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Science 17 September 1993:
Vol. 261. no. 5128, pp. 1591 - 1594
DOI: 10.1126/science.8372354
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Articles

Science, Vol 261, Issue 5128, 1591-1594
Copyright © 1993 by American Association for the Advancement of Science

articles

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

LM Wang, MG Myers Jr, XJ Sun, SA Aaronson, M White, and JH Pierce

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

Although several interleukin-3 (IL-3)-dependent cell lines proliferate in response to IL-4 or insulin, the 32D line does not. Insulin and IL-4 sensitivity was restored to 32D cells by expression of IRS-1, the principal substrate of the insulin receptor. Although 32D cells possessed receptors for both factors, they lacked the IRS-1--related protein, 4PS, which becomes phosphorylated by tyrosine in insulin- or IL-4--responsive lines after stimulation. These results indicate that factors that bind unrelated receptors can use similar mitogenic signaling pathways in hematopoietic cells and that 4PS and IRS-1 are functionally similar proteins that are essential for insulin- and IL-4--induced proliferation.


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A. Guilherme, K. Torres, and M. P. Czech (1998)
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Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor.
J. J. Ryan, L. J. McReynolds, H. Huang, K. Nelms, and W. E. Paul (1998)
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Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes.
K. I. Rother, Y. Imai, M. Caruso, F. Beguinot, P. Formisano, and D. Accili (1998)
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ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4.
L.-M. Wang, A. Kuo, M. Alimandi, M. C. Veri, C.-C. Lee, V. Kapoor, N. Ellmore, X.-H. Chen, and J. H. Pierce (1998)
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J. G. Jackson, M. F. White, and D. Yee (1998)
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Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.
B. K. R. Patel, J. H. Pierce, and W. J. LaRochelle (1998)
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   Abstract »    Full Text »    PDF »
HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor.
D. Wang, J. Zamorano, A. D. Keegan, and M. Boothby (1997)
J. Biol. Chem. 272, 25083-25090
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The IRS-Pathway Operates Distinctively From the Stat-Pathway in Hematopoietic Cells and Transduces Common and Distinct Signals During Engagement of the Insulin or Interferon-alpha Receptors.
S. Uddin, E. N. Fish, D. Sher, C. Gardziola, O. R. Colamonici, M. Kellum, P. M. Pitha, M. F. White, and L. C. Platanias (1997)
Blood 90, 2574-2582
   Abstract »    Full Text »    PDF »
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons.
M. S. Burfoot, N. C. Rogers, D. Watling, J. M. Smith, S. Pons, G. Paonessaw, S. Pellegrini, M. F. White, and I. M. Kerr (1997)
J. Biol. Chem. 272, 24183-24190
   Abstract »    Full Text »    PDF »
An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4.
P. L. Orchansky, S. D. Ayres, D. J. Hilton, and J. W. Schrader (1997)
J. Biol. Chem. 272, 22940-22947
   Abstract »    Full Text »    PDF »
Insulin and Interleukin-4 Induce Desensitization to the Mitogenic Effects of Insulin-like Growth Factor-I. PIVOTAL ROLE FOR INSULIN RECEPTOR SUBSTRATE-2.
T. C. Haddad and C. A. Conover (1997)
J. Biol. Chem. 272, 19525-19531
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Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor.
D. Sawka-Verhelle, V. Baron, I. Mothe, C. Filloux, M. F. White, and E. Van Obberghen (1997)
J. Biol. Chem. 272, 16414-16420
   Abstract »    Full Text »    PDF »
14-3-3 (epsilon ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner.
A. Craparo, R. Freund, and T. A. Gustafson (1997)
J. Biol. Chem. 272, 11663-11669
   Abstract »    Full Text »    PDF »
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
C. M. Rondinone, L.-M. Wang, P. Lonnroth, C. Wesslau, J. H. Pierce, and U. Smith (1997)
PNAS 94, 4171-4175
   Abstract »    Full Text »    PDF »
Interaction of MAD2 with the Carboxyl Terminus of the Insulin Receptor but Not with the IGFIR. EVIDENCE FOR RELEASE FROM THE INSULIN RECEPTOR AFTER ACTIVATION.
T. J. O'Neill, Y. Zhu, and T. A. Gustafson (1997)
J. Biol. Chem. 272, 10035-10040
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Interleukin-4 Signaling in B Lymphocytes from Patients with X-linked Severe Combined Immunodeficiency.
N. Taylor, F. Candotti, S. Smith, S. A. Oakes, T. Jahn, J. Isakov, J. M. Puck, J. J. O'Shea, K. Weinberg, and J. A. Johnston (1997)
J. Biol. Chem. 272, 7314-7319
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Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules.
X. H. Chen, B. K.R. Patel, L.-M. Wang, M. Frankel, N. Ellmore, R. A. Flavell, W. J. LaRochelle, and J. H. Pierce (1997)
J. Biol. Chem. 272, 6556-6560
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The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action.
X. J. Sun, S. Pons, L.-M. Wang, Y. Zhang, L. Yenush, D. Burks, M. G. Myers Jr., E. Glasheen, N. G. Copeland, N. A. Jenkins, et al. (1997)
Mol. Endocrinol. 11, 251-262
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A Casein Kinase I Activity Is Constitutively Associated with Nck.
G. Lussier and L. Larose (1997)
J. Biol. Chem. 272, 2688-2694
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Insulin Receptor Substrate-2 Is the Major 170-kDa Protein Phosphorylated on Tyrosine in Response to Cytokines in Murine Lymphohemopoietic Cells.
M. J. Welham, H. Bone, M. Levings, L. Learmonth, L.-M. Wang, K. B. Leslie, J. H. Pierce, and J. W. Schrader (1997)
J. Biol. Chem. 272, 1377-1381
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Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation.
S. Harada, R. M. Smith, J. A. Smith, M. F. White, and L. Jarett (1996)
J. Biol. Chem. 271, 30222-30226
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The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1.
L. Yenush, K. J. Makati, J. Smith-Hall, O. Ishibashi, M. G. Myers Jr., and M. F. White (1996)
J. Biol. Chem. 271, 24300-24306
   Abstract »    Full Text »    PDF »
Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors. EVIDENCE FOR A ROLE IN MITOGENIC SIGNALING.
T. J. O'Neill, D. W. Rose, T. S. Pillay, K. Hotta, J. M. Olefsky, and T. A. Gustafson (1996)
J. Biol. Chem. 271, 22506-22513
   Abstract »    Full Text »    PDF »
Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts.
B. K.R. Patel, L.-M. Wang, C.-C. Lee, W. G. Taylor, J. H. Pierce, and W. J. LaRochelle (1996)
J. Biol. Chem. 271, 22175-22182
   Abstract »    Full Text »    PDF »
Functional Importance of Amino-terminal Domain of Shc for Interaction with Insulin and Epidermal Growth Factor Receptors in Phosphorylation-independent Manner.
T. Sasaoka, H. Ishihara, T. Sawa, M. Ishiki, H. Morioka, T. Imamura, I. Usui, Y. Takata, and M. Kobayashi (1996)
J. Biol. Chem. 271, 20082-20087
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor (TNF)-alpha Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase.
P. Peraldi, G. S. Hotamisligil, W. A. Buurman, M. F. White, and B. M. Spiegelman (1996)
J. Biol. Chem. 271, 13018-13022
   Abstract »    Full Text »    PDF »
Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors.
W. He, A. Craparo, Y. Zhu, T. J. O'Neill, L.-M. Wang, J. H. Pierce, and T. A. Gustafson (1996)
J. Biol. Chem. 271, 11641-11645
   Abstract »    Full Text »    PDF »


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