Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 15 October 1993:
Vol. 262. no. 5132, pp. 436 - 438
DOI: 10.1126/science.7692600

Articles

Science, Vol 262, Issue 5132, 436-438
Copyright © 1993 by American Association for the Advancement of Science


articles

Binding of L-selectin to the vascular sialomucin CD34

S Baumheter, MS Singer, W Henzel, S Hemmerich, M Renz, SD Rosen, and LA Lasky

Department of Immunology, Genentech, Inc., South San Francisco, CA 94080.

The adhesive interactions between leukocyte L-selectin and the endothelium are involved in the migration of lymphocytes through peripheral lymph nodes and of neutrophils to sites of inflammation. A recombinant L-selectin stains high endothelial venules (HEVs) in lymph nodes and recognizes sulfated carbohydrates found on two endothelial glycoproteins, Sgp50 and Sgp90. Amino acid sequencing of purified Sgp90 revealed a protein core identical to that CD34, a sialomucin expressed on hematopoietic stem cells and endothelium. A polyclonal antiserum to recombinant murine CD34 stains peripheral lymph node endothelium and recognizes Sgp90 that is functionally bound by L-selectin. Thus, an HEV glycoform of CD34 can function as a ligand for L-selectin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
P-Selectin Glycoprotein Ligand-1 Negatively Regulates T-Cell Immune Responses.
M. Matsumoto, M. Miyasaka, and T. Hirata (2009)
J. Immunol. 183, 7204-7211
   Abstract »    Full Text »    PDF »
Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo.
J. E. Testa, A. Chrastina, P. Oh, Y. Li, H. Witkiewicz, M. Czarny, T. Buss, and J. E. Schnitzer (2009)
Am J Physiol Lung Cell Mol Physiol 297, L251-L262
   Abstract »    Full Text »    PDF »
The Role of Podocalyxin in Health and Disease.
J. S. Nielsen and K. M. McNagny (2009)
J. Am. Soc. Nephrol. 20, 1669-1676
   Abstract »    Full Text »    PDF »
Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans.
G. H. Mir, J. Helin, K.-P. Skarp, R. D. Cummings, A. Makitie, R. Renkonen, and A. Leppanen (2009)
Blood 114, 733-741
   Abstract »    Full Text »    PDF »
Novel functions of the CD34 family.
J. S. Nielsen and K. M. McNagny (2008)
J. Cell Sci. 121, 3683-3692
   Abstract »    Full Text »    PDF »
Endoglycan, a Member of the CD34 Family of Sialomucins, Is a Ligand for the Vascular Selectins.
S. C. Kerr, C. B. Fieger, K. R. Snapp, and S. D. Rosen (2008)
J. Immunol. 181, 1480-1490
   Abstract »    Full Text »    PDF »
Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes.
I. Ahrens, C. Ellwanger, B. K. Smith, N. Bassler, Y. C. Chen, I. Neudorfer, A. Ludwig, C. Bode, and K. Peter (2008)
J. Leukoc. Biol. 83, 1388-1395
   Abstract »    Full Text »    PDF »
CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice.
C. S. Trempus, R. J. Morris, M. Ehinger, A. Elmore, C. D. Bortner, M. Ito, G. Cotsarelis, J. G.W. Nijhof, J. Peckham, N. Flagler, et al. (2007)
Cancer Res. 67, 4173-4181
   Abstract »    Full Text »    PDF »
Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.
E. Umemoto, T. Tanaka, H. Kanda, S. Jin, K. Tohya, K. Otani, T. Matsutani, M. Matsumoto, Y. Ebisuno, M. H. Jang, et al. (2006)
J. Exp. Med. 203, 1603-1614
   Abstract »    Full Text »    PDF »
Multiple Hepatic Receptors Cooperate to Eliminate Secretory Mucins Aberrantly Entering the Bloodstream: Are Circulating Cancer Mucins the "Tip of the Iceberg"?.
M. G. Wahrenbrock and A. Varki (2006)
Cancer Res. 66, 2433-2441
   Abstract »    Full Text »    PDF »
Selectin Ligand-Independent Priming and Maintenance of T Cell Immunity during Airborne Tuberculosis.
T. Schreiber, S. Ehlers, S. Aly, A. Holscher, S. Hartmann, M. Lipp, J. B. Lowe, and C. Holscher (2006)
J. Immunol. 176, 1131-1140
   Abstract »    Full Text »    PDF »
CD43 Functions as a Ligand for E-Selectin on Activated T Cells.
M. Matsumoto, K. Atarashi, E. Umemoto, Y. Furukawa, A. Shigeta, M. Miyasaka, and T. Hirata (2005)
J. Immunol. 175, 8042-8050
   Abstract »    Full Text »    PDF »
Core 2 branching {beta}1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes.
J.-M. Gauguet, S. D. Rosen, J. D. Marth, and U. H. von Andrian (2004)
Blood 104, 4104-4112
   Abstract »    Full Text »    PDF »
Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling.
H. Kanda, T. Tanaka, M. Matsumoto, E. Umemoto, Y. Ebisuno, M. Kinoshita, M. Noda, R. Kannagi, T. Hirata, T. Murai, et al. (2004)
Int. Immunol. 16, 1265-1274
   Abstract »    Full Text »    PDF »
N-Acetylglucosamine 6-O-Sulfotransferase-1 Regulates Expression of L-Selectin Ligands and Lymphocyte Homing.
K. Uchimura, K. Kadomatsu, F. M. El-Fasakhany, M. S. Singer, M. Izawa, R. Kannagi, N. Takeda, S. D. Rosen, and T. Muramatsu (2004)
J. Biol. Chem. 279, 35001-35008
   Abstract »    Full Text »    PDF »
Molecular Cloning, Genomic Structure, and Expression Analysis of MUC20, a Novel Mucin Protein, Up-regulated in Injured Kidney.
T. Higuchi, T. Orita, S. Nakanishi, K. Katsuya, H. Watanabe, Y. Yamasaki, I. Waga, T. Nanayama, Y. Yamamoto, W. Munger, et al. (2004)
J. Biol. Chem. 279, 1968-1979
   Abstract »    Full Text »    PDF »
Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury.
M. Yamada, H. Kubo, S. Kobayashi, K. Ishizawa, M. Numasaki, S. Ueda, T. Suzuki, and H. Sasaki (2004)
J. Immunol. 172, 1266-1272
   Abstract »    Full Text »    PDF »
Molecular Identification of Aggrus/T1{alpha} as a Platelet Aggregation-inducing Factor Expressed in Colorectal Tumors.
Y. Kato, N. Fujita, A. Kunita, S. Sato, M. Kaneko, M. Osawa, and T. Tsuruo (2003)
J. Biol. Chem. 278, 51599-51605
   Abstract »    Full Text »    PDF »
Lymphocyte-HEV Interactions in Lymph Nodes of a Sulfotransferase-deficient Mouse.
A. van Zante, J.-M. Gauguet, A. Bistrup, D. Tsay, U. H. von Andrian, and S. D. Rosen (2003)
J. Exp. Med. 198, 1289-1300
   Abstract »    Full Text »    PDF »
A Novel Endothelial L-Selectin Ligand Activity in Lymph Node Medulla That Is Regulated by {alpha}(1,3)-Fucosyltransferase-IV.
C. M'Rini, G. Cheng, C. Schweitzer, L. L. Cavanagh, R. T. Palframan, T. R. Mempel, R. A. Warnock, J. B. Lowe, E. J. Quackenbush, and U. H. von Andrian (2003)
J. Exp. Med. 198, 1301-1312
   Abstract »    Full Text »    PDF »
Expression of CD34 and L-Selectin on Human Corneal Keratocytes.
A. Joseph, P. Hossain, S. Jham, R. E. Jones, P. Tighe, R. S. McIntosh, and H. S. Dua (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4689-4692
   Abstract »    Full Text »    PDF »
Golgi Localization of Carbohydrate Sulfotransferases Is a Determinant of L-selectin Ligand Biosynthesis.
C. L. de Graffenried and C. R. Bertozzi (2003)
J. Biol. Chem. 278, 40282-40295
   Abstract »    Full Text »    PDF »
A functional overlap of plasminogen and MMPs regulates vascularization during placental development.
H. Solberg, J. Rinkenberger, K. Dano, Z. Werb, and L. R. Lund (2003)
Development 130, 4439-4450
   Abstract »    Full Text »    PDF »
TNF-{alpha} increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans.
M. Delcommenne, R. Kannagi, and P. Johnson (2002)
Glycobiology 12, 613-622
   Abstract »    Full Text »    PDF »
Distinct Sulfation Requirements of Selectins Disclosed Using Cells That Support Rolling Mediated by All Three Selectins under Shear Flow. L-SELECTIN PREFERS CARBOHYDRATE 6-SULFATION TO TYROSINE SULFATION, WHEREAS P-SELECTIN DOES NOT.
A. Kanamori, N. Kojima, K. Uchimura, T. Muramatsu, T. Tamatani, M. C. Berndt, G. S. Kansas, and R. Kannagi (2002)
J. Biol. Chem. 277, 32578-32586
   Abstract »    Full Text »    PDF »
A Functional Role for Circulating Mouse L-Selectin in Regulating Leukocyte/Endothelial Cell Interactions In Vivo.
L. Tu, J. C. Poe, T. Kadono, G. M. Venturi, D. C. Bullard, T. F. Tedder, and D. A. Steeber (2002)
J. Immunol. 169, 2034-2043
   Abstract »    Full Text »    PDF »
The myelin basic protein gene is expressed in differentiated blood cell lineages and in hemopoietic progenitors.
M. C. Marty, F. Alliot, J. Rutin, R. Fritz, D. Trisler, and B. Pessac (2002)
PNAS 99, 8856-8861
   Abstract »    Full Text »    PDF »
Vascular Morphogenesis and Differentiation after Adoptive Transfer of Human Endothelial Cells to Immunodeficient Mice.
D. K. Skovseth, T. Yamanaka, P. Brandtzaeg, E. C. Butcher, and G. Haraldsen (2002)
Am. J. Pathol. 160, 1629-1637
   Abstract »    Full Text »    PDF »
Human Endomucin : Distribution Pattern, Expression on High Endothelial Venules, and Decoration with the MECA-79 Epitope.
U. Samulowitz, A. Kuhn, G. Brachtendorf, R. Nawroth, A. Braun, A. Bankfalvi, W. Bocker, and D. Vestweber (2002)
Am. J. Pathol. 160, 1669-1681
   Abstract »    Full Text »    PDF »
Specificities of N-Acetylglucosamine-6-O-sulfotransferases in Relation to L-selectin Ligand Synthesis and Tumor-associated Enzyme Expression.
K. Uchimura, F. M. El-Fasakhany, M. Hori, S. Hemmerich, S. E. Blink, G. S. Kansas, A. Kanamori, K. Kumamoto, R. Kannagi, and T. Muramatsu (2002)
J. Biol. Chem. 277, 3979-3984
   Abstract »    Full Text »    PDF »
Gene Expression Profiling of Mucosal Addressin Cell Adhesion Molecule-1+ High Endothelial Venule Cells (HEV) and Identification of a Leucine-Rich HEV Glycoprotein as a HEV Marker.
K. Saito, T. Tanaka, H. Kanda, Y. Ebisuno, D. Izawa, S. Kawamoto, K. Okubo, and M. Miyasaka (2002)
J. Immunol. 168, 1050-1059
   Abstract »    Full Text »    PDF »
Hydrodynamic Shear Regulates the Kinetics and Receptor Specificity of Polymorphonuclear Leukocyte-Colon Carcinoma Cell Adhesive Interactions.
S. Jadhav, B. S. Bochner, and K. Konstantopoulos (2001)
J. Immunol. 167, 5986-5993
   Abstract »    Full Text »    PDF »
Anuria, Omphalocele, and Perinatal Lethality in Mice Lacking the Cd34-Related Protein Podocalyxin.
R. Doyonnas, D. B. Kershaw, C. Duhme, H. Merkens, S. Chelliah, T. Graf, and K. M. McNagny (2001)
J. Exp. Med. 194, 13-28
   Abstract »    Full Text »    PDF »
The adapter protein CrkL associates with CD34.
D. M. Felschow, M. L. McVeigh, G. T. Hoehn, C. I. Civin, and M. J. Fackler (2001)
Blood 97, 3768-3775
   Abstract »    Full Text »    PDF »
CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.
X. Li, L. Tu, P. G Murphy, T. Kadono, D. A Steeber, and T. F. Tedder (2001)
J. Leukoc. Biol. 69, 565-574
   Abstract »    Full Text »
CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages.
S. Matsuoka, Y. Ebihara, M.-j. Xu, T. Ishii, D. Sugiyama, H. Yoshino, T. Ueda, A. Manabe, R. Tanaka, Y. Ikeda, et al. (2001)
Blood 97, 419-425
   Abstract »    Full Text »    PDF »
A Significant Role of Stromal Fibroblasts in Rapidly Progressive Dry Eye in Patients with Chronic GVHD.
Y. Ogawa, K. Yamazaki, M. Kuwana, Y. Mashima, Y. Nakamura, S. Ishida, I. Toda, Y. Oguchi, K. Tsubota, S. Okamoto, et al. (2001)
Invest. Ophthalmol. Vis. Sci. 42, 111-119
   Abstract »    Full Text »
A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity.
R. Sackstein and C. J. Dimitroff (2000)
Blood 96, 2765-2774
   Abstract »    Full Text »    PDF »
MINI REVIEW Carbohydrate sulfotransferases in lymphocyte homing.
S. Hemmerich and S. D. Rosen (2000)
Glycobiology 10, 849-856
   Abstract »    Full Text »    PDF »
CD164 Monoclonal Antibodies That Block Hemopoietic Progenitor Cell Adhesion and Proliferation Interact with the First Mucin Domain of the CD164 Receptor.
R. Doyonnas, J. Yi-Hsin Chan, L. H. Butler, I. Rappold, J. E. Lee-Prudhoe, A. C. W. Zannettino, P. J. Simmons, H.-J. Buhring, J.-P. Levesque, and S. M. Watt (2000)
J. Immunol. 165, 840-851
   Abstract »    Full Text »    PDF »
Identification of Endoglycan, a Member of the CD34/Podocalyxin Family of Sialomucins.
C. Sassetti, A. Van Zante, and S. D. Rosen (2000)
J. Biol. Chem. 275, 9001-9010
   Abstract »    Full Text »    PDF »
Therapeutic Relevance of CD34 Cell Dose in Blood Cell Transplantation for Cancer Therapy.
S. Siena, R. Schiavo, P. Pedrazzoli, and C. Carlo-Stella (2000)
J. Clin. Oncol. 18, 1360-1377
   Abstract »    Full Text »    PDF »
Vasculogenesis in the day 6.5 to 9.5 mouse embryo.
C. J. Drake and P. A. Fleming (2000)
Blood 95, 1671-1679
   Abstract »    Full Text »    PDF »
Targeted Gene Disruption Demonstrates That P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is Required for P-Selectin-Mediated but Not E-Selectin-Mediated Neutrophil Rolling and Migration.
J. Yang, T. Hirata, K. Croce, G. Merrill-Skoloff, B. Tchernychev, E. Williams, R. Flaumenhaft, B. C. Furie, and B. Furie (1999)
J. Exp. Med. 190, 1769-1782
   Abstract »    Full Text »    PDF »
L-Selectin Ligands Expressed by Human Leukocytes Are HECA-452 Antibody-Defined Carbohydrate Epitopes Preferentially Displayed by P-Selectin Glycoprotein Ligand-1.
L. Tu, P. G. Murphy, X. Li, and T. F. Tedder (1999)
J. Immunol. 163, 5070-5078
   Abstract »    Full Text »    PDF »
Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules.
J.-P. Girard, E. S. Baekkevold, J. Feliu, P. Brandtzaeg, and F. Amalric (1999)
PNAS 96, 12772-12777
   Abstract »    Full Text »    PDF »
Endothelial Ligands for L-Selectin : From Lymphocyte Recirculation to Allograft Rejection.
S. D. Rosen (1999)
Am. J. Pathol. 155, 1013-1020
   Full Text »    PDF »
Endothelial L-Selectin Ligands Are Likely to Recruit Lymphocytes into Rejecting Human Heart Transplants.
S. Toppila, T. Paavonen, M. S. Nieminen, P. Hayry, and R. Renkonen (1999)
Am. J. Pathol. 155, 1303-1310
   Abstract »    Full Text »    PDF »
Lymphocyte Adhesion to Epithelia and Endothelia Mediated by the Lymphocyte Endothelial-Epithelial Cell Adhesion Molecule Glycoprotein.
C.-C. Shieh, B. K. Sadasivan, G. J. Russell, M. P. Schon, C. M. Parker, and M. B. Brenner (1999)
J. Immunol. 163, 1592-1601
   Abstract »    Full Text »    PDF »
A Common Signaling Pathway Via Syk and Lyn Tyrosine Kinases Generated From Capping of the Sialomucins CD34 and CD43 in Immature Hematopoietic Cells.
J.-i. Tada, M. Omine, T. Suda, and N. Yamaguchi (1999)
Blood 93, 3723-3735
   Abstract »    Full Text »    PDF »
Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin.
A. Bistrup, S. Bhakta, J. K. Lee, Y. Y. Belov, M. D. Gunn, F.-R. Zuo, C.-C. Huang, R. Kannagi, S. D. Rosen, and S. Hemmerich (1999)
J. Cell Biol. 145, 899-910
   Abstract »    Full Text »    PDF »
The Proteoglycan Lectin Domain Binds Sulfated Cell Surface Glycolipids and Promotes Cell Adhesion.
R. Miura, A. Aspberg, I. M. Ethell, K. Hagihara, R. L. Schnaar, E. Ruoslahti, and Y. Yamaguchi (1999)
J. Biol. Chem. 274, 11431-11438
   Abstract »    Full Text »    PDF »
Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha 1right-arrow3 fucosyltransferase VII and newly cloned GlcNAcbeta :6-sulfotransferase cDNA.
N. Kimura, C. Mitsuoka, A. Kanamori, N. Hiraiwa, K. Uchimura, T. Muramatsu, T. Tamatani, G. S. Kansas, and R. Kannagi (1999)
PNAS 96, 4530-4535
   Abstract »    Full Text »    PDF »
Identification and characterization of ligands for L-selectin in the kidney. I. Versican, a large chondroitin sulfate proteoglycan, is a ligand for L-selectin.
H. Kawashima, Y.-F. Li, N. Watanabe, J. Hirose, M. Hirose, and M. Miyasaka (1999)
Int. Immunol. 11, 393-405
   Abstract »    Full Text »    PDF »
The Cutaneous Lymphocyte Antigen Is an Essential Component of the L-selectin Ligand Induced on Human Vascular Endothelial Cells.
L. Tu, M. D. Delahunty, H. Ding, F. W. Luscinskas, and T. F. Tedder (1999)
J. Exp. Med. 189, 241-252
   Abstract »    Full Text »    PDF »
Biochemical Characterization and Molecular Cloning of a Novel Endothelial-Specific Sialomucin.
S. M. Morgan, U. Samulowitz, L. Darley, D. L. Simmons, and D. Vestweber (1999)
Blood 93, 165-175
   Abstract »    Full Text »    PDF »
Synthesis of Poly-N-acetyllactosamine in Core 2 Branched O-Glycans. THE REQUIREMENT OF NOVEL beta -1,4-GALACTOSYLTRANSFERASE IV AND beta -1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE.
M. Ujita, J. McAuliffe, T. Schwientek, R. Almeida, O. Hindsgaul, H. Clausen, and M. Fukuda (1998)
J. Biol. Chem. 273, 34843-34849
   Abstract »    Full Text »    PDF »
Integration of Endothelial Cells in Multicellular Spheroids Prevents Apoptosis and Induces Differentiation.
T. Korff and H. G. Augustin (1998)
J. Cell Biol. 143, 1341-1352
   Abstract »    Full Text »    PDF »
Regulation of T Lymphocyte Trafficking into Lymph Nodes During an Immune Response by the Chemokines Macrophage Inflammatory Protein (MIP)-1{alpha} and MIP-1{beta}.
N. Tedla, H.-W. Wang, H. P. McNeil, N. Di Girolamo, T. Hampartzoumian, D. Wakefield, and A. Lloyd (1998)
J. Immunol. 161, 5663-5672
   Abstract »    Full Text »    PDF »
Antagonism of Selectin-Dependent Adhesion of Human Eosinophils and Neutrophils by Glycomimetics and Oligosaccharide Compounds.
M.-K. Kim, B. K. Brandley, M. B. Anderson, and B. S. Bochner (1998)
Am. J. Respir. Cell Mol. Biol. 19, 836-841
   Abstract »    Full Text »
Relationship Between Cleaved L-Selectin Levels and the Outcome of Acute Myeloid Leukemia.
M. Extermann, M. Bacchi, N. Monai, M. Fopp, M. Fey, A. Tichelli, M. Schapira, and O. Spertini (1998)
Blood 92, 3115-3122
   Abstract »    Full Text »    PDF »
The Sialomucin CD164 (MGC-24v) Is an Adhesive Glycoprotein Expressed by Human Hematopoietic Progenitors and Bone Marrow Stromal Cells That Serves as a Potent Negative Regulator of Hematopoiesis.
A. C.W. Zannettino, H.-J. Buhring, S. Niutta, S. M. Watt, M. A. Benton, and P. J. Simmons (1998)
Blood 92, 2613-2628
   Abstract »    Full Text »    PDF »
CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21.
S. M. Watt, H.-J. Buhring, I. Rappold, J. Y.-H. Chan, J. Lee-Prudhoe, T. Jones, A. C.W. Zannettino, P. J. Simmons, R. Doyonnas, D. Sheer, et al. (1998)
Blood 92, 849-866
   Abstract »    Full Text »    PDF »
Identification of Podocalyxin-like Protein as a High Endothelial Venule Ligand for L-selectin: Parallels to CD34.
C. Sassetti, K. Tangemann, M. S. Singer, D. B. Kershaw, and S. D. Rosen (1998)
J. Exp. Med. 187, 1965-1975
   Abstract »    Full Text »    PDF »
The Role of Two Distinct Endothelial Molecules, Vascular Adhesion Protein-1 and Peripheral Lymph Node Addressin, in the Binding of Lymphocyte Subsets to Human Lymph Nodes.
M. Salmi, J. Hellman, and S. Jalkanen (1998)
J. Immunol. 160, 5629-5636
   Abstract »    Full Text »    PDF »
Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase.
J.-P. Girard, E. S. Baekkevold, and F. Amalric (1998)
FASEB J 12, 603-612
   Abstract »    Full Text »
The Cytoplasmic Domain of Stem Cell Antigen CD34 Is Essential for Cytoadhesion Signaling But Not Sufficient for Proliferation Signaling.
M. C.-T. Hu and S. L. Chien (1998)
Blood 91, 1152-1162
   Abstract »    Full Text »    PDF »
L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules.
R. A. Clark, R. C. Fuhlbrigge, and T. A. Springer (1998)
J. Cell Biol. 140, 721-731
   Abstract »    Full Text »    PDF »
Affinity and Kinetic Analysis of L-selectin (CD62L) Binding to Glycosylation-dependent Cell-adhesion Molecule-1.
M. W. Nicholson, A. N. Barclay, M. S. Singer, S. D. Rosen, and P. A. van der Merwe (1998)
J. Biol. Chem. 273, 763-770
   Abstract »    Full Text »    PDF »
A Novel P-Selectin Glycoprotein Ligand-1 Monoclonal Antibody Recognizes an Epitope Within the Tyrosine Sulfate Motif of Human PSGL-1 and Blocks Recognition of Both P- and L-Selectin.
K. R. Snapp, H. Ding, K. Atkins, R. Warnke, F. W. Luscinskas, and G. S. Kansas (1998)
Blood 91, 154-164
   Abstract »    Full Text »    PDF »
CD34 Expression Patterns During Early Mouse Development Are Related to Modes of Blood Vessel Formation and Reveal Additional Sites of Hematopoiesis.
H. B. Wood, G. May, L. Healy, T. Enver, and G. M. Morriss-Kay (1997)
Blood 90, 2300-2311
   Abstract »    Full Text »    PDF »
The P-Selectin Glycoprotein Ligand-1 Is Important for Recruitment of Neutrophils Into Inflamed Mouse Peritoneum.
E. Borges, R. Eytner, T. Moll, M. Steegmaier, M. A. Campbell, K. Ley, H. Mossmann, and D. Vestweber (1997)
Blood 90, 1934-1942
   Abstract »    Full Text »    PDF »
Heterogeneity of Endothelial Cells : Specific Markers.
C. Garlanda and E. Dejana (1997)
Arterioscler Thromb Vasc Biol 17, 1193-1202
   Abstract »    Full Text »
Glucocorticoid Receptor Regulates Expression of L-Selectin and CD11/CD18 on Human Neutrophils.
J. G. Filep, A. Delalandre, Y. Payette, and E. Foldes-Filep (1997)
Circulation 96, 295-301
   Abstract »    Full Text »
L-Selectin-Dependent Leukocyte Adhesion to Microvascular But Not to Macrovascular Endothelial Cells of the Human Coronary System.
A. Zakrzewicz, M. Grafe, D. Terbeek, M. Bongrazio, W. Auch-Schwelk, B. Walzog, K. Graf, E. Fleck, K. Ley, and P. Gaehtgens (1997)
Blood 89, 3228-3235
   Abstract »    Full Text »    PDF »
A Hematopoietic Cell L-Selectin Ligand Exhibits Sulfate-Independent Binding Activity.
R. Sackstein, L. Fu, and K. L. Allen (1997)
Blood 89, 2773-2781
   Abstract »    Full Text »    PDF »
CD34+ Cells in the Blood of Patients With Multiple Myeloma Express CD19 and IgH mRNA and Have Patient-Specific IgH VDJ Gene Rearrangements.
A. J. Szczepek, P.L. Bergsagel, L. Axelsson, C. B. Brown, A. R. Belch, and L. M. Pilarski (1997)
Blood 89, 1824-1833
   Abstract »    Full Text »    PDF »
Monocyte Adhesion to Activated Aortic Endothelium: Role of L-Selectin and Heparan Sulfate Proteoglycans.
L. Giuffre, A.-S. Cordey, N. Monai, Y. Tardy, M. Schapira, and O. Spertini (1997)
J. Cell Biol. 136, 945-956
   Abstract »    Full Text »    PDF »
L-Selectin from Human, but Not from Mouse Neutrophils Binds Directly to E-Selectin.
O. Zollner, M. C. Lenter, J. E. Blanks, E. Borges, M. Steegmaier, H.-G. Zerwes, and D. Vestweber (1997)
J. Cell Biol. 136, 707-716
   Abstract »    Full Text »    PDF »
The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface.
M Steegmaier, E Borges, J Berger, H Schwarz, and D Vestweber (1997)
J. Cell Sci. 110, 687-694
   Abstract »    PDF »
Transendothelial Migration of CD34+ and Mature Hematopoietic Cells: An In Vitro Study Using a Human Bone Marrow Endothelial Cell Line.
R. Mohle, M. A.S. Moore, R. L. Nachman, and S. Rafii (1997)
Blood 89, 72-80
   Abstract »    Full Text »    PDF »
6'-Sulfo Sialyl Lex but Not 6-Sulfo Sialyl Lex Expressed on the Cell Surface Supports L-selectin-mediated Adhesion.
S. Tsuboi, Y. Isogai, N. Hada, J. K. King, O. Hindsgaul, and M. Fukuda (1996)
J. Biol. Chem. 271, 27213-27216
   Abstract »    Full Text »    PDF »
ESM-1 Is a Novel Human Endothelial Cell-specific Molecule Expressed in Lung and Regulated by Cytokines.
P. Lassalle, S. Molet, A. Janin, J. V. d. Heyden, J. Tavernier, W. Fiers, R. Devos, and A.-B. Tonnel (1996)
J. Biol. Chem. 271, 20458-20464
   Abstract »    Full Text »    PDF »
Expression of the alpha(1,3)Fucosyltransferase Fuc-TVII in Lymphoid Aggregate High Endothelial Venules Correlates with Expression of L-Selectin Ligands.
P. L. Smith, K. M. Gersten, B. Petryniak, R. J. Kelly, C. Rogers, Y. Natsuka, J. A. Alford III, E. P. Scheidegger, S. Natsuka, and J. B. Lowe (1996)
J. Biol. Chem. 271, 8250-8259
   Abstract »    Full Text »    PDF »
A Schiff Base with Mildly Oxidized Carbohydrate Ligands Stabilizes L-selectin and not P-selectin or E-selectin Rolling Adhesions in Shear Flow.
K. D. Puri and T. A. Springer (1996)
J. Biol. Chem. 271, 5404-5413
   Abstract »    Full Text »    PDF »
Modulation of Endothelial Cell Adhesion by Hevin, an Acidic Protein Associated with High Endothelial Venules.
J.-P. Girard and T. A. Springer (1996)
J. Biol. Chem. 271, 4511-4517
   Abstract »    Full Text »    PDF »
Tyrosine Sulfation of P-selectin Glycoprotein Ligand-1 Is Required for High Affinity Binding to P-selectin.
P. P. Wilkins, K. L. Moore, R. P. McEver, and R. D. Cummings (1995)
J. Biol. Chem. 270, 22677-22680
   Abstract »    Full Text »    PDF »
Biosynthesis of GlyCAM-1, a Mucin-like Ligand for L-Selectin.
D. Crommie and S. D. Rosen (1995)
J. Biol. Chem. 270, 22614-22624
   Abstract »    Full Text »    PDF »
P-selectin Glycoprotein Ligand-1 Is the Major Counter-receptor for P-selectin on Stimulated T Cells and Is Widely Distributed in Non-functional Form on Many Lymphocytic Cells.
G. Vachino, X.-J. Chang, G. M. Veldman, R. Kumar, D. Sako, L. A. Fouser, M. C. Berndt, and D. A. Cumming (1995)
J. Biol. Chem. 270, 21966-21974
   Abstract »    Full Text »    PDF »
Peptides Which Bind to E-selectin and Block Neutrophil Adhesion.
C. L. Martens, S. E. Cwirla, R. Y.-W. Lee, E. Whitehorn, E. Y.-F. Chen, A. Bakker, E. L. Martin, C. Wagstrom, P. Gopalan, C. W. Smith, et al. (1995)
J. Biol. Chem. 270, 21129-21136
   Abstract »    Full Text »    PDF »
Signaling Functions of L-selectin.
T. K. Waddell, L. Fialkow, C. K. Chan, T. K. Kishimoto, and G. P. Downey (1995)
J. Biol. Chem. 270, 15403-15411
   Abstract »    Full Text »    PDF »
Purification of Cranin, a Laminin Binding Membrane Protein.
N. R. Smalheiser and E. Kim (1995)
J. Biol. Chem. 270, 15425-15433
   Abstract »    Full Text »    PDF »
Inhibition of Selectin-mediated Cell Adhesion and Prevention of Acute Inflammation by Nonanticoagulant Sulfated Saccharides. STUDIES WITH CARBOXYL-REDUCED AND SULFATED HEPARIN AND WITH TRESTATIN A SULFATE.
X. Xie, A.-S. Rivier, A. Zakrzewicz, M. Bernimoulin, X.-L. Zeng, H. P. Wessel, M. Schapira, and O. Spertini (2000)
J. Biol. Chem. 275, 34818-34825
   Abstract »    Full Text »    PDF »
Minimal Sulfated Carbohydrates for Recognition by L-selectin and the MECA-79 Antibody.
R. E. Bruehl, C. R. Bertozzi, and S. D. Rosen (2000)
J. Biol. Chem. 275, 32642-32648
   Abstract »    Full Text »    PDF »
Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44.
H. Kawashima, M. Hirose, J. Hirose, D. Nagakubo, A. H. K. Plaas, and M. Miyasaka (2000)
J. Biol. Chem. 275, 35448-35456
   Abstract »    Full Text »    PDF »
A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.
C. J. Dimitroff, J. Y. Lee, R. C. Fuhlbrigge, and R. Sackstein (2000)
PNAS 97, 13841-13846
   Abstract »    Full Text »    PDF »
Infection of Endothelium With E1-E4+, but Not E1-E4-, Adenovirus Gene Transfer Vectors Enhances Leukocyte Adhesion and Migration by Modulation of ICAM-1, VCAM-1, CD34, and Chemokine Expression.
S. Rafii, S. Dias, S. Meeus, K. Hattori, R. Ramachandran, F. Feuerback, S. Worgall, N. R. Hackett, and R. G. Crystal (2001)
Circ. Res. 88, 903-910
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)