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Science 29 October 1993:
Vol. 262. no. 5134, pp. 695 - 700
DOI: 10.1126/science.8235590

Articles

Science, Vol 262, Issue 5134, 695-700
Copyright © 1993 by American Association for the Advancement of Science


articles

Programmed cell death and the control of cell survival: lessons from the nervous system

MC Raff, BA Barres, JF Burne, HS Coles, Y Ishizaki, and MD Jacobson

Developmental Neurobiology Programme, University College London, United Kingdom.

During the development of the vertebrate nervous system, up to 50 percent or more of many types of neurons normally die soon after they form synaptic connections with their target cells. This massive cell death is thought to reflect the failure of these neurons to obtain adequate amounts of specific neurotrophic factors that are produced by the target cells and that are required for the neurons to survive. This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive. These survival signals seem to act by suppressing an intrinsic cell suicide program, the protein components of which are apparently expressed constitutively in most cell types.


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The intracellular parasite Theileria parva protects infected T cells from apoptosis.
V. T. Heussler, J. Machado Jr, P. C. Fernandez, C. Botteron, C.-G. Chen, M. J. Pearse, and D. A. E. Dobbelaere (1999)
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The p75NTR-induced Apoptotic Program Develops through a Ceramide-Caspase Pathway Negatively Regulated by Nitric Oxide.
J.-P. Lievremont, C. Sciorati, E. Morandi, C. Paolucci, G. Bunone, G. Della Valle, J. Meldolesi, and E. Clementi (1999)
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Developing Schwann Cells Acquire the Ability to Survive without Axons by Establishing an Autocrine Circuit Involving Insulin-Like Growth Factor, Neurotrophin-3, and Platelet-Derived Growth Factor-BB.
C. Meier, E. Parmantier, A. Brennan, R. Mirsky, and K. R. Jessen (1999)
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Tumor Necrosis Factor-alpha Mediates Both Apoptotic Cell Death and Cell Proliferation in a Human Hematopoietic Cell Line Dependent on Mitotic Activity and Receptor Subtype Expression.
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J. Biol. Chem. 274, 9539-9547
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The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
A. Delacourte, J. P. David, N. Sergeant, L. Buee, A. Wattez, P. Vermersch, F. Ghozali, C. Fallet-Bianco, F. Pasquier, F. Lebert, et al. (1999)
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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
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   Abstract »    Full Text »    PDF »
Acetyl-11-Keto-beta -Boswellic Acid Induces Apoptosis in HL-60 and CCRF-CEM Cells and Inhibits Topoisomerase I.
R. F. Hoernlein, Th. Orlikowsky, C. Zehrer, D. Niethammer, E. R. Sailer, Th. Simmet, G. E. Dannecker, and H. P. T. Ammon (1999)
J. Pharmacol. Exp. Ther. 288, 613-619
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Migration and function of glia in the developing Drosophila eye.
R Rangarajan, Q Gong, and U Gaul (1999)
Development 126, 3285-3292
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Neurogenesis, cell death and regeneration in the adult gymnotiform brain.
G. Zupanc (1999)
J. Exp. Biol. 202, 1435-1446
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Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death.
H. Le-Niculescu, E. Bonfoco, Y. Kasuya, F.-X. Claret, D. R. Green, and M. Karin (1999)
Mol. Cell. Biol. 19, 751-763
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