Science 8 October 1993: Vol. 262. no. 5131, pp. 242 - 244 DOI: 10.1126/science.8105536

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Articles

CD27 Expression on CD4+ T Cells Differentiates Effector from Regulatory T Cell Subsets in the Lung.

D. G. Mack, A. M. Lanham, B. E. Palmer, L. A. Maier, and A. P. Fontenot (2009)
J. Immunol. 182, 7317-7324
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Short- and long-term response to corticosteroid therapy in chronic beryllium disease.

S. Marchand-Adam, A. El Khatib, F. Guillon, M. W. Brauner, C. Lamberto, V. Lepage, J-M. Naccache, and D. Valeyre (2008)
Eur. Respir. J. 32, 687-693
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Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.

J. A Snyder, E. Demchuk, E. C McCanlies, C. R Schuler, K. Kreiss, M. E Andrew, B. L Frye, J. S Ensey, M. L Stanton, and A. Weston (2008)
J R Soc Interface 5, 749-758
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The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping.

M Heckmann, J U Holle, L Arning, S Knaup, B Hellmich, M Nothnagel, P Jagiello, W L Gross, J T Epplen, and S Wieczorek (2008)
Ann Rheum Dis 67, 972-979
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Genetic susceptibility to occupational exposures.

D C Christiani, A J Mehta, and C-L Yu (2008)
Occup. Environ. Med. 65, 430-436
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Association between Heat Shock Protein 70/Hom Genetic Polymorphisms and Uveitis in Patients with Sarcoidosis.

P. Spagnolo, H. Sato, S. E. Marshall, K. M. Antoniou, T. Ahmad, A. U. Wells, M. A. Ahad, S. Lightman, R. M. du Bois, and K. I. Welsh (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3019-3025
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Genetics of Sarcoidosis: Candidate Genes and Genome Scans.

M. C. Iannuzzi and B. A. Rybicki (2007)
Proceedings of the ATS 4, 108-116
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Recombinant HLA-DP2 Binds Beryllium and Tolerizes Beryllium-Specific Pathogenic CD4+ T Cells.

A. P. Fontenot, T. S. Keizer, M. McCleskey, D. G. Mack, R. Meza-Romero, J. Huan, D. M. Edwards, Y. K. Chou, A. A. Vandenbark, B. Scott, et al. (2006)
J. Immunol. 177, 3874-3883
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Diagnoses of chronic beryllium disease within cohorts of sarcoidosis patients.

J. Muller-Quernheim, K. I. Gaede, E. Fireman, and G. Zissel (2006)
Eur. Respir. J. 27, 1190-1195
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Is idiopathic pulmonary fibrosis an environmental disease?.

V. S. Taskar and D. B. Coultas (2006)
Proceedings of the ATS 3, 293-298
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Beryllium Presentation to CD4+ T Cells Is Dependent on a Single Amino Acid Residue of the MHC Class II {beta}-Chain.

J. R. Bill, D. G. Mack, M. T. Falta, L. A. Maier, A. K. Sullivan, F. G. Joslin, A. K. Martin, B. M. Freed, B. L. Kotzin, and A. P. Fontenot (2005)
J. Immunol. 175, 7029-7037
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C-C Chemokine Receptor 5 Gene Variants in Relation to Lung Disease in Sarcoidosis.

P. Spagnolo, E. A. Renzoni, A. U. Wells, S. J. Copley, S. R. Desai, H. Sato, J. C. Grutters, A. Abdallah, A. Taegtmeyer, R. M. du Bois, et al. (2005)
Am. J. Respir. Crit. Care Med. 172, 721-728
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The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DR{beta}1 chain is associated with the clinical course of multiple sclerosis.

J M Greer and M P Pender (2005)
J. Neurol. Neurosurg. Psychiatry 76, 656-662
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Activation Pathways Implicate Anti-HLA-DP and Anti-LFA-1 Antibodies as Lead Candidates for Intervention in Chronic Berylliosis.

Y. K. Chou, D. M. Edwards, A. D. Weinberg, A. A. Vandenbark, B. L. Kotzin, A. P. Fontenot, and G. G. Burrows (2005)
J. Immunol. 174, 4316-4324
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The Inherent Complexities of Gene-Environment Interactions.

E. L. Grigorenko (2005)
J. Gerontol. B. Psychol. Sci. Soc. Sci. 60, 53-64
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Beryllium Sensitization Progresses to Chronic Beryllium Disease: A Longitudinal Study of Disease Risk.

L. S. Newman, M. M. Mroz, R. Balkissoon, and L. A. Maier (2005)
Am. J. Respir. Crit. Care Med. 171, 54-60
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Variable Response to Long-term Corticosteroid Therapy in Chronic Beryllium Disease.

A. Sood, W. S. Beckett, and M. R. Cullen (2004)
Chest 126, 2000-2007
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Future Directions in Sarcoidosis Research: Summary of an NHLBI Working Group.

W. J. Martin II, M. C. Iannuzzi, D. B. Gail, and H. H. Peavy (2004)
Am. J. Respir. Crit. Care Med. 170, 567-571
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Influence of MHC CLASS II in Susceptibility to Beryllium Sensitization and Chronic Beryllium Disease.

L. A. Maier, D. S. McGrath, H. Sato, P. Lympany, K. Welsh, R. du Bois, L. Silveira, A. P. Fontenot, R. T. Sawyer, E. Wilcox, et al. (2003)
J. Immunol. 171, 6910-6918
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The Gene for Acute Sarcoidosis?.

A. W. O'Regan and J. S. Berman (2003)
Am. J. Respir. Crit. Care Med. 168, 1142-1143
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Clinical Application of Beryllium Lymphocyte Proliferation Testing.

B. P. Barna, D. A. Culver, B. Yen-Lieberman, R. A. Dweik, and M. J. Thomassen (2003)
Clin. Vaccine Immunol. 10, 990-994
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Molecular Interaction and Enzymatic Activity of Macrophage Migration Inhibitory Factor with Immunorelevant Peptides.

I. Potolicchio, L. Santambrogio, and J. L. Strominger (2003)
J. Biol. Chem. 278, 30889-30895
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A New Type of Metal Recognition by Human T Cells: Contact Residues for Peptide-independent Bridging of T Cell Receptor and Major Histocompatibility Complex by Nickel.

K. Gamerdinger, C. Moulon, D. R. Karp, J. van Bergen, F. Koning, D. Wild, U. Pflugfelder, and H. U. Weltzien (2003)
J. Exp. Med. 197, 1345-1353
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Functional analysis of HLA-DP polymorphism: a crucial role for DP{beta} residues 9, 11, 35, 55, 56, 69 and 84-87 in T cell allorecognition and peptide binding.

G. Diaz, M. Amicosante, D. Jaraquemada, R. H. Butler, M. V. Guillen, M. Sanchez, C. Nombela, and J. Arroyo (2003)
Int. Immunol. 15, 565-576
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Sarcoidosis Susceptibility and Resistance HLA-DQB1 Alleles in African Americans.

M. C. Iannuzzi, M. J. Maliarik, L. M. Poisson, and B. A. Rybicki (2003)
Am. J. Respir. Crit. Care Med. 167, 1225-1231
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HLA-DPB1 and Chronic Beryllium Disease: A HuGE Review.

E. C. McCanlies, K. Kreiss, M. Andrew, and A. Weston (2003)
Am. J. Epidemiol. 157, 388-398
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HLA-DP-unrestricted TNF-{alpha} release in beryllium-stimulated peripheral blood mononuclear cells.

M. Amicosante, F. Berretta, A. Franchi, P. Rogliani, C. Dotti, M. Losi, R. Dweik, and C. Saltini (2002)
Eur. Respir. J. 20, 1174-1178
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Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201.

G. Malcolm Taylor, S. Dearden, P. Ravetto, M. Ayres, P. Watson, A. Hussain, M. Greaves, F. Alexander, O. B. Eden, and UKCCS Investigators (2002)
Hum. Mol. Genet. 11, 1585-1597
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Beryllium Skin Patch Testing to Analyze T Cell Stimulation and Granulomatous Inflammation in the Lung.

A. P. Fontenot, L. A. Maier, S. J. Canavera, T. B. Hendry-Hofer, M. Boguniewicz, E. A. Barker, L. S. Newman, and B. L. Kotzin (2002)
J. Immunol. 168, 3627-3634
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Human Leukocyte Antigen Class II Amino Acid Epitopes . Susceptibility and Progression Markers for Beryllium Hypersensitivity.

M. D. ROSSMAN, J. STUBBS, C. W. LEE, E. ARGYRIS, E. MAGIRA, and D. MONOS (2002)
Am. J. Respir. Crit. Care Med. 165, 788-794
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The Genetic Predisposition to Interstitial Lung Disease : Functional Relevance.

R. M. du Bois (2002)
Chest 121, 14S-20S
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Possible Relation of Tunisian Pemphigus with Traditional Cosmetics: A Multicenter Case-Control Study.

S. Bastuji-Garin, H. Turki, I. Mokhtar, R. Nouira, B. Fazaa, B. Jomaa, A. Zahaf, A. B. Osman, R. Souissi, D. Hemon, et al. (2002)
Am. J. Epidemiol. 155, 249-256
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Major histocompatibility locus genetic markers of beryllium sensitization and disease.

C. Saltini, L. Richeldi, M. Losi, M. Amicosante, C. Voorter, E. van den Berg-Loonen, R.A. Dweik, H.P. Wiedemann, D.C. Deubner, and C. Tinelli (2001)
Eur. Respir. J. 18, 677-684
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High Beryllium-stimulated TNF-alpha Is Associated with the -308 TNF-alpha Promoter Polymorphism and with Clinical Severity in Chronic Beryllium Disease.

L. A. MAIER, R. T. SAWYER, R. A. BAUER, L. A. KITTLE, P. LYMPANY, D. MCGRATH, R. DUBOIS, E. DANILOFF, C. S. ROSE, and L. S. NEWMAN (2001)
Am. J. Respir. Crit. Care Med. 164, 1192-1199
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Genetic predisposition and pathogenetic mechanisms of interstitial lung diseases of unknown origin.

G.M. Verleden, R.M. du Bois, D. Bouros, M. Drent, A. Millar, J. Muller-Quernheim, G. Semenzato, S. Johnson, G. Sourvinos, D. Olivieri, et al. (2001)
Eur. Respir. J. 18, 17S-29s
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Interstitial lung disease induced by exogenous agents: factors governing susceptibility.

B. Nemery, A. Bast, J. Behr, P.J.A. Borm, S.J. Bourke, Ph. Camus, P. De Vuyst, H.M. Jansen, V.L. Kinnula, D. Lison, et al. (2001)
Eur. Respir. J. 18, 30S-42s
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Hypersensitivity pneumonitis: current concepts.

S.J. Bourke, J.C. Dalphin, G. Boyd, C. McSharry, C.I. Baldwin, and J.E. Calvert (2001)
Eur. Respir. J. 18, 81S-92s
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Are Polymorphisms the Answer in Hypersensitivity Pneumonitis?.

M. Schuyler (2001)
Am. J. Respir. Crit. Care Med. 163, 1513-1514
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HLA-DP Allele-Specific T Cell Responses to Beryllium Account for DP-Associated Susceptibility to Chronic Beryllium Disease.

G. Lombardi, C. Germain, J. Uren, M. T. Fiorillo, R. M. du Bois, W. Jones-Williams, C. Saltini, R. Sorrentino, and R. Lechler (2001)
J. Immunol. 166, 3549-3555
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Marked Tachypnea in Siblings With Chronic Beryllium Disease due to Copper-Beryllium Alloy.

S. M. Tarlo, K. Rhee, E. Powell, E. Amer, L. Newman, G. Liss, and N. Jones (2001)
Chest 119, 647-650
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Familial Sarcoidosis Is Linked to the Major Histocompatibility Complex Region.

M. SCHÜRMANN, P. A. LYMPANY, P. REICHEL, B. MÜLLER-MYHSOK, K. WURM, M. SCHLAAK, J. MÜLLER-QUERNHEIM, R. M. du BOIS, and E. SCHWINGER (2000)
Am. J. Respir. Crit. Care Med. 162, 861-864
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Partial IL-10 Inhibition of the Cell-Mediated Immune Response in Chronic Beryllium Disease.

S. S. Tinkle, L. A. Kittle, and L. S. Newman (1999)
J. Immunol. 163, 2747-2753
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Differential Susceptibilities to Chronic Beryllium Disease Contributed by Different Glu69 HLA-DPB1 and -DPA1 Alleles.

Z. Wang, P. S. White, M. Petrovic, O. L. Tatum, L. S. Newman, L. A. Maier, and B. L. Marrone (1999)
J. Immunol. 163, 1647-1653
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Identification of Pathogenic T Cells in Patients with Beryllium-Induced Lung Disease.

A. P. Fontenot, M. T. Falta, B. M. Freed, L. S. Newman, and B. L. Kotzin (1999)
J. Immunol. 163, 1019-1026
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Angiotensin-1 Converting Enzyme Polymorphisms in Chronic Beryllium Disease.

L. A. MAIER, M. V. RAYNOLDS, D. A. YOUNG, E. A. BARKER, and L. S. NEWMAN (1999)
Am. J. Respir. Crit. Care Med. 159, 1342-1350
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Ovine MHC Class II DRB1 Alleles Associated with Resistance or Susceptibility to Development of Bovine Leukemia Virus-induced Ovine Lymphoma.

Y. Nagaoka, H. Kabeya, M. Onuma, N. Kasai, K. Okada, and Y. Aida (1999)
Cancer Res. 59, 975-981
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of HLA-DPB1 Polymorphisms in African-Americans with Sarcoidosis.

M. J. MALIARIK, K. M. CHEN, M. L. MAJOR, R. G. SHEFFER, J. POPOVICH Jr., B. A. RYBICKI, and M. C. IANNUZZI (1998)
Am. J. Respir. Crit. Care Med. 158, 111-114
 |  Abstract »  |  Full Text »  |  PDF »

Expansions of T-cell Subsets Expressing Particular T-cell Receptor Variable Regions in Chronic Beryllium Disease.

A. P. Fontenot, B. L. Kotzin, C. E. Comment, and L. S. Newman (1998)
Am. J. Respir. Cell Mol. Biol. 18, 581-589
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Sarcoidosis.

L. S. Newman, C. S. Rose, and L. A. Maier (1997)
N. Engl. J. Med. 336, 1224-1234
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Chronic Granulomatous Pneumonia and Lymphocytic Responses Induced by Inhaled Beryllium Metal in A/J and C3H/HeJ Mice.

K. J. Nikula, D. S. Swafford, M. D. Hoover, M. D. Tohulka, and G. L. Finch (1997)
Toxicol Pathol 25, 2-12
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Occupational Illness.

L. S. Newman (1995)
N. Engl. J. Med. 333, 1128-1134
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Drug and Environmental Lupus Syndromes.

E. V. Hess (1994)
Lupus 3, 441-442
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Role of Genetic Factors in Drug-Related Autoimmunity.

L. E. Adams and A.-B. Mongey (1994)
Lupus 3, 443-447
 |  Abstract »  |  PDF »

To Be2+ or not to Be2+: immunogenetics and occupational exposure.

L. Newman (1993)
Science 262, 197-198
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Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease.

A. P. Fontenot, M. Torres, W. H. Marshall, L. S. Newman, and B. L. Kotzin (2000)
PNAS 97, 12717-12722
 |  Abstract »  |  Full Text »  |  PDF »

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