson, and H. Band (1995)
J. Biol. Chem. 270, 19141-19150
   Abstract »    Full Text »    PDF »
Specificity of the PTB Domain of Shc for beta Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine.
T. Trb, W. E. Choi, G. Wolf, E. Ottinger, Y. Chen, M. Weiss, and S. E. Shoelson (1995)
J. Biol. Chem. 270, 18205-18208
   Abstract »    Full Text »    PDF »
Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-[IMAGE]1, and Other Phosphoproteins with Grb2 and the [IMAGE]-Chain of the TCR.
AndrE. Nel, S. Gupta, L. Lee, J. A. Ledbetter, and S. B. Kanner (1995)
J. Biol. Chem. 270, 18428-18436
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Non-SH2 Domains within Insulin Receptor Substrate-1 and SHC Mediate Their Phosphotyrosine-dependent Interaction with the NPEY Motif of the Insulin-like Growth Factor I Receptor.
A. Craparo, T. J. O'Neill, and T. A. Gustafson (1995)
J. Biol. Chem. 270, 15639-15643
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The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif.
Z. Songyang, B. Margolis, M. Chaudhuri, S. E. Shoelson, and L. C. Cantley (1995)
J. Biol. Chem. 270, 14863-14866
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A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor [IMAGE] Chain Tyrosine-based Activation Motif.
N. Osman, S. C. Lucas, H. Turner, and D. Cantrell (1995)
J. Biol. Chem. 270, 13981-13986
   Abstract »    Full Text »    PDF »
The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells.
H. Odai, K. Sasaki, A. Iwamatsu, Y. Hanazono, T. Tanaka, K. Mitani, Y. Yazaki, and H. Hirai (1995)
J. Biol. Chem. 270, 10800-10805
   Abstract »    Full Text »    PDF »
Regulation of the Adapter Molecule Grb2 by the Fc[IMAGE]R1 in the Mast Cell Line RBL2H3.
H. Turner, K. Reif, J. Rivera, and D. A. Cantrell (1995)
J. Biol. Chem. 270, 9500-9506
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling.
K. Nagai, M. Takata, H. Yamamura, and T. Kurosaki (1995)
J. Biol. Chem. 270, 6824-6829
   Abstract »    Full Text »    PDF »
Crk Interacts with Tyrosine-phosphorylated p116 upon T Cell Activation.
S. Sawasdikosol, K. S. Ravichandran, K. K. Lee, J.-H. Chang, and S. J. Burakoff (1995)
J. Biol. Chem. 270, 2893-2896
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F(2)(Pmp)(2)-TAM[IMAGE](3), a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling.
R. L. Wange, N. Isakov, T. R. Burke Jr., A. Otaka, P. P. Roller, J. D. Watts, R. Aebersold, and L. E. Samelson (1995)
J. Biol. Chem. 270, 944-948
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Identification of Shc as the Primary Protein Binding to the Tyrosine-phosphorylated beta 3 Subunit of alpha IIbbeta 3 during Outside-in Integrin Platelet Signaling.
K. J. Cowan, D. A. Law, and D. R. Phillips (2000)
J. Biol. Chem. 275, 36423-36429
   Abstract »    Full Text »    PDF »
Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.
M. Iwashima, M. Takamatsu, H. Yamagishi, Y. Hatanaka, Y.-Y. Huang, C. McGinty, S. Yamasaki, and T. Koike (2002)
PNAS 99, 4544-4549
   Abstract »    Full Text »    PDF »


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