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Science 24 September 1993:
Vol. 261. no. 5129, pp. 1733 - 1736
DOI: 10.1126/science.8378774
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Articles

Science, Vol 261, Issue 5129, 1733-1736
Copyright © 1993 by American Association for the Advancement of Science

articles

Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei

S Ruff-Jamison, K Chen, and S Cohen

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.

Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF. Administration of interferon-gamma (IFN-gamma) resulted in the appearance in liver nuclei of two tyrosine phosphorylated proteins (84 and 91 kilodaltons). The 84- and 91-kilodalton proteins detected after either EGF or IFN-gamma administration were identified as the IFN-gamma activation factors (GAF). Furthermore, gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN-gamma administration, specifically bound to the sis-inducible element of the c-fos promoter. Thus, GAF proteins participate in nuclear signaling in both IFN-gamma and EGF pathways.


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