Transsynaptic expression of a presynaptic glutamate receptor during hippocampal long-term potentiation

doi:10.1126/science.8105538

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Science 15 October 1993:
Vol. 262. no. 5132, pp. 433 - 436
DOI: 10.1126/science.8105538

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Science, Vol 262, Issue 5132, 433-436
Copyright © 1993 by American Association for the Advancement of Science

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Transsynaptic expression of a presynaptic glutamate receptor during hippocampal long-term potentiation

T Smirnova, S Laroche, ML Errington, AA Hicks, TV Bliss, and J Mallet

Laboratoire de genetique moleculaire de la neurotransmission et des processus neurodegeneratifs, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France.

Repetitive activation of excitatory synapses in the hippocampus produces a persistent enhancement of synaptic efficiency known as long-term potentiation (LTP). In anesthetized and in freely moving rats, the induction of LTP in the perforant path led to a transient increase in the amount of messenger RNA (mRNA) coding for a presynaptic glutamate receptor (GR33) in dentate granule cells. The amount of GR33 mRNA was increased for at least 5 hours after the induction of LTP but was indistinguishable from control values 1 day after induction. The N-methyl-D-aspartate receptor antagonist 2-aminophosphonovalerate prevented the induction of both LTP and the increase in GR33 mRNA. The amount of GR33 protein was increased in the mossy fiber terminal zone of dentate granule cells 5 hours after the induction of LTP. These results suggest that the induction of LTP in synapses at one stage in a neural network may lead to modification in synaptic function at the next stage in the network.

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