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Science 10 September 1993: Vol. 261. no. 5127, pp. 1445 - 1448 DOI: 10.1126/science.7690156
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Articles
Science, Vol 261, Issue 5127, 1445-1448
Copyright © 1993 by American Association for the Advancement of Science
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
G Karupiah,
QW Xie,
RM Buller,
C Nathan,
C Duarte,
and
JD MacMicking
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Interferons (IFNs) induce antiviral activity in many cell types. The ability of IFN-gamma to inhibit replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages correlated with the cells' production of nitric oxide (NO). Viral replication was restored in IFN-gamma-treated macrophages exposed to inhibitors of NO synthase. Conversely, epithelial cells with no detectable NO synthesis restricted viral replication when transfected with a complementary DNA encoding inducible NO synthase or treated with organic compounds that generate NO. In mice, an inhibitor of NO synthase converted resolving ectromelia virus infection into fulminant mousepox. Thus, induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-gamma.
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| Full Text »
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| Full Text »
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| Full Text »
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
| PDF »
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J. Immunol.
166, 3533-3541
| Abstract »
| Full Text »
| PDF »
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J. Exp. Med.
193, 483-496
| Abstract »
| Full Text »
| PDF »
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- R. J. Jackson, A. J. Ramsay, C. D. Christensen, S. Beaton, D. F. Hall, and I. A. Ramshaw (2001)
J. Virol.
75, 1205-1210
| Abstract »
| Full Text »
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- P. Harle, S. Noisakran, and D. J. J. Carr (2001)
J. Immunol.
166, 1803-1812
| Abstract »
| Full Text »
| PDF »
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- U. Dittmer, K. E. Peterson, R. Messer, I. M. Stromnes, B. Race, and K. J. Hasenkrug (2001)
J. Virol.
75, 654-660
| Abstract »
| Full Text »
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- M. Franchini, C. Abril, C. Schwerdel, C. Ruedl, M. Ackermann, and M. Suter (2001)
J. Virol.
75, 83-89
| Abstract »
| Full Text »
- The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN.
- A. Alcamí, J. A. Symons, and G. L. Smith (2000)
J. Virol.
74, 11230-11239
| Abstract »
| Full Text »
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- D. F. Stojdl, N. Abraham, S. Knowles, R. Marius, A. Brasey, B. D. Lichty, E. G. Brown, N. Sonenberg, and J. C. Bell (2000)
J. Virol.
74, 9580-9585
| Abstract »
| Full Text »
- Nitric Oxide Synthesis Enhances Human Immunodeficiency Virus Replication in Primary Human Macrophages.
- D. Blond, H. Raoul, R. Le Grand, and D. Dormont (2000)
J. Virol.
74, 8904-8912
| Abstract »
| Full Text »
- Characterization of the ectromelia virus serpin, SPI-2.
- S. J. Turner, J. Silke, B. Kenshole, and J. Ruby (2000)
J. Gen. Virol.
81, 2425-2430
| Abstract »
| Full Text »
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- B. A. Lidbury and S. Mahalingam (2000)
J. Virol.
74, 8376-8381
| Abstract »
| Full Text »
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- M. M. Gherardi, J. C. Ramírez, and M. Esteban (2000)
J. Virol.
74, 6278-6286
| Abstract »
| Full Text »
- Gamma Interferon Impedes the Establishment of Herpes Simplex Virus Type 1 Latent Infection but Has No Impact on Its Maintenance or Reactivation in Mice.
- J. A. Lekstrom-Himes, R. A. LeBlanc, L. Pesnicak, M. Godleski, and S. E. Straus (2000)
J. Virol.
74, 6680-6683
| Abstract »
| Full Text »
- Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase.
- K. Uetani, S. D. Der, M. Zamanian-Daryoush, C. de la Motte, B. Y. Lieberman, B. R. G. Williams, and S. C. Erzurum (2000)
J. Immunol.
165, 988-996
| Abstract »
| Full Text »
| PDF »
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- S. F. Wieland, L. G. Guidotti, and F. V. Chisari (2000)
J. Virol.
74, 4165-4173
| Abstract »
| Full Text »
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- A. A. Nash (2000)
J. Exp. Med.
191, 1455-1458
| Full Text »
| PDF »
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- Z. Xing and K. A. Schat (2000)
J. Virol.
74, 3605-3612
| Abstract »
| Full Text »
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68, 1827-1833
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| PDF »
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J. Immunol.
164, 926-933
| Abstract »
| Full Text »
| PDF »
- IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-{gamma} and Nitric Oxide Synthetase 2.
- M. van den Broek, M. F. Bachmann, G. Kohler, M. Barner, R. Escher, R. Zinkernagel, and M. Kopf (2000)
J. Immunol.
164, 371-378
| Abstract »
| Full Text »
| PDF »
- Inducible nitric oxide synthase and cardiovascular disease.
- A. M Shah (2000)
Cardiovasc Res
45, 148-155
| Full Text »
| PDF »
- Methylation-Dependent Gene Silencing Induced by Interleukin 1{beta} via Nitric Oxide Production.
- A. Hmadcha, F. J. Bedoya, F. Sobrino, and E. Pintado (1999)
J. Exp. Med.
190, 1595-1604
| Abstract »
| Full Text »
| PDF »
- Compromised Virus Control and Augmented Perforin-Mediated Immunopathology in IFN-{gamma}-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus.
- A. Nansen, T. Jensen, J. P. Christensen, S. O. Andreasen, C. Ropke, O. Marker, and A. R. Thomsen (1999)
J. Immunol.
163, 6114-6122
| Abstract »
| Full Text »
| PDF »
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- C. Zaragoza, C. J. Ocampo, M. Saura, C. Bao, M. Leppo, A. Lafond-Walker, D. R. Thiemann, R. Hruban, and C. J. Lowenstein (1999)
J. Immunol.
163, 5497-5504
| Abstract »
| Full Text »
| PDF »
- Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology.
- C. Bartholdy, A. Nansen, J. E. Christensen, O. Marker, and A. R. Thomsen (1999)
J. Gen. Virol.
80, 2997-3005
| Abstract »
| Full Text »
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- A. Hirano, Z. Yang, Y. Katayama, J. Korte-Sarfaty, and T. C. Wong (1999)
J. Virol.
73, 4776-4785
| Abstract »
| Full Text »
- Double-stranded RNA Inhibits beta -Cell Function and Induces Islet Damage by Stimulating beta -Cell Production of Nitric Oxide.
- M. R. Heitmeier, A. L. Scarim, and J. A. Corbett (1999)
J. Biol. Chem.
274, 12531-12536
| Abstract »
| Full Text »
| PDF »
- Effect of Nitric Oxide on Rhinovirus Replication and Virus-Induced Interleukin-8 Elaboration.
- P. KAUL, I. SINGH, and R. B. TURNER (1999)
Am. J. Respir. Crit. Care Med.
159, 1193-1198
| Abstract »
| Full Text »
| PDF »
- Overexpression of Protein Kinase C Isoforms Protects RAW 264.7 Macrophages from Nitric Oxide-Induced Apoptosis: Involvement of c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase, p38 Kinase, and CPP-32 Protease Pathways.
- C.-D. Jun, C.-D. Oh, H.-J. Kwak, H.-O. Pae, J.-C. Yoo, B.-M. Choi, J.-S. Chun, R.-K. Park, and H.-T. Chung (1999)
J. Immunol.
162, 3395-3401
| Abstract »
| Full Text »
| PDF »
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- K. Hori, P. R. Burd, K. Furuke, J. Kutza, K. A. Weih, and K. A. Clouse (1999)
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- P. Boudinot, P. Massin, M. Blanco, S. Riffault, and A. Benmansour (1999)
J. Virol.
73, 1846-1852
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- N. Fujioka, R. Akazawa, K. Ohashi, M. Fujii, M. Ikeda, and M. Kurimoto (1999)
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- P. Kodukula, T. Liu, N. V. Rooijen, M. J. Jager, and R. L. Hendricks (1999)
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- E. D. Chan, B. W. Winston, S.-T. Uh, M. W. Wynes, D. M. Rose, and D. W. H. Riches (1999)
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| Full Text »
| PDF »
- Study of Dengue Virus Infection in SCID Mice Engrafted with Human K562 Cells.
- Y.-L. Lin, C.-L. Liao, L.-K. Chen, C.-T. Yeh, C.-I Liu, S.-H. Ma, Y.-Y. Huang, Y.-L. Huang, C.-L. Kao, and C.-C. King (1998)
J. Virol.
72, 9729-9737
| Abstract »
| Full Text »
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- A Redox-triggered Ras-Effector Interaction. RECRUITMENT OF PHOSPHATIDYLINOSITOL 3'-KINASE TO Ras BY REDOX STRESS.
- A. A. Deora, T. Win, B. Vanhaesebroeck, and H. M. Lander (1998)
J. Biol. Chem.
273, 29923-29928
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| Full Text »
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- Rapid Interferon {gamma}-dependent Clearance of Influenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2-deficient Mice.
- G. Karupiah, J.-H. Chen, S. Mahalingam, C. F. Nathan, and J. D. MacMicking (1998)
J. Exp. Med.
188, 1541-1546
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- Integrin-mediated Ras-Extracellular Regulated Kinase (ERK) Signaling Regulates Interferon {gamma} Production in Human Natural Killer Cells.
- F. Mainiero, A. Gismondi, A. Soriani, M. Cippitelli, G. Palmieri, J. Jacobelli, M. Piccoli, L. Frati, and A. Santoni (1998)
J. Exp. Med.
188, 1267-1275
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- A Role for Transforming Growth Factor-beta 1 in the Increased Pneumonitis in Murine Allogeneic Bone Marrow Transplant Recipients With Graft-Versus-Host Disease After Pulmonary Herpes Simplex Virus Type 1 Infection.
- H. Adler, J. L. Beland, W. Kozlow, N. C. Del-Pan, L. Kobzik, and I. J. Rimm (1998)
Blood
92, 2581-2589
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- Resistance to Murine Hepatitis Virus Strain 3 Is Dependent on Production of Nitric Oxide.
- M. Pope, P. A. Marsden, E. Cole, S. Sloan, L. S. Fung, Q. Ning, J. W. Ding, J. L. Leibowitz, M. J. Phillips, and G. A. Levy (1998)
J. Virol.
72, 7084-7090
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- Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection.
- G. Karupiah, J.-H. Chen, C. F. Nathan, S. Mahalingam, and J. D. MacMicking (1998)
J. Virol.
72, 7703-7706
| Abstract »
| Full Text »
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- Protective Role of Gamma Interferon during the Recall Response to Influenza Virus.
- A. Bot, S. Bot, and C. A. Bona (1998)
J. Virol.
72, 6637-6645
| Abstract »
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- Double-stranded RNA-induced Inducible Nitric-oxide Synthase Expression and Interleukin-1 Release by Murine Macrophages Requires NF-kappa B Activation.
- M. R. Heitmeier, A. L. Scarim, and J. A. Corbett (1998)
J. Biol. Chem.
273, 15301-15307
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- Does Nitric Oxide Play a Critical Role in Viral Infections?.
- C. S. Reiss and T. Komatsu (1998)
J. Virol.
72, 4547-4551
| Full Text »
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- The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide.
- S. Luckhart, Y. Vodovotz, L. Cui, and R. Rosenberg (1998)
PNAS
95, 5700-5705
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- The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis.
- C. Zaragoza, C. Ocampo, M. Saura, M. Leppo, X.-Q. Wei, R. Quick, S. Moncada, F. Y. Liew, and C. J. Lowenstein (1998)
PNAS
95, 2469-2474
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- Protective Role of Nitric Oxide in Staphylococcus aureus Infection in Mice.
- S. Sasaki, T. Miura, S. Nishikawa, K. Yamada, M. Hirasue, and A. Nakane (1998)
Infect. Immun.
66, 1017-1022
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- Distinct Pathways for Tumor Necrosis Factor Alpha and Ceramides in Human Cytomegalovirus Infection.
- J. Allan-Yorke, M. Record, C. de Preval, C. Davrinche, and J.-L. Davignon (1998)
J. Virol.
72, 2316-2322
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- Effect of Nitric Oxide on Poliovirus Infection of Two Human Cell Lines.
- J. A. Lopez-Guerrero and L. Carrasco (1998)
J. Virol.
72, 2538-2540
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- Inhibition of NF-kappa B and HIV-1 Long Terminal Repeat Transcriptional Activation by Inducible Nitric Oxide Synthase 2 Activity.
- D. Sekkai, F. Aillet, N. Israel, and M. Lepoivre (1998)
J. Biol. Chem.
273, 3895-3900
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- Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1{alpha} (MIP-1{alpha})-dependent Pathways.
- T. P. Salazar-Mather, J. S. Orange, and C. A. Biron (1998)
J. Exp. Med.
187, 1-14
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- Interferon (IFN)-{alpha} Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti-Hepatitis C Effects of IFN-{alpha} In Vivo.
- A. I. Sharara, D. J. Perkins, M. A. Misukonis, S. U. Chan, J. A. Dominitz, and J. B. Weinberg (1997)
J. Exp. Med.
186, 1495-1502
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- Role of nitric oxide in poly(I-C)-induced endothelial cell expression of leukocyte adhesion molecules.
- T. R. Faruqi, S. C. Erzurum, F. T. Kaneko, and P. E. Dicorleto (1997)
Am J Physiol Heart Circ Physiol
273, H2490-H2497
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- Low-Dose N{omega}-Nitro-L-Arginine Methyl Ester Treatment Improves Survival Rate and Decreases Myocardial Injury in a Murine Model of Viral Myocarditis Induced by Coxsackievirus B3.
- S. Mikami, S. Kawashima, K. Kanazawa, K.-i. Hirata, H. Hotta, Y. Hayashi, H. Itoh, and M. Yokoyama (1997)
Circ. Res.
81, 504-511
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