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Science 24 September 1993:
Vol. 261. no. 5129, pp. 1727 - 1730
DOI: 10.1126/science.8378772
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Articles

Science, Vol 261, Issue 5129, 1727-1730
Copyright © 1993 by American Association for the Advancement of Science

articles

Effects of oral administration of type II collagen on rheumatoid arthritis

DE Trentham, RA Dynesius-Trentham, EJ Orav, D Combitchi, C Lorenzo, KL Sewell, DA Hafler, and HL Weiner

Department of Medicine, Beth Israel Hospital, Boston, MA.

Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. Type II collagen is the major protein in articular cartilage and is a potential autoantigen in this disease. Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. In this randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. These data demonstrate clinical efficacy of an oral tolerization approach for rheumatoid arthritis.


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