Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 September 1993:
Vol. 261. no. 5128, pp. 1588 - 1591
DOI: 10.1126/science.7690497
Prev | Table of Contents | Next

Articles

Science, Vol 261, Issue 5128, 1588-1591
Copyright © 1993 by American Association for the Advancement of Science

articles

Immunoglobulin VH3 gene products: natural ligands for HIV gp120

L Berberian, L Goodglick, TJ Kipps, and J Braun

Department of Pathology and Laboratory Medicine, University of California, Los Angeles 90024.

Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed VH3 family Ig. Serum VH3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by VH3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring VH3 Ig is a second ligand for gp120 and a candidate superantigen for VH3 B cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia.
G. D. Tomaras, N. L. Yates, P. Liu, L. Qin, G. G. Fouda, L. L. Chavez, A. C. Decamp, R. J. Parks, V. C. Ashley, J. T. Lucas, et al. (2008)
J. Virol. 82, 12449-12463
   Abstract »    Full Text »    PDF »
Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis.
D. Capello, M. Martini, A. Gloghini, M. Cerri, S. Rasi, C. Deambrogi, D. Rossi, M. Spina, U. Tirelli, L. M. Larocca, et al. (2008)
Haematologica 93, 1178-1185
   Abstract »    Full Text »    PDF »
HIV-1 Envelope Triggers Polyclonal Ig Class Switch Recombination through a CD40-Independent Mechanism Involving BAFF and C-Type Lectin Receptors.
B. He, X. Qiao, P. J. Klasse, A. Chiu, A. Chadburn, D. M. Knowles, J. P. Moore, and A. Cerutti (2006)
J. Immunol. 176, 3931-3941
   Abstract »    Full Text »    PDF »
Pathogenesis of B-Cell Superantigen-Induced Immune Complex-Mediated Inflammation.
A. L. Anderson, R. Sporici, J. Lambris, D. LaRosa, and A. I. Levinson (2006)
Infect. Immun. 74, 1196-1203
   Abstract »    Full Text »    PDF »
Cryptococcus neoformans-Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans.
K. Subramaniam, N. French, and L.-a. Pirofski (2005)
Clin. Vaccine Immunol. 12, 1168-1176
   Abstract »    Full Text »    PDF »
HIV Type 1 Glycoprotein 120 Inhibits Human B Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 12, CC Chemokine Ligand (CCL)20, and CCL21.
G. Badr, G. Borhis, D. Treton, C. Moog, O. Garraud, and Y. Richard (2005)
J. Immunol. 175, 302-310
   Abstract »    Full Text »    PDF »
An immunoglobulin C{kappa}-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.
D. Ait-Azzouzene, L. Verkoczy, J. Peters, A. Gavin, P. Skog, J. L. Vela, and D. Nemazee (2005)
J. Exp. Med. 201, 817-828
   Abstract »    Full Text »    PDF »
The VP6 Protein of Rotavirus Interacts with a Large Fraction of Human Naive B Cells via Surface Immunoglobulins.
N. Parez, A. Garbarg-Chenon, C. Fourgeux, F. Le Deist, A. Servant-Delmas, A. Charpilienne, J. Cohen, and I. Schwartz-Cornil (2004)
J. Virol. 78, 12489-12496
   Abstract »    Full Text »    PDF »
Naturally Occurring Proteolytic Antibodies: SELECTIVE IMMUNOGLOBULIN M-CATALYZED HYDROLYSIS OF HIV gp120.
S. Paul, S. Karle, S. Planque, H. Taguchi, M. Salas, Y. Nishiyama, B. Handy, R. Hunter, A. Edmundson, and C. Hanson (2004)
J. Biol. Chem. 279, 39611-39619
   Abstract »    Full Text »    PDF »
Specific In Vivo Deletion of B-Cell Subpopulations Expressing Human Immunoglobulins by the B-Cell Superantigen Protein L.
M. Viau, N. S. Longo, P. E. Lipsky, L. Bjorck, and M. Zouali (2004)
Infect. Immun. 72, 3515-3523
   Abstract »    Full Text »    PDF »
Mucosal Plasma Cell Repertoire During HIV-1 Infection.
R. W. Scamurra, D. B. Nelson, X. M. Lin, D. J. Miller, G. J. Silverman, T. Kappel, J. R. Thurn, E. Lorenz, A. Kulkarni-Narla, and E. N. Janoff (2002)
J. Immunol. 169, 4008-4016
   Abstract »    Full Text »    PDF »
Structure-Function Relationships for Human Antibodies to Pneumococcal Capsular Polysaccharide from Transgenic Mice with Human Immunoglobulin Loci.
Q. Chang, Z. Zhong, A. Lees, M. Pekna, and L. Pirofski (2002)
Infect. Immun. 70, 4977-4986
   Abstract »    Full Text »    PDF »
Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation.
J. H. Roark, J. B. Bussel, D. B. Cines, and D. L. Siegel (2002)
Blood 100, 1388-1398
   Abstract »    Full Text »    PDF »
High Frequency of Virus-Specific B Lymphocytes in Germinal Centers of Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.
D. H. Margolin, E. F. Helmuth Saunders, B. Bronfin, N. de Rosa, M. K. Axthelm, X. Alvarez, and N. L. Letvin (2002)
J. Virol. 76, 3965-3973
   Abstract »    Full Text »    PDF »
B Cells of HIV-1-infected Patients Bind Virions through CD21-Complement Interactions and Transmit Infectious Virus to Activated T Cells.
S. Moir, A. Malaspina, Y. Li, T.-W. Chun, T. Lowe, J. Adelsberger, M. Baseler, L. A. Ehler, S. Liu, R. T. Davey , Jr., et al. (2000)
J. Exp. Med. 192, 637-646
   Abstract »    Full Text »    PDF »
Intestinal Microflora and Diversification of the Rabbit Antibody Repertoire.
D. Lanning, P. Sethupathi, K.-J. Rhee, S.-K. Zhai, and K. L. Knight (2000)
J. Immunol. 165, 2012-2019
   Abstract »    Full Text »    PDF »
A B Cell Superantigen-induced Persistent "Hole" in the B-1 Repertoire.
G. J. Silverman, S. P. Cary, D. C. Dwyer, L. Luo, R. Wagenknecht, and V. E. Curtiss (2000)
J. Exp. Med. 192, 87-98
   Abstract »    Full Text »    PDF »
Additive Effect of Neutralizing Antibody and Antiviral Drug Treatment in Preventing Virus Escape and Persistence.
P. Seiler, B. M. Senn, P. Klenerman, U. Kalinke, H. Hengartner, and R. M. Zinkernagel (2000)
J. Virol. 74, 5896-5901
   Abstract »    Full Text »
Impact of HIV-1 Infection on VH3 Gene Repertoire of Naive Human B Cells.
R. W. Scamurra, D. J. Miller, L. Dahl, M. Abrahamsen, V. Kapur, S. M. Wahl, E. C. B. Milner, and E. N. Janoff (2000)
J. Immunol. 164, 5482-5491
   Abstract »    Full Text »    PDF »
Characterization of Superantigen-Induced Clonal Deletion with a Novel Clan III-Restricted Avian Monoclonal Antibody: Exploiting Evolutionary Distance to Create Antibodies Specific for a Conserved VH Region Surface.
S. P. Cary, J. Lee, R. Wagenknecht, and G. J. Silverman (2000)
J. Immunol. 164, 4730-4741
   Abstract »    Full Text »    PDF »
Production of Protective Human Antipneumococcal Antibodies by Transgenic Mice with Human Immunoglobulin Loci.
N. D. Russell, J. R. F. Corvalan, M. L. Gallo, C. G. Davis, and L.-a. Pirofski (2000)
Infect. Immun. 68, 1820-1826
   Abstract »    Full Text »    PDF »
Mapping the B cell superantigen binding site for HIV-1 gp120 on a VH3 Ig.
M. N. Neshat, L. Goodglick, K. Lim, and J. Braun (2000)
Int. Immunol. 12, 305-312
   Abstract »    Full Text »    PDF »
HIV-1 gp120 Induces IL-4 and IL-13 Release from Human Fc{epsilon}RI+ Cells Through Interaction with the VH3 Region of IgE.
V. Patella, G. Florio, A. Petraroli, and G. Marone (2000)
J. Immunol. 164, 589-595
   Abstract »    Full Text »    PDF »
Primary Central Nervous System Lymphomas Are Derived from Germinal-Center B Cells and Show a Preferential Usage of the V4-34 Gene Segment.
M. Montesinos-Rongen, R. Kuppers, D. Schluter, T. Spieker, D. Van Roost, C. Schaller, G. Reifenberger, O. D. Wiestler, and M. Deckert-Schluter (1999)
Am. J. Pathol. 155, 2077-2086
   Abstract »    Full Text »    PDF »
In Vivo Selection of Neutralization-Resistant Virus Variants But No Evidence of B Cell Tolerance in Lymphocytic Choriomeningitis Virus Carrier Mice Expressing a Transgenic Virus-Neutralizing Antibody.
P. Seiler, B. M. Senn, M.-A. Brundler, R. M. Zinkernagel, H. Hengartner, and U. Kalinke (1999)
J. Immunol. 162, 4536-4541
   Abstract »    Full Text »    PDF »
Predictive Value of CD19 Measurements for Bacterial Infections in Children Infected with Human Immunodeficiency Virus.
R. A. Betensky, T. Calvelli, and S. Pahwa (1999)
Clin. Vaccine Immunol. 6, 247-253
   Abstract »    Full Text »    PDF »
AIDS Primary Central Nervous System Lymphoma: Molecular Analysis of the Expressed VH Genes and Possible Implications for Lymphomagenesis.
S. Julien, M. Radosavljevic, N. Labouret, S. Camilleri-Broet, F. Davi, M. Raphael, T. Martin, and J.-L. Pasquali (1999)
J. Immunol. 162, 1551-1558
   Abstract »    Full Text »    PDF »
Structural Basis of the gp120 Superantigen-Binding Site on Human Immunoglobulins.
S. Karray, L. Juompan, R. C. Maroun, D. Isenberg, G. J. Silverman, and M. Zouali (1998)
J. Immunol. 161, 6681-6688
   Abstract »    Full Text »    PDF »
Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection.
L. Juompan, P. Lambin, and M. Zouali (1998)
FASEB J 12, 1473-1480
   Abstract »    Full Text »
Aberrant and Unstable Expression of Immunoglobulin Genes in Persons Infected With Human Immunodeficiency Virus.
A. Bessudo, L. Rassenti, D. Havlir, D. Richman, E. Feigal, and T. J. Kipps (1998)
Blood 92, 1317-1323
   Abstract »    Full Text »    PDF »
Staphylococcal Enterotoxin A Induces Survival of VH3-Expressing Human B Cells by Binding to the VH Region with Low Affinity.
R. Domiati-Saad and P. E. Lipsky (1998)
J. Immunol. 161, 1257-1266
   Abstract »    Full Text »    PDF »
HIV-1 Antigen-specific and -nonspecific B Cell Responses Are Sensitive to Combination Antiretroviral Therapy.
L. Morris, J. M. Binley, B. A. Clas, S. Bonhoeffer, T. P. Astill, R. Kost, A. Hurley, Y. Cao, M. Markowitz, D. D. Ho, et al. (1998)
J. Exp. Med. 188, 233-245
   Abstract »    Full Text »    PDF »
In Vivo Inflammatory Response to a Prototypic B Cell Superantigen: Elicitation of an Arthus Reaction by Staphylococcal Protein A.
L. M. Kozlowski, W. Li, M. Goldschmidt, and A. I. Levinson (1998)
J. Immunol. 160, 5246-5252
   Abstract »    Full Text »    PDF »
From Natural Polyreactive Autoantibodies to A La Carte Monoreactive Antibodies to Infectious Agents: Is It a Small World after All?.
J.-P. Bouvet and G. Dighiero (1998)
Infect. Immun. 66, 1-4
   Full Text »    PDF »
Identification of the B cell superantigen-binding site of HIV-1 gp120.
S. Karray and M. Zouali (1997)
PNAS 94, 1356-1360
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)