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Science 8 October 1993:
Vol. 262. no. 5131, pp. 240 - 242
DOI: 10.1126/science.8211142
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Articles

Science, Vol 262, Issue 5131, 240-242
Copyright © 1993 by American Association for the Advancement of Science

articles

Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS)

O Kanagawa, BA Vaupel, S Gayama, G Koehler, and M Kopf

Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110.

The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus. The presence of both B cells and CD4+ T cells is critical for the development of the disease. Furthermore, a Th2 cytokine response dominates during the progression of the disease. When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Pathways in Virus-Induced Cytokine Production.
T. H. Mogensen and S. R. Paludan (2001)
Microbiol. Mol. Biol. Rev. 65, 131-150
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Role of Interleukin-4 (IL-4), IL-12, and Gamma Interferon in Primary and Vaccine-Primed Immune Responses to Friend Retrovirus Infection.
U. Dittmer, K. E. Peterson, R. Messer, I. M. Stromnes, B. Race, and K. J. Hasenkrug (2001)
J. Virol. 75, 654-660
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Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans.
K. Furukawa, H. Sasaki, R. B. Pollard, and F. Suzuki (2000)
J. Antimicrob. Chemother. 46, 443-450
   Abstract »    Full Text »    PDF »
Disruption of T Cell Homeostasis in Mice Expressing a T Cell-specific Dominant Negative Transforming Growth Factor {beta} II Receptor.
P. J. Lucas, S.-J. Kim, S. J. Melby, and R. E. Gress (2000)
J. Exp. Med. 191, 1187-1196
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HIV-1 gp120 Induces IL-4 and IL-13 Release from Human Fc{epsilon}RI+ Cells Through Interaction with the VH3 Region of IgE.
V. Patella, G. Florio, A. Petraroli, and G. Marone (2000)
J. Immunol. 164, 589-595
   Abstract »    Full Text »    PDF »
T Helper Cell Type 1-associated and Cytotoxic T Lymphocyte-mediated Tumor Immunity Is Impaired in Interleukin 4-deficient Mice.
T. Schuler, Z. Qin, S. Ibe, N. Noben-Trauth, and T. Blankenstein (1999)
J. Exp. Med. 189, 803-810
   Abstract »    Full Text »    PDF »
Novel Diversity in Th1, Th2 Type Differentiation of Hemagglutinin-Specific T Cell Clones Elicited by Natural Influenza Virus Infection in Three Major Haplotypes (H-2b,d,k).
C. M. Graham, C. A. Smith, and D. B. Thomas (1998)
J. Immunol. 161, 1094-1103
   Abstract »    Full Text »    PDF »
Differences in the Immune Response During the Acute Phase of E-55+ Murine Leukemia Virus Infection in Progressor BALB and Long Term Nonprogressor C57BL Mice.
V. Panoutsakopoulou, C. S. Little, T. G. Sieck, E. P. Blankenhorn, and K. J. Blank (1998)
J. Immunol. 161, 17-26
   Abstract »    Full Text »    PDF »
Response.
O. Kanagawa, B. A. Vaupel, S. Gayama, G. Koehler, and M. Kipf (1994)
Science 265, 267
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