Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 September 1993:
Vol. 261. no. 5129, pp. 1730 - 1733
DOI: 10.1126/science.8378773
Prev | Table of Contents | Next

Articles

Science, Vol 261, Issue 5129, 1730-1733
Copyright © 1993 by American Association for the Advancement of Science

articles

Tyrosine phosphorylation of DNA binding proteins by multiple cytokines

AC Larner, M David, GM Feldman, K Igarashi, RH Hackett, DS Webb, SM Sweitzer, EF Petricoin 3rd, and DS Finbloom

Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892.

Interferon-alpha (IFN-alpha) and IFN-gamma regulate gene expression by tyrosine phosphorylation of several transcription factors that have the 91-kilodalton (p91) protein of interferon-stimulated gene factor-3 (ISGF-3) as a common component. Interferon-activated protein complexes bind enhancers present in the promoters of early response genes such as the high-affinity Fc gamma receptor gene (Fc gamma RI). Treatment of human peripheral blood monocytes or basophils with interleukin-3 (IL-3), IL-5, IL-10, or granulocyte-macrophage colony-stimulating factor (GM-CSF) activated DNA binding proteins that recognized the IFN-gamma response region (GRR) located in the promoter of the Fc gamma RI gene. Although tyrosine phosphorylation was required for the assembly of each of these GRR binding complexes, only those formed as a result of treatment with IFN-gamma or IL-10 contained p91. Instead, complexes activated by IL-3 or GM-CSF contained a tyrosine-phosphorylated protein of 80 kilodaltons. Induction of Fc gamma RI RNA occurred only with IFN-gamma and IL-10, whereas pretreatment of cells with GM-CSF or IL-3 inhibited IFN-gamma induction of Fc gamma RI RNA. Thus, several cytokines other than interferons can activate putative transcription factors by tyrosine phosphorylation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cutting Edge: Selective Tyrosine Dephosphorylation of Interferon-Activated Nuclear STAT5 by the VHR Phosphatase.
R. Hoyt, W. Zhu, F. Cerignoli, A. Alonso, T. Mustelin, and M. David (2007)
J. Immunol. 179, 3402-3406
   Abstract »    Full Text »    PDF »
Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages.
L. M. Williams, U. Sarma, K. Willets, T. Smallie, F. Brennan, and B. M. J. Foxwell (2007)
J. Biol. Chem. 282, 6965-6975
   Abstract »    Full Text »    PDF »
Tyk2 Tyrosine Kinase Expression Is Required for the Maintenance of Mitochondrial Respiration in Primary Pro-B Lymphocytes.
R. Potla, T. Koeck, J. Wegrzyn, S. Cherukuri, K. Shimoda, D. P. Baker, J. Wolfman, S. M. Planchon, C. Esposito, B. Hoit, et al. (2006)
Mol. Cell. Biol. 26, 8562-8571
   Abstract »    Full Text »    PDF »
PIASy-Deficient Mice Display Modest Defects in IFN and Wnt Signaling.
W. Roth, C. Sustmann, M. Kieslinger, A. Gilmozzi, D. Irmer, E. Kremmer, C. Turck, and R. Grosschedl (2004)
J. Immunol. 173, 6189-6199
   Abstract »    Full Text »    PDF »
Histone Deacetylase Activity Is Required to Recruit RNA Polymerase II to the Promoters of Selected Interferon-stimulated Early Response Genes.
S. Sakamoto, R. Potla, and A. C. Larner (2004)
J. Biol. Chem. 279, 40362-40367
   Abstract »    Full Text »    PDF »
An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells.
S. Kamiya, T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto (2004)
J. Immunol. 173, 3871-3877
   Abstract »    Full Text »    PDF »
Identification of a Novel Conserved Motif in the STAT Family That Is Required for Tyrosine Phosphorylation.
A. M. Gamero, S. Sakamoto, J. Montenegro, and A. C. Larner (2004)
J. Biol. Chem. 279, 12379-12385
   Abstract »    Full Text »    PDF »
Cells Previously Desensitized to Type 1 Interferons Display Different Mechanisms of Activation of Stat-dependent Gene Expression from Naive Cells.
S. Sakamoto, J. Qin, A. Navarro, A. Gamero, R. Potla, T. Yi, W. Zhu, D. P. Baker, G. Feldman, and A. C. Larner (2004)
J. Biol. Chem. 279, 3245-3253
   Abstract »    Full Text »    PDF »
Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages.
L. Williams, L. Bradley, A. Smith, and B. Foxwell (2004)
J. Immunol. 172, 567-576
   Abstract »    Full Text »    PDF »
EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching.
B. He, N. Raab-Traub, P. Casali, and A. Cerutti (2003)
J. Immunol. 171, 5215-5224
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor Receptor-independent Constitutive Activation of STAT3 in Head and Neck Squamous Cell Carcinoma Is Mediated by the Autocrine/Paracrine Stimulation of the Interleukin 6/gp130 Cytokine System.
V. Sriuranpong, J. I. Park, P. Amornphimoltham, V. Patel, B. D. Nelkin, and J. S. Gutkind (2003)
Cancer Res. 63, 2948-2956
   Abstract »    Full Text »    PDF »
IL-10 expression profiling in human monocytes.
L. Williams, G. Jarai, A. Smith, and P. Finan (2002)
J. Leukoc. Biol. 72, 800-809
   Abstract »    Full Text »    PDF »
Differential IL-10R1 Expression Plays a Critical Role in IL-10-Mediated Immune Regulation.
Y. Ding, L. Qin, D. Zamarin, S. V. Kotenko, S. Pestka, K. W. Moore, and J. S. Bromberg (2001)
J. Immunol. 167, 6884-6892
   Abstract »    Full Text »    PDF »
The Carboxyl Terminus of the Granulocyte Colony- Stimulating Factor Receptor, Truncated in Patients with Severe Congenital Neutropenia/Acute Myeloid Leukemia, Is Required for SH2-Containing Phosphatase-1 Suppression of Stat Activation.
F. Dong, Y. Qiu, T. Yi, I. P. Touw, and A. C. Larner (2001)
J. Immunol. 167, 6447-6452
   Abstract »    Full Text »    PDF »
Protein tyrosine phosphatase epsilon C selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.
N. Tanuma, H. Shima, K. Nakamura, and K. Kikuchi (2001)
Blood 98, 3030-3034
   Abstract »    Full Text »    PDF »
HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors.
M. Federico, Z. Percario, E. Olivetta, G. Fiorucci, C. Muratori, A. Micheli, G. Romeo, and E. Affabris (2001)
Blood 98, 2752-2761
   Abstract »    Full Text »    PDF »
Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10.
L. Crepaldi, S. Gasperini, J. A. Lapinet, F. Calzetti, C. Pinardi, Y. Liu, S. Zurawski, R. de Waal Malefyt, K. W. Moore, and M. A. Cassatella (2001)
J. Immunol. 167, 2312-2322
   Abstract »    Full Text »    PDF »
Regulation of STAT1 Nuclear Export by Jak1.
K. Mowen and M. David (2000)
Mol. Cell. Biol. 20, 7273-7281
   Abstract »    Full Text »    PDF »
The Role of p21 in Interferon {{gamma}}-mediated Growth Inhibition of Human Breast Cancer Cells.
J. L. Gooch, R. E. Herrera, and D. Yee (2000)
Cell Growth Differ. 11, 335-342
   Abstract »    Full Text »
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4.
K. S. Wang, D. A. Frank, and J. Ritz (2000)
Blood 95, 3183-3190
   Abstract »    Full Text »    PDF »
Distinct Mechanisms of STAT Phosphorylation via the Interferon-alpha /beta Receptor. SELECTIVE INHIBITION OF STAT3 AND STAT5 BY PICEATANNOL.
L. Su and M. David (2000)
J. Biol. Chem. 275, 12661-12666
   Abstract »    Full Text »    PDF »
Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the janus kinases.
F. Dong and A. C. Larner (2000)
Blood 95, 1656-1662
   Abstract »    Full Text »    PDF »
Rapid STAT Phosphorylation via the B Cell Receptor. MODULATORY ROLE OF CD19.
L. Su, R. C. Rickert, and M. David (1999)
J. Biol. Chem. 274, 31770-31774
   Abstract »    Full Text »    PDF »
Serine Phosphorylation and Negative Regulation of Stat3 by JNK.
C. P. Lim and X. Cao (1999)
J. Biol. Chem. 274, 31055-31061
   Abstract »    Full Text »    PDF »
Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10-Induced Pathway That Is Independent of STAT Protein Activation.
M. A. Cassatella, S. Gasperini, C. Bovolenta, F. Calzetti, M. Vollebregt, P. Scapini, M. Marchi, R. Suzuki, A. Suzuki, and A. Yoshimura (1999)
Blood 94, 2880-2889
   Abstract »    Full Text »    PDF »
Divergence of Binding, Signaling, and Biological Responses to Recombinant Human Hybrid IFN.
R. Hu, J. Bekisz, M. Hayes, S. Audet, J. Beeler, E. Petricoin, and K. Zoon (1999)
J. Immunol. 163, 854-860
   Abstract »    Full Text »    PDF »
STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules.
E. M. Coccia, N. D. Russo, E. Stellacci, U. Testa, G. Marziali, and A. Battistini (1999)
Int. Immunol. 11, 1075-1083
   Abstract »    Full Text »    PDF »
The Role of STAT3 in Granulocyte Colony-stimulating Factor-induced Enhancement of Neutrophilic Differentiation of Me2SO-treated HL-60 Cells. GM-CSF INHIBITS THE NUCLEAR TRANSLOCATION OF TYROSINE-PHOSPHORYLATED STAT3.
T. Yamaguchi, T. Mukasa, E. Uchida, T. Kanayasu-Toyoda, and T. Hayakawa (1999)
J. Biol. Chem. 274, 15575-15581
   Abstract »    Full Text »    PDF »
Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors.
C. Rusterholz, P. C. Henrioud, and M. Nabholz (1999)
Mol. Cell. Biol. 19, 2681-2689
   Abstract »    Full Text »    PDF »
Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-beta : Relationship With IL-12 Signaling.
C. Pardoux, X. Ma, S. Gobert, S. Pellegrini, P. Mayeux, F. Gay, G. Trinchieri, and S. Chouaib (1999)
Blood 93, 1448-1455
   Abstract »    Full Text »    PDF »
Interleukin-10 Inhibits Expression of Both Interferon alpha - and Interferon gamma - Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1.
S. Ito, P. Ansari, M. Sakatsume, H. Dickensheets, N. Vazquez, R. P. Donnelly, A. C. Larner, and D. S. Finbloom (1999)
Blood 93, 1456-1463
   Abstract »    Full Text »    PDF »
Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase.
S. Hunter, E. A. Burton, S. C. Wu, and S. M. Anderson (1999)
J. Biol. Chem. 274, 2097-2106
   Abstract »    Full Text »    PDF »
Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor.
F. Dong, X. Liu, J. P. de Koning, I. P. Touw, L. Henninghausen, A. Larner, and P. M. Grimley (1998)
J. Immunol. 161, 6503-6509
   Abstract »    Full Text »    PDF »
Role of the STAT1-SH2 Domain and STAT2 in the Activation and Nuclear Translocation of STAT1.
K. Mowen and M. David (1998)
J. Biol. Chem. 273, 30073-30076
   Abstract »    Full Text »    PDF »
Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells.
L. M.L. Tuyt, K. Bregman, C. Lummen, W. H.A. Dokter, and E. Vellenga (1998)
Blood 92, 1364-1373
   Abstract »    Full Text »    PDF »
Activation of Raf-1 by Interferon gamma  and Oncostatin M Requires Expression of the Stat1 Transcription Factor.
L. F. Stancato, C.-R. Yu, E. F. Petricoin III, and A. C. Larner (1998)
J. Biol. Chem. 273, 18701-18704
   Abstract »    Full Text »    PDF »
Prolonged STAT1 Activation Related to the Growth Arrest of Malignant Lymphoma Cells by Interferon-alpha.
P. M. Grimley, H. Fang, H. Rui, E. F. Petricoin III, S. Ray, F. Dong, K. H. Fields, R. Hu, K. C. Zoon, S. Audet, et al. (1998)
Blood 91, 3017-3027
   Abstract »    Full Text »    PDF »
Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein.
M. Ichiba, K. Nakajima, Y. Yamanaka, N. Kiuchi, and T. Hirano (1998)
J. Biol. Chem. 273, 6132-6138
   Abstract »    Full Text »    PDF »
Activation of STAT5 by Lipopolysaccharide Through Granulocyte-Macrophage Colony-Stimulating Factor Production in Human Monocytes.
K. Yamaoka, T. Otsuka, H. Niiro, Y. Arinobu, Y. Niho, N. Hamasaki, and K. Izuhara (1998)
J. Immunol. 160, 838-845
   Abstract »    Full Text »    PDF »
High Affinity Receptor for IgG (Fc{gamma}RI/CD64) Gene and STAT Protein Binding to the IFN-{gamma} Response Region (GRR) Are Regulated Differentially in Human Neutrophils and Monocytes by IL-10.
C. Bovolenta, S. Gasperini, P. P. McDonald, and M. A. Cassatella (1998)
J. Immunol. 160, 911-919
   Abstract »    Full Text »    PDF »
Regulation of Monocyte IL-10 Synthesis by Endogenous IL-1 and TNF-{alpha}: Role of the p38 and p42/44 Mitogen-Activated Protein Kinases.
A. D. Foey, S. L. Parry, L. M. Williams, M. Feldmann, B. M. J. Foxwell, and F. M. Brennan (1998)
J. Immunol. 160, 920-928
   Abstract »    Full Text »    PDF »
Differential activation of the Stat signaling pathway in the liver after burn injury.
S. Wang, S. E. Wolf, and B. M. Evers (1997)
Am J Physiol Gastrointest Liver Physiol 273, G1153-G1159
   Abstract »    Full Text »    PDF »
STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Proliferation and Gene Expression.
G. M. Feldman, L. A. Rosenthal, X. Liu, M. P. Hayes, A. Wynshaw-Boris, W. J. Leonard, L. Hennighausen, and D. S. Finbloom (1997)
Blood 90, 1768-1776
   Abstract »    Full Text »    PDF »
New Advances in Interferon Therapy of Cancer.
S. Wadler and E. L. Schwartz (1997)
Oncologist 2, 254-267
   Abstract »    Full Text »    PDF »
Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes.
R. A. Kirken, M. G. Malabarba, J. Xu, X. Liu, W. L. Farrar, L. Hennighausen, A. C. Larner, P. M. Grimley, and H. Rui (1997)
J. Biol. Chem. 272, 14098-14103
   Abstract »    Full Text »    PDF »
Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins.
R. H. Hackett, Y.-D. Wang, S. Sweitzer, G. Feldman, W. I. Wood, and A. C. Larner (1997)
J. Biol. Chem. 272, 11128-11132
   Abstract »    Full Text »    PDF »
The Amino Acid Residues Immediately Carboxyl-terminal to the Tyrosine Phosphorylation Site Contribute to Interleukin 6-specific Activation of Signal Transducer and Activator of Transcription 3.
M. Inoue, M. Minami, M. Matsumoto, T. Kishimoto, and S. Akira (1997)
J. Biol. Chem. 272, 9550-9555
   Abstract »    Full Text »    PDF »
Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain.
R. M. Weber-Nordt, J. K. Riley, A. C. Greenlund, K. W. Moore, J. E. Darnell, and R. D. Schreiber (1996)
J. Biol. Chem. 271, 27954-27961
   Abstract »    Full Text »    PDF »
IL-10 differentially regulates mRNA expression induced by lipopolysaccharide and interferons in murine peritoneal macrophages.
J. Sivo and S.N. Vogel (1996)
Innate Immunity 3, 407-414
   Abstract »    PDF »
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon alpha /beta -induced Gene Expression.
M. David, G. Zhou, R. Pine, J. E. Dixon, and A. C. Larner (1996)
J. Biol. Chem. 271, 15862-15865
   Abstract »    Full Text »    PDF »
Receptors for Interleukin (IL)-10 and IL-6-type Cytokines Use Similar Signaling Mechanisms for Inducing Transcription through IL-6 Response Elements.
C.-F. Lai, J. Ripperger, K. K. Morella, J. Jurlander, T. S. Hawley, W. E. Carson, T. Kordula, M. A. Caligiuri, R. G. Hawley, G. H. Fey, et al. (1996)
J. Biol. Chem. 271, 13968-13975
   Abstract »    Full Text »    PDF »
Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation.
L. F. Stancato, M. David, C. Carter-Su, A. C. Larner, and W. B. Pratt (1996)
J. Biol. Chem. 271, 4134-4137
   Abstract »    Full Text »    PDF »
Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93[IMAGE], STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes.
M. F. Brizzi, M. G. Aronica, A. Rosso, G. P. Bagnara, Y. Yarden, and L. Pegoraro (1996)
J. Biol. Chem. 271, 3562-3567
   Abstract »    Full Text »    PDF »
Triggering of the Human Interleukin-6 Gene by Interferon-[IMAGE] and Tumor Necrosis Factor-alpha in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFkappaB, and Sp1 Transcription Factors.
J. Sancéau, T. Kaisho, T. Hirano, and J. Wietzerbin (1995)
J. Biol. Chem. 270, 27920-27931
   Abstract »    Full Text »    PDF »
Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5.
E. Caldenhoven, T. van Dijk, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, and R. P. de Groot (1995)
J. Biol. Chem. 270, 25778-25784
   Abstract »    Full Text »    PDF »
Cloning and Expression of a Long Form of the beta Subunit of the Interferon alphabeta Receptor That Is Required for Signaling.
P. Domanski, M. Witte, M. Kellum, M. Rubinstein, R. Hackett, P. Pitha, and O. R. Colamonici (1995)
J. Biol. Chem. 270, 21606-21611
   Abstract »    Full Text »    PDF »
.
(1995)
J. Biol. Chem. 270, 20952-20961
   Abstract »    Full Text »    PDF »
Mapping of the Cytoplasmic Domain of the Human Growth Hormone Receptor Required for the Activation of Jak2 and Stat Proteins.
R. H. Hackett, Y.-D. Wang, and A. C. Larner (1995)
J. Biol. Chem. 270, 21326-21330
   Abstract »    Full Text »    PDF »
Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins.
H. Kotanides, M. Moczygemba, M. F. White, and N. C. Reich (1995)
J. Biol. Chem. 270, 19481-19486
   Abstract »    Full Text »    PDF »
Signal Transduction by a CD16/CD7/Jak2 Fusion Protein.
I. Sakai, L. Nabell, and A. S. Kraft (1995)
J. Biol. Chem. 270, 18420-18427
   Abstract »    Full Text »    PDF »
Characterization of a Stat-like DNA Binding Activity in Drosophila melanogaster.
S. M. Sweitzer, S. Calvo, M. H. Kraus, D. S. Finbloom, and A. C. Larner (1995)
J. Biol. Chem. 270, 16510-16513
   Abstract »    Full Text »    PDF »
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
C. Yu, D. Meyer, G. Campbell, A. Larner, C Carter-Su, J Schwartz, and R Jove (1995)
Science 269, 81-83
   Abstract »    PDF »
Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells.
C. Pallard, F. Gouilleux, M. Charon, B. Groner, S. Gisselbrecht, and I. Dusanter-Fourt (1995)
J. Biol. Chem. 270, 15942-15945
   Abstract »    Full Text »    PDF »
Transcriptional Activation of egr-1 by Granulocyte-Macrophage Colony-stimulating Factor but Not Interleukin 3 Requires Phosphorylation of cAMP Response Element-binding Protein (CREB) on Serine 133.
H.-J. J. Lee, R. C. Mignacca, and K. M. Sakamoto (1995)
J. Biol. Chem. 270, 15979-15983
   Abstract »    Full Text »    PDF »
Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.
D. J. Waxman, P. A. Ram, S.-H. Park, and H. K. Choi (1995)
J. Biol. Chem. 270, 13262-13270
   Abstract »    Full Text »    PDF »
Growth Hormone Signaling Leading to CYP2C12 Gene Expression in Rat Hepatocytes Involves Phospholipase A[IMAGE].
P. Tollet, M. Hamberg, J. Gustafsson, and A. Mode (1995)
J. Biol. Chem. 270, 12569-12577
   Abstract »    Full Text »    PDF »
Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5.
T. J. J. Wood, D. Sliva, P. E. Lobie, T. J. Pircher, F. Gouilleux, H. Wakao, J. Gustafsson, B. Groner, G. Norstedt, and , and Lars-Arne Haldosén (1995)
J. Biol. Chem. 270, 9448-9453
   Abstract »    Full Text »    PDF »
Interleukin (IL)-10 Inhibits Nuclear Factor [IMAGE]B (NF[IMAGE]B) Activation in Human Monocytes.
P. Wang, P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah (1995)
J. Biol. Chem. 270, 9558-9563
   Abstract »    Full Text »    PDF »
Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation.
Y.-D. Wang, K. Wong, and W. I. Wood (1995)
J. Biol. Chem. 270, 7021-7024
   Abstract »    Full Text »    PDF »
Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone.
G. S. Campbell, D. J. Meyer, R. Raz, D. E. Levy, J. Schwartz, and C. Carter-Su (1995)
J. Biol. Chem. 270, 3974-3979
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Interferon-[IMAGE]-inducible Tryptophanyl-tRNA Synthetase Includes Alternative Splicing.
A. B. Tolstrup, A. Bejder, J. Fleckner, and J. Justesen (1995)
J. Biol. Chem. 270, 397-403
   Abstract »    Full Text »    PDF »
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
J. Darnell Jr, I. Kerr, and G. Stark (1994)
Science 264, 1415-1421
   Abstract »    PDF »
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
Z Zhong, Z Wen, and J. Darnell Jr (1994)
Science 264, 95-98
   Abstract »    PDF »
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.
C Lutticken, U. Wegenka, J Yuan, J Buschmann, C Schindler, A Ziemiecki, A. Harpur, A. Wilks, K Yasukawa, T Taga, et al. (1994)
Science 263, 89-92
   Abstract »    PDF »
Trying on a new pair of SH2s.
M Montminy (1993)
Science 261, 1694-1695
   PDF »
DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES.
G. B. Ehret, P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher (2001)
J. Biol. Chem. 276, 6675-6688
   Abstract »    Full Text »    PDF »
Vanadate Facilitates Interferon alpha -mediated Apoptosis That Is Dependent on the Jak/Stat Pathway.
A. M. Gamero and A. C. Larner (2001)
J. Biol. Chem. 276, 13547-13553
   Abstract »    Full Text »    PDF »
Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion.
B. Xie, J. Zhao, M. Kitagawa, J. Durbin, J. A. Madri, J.-L. Guan, and X.-Y. Fu (2001)
J. Biol. Chem. 276, 19512-19523
   Abstract »    Full Text »    PDF »
Interferon alpha /beta Promotes Cell Survival by Activating Nuclear Factor kappa B through Phosphatidylinositol 3-Kinase and Akt.
C. H. Yang, A. Murti, S. R. Pfeffer, J. G. Kim, D. B. Donner, and L. M. Pfeffer (2001)
J. Biol. Chem. 276, 13756-13761
   Abstract »    Full Text »    PDF »
IFNalpha /beta promotes cell survival by activating NF-kappa B.
C. H. Yang, A. Murti, S. R. Pfeffer, L. Basu, J. G. Kim, and L. M. Pfeffer (2000)
PNAS 97, 13631-13636
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)