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Science 29 October 1993: Vol. 262. no. 5134, pp. 695 - 700 DOI: 10.1126/science.8235590
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Articles
Science, Vol 262, Issue 5134, 695-700
Copyright © 1993 by American Association for the Advancement of Science
Programmed cell death and the control of cell survival: lessons from the nervous system
MC Raff,
BA Barres,
JF Burne,
HS Coles,
Y Ishizaki,
and
MD Jacobson
Developmental Neurobiology Programme, University College London, United Kingdom.
During the development of the vertebrate nervous system, up to 50 percent or more of many types of neurons normally die soon after they form synaptic connections with their target cells. This massive cell death is thought to reflect the failure of these neurons to obtain adequate amounts of specific neurotrophic factors that are produced by the target cells and that are required for the neurons to survive. This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive. These survival signals seem to act by suppressing an intrinsic cell suicide program, the protein components of which are apparently expressed constitutively in most cell types.
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PNAS
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