Science, Vol 261, Issue 5129, 1696-1701
Copyright © 1993 by American Association for the Advancement of Science
Zirconocene complexes of unsaturated organic molecules: new vehicles for organic synthesis
RD Broene
and
SL Buchwald
Department of Chemistry, Massachusetts Insitute of Technology, Cambridge 02139.
Transition metals are known to stabilize high-energy species and to activate otherwise unreactive ones. The zirconocene unit stabilizes highly strained alkynes and alkenes, allowing their use in selective carbon-carbon bond-forming reactions. This unit also increases the reactivity of unactivated molecules, enabling them to participate in nontraditional transformations. A general route has been developed that allows a wider variety of unsaturated fragments to participate in these reactions. The use of these zirconocene complexes in organic synthesis has led to the development of novel routes to a number of polyfunctionalized organic molecules.
